TRANQUIL 30 Capsules

HawthornMedicinal use Some species are used in Western herbal medicine, where the plant is believed to strengthen cardiovascular function. In recent years, this use has been noted and adopted by Chinese herbalists as well. Hawthorn is also used as an aid to lower blood pressure, lower cholesterol, and treat some heart related diseases.Hawthorn has been used for heart failure, irregular heart beat (arrhythmia), heart pain (angina), high or low blood pressure and for blood circulation. Hawthorn has also been used as a sedative. Magnolia Magnolia bark, Magnolia officinalis Rehd. et Wils., M. glauca L. and other Magnolia species [Fam. Magnoliace], is a traditional Chinese medicine known as houpu or hou po used since 100 A.D. for treating "stagnation of qi" (low energy) as well as a variety of syndromes, such as digestive disturbances caused by emotional distress and emotional turmoil. All magnolia species have been found to have similar active ingredients and are used interchangeably. The bark and flowers of Sweet Bay Magnolia, M. glauca L., are also recommended for treating chest pain and fainting, although no studies have been done to substantiate their effectiveness for treating these problems. Magnolia bark is generally used as an anti-stress and anti-anxiety agent. Medical research indicates that magnolia's anti-stress benefits are linked to it's ability to control levels of the body's primary stress hormone, cortisol. Myriad health benefits are associated with normal cortisol levels versus elevated cortisol. Elevated cortisol levels are associated with conditions including obesity, diabetes, osteoporosis, memory problems and suppressed immune function. Magnolia bark is rich in two biphenol compounds, (magnolol and honokiol), which are thought to contribute to the primary anti-stress and cortisol-lowering effects of the plant. Two of the most popular herbal medicines used in Japan, one called saiboku-to and another called hange-kobuku-to, contain magnolia bark and have been used for treating ailments from bronchial asthma to depression to anxiety. Japanese researchers have determined that the magnolol and honokiol components of Magnolia officinalis are one thousand times more potent than alpha-tocopherol (vitamin E) in their antioxidant activity, thereby offering a potential heart-health benefit. Research has shown both magnolol and honokiol to possess powerful "brain-health" benefits via their actions in modulating the activity of various neurotransmitters and related enzymes in the brain (increased choline acetyltransferase activity, inhibition of acetylcholinesterase, and increased acetylcholine release

26 ( 3 )

Passion flower Medical and entheogenic uses Maypop (P. incarnata) leaves and roots have a long history of use among Native Americans in North America and were adapted by the colonists. The fresh or dried leaves of Maypop are used to make an infusion, a tea that is used to treat insomnia, hysteria, and epilepsy, and is also valued for its painkilling properties. Maracuj (P. edulis) and a few other species are used in Central and South America for similar purposes. Harman, a harmala alkaloid found in many species of Passiflora. Many species have been found to contain betacarboline harmala alkaloids which are MAOIs with anti-depressant properties. The flower and fruit has only traces of these chemicals, but the leaves and the roots are often more potent and have been used to enhance the effects of mind-altering drugs. Once dried, the leaves can also be smoked. Chrysin, a commercially important flavone found in the Blue Passion Flower. Blue Passion Flower (P. caerulea) and perhaps others contain chrysin, a flavone with confirmed anxiolytic properties. The medical utility of very few species of Passiflora has been scientifically studied. In initial trials against generalized anxiety disorder, Maypop extract performed as well as oxazepam but with less short-term side effects. St Johns Wort-St John's wort is today most widely known as a herbal treatment for major depression. In some countries, such as Germany, it is commonly prescribed for mild depression, especially in children, adolescents, and where cost is a concern. Standardized extracts are generally available over the counter however, in some countries (such as Ireland) a prescription is required. Extracts are usually in tablet or capsule form, and also in teabags and tinctures.The exact mechanism by which St John's wort and even conventional antidepressants functions is unclear and subject to conjecture. The St John's wort mechanism is believed to involve inhibition of serotonin (5-HT) reuptake, much like the conventional selective serotonin reuptake inhibitor (SSRI) antidepressants.[The major active antidepressive constituents in St John's wort are thought to be hyperforin and hypericin, although other biologically active constituents present, for example, flavonoids and tannins, may also be involved Valerian. Mechanism of action Because of valerian's historical use as a sedative, anti-convulsant, migraine treatment and pain reliever, most basic science research has been directed at the interaction of valerian constituents with the GABA neurotransmitter receptor system. These studies remain inconclusive and all require independent replication. 26 ( 3 )

The mechanism of action of valerian in general, as a mild sedative in particular, remains unknown. Valerian extracts appear to have some affinity for the GABAA (benzodiazepine) receptor. Valerian also contains isovaltrate, which has been shown to be an agonist for adenosine A1 receptor sites[This action may contribute to the herb's sedative effects

Medicinal use
Valerian is used for insomnia and other disorders and can be a useful alternative to benzodiazepine drugs. Valerian is used against sleeping disorders, restlessness and anxiety, and as a muscle relaxant. Valerian often seems only to work when taken over longer periods (several weeks), though many users find that it takes effect immediately[citation needed]. Some studies have demonstrated that valerian extracts interact with the GABA and benzodiazepine receptors. Valerian is sometimes recommended as a first-line treatment when benefit-risk analysis dictates. Valerian is often indicated as transition medication when discontinuing benzodiazepines. Valerian has uses in herbal medicine as a sedative. The main current use of valerian is as a remedy for insomnia, with a recent meta-analysis providing some evidence of effectiveness.

CONTRAINDICATIONS/SIDE EFFECTS
Nausea, stomach upset, dizziness or drowsiness may occur. : If you have any of the following health problems, consult your doctor before using this product: heart disease (e.g., heart failure, angina), irregular pulse (arrhythmia), high or low blood pressure. This product may make you dizzy or drowsy; use caution engaging in activities requiring alertness such as driving or using machinery. Limit alcohol intake because it can intensify the dizziness or drowsiness effects of this product. Caution is advised if you have diabetes, alcohol dependence or liver disease

26 ( 3 )