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February 18, 2013 Pill Identifier Search

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home > drugs a-z list > nexavar (sorafenib) side effects drug center > nexavar (sorafenib) drug

Nexavar
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NEXAVAR (sorafenib) Tablets

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NEXAVAR, a kinase inhibitor, is the tosylate salt of sorafenib. Sorafenib tosylate has the chemical name 4-(4-{3-[4-Chloro-3(trifluoromethyl)phenyl]ureido}phenoxy)N2- methylpyridine-2-carboxamide 4methylbenzenesulfonate and its structural formula is:

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Sorafenib tosylate is a white to yellowish or brownish solid with a molecular formula of C21H16ClF3N4O3 x C7H8O3S and a molecular weight of 637.0 g/mole. Sorafenib tosylate is practically insoluble in aqueous media, slightly soluble in ethanol and soluble in PEG 400. Each red, round NEXAVAR film-coated tablet contains sorafenib tosylate (274 mg) equivalent to 200 mg of sorafenib and the following inactive ingredients: croscarmellose sodium, microcrystalline cellulose, hypromellose, sodium lauryl sulphate, magnesium stearate, polyethylene glycol, titanium dioxide and ferric oxide red.

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What are the possible side effects of sorafenib (Nexavar)?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; sw elling of your face, lips, tongue, or throat. Stop using sorafenib and call your doctor at once if you have a serious side effect such as: rash, blisters, oozing, or severe pain in the palms of your hands or the soles of your feet; mouth sores; black, bloody, or tarry stools; coughing up blood or vomit that looks like coffee grounds;

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What are the precautions when taking sorafenib (Nexavar)?

Before taking sorafenib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, w hich can cause allergic reactions or other problems. Talk to your pharmacist for more details. Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, heart problems (e.g., heart attack, angina), high blood pressure, liver problems. Sorafenib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right aw ay. The risk of QT prolongation may be increased if you...

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Last reviewed on RxList: 9/21/2012 This monograph has been modified to include the generic and brand name in many instances.

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Report Problems to the Food and Drug Administration You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

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