Ancer: 1.6 Million

Few things cause more fear and apprehension
than a cancer diagnosis. But todaybecause

of early detection and a steady stream of new
and improved treatmentscancer increasingly
can be managed and even beaten. But patients
and their families are looking for more and bet-
ter treatments, and Americas biopharmaceuti-
cal research companies are responding.
Biopharmaceutical researchers are now work-
ing on 981 medicines for cancer. Many are
|||-lec| Weapors lo l|l l|e d|sease, W|||e
some involve innovative research into using
existing medicines in new ways.
Researchers deep commitment to patients and
advancing science is at the core of the remark-
ao|e proress rade |r l|l|r carcer. lr re-
cerl years We |ave seer s|r|lcarl dec||res |r
cancer deaths. The number of cancer survivors
living in the United States has increased from
3 million in 1971 to nearly 12 million in 2008.
The increase in survivors is attributed in large
measure to earlier diagnosis and detection and
better treatments and follow-up care.
Americas biopharmaceutical research com-
panies are working on many new cutting-edge
approac|es lo l|l carcer. T|ey |rc|ude:
A red|c|re l|al |rlerleres W|l| l|e re-
tabolism of cancer cells by depriving them
of the energy provided by glucose.
A red|c|re lor acule rye|o|d |eu|er|a
(AML) that inhibits cancer cells with a
mutation found in about a third of AML
sufferers.
A l|erapy l|al uses rarolec|ro|oy lo
target the delivery of medicines to cancer
cells, potentially overcoming some limita-
tions of existing treatments.
Despite recent progress, cancer remains the
second leading cause of death by disease
in the United States, exceeded only by heart
d|sease. lr 2012, sore 5ZZ,190 Arer|cars are
expecled lo d|e ol carcerrore l|ar 1,500
people a day. The hundreds of new medicines
to treat cancer now being developed are our
best hope for lessening the burden of cancer to
patients, their families and society.
More Than 900 Medicines and Vaccines in
Clinical Testing Offer New Hope in the Fight
Against Cancer
Medicines in Development
CANCER
PRESENTED BY AMERICAS BIOPHARMACEUTICAL
RESEARCH COMPANIES
2
0
1
2

R
E
P
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R
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111
66
121
117
94
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67
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C
a
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Medicines in Development
for Selected Cancer Types
More Than
1.6 million
New Cases
of Cancer
Are Expected
This Year
Medicines in Development Cancer 2012
2
For rore |rlorral|or aooul a spec|lc red|c|re |r l||s reporl, p|ease ca|| l|e le|ep|ore ruroer ||sled.
Lung Cancer
Liver Cancer
Leukemia
Kidney Cancer
Head/Neck Cancer
Colorectal Cancer
Cervical Cancer
Breast Cancer
Brain Cancer
Bladder Cancer 9
62
66
111
8
25
35
120
36
121
Multiple Myeloma
Lymphoma 117
57
Ovarian Cancer 63
Cancer-Related Conditions
Stomach Cancer
Solid Tumors
Skin Cancer
Sarcoma
Prostate Cancer
Pancreatic Cancer
94
58
21
67
280
23
38
Unspecified Cancer
Other Cancers 102
72
* Some medicines are listed in more than one category.
Medicines in Development for Cancer
*
BLADDER CANCER
Product Name Sponsor Indication Development Status*
Abraxane
albumin-bound paclitaxel
Celgene
Summit, NJ
second-line bladder cancer
(see also breast, lung, ovarian,
pancreatic, skin)
P|ase ll
(908) 673-9000
AEZS-108 AEterna Zentaris
Basking Ridge, NJ
(see also ovarian, prostate, other) P|ase ll
(908) 2-5128
BC-819
(gene therapy)
BioCancell Therapeutics
Jerusalem, Israel
(see also ovarian, pancreatic) P|ase ll
www.biocancell.com
EN3188
(mycobacterium cell wall-DNA
complex)
Endo Pharmaceuticals
Chadds Ford, PA
non-muscle invasive bladder cancer
(Fast Track)
P|ase lll
(10) 558-9800
3
BLADDER CANCE
Product Name Sponsor Indication Development Status
EOquin
apaziquone
Allergan
Irvine, CA
Spectrum Pharmaceuticals
Irvine, CA
non-invasive bladder cancer
(Fast Track)
P|ase lll
(919) Z88-Z00
Folotyn
pralatrexate
(Orphan Drug)
Allos Therapeutics
Westminster, CO
(see also breast, lung, lymphoma) P|ase ll
(303) 12-22
icrucumab
(LY3012212/lVC-18F1)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
(see also breast, colorectal) P|ase ll
(800) 515-59Z9
tesetaxel Genta
Berkeley Heights, NJ
second-line bladder cancer
(see also breast, prostate, skin,
stomach)
P|ase ll
(908) 286-9800
v81-815 Viventia Biotechnologies
Mississauga, Canada
(see also head/neck) P|ase ll
(905) 32-29Z3
BRAIN CANCER
8l9 l-131 rAo United Therapeutics
Silver Spring, MD
(see also sarcoma, other) P|ase l
(301) 608-9292
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
(see also breast, colorectal, lung,
lymphoma, ovarian, prostate, skin,
other)
P|ase l
(81Z) 93Z-100
AC180
(pan-HER inhibitor)
Ambit Biosciences
San Diego, CA
glioma
(see also breast, lung)
P|ase l
(858) 331-2100
AEE788 Novartis Pharmaceuticals
East Hanover, NJ
glioblastoma P|ase l/ll
(888) 669-6682
afatinib
(8l8w2992)
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
glioblastoma
(see also breast, head/neck, lung)
P|ase l/ll
(800) 213-012Z
APN301
(c|11.18 rAo/|rler|eu||r-2
fusion protein)
Apeiron Biologics
Vienna, Austria
neuroblastoma in children
(see also skin)
P|ase ll corp|eled
www.apeiron-biologics.com
4
BRAIN CANCER
AR-67 Arno Therapeutics
Flemington, NJ
glioblastoma
(see also leukemia, solid tumors)
P|ase ll
(862) 703-7170
ARC-100 Archer Biosciences
New York, NY
glioblastoma (recurrent)
(see also breast, prostate, skin)
--------------------------------------------------
neuroblastoma
(combination therapy)
--------------------------------------------------
medulloblastoma
P|ase ll
(1) Z1Z-9090
-------------------------------------------
P|ase l/ll
(1) Z1Z-9090
-------------------------------------------
P|ase l
(1) Z1Z-9090
AT-101
(oral pan Bcl-2 inhibitor)
Ascenta Therapeutics
Malvern, PA
glioblastoma
(see also leukemia, lung, lymphoma,
prostate, stomach)
P|ase ll
(10) 108-0301
Avastin
bevacizumab
Genentech
South San Francisco, CA
lrsl-||re ||oo|aslora ru|l|lorre
ovarian, other)
P|ase lll
(800) 2-3553
Azedra
rela|odooerzy|uar|d|re l-131
(Orphan Drug)
Vo|ecu|ar lrs||ls P|arraceul|ca|s
Cambridge, MA
neuroblastoma (pediatric)
(Fast Track), paraganglioma,
pheochromocytoma (Fast Track)
P|ase ll
(1Z) 192-5551
bafetinib CytRx
Los Angeles, CA
second-line brain cancer
(see also leukemia, prostate)
P|ase l
(310) 82-518
BKM120
(Pl3K |r||o|lor)
Novartis Pharmaceuticals
East Hanover, NJ
glioblastoma
(see also breast, lung, other)
P|ase l/ll
(888) 669-6682
c|11.18 rAo
(Orphan Drug)
United Therapeutics
Silver Spring, MD
neuroblastoma (children) P|ase lll
(301) 608-9292
cilengitide
(Orphan Drug)
EMD Serono
Rockland, MA
newly-diagnosed glioblastoma
(see also prostate)
P|ase lll
(800) 283-8088
cintredekin besudotox
(Orphan Drug)
lN3Y3 T|erapeul|cs
Phoenix, AZ
glioma (adolescents and children)
(Fast Track)
P|ase l
(602) 910-2617
Cotara
monoclonal antibody TNT-1

(Orphan Drug)
Peregrine Pharmaceuticals
Tusr|n, 0/
recurrent glioblastoma
(Fast Track)
P|ase ll
(Z11) 508-000
CPP-1X
(elorr|l||re)
Cancer Prevention Pharmaceuticals
Tuoson, /Z
neuroblastoma P|ase l
(520) 908-ZZZ1
5
BRAIN CANCER
crenolanib
(CP-88-59)
AROG Pharmaceuticals
0a||as, TX
glioma (adults)
(see also stomach)
--------------------------------------------------
glioma (pediatric)
P|ase ll
(211) 591-0002
-------------------------------------------
P|ase l
(211) 591-0002
DCVax
-Brain
brain cancer vaccine
(Orphan Drug)
Northwest Biotherapeutics
Bethesda, MD
glioblastoma P|ase ll
(210) 19Z-9021
EZ050 Eisai
Woodcliff Lake, NJ
second-line glioblastoma
(see also head/neck, liver, skin,
solid tumors, stomach)
P|ase l/ll
(888) 122-1Z13
E7080
(lenvatinib)
Eisai
Woodcliff Lake, NJ
glioma
(see also skin, other)
P|ase ll
(888) 122-1Z13
EPO-806
(patupilone)
East Hanover, NJ
brain metastases from lung cancer
(see also prostate)
P|ase ll
(888) 669-6682
G-100 prophage cancer vaccine
(vitespen)
(Orphan Drug)
Agenus
Lexington, MA
newly-diagnosed glioma P|ase ll
(Z81) Z1-1100
G-200 prophage cancer vaccine
(vitespen)
(Orphan Drug)
Agenus
Lexington, MA
recurrent glioma P|ase ll
(Z81) Z1-1100
GliAtak
gene therapy
(Orphan Drug)
Advantagene
Auburndale, MA
glioma
--------------------------------------------------
brain cancer (children)
P|ase ll
(1Z) 91-5115
-------------------------------------------
P|ase l
(1Z) 91-5115
GMB-Vax
dendritic cell cancer vaccine
Activartis Biotech
Vienna, Austria
lrsl-||re ||oo|aslora P|ase ll
www.activartis.com
0RN1005
(LRP directed peptide-drug
conjugate)
Geron
Menlo Park, CA
brain metastases
--------------------------------------------------
glioma
P|ase ll
(50) 1Z3-ZZ00
-------------------------------------------
P|ase l corp|eled
(50) 1Z3-ZZ00
03K211813
(BRaf protein kinase inhibitor)
GlaxoSmithKline
Pson. Tr|ang|e Park, h0
brain metastases from melanoma
(see also lung, skin)
P|ase ll
(888) 825-5219
Hycamtin
topotecan
GlaxoSmithKline
metastatic brain cancer P|ase lll
(888) 825-5219
6
BRAIN CANCER
lCT-10Z
(dendritic cell vaccine)
(Orphan Drug)
lrruroCe||u|ar T|erapeul|cs
Woodland Hills, CA
glioblastoma P|ase ll
(818) 992-2907
Levulan
PDT
aminolevulinic acid
DUSA Pharmaceuticals
Wilmington, MA
P|ase ll
(9Z8) 5Z-Z500
lonafarnib Merck
Whitehouse Station, NJ
glioblastoma P|ase l
(800) 672-6372
Lucanix
belagenpumatucel-L
NovaRx
San Diego, CA
glioma
(see also lung)
P|ase l
(858) 522-800
macitentan Actelion Pharmaceuticals US
glioblastoma (combination therapy) P|ase l
(50) 21-900
VE0l-5Z5
(anti-PDGFR-alpha mAb)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
glioblastoma
(see also lung)
P|ase ll
(800) 236-9933
(301) 398-0000
mibefradil
(T-type calcium channel
inhibitor)
(Orphan Drug)
Tau Therapeutics
Charlottesville, VA
(131) 9Z1-99
rolexalr ado||r|ur Pharmacyclics
Sunnyvale, CA
glioblastoma (combination therapy) P|ase ll
(108) ZZ1-0330
nimotuzumab
(Orphan Drug)
YM Biosciences USA
Lehigh Valley, PA
metastatic brain cancer,
recurrent glioma (pediatric)
(see also breast, prostate)
P|ase ll
(10) 50-000
olaratumab
(LY3012207)
Eli Lilly
Indianapolis, IN
lrC|ore 3yslers
Bridgewater, NJ
glioblastoma
(see also ovarian)
P|ase ll
(800) 515-59Z9
Opaxio
paclitaxel poliglumex
Cell Therapeutics
Seattle, WA
glioma, glioblastoma
(see also lung, ovarian, stomach,
other)
P|ase ll
(800) 215-2355
perifosine AEterna Zentaris
Basking Ridge, NJ
refractory metastatic glioma
(see also colorectal, kidney,
leukemia, lung, lymphoma, multiple
myeloma, sarcoma, solid tumors,
stomach)
P|ase ll
(908) 2-5128
7
BRAIN CANCER
PLX3397
(CSF-1R kinase inhibitor)
Plexxikon
Berkeley, CA
recurrent glioblastoma
(see also leukemia, lymphoma,
solid tumors)
P|ase ll
(510) 1Z-1000
Po|y-lCLC
(Orphan Drug)
Oncovir
Washington, DC
anaplastic astrocytoma (adolescents
and children), glioblastoma
(adolescents and children)
P|ase ll
www.oncovir.com
PX-866 Oncothyreon
Seattle, WA
(see also head/neck, lung, prostate)
P|ase ll
(206) 801-2100
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
glioma
(see also colorectal, head/neck, lung,
ovarian, pancreatic, sarcoma,
skin, solid tumors)
P|ase l/ll
(103) Z0-Z3ZZ
rindopepimut
(Orphan Drug)
Celldex Therapeutics
Needham, MA
lrsl-||re ||oo|aslora
(Fast Track)
--------------------------------------------------
(Fast Track)
P|ase lll
(Z81) 133-0ZZ1
-------------------------------------------
P|ase ll
(Z81) 133-0ZZ1
SB-313-xTZ Sangamo Biosciences
Richmond, CA
(510) 9Z0-000
SBG Biotec Pharmacon
Troms, horuay
neuroblastoma (pediatric) P|ase l/ll corp|eled
www.biotec.no
SL-701
(brain cancer vaccine)
Stemline Therapeutics
New York, NY
glioma (adults)
--------------------------------------------------
glioma (children)
P|ase l/ll
(212) 831-1111
-------------------------------------------
P|ase l/ll
(212) 831-1111
SPRYCEL
dasatinib
Bristol-Myers Squibb
Princeton, NJ
glioblastoma
(see also breast, pancreatic,
prostate, other)
in clinical trials
(800) 332-205
Tarceva
erlotinib
(Orphan Drug)
Genentech
03l P|arraceul|ca|s
Farmingdale, NY
late-stage brain metastases,
recurrent ependymoma (children),
glioblastoma
(see also breast, head/neck,
leukemia, liver, lung, other)
P|ase ll
(800) 2-3553
(631) 962-0600
terameprocol Erimos Pharmaceuticals
lousron, TX
glioma (intravenous)
(see also cervical, head/neck,
solid tumors, other)
P|ase l/ll
(Z13) 511-2000
TGF- R1 inhibitor
(LY215Z299)
Eli Lilly
Indianapolis, IN
(see also liver) P|ase ll
(800) 515-59Z9
8
BRAIN CANCER
TH-302 Threshold Pharmaceuticals
astrocytoma
(see also leukemia, multiple
myeloma, pancreatic, sarcoma)
P|ase ll
(50) 1Z1-8200
Toca 511/Toca FC
(cytosine deaminase gene
therapy)
Tocagen
San Diego, CA
glioblastoma P|ase l/ll
(858) 112-8100
trans-sodium crocetinate (TSC)
(Orphan Drug)
Diffusion Pharmaceuticals
Charlottesville, VA
gliobastoma P|ase l/ll
(131) 220-0Z18
Tvl-8ra|r-1
(cellular immunotherapy
vaccine)
TVAX Biomedical
Lenexa, KS
glioma P|ase ll
(913) 192-2221
VAL-083 Del Mar Pharmaceuticals
Vancouver, Canada
rade lv ra||rarl ||ora P|ase l/ll
(01) 29-5989
VB-111 VBL Therapeutics
Or Yehuda, Israel
glioblastoma
(see also other)
P|ase l/ll
www.vblrx.com
Xeloda
capecitabine
Genentech
newly-diagnosed glioma
(adolescents and children)
(see also colorectal, liver, stomach)
P|ase l
(800) 2-3553
Zelboraf
vemurafenib
Genentech
Plexxikon
Berkeley, CA
brain metastases
(see also colorectal, other)
P|ase ll
(800) 2-3553
BREAST CANCER
18F-luorol|yr|d|re Merck
breast cancer (diagnosis) P|ase ll
(800) 672-6372
Abraxane
Celgene
Summit, NJ
lrsl-||re relaslal|c oreasl carcer
(see also bladder, lung, ovarian,
pancreatic, skin)
P|ase ll
(908) 673-9000
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
(see also brain, colorectal, lung,
other)
P|ase ll
(81Z) 93Z-100
AC180
(pan-HER inhibitor)
Ambit Biosciences
San Diego, CA
(see also brain, lung) P|ase l
(858) 331-2100
9
BREAST CANCER
acolbifene
(1l|-ereral|or 3ERV)
EndoCeutics
Quebec, Canada
P|ase ll
(118) 53-0033
AE37 peptide vaccine Antigen Express
Worcester, MA
(see also ovarian) P|ase ll
(508) 852-8Z83
afatinib
(8l8w2992)
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
second-line metastatic breast cancer
(see also brain, head/neck, lung)
--------------------------------------------------
lrsl-||re oreasl carcer
P|ase lll
(800) 213-012Z
-------------------------------------------
P|ase ll
(800) 213-012Z
alrox|lere ASCEND Therapeutics
Herndon, VA
breast cancer (prevention) P|ase ll
(Z03) 1Z1-1Z11
$QLWRU
everolimus
East Hanover, NJ
HER2-positive breast cancer
(see also kidney, lymphoma)
P|ase lll
(888) 669-6682
AFP11 Kirax
Bonita Springs, FL
P|ase ll
(239) 111-5100
amrubicin Celgene
Summit, NJ
late-stage breast cancer
(see also lung)
P|ase l/ll
(908) 673-9000
New York, NY
(see also brain, prostate, skin) P|ase ll
(1) Z1Z-9090
ARRY-380
(HER2 inhibitor)
Array BioPharma
Boulder, CO
P|ase l
(8ZZ) 33-213
AUY922
(Hsp90 inhibitor)
East Hanover, NJ
breast cancer (monotherapy)
(see also colorectal, lung, multiple
myeloma, stomach)
--------------------------------------------------
breast cancer (combination therapy)
P|ase ll
(888) 669-6682
-------------------------------------------
P|ase l/ll
(888) 669-6682
10
BREAST CANCER
Avastin
bevacizumab
Genentech
adjuvant HER2-negative breast can-
cer, adjuvant HER2-positive breast
cancer, adjuvant triple negative
breast cancer
ovarian, other)
P|ase lll
(800) 2-3553
AZD8931
(erbB kinase inhibitor)
AstraZeneca
Wilmington, DE
advanced breast cancer
(see also solid tumors)
P|ase ll
(800) 236-9933
8AY 8-5011
(lonaprisan)
Bayer HealthCare Pharmaceuticals
Wayne, NJ
metastatic breast cancer P|ase ll corp|eled
(888) 812-293Z
8ll8 2021 8|oer ldec
Cambridge, MA
(see also stomach) P|ase ll corp|eled
(617) 679-2000
BKM120
(Pl3K |r||o|lor)
East Hanover, NJ
second-line breast cancer
(see also brain, lung, other)
P|ase l/ll
(888) 669-6682
breast cancer vaccine
0uarlur lrruro|o|cs
Tama, FL
P|ase l/ll
(8) 213-1591
brostallicin Cell Therapeutics
Seattle, WA
triple-negative breast cancer P|ase l
(800) 215-2355
BTSCAN Molecular Targeting Technologies
West Chester, PA
breast cancer (diagnosis) P|ase l
(610) 738-7938
BZL-101 Bionovo
Emeryville, CA
P|ase l
(510) 01-2000
cabozantinib
(XL181)
Exelixis
(see also kidney, lung, ovarian,
prostate, other)
P|ase ll
(50) 83Z-Z000
cancer vaccine MabVax Therapeutics
San Diego, CA
(see also sarcoma) P|ase l
(858) 259-9105
CDX-011
(glembatumumab vedotin)
Needham, MA
breast cancer (Fast Track)
(see also skin)
P|ase ll
(Z81) 133-0ZZ1
CV-301
(cancer vaccine)
8N lrruroT|erapeul|cs
Mountain View, CA
metastatic breast cancer P|ase ll
(50) 81-10
D-1MT NewLink Genetics
Ames, IA
P|ase l/ll
(515) 29-5555
11
BREAST CANCER
dalotuzumab
(VK-01)
Merck
second-line breast cancer
(see also lung, pancreatic, other)
--------------------------------------------------
P|ase ll
(800) 672-6372
-------------------------------------------
P|ase l
(800) 672-6372
DPX-0907 lrrurovacc|re
Halifax, Canada
(see also ovarian, prostate) P|ase l
(902) 192-1819
eniluracil Adherex Technologies
metastatic breast cancer
P|ase ll
(919) 3-1530
entinostat Syndax Pharmaceuticals
Waltham, MA
leukemia, lung, lymphoma)
P|ase ll
(Z81) 119-1100
etirinotecan pegol
(NKTR-102)
Nektar Therapeutics
San Francisco, CA
(see also colorectal, ovarian,
solid tumors)
P|ase lll
(855) 182-58Z
EZN-2208
(PE0-3N38, lrlecar peo|)
Enzon Pharmaceuticals
Piscataway, NJ
(see also colorectal, solid tumors)
P|ase ll
(9Z3) 980-1500
Faslodex
fulvestrant
AstraZeneca
Wilmington, DE
lrsl-||re advarced oreasl carcer P|ase lll
(800) 236-9933
folate binding protein (E39)
vaccine
Galena Biopharma
Lake Oswego, OR
(see also ovarian, other) P|ase l
(855) 855-1253
Folotyn
pralatrexate
Allos Therapeutics
Westminster, CO
(see also bladder, lung, lymphoma) P|ase ll
(303) 12-22
ganetespib
(Hsp90i)
Synta Pharmaceuticals
Lexington, MA
(see also colorectal, leukemia, liver,
lung, multiple myeloma, pancreatic,
prostate, skin, stomach)
P|ase ll
(Z81) 2Z1-8200
ganitumab
(AV0 1Z9)
Amgen
Tnousano Daks, 0/
combination therapy
(see also colorectal, lung, pancreatic,
sarcoma)
P|ase ll
(800) ZZ2-13
GDC-0980
(Pl3 ||rase/rT0R dua|
inhibitor)
Genentech
hormone receptor-positive breast
cancer
(see also lymphoma, solid tumors)
P|ase ll
(800) 2-3553
03K2302021A
(wT1 arl|er-spec|lc carcer
immunotherapeutic)
GlaxoSmithKline
neoadjuvant breast cancer P|ase l/ll
(888) 825-5219
GVAX
Breast
cancer vaccine
BioSante Pharmaceuticals
Lincolnshire, IL
P|ase l
(81Z) 1Z8-0500
12
BREAST CANCER
lER2 arl|er-spec|lc carcer
immunotherapeutic
GlaxoSmithKline
P|ase ll
(888) 825-5219
icrucumab
(LY3012212/lVC-18F1)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
(see also bladder, colorectal)
P|ase ll
(800) 515-59Z9
imetelstat Geron
Menlo Park, CA
(see also leukemia, lung,
multiple myeloma)
P|ase ll
(50) 1Z3-ZZ00
lVT-1012 |rrurol|erapeul|c
vaccine
lrrurolope
Doylestown, PA
(see also ovarian) P|ase l
(215) 253-1180
indibulin
(Zl0-301)
Zl0PlARV 0rco|oy
New York, NY
late-stage breast cancer P|ase l/ll
(1) 211-0Z00
iniparib
(83l-201)
3arol u3
Bridgewater, NJ
neoadjuvant breast cancer
(see also lung, ovarian)
P|ase ll
(800) 981-2191
Kw-2150 Kyowa Hakko Kirin Pharma
Princeton, NJ
lrsl-||re oreasl carcer, secord-||re
breast cancer
P|ase l/ll
(609) 919-1100
LFA102
(anti-prolactin receptor anti-
body)
East Hanover, NJ
XOMA
Berkeley, CA
(see also prostate) P|ase l
(888) 669-6682
L0K9Z1
(wNT s|ra||r pal|Way
inhibitor)
East Hanover, NJ
(see also skin) P|ase l
(888) 669-6682
linifanib Abbott Laboratories
Abbott Park, IL
(see also colorectal, kidney, liver,
lung)
P|ase ll
(81Z) 93Z-100
liposome encapsulated
paclitaxel (LEP-ETU)
lrsys T|erapeul|cs
Phoenix, AZ
P|ase ll
(602) 910-2617
litronesib
(LY2523355)
Eli Lilly
Indianapolis, IN
(see also lung)
P|ase ll
(800) 515-59Z9
L0R-2010 Lorus Therapeutics
Toronro, 0anaoa
leukemia, prostate)
P|ase ll
(11) Z98-1200
Lymphoseek
Tc-99m tilmanocept
Navidea Pharmaceuticals
Dublin, OH
breast cancer (diagnosis)
(see also head/neck, skin)
application submitted
(11) Z93-Z500
13
BREAST CANCER
maraciclatide GE Healthcare
Waukesha, WI
breast cancer (diagnosis) in clinical trials
www.gehealthcare.com
VK-0Z52
(notch signaling pathway
inhibitor)
Merck
early-stage breast cancer,
late-stage breast cancer
(see also other)
P|ase l
(800) 672-6372
MK-2206
(c-akt inhibitor)
Merck
HER2-positive breast cancer
(see also other)
P|ase l
(800) 672-6372
MM-111 Merrimack Pharmaceuticals
Cambridge, MA
breast cancer (combination therapy) P|ase l/ll
(1Z) 111-1000
MM-302
(anti-HER2 antibody
doxorubicin conjugate)
Merrimack Pharmaceuticals
Cambridge, MA
P|ase l
(1Z) 111-1000
motesanib Amgen
Tnousano Daks, 0/
(see also colorectal, lung, other) P|ase l/ll
(800) ZZ2-13
MVA-BN
HER2
(HER-2/neu-based MVA
vaccine)
Mountain View, CA
P|ase l
(50) 81-10
Myocet
doxorubicin liposomal
Sopherion Therapeutics
Princeton, NJ
(combination therapy) (Fast Track)
P|ase lll
(609) 986-2020
NeuVax
carcer vacc|re EZ5
Galena Biopharma
Lake Oswego, OR
early-stage breast cancer
(prevention of relapse)
(see also prostate)
P|ase lll
(855) 855-1253
Nexavar
sorafenib
Wayne, NJ
(see also colorectal, head/neck,
kidney, leukemia, liver, lung, multiple
myeloma, ovarian, other)
P|ase lll
(888) 812-293Z
nimotuzumab YM Biosciences USA
Lehigh Valley, PA
(see also brain, prostate) P|ase l
(10) 50-000
NK-012 Nippon Kayaku
Tokyo, Jaan
(see also lung) P|ase ll
www.nipponkayaku.co.jp
OBP-301 Oncolys Biopharma
Tokyo, Jaan
(see also head/neck, liver, lung) P|ase l
www.oncolys.com
00X-12Z OncoGenex Pharmaceuticals
Bothell, WA
(see also lung, ovarian) P|ase l
(125) 8-1500
14
BREAST CANCER
onartuzumab Genentech
(see also colorectal, lung)
P|ase ll
(800) 2-3553
OPT-822/OPT-821 Optimer Biotechnology
San Diego, CA
P|ase ll/lll
(858) 909-0Z3
PB-272 (neratinib) Puma Biotechnology
Los Angeles, CA
second-line breast cancer,
P|ase ll
(121) 218-500
pertuzumab Genentech
lrsl-||re relaslal|c oreasl carcer
--------------------------------------------------
second-line late-stage breast cancer
(800) 2-3553
-------------------------------------------
P|ase ll
(800) 2-3553
pertuzumab companion
diagnostic
(lER2 Fl3l p|arr0x)
Dako
Glostrup, Denmark
Genentech
breast cancer (diagnostic) P|ase lll
www.dako.com
(800) 2-3553
pertuzumab companion
diagnostic
(HercepTest)
Dako
Glostrup, Denmark
Genentech
breast cancer (diagnosis) P|ase lll
www.dako.com
(800) 2-3553
pixantrone Cell Therapeutics
Seattle, WA
breast cancer (Fast Track)
(see also lymphoma)
P|ase ll
(800) 215-2355
PTC299 PTC Therapeutics
$ourn P|a|nle|o, hJ
(see also solid tumors, other) P|ase l/ll
(908) 222-7000
Quinamed
aroralde
Cephalon
Frazer, PA
(see also ovarian, prostate) P|ase ll
(10) 311-0200
ramucirumab
(lVC-11218)
Eli Lilly
Indianapolis, IN
lrC|ore 3yslers
Bridgewater, NJ
(see also colorectal, stomach)
P|ase lll
(800) 515-59Z9
Reximmune-C
personalized cancer vaccine

Epeius Biotechnologies
San Marino, CA
P|ase l/ll
(2) 111-95
Rexin-G
San Marino, CA
(see also pancreatic, sarcoma)
P|ase l/ll
(2) 111-95
15
BREAST CANCER
ridaforolimus ARlA0 P|arraceul|ca|s
Cambridge, MA
Merck
(see also kidney, lung, prostate,
sarcoma, other)
P|ase ll
(800) 672-6372
rucaparib Clovis Oncology
Boulder, CO
(see also ovarian) P|ase ll
(303) 25-5000
sagopilone Bayer HealthCare Pharmaceuticals
Wayne, NJ
(see also ovarian, prostate) P|ase ll corp|eled
(888) 812-293Z
sarar|ur 3V-153 |ex|drorar
injection
EUSA Pharma
Langhorne, PA
(see also multiple myeloma, prostate,
sarcoma, other)
P|ase ll
(800) 833-3533
3AR215108
(XL11Z)
(ora| Pl3K |r||o|lor)
3arol u3
Bridgewater, NJ
Exelixis
(see also other) P|ase ll
(800) 981-2191
(50) 83Z-Z000
3AR215109
(XLZ5)
(Pl3K/rT0R |r||o|lor)
3arol u3
Bridgewater, NJ
Exelixis
(see also lymphoma) P|ase ll
(800) 981-2191
(50) 83Z-Z000
3AR25212
(MM-121)
(anti-ErbB3 mAb)
Cambridge, MA
3arol u3
Bridgewater, NJ
(see also lung, ovarian) P|ase ll
(800) 981-2191
SF1 (sonodynamic therapy) SonneMed
Boston, MA
advanced breast cancer P|ase l/ll
www.sonnemed.com
SPRYCEL
dasatinib
Princeton, NJ
(see also brain, pancreatic, prostate,
other)
in clinical trials
(800) 332-205
3R 1231 3Rl lrlerral|ora|
Menlo Park, CA
P|ase ll
(50) 859-2000
Tarceva
erlotinib
Genentech
03l P|arraceul|ca|s
Farmingdale, NY
(see also brain, head/neck, leukemia,
liver, lung, other)
P|ase ll
(800) 2-3553
(631) 962-0600
tesetaxel Genta
(see also bladder, prostate, skin,
stomach)
P|ase ll
(908) 286-9800
16
BREAST CANCER
ThermoDox
Celsion
Lawrenceville, NJ
recurrent breast cancer
(see also colorectal, liver)
P|ase l/ll
(609) 896-9100
tigatuzumab
(arl|-0R5 arl|oody)
Daiichi Sankyo
Parsippany, NJ
(see also colorectal, liver, lymphoma,
ovarian, pancreatic)
P|ase ll
(9Z3) 911-200
tivozanib
(A3P1130/Av-951)
Astellas Pharma US
0eerle|o, lL
AVEO Pharmaceuticals
Cambridge, MA
(see also colorectal, kidney)
P|ase l/ll
(800) 95-1321
(1Z) 299-5000
TKl258
(dovitinib)
East Hanover, NJ
(see also kidney, multiple myeloma,
prostate, skin, other)
P|ase ll
(888) 669-6682
trabectedin Johnson & Johnson Pharmaceutical
Research & Development
Raritan, NJ
(see also ovarian, prostate, sarcoma)
P|ase lll
(800) 81Z-528
trastuzumab-DM1
(R03502)
Genentech
P|ase lll
(800) 2-3553
trastuzumab-DM1
companion diagnostic
(HercepTest)
Dako
Glostrup, Denmark
Genentech
www.dako.com
(800) 2-3553
trastuzumab-DM1
(lER2 Fl3l p|arr0x)
Dako
Glostrup, Denmark
Genentech
www.dako.com
(800) 2-3553
TRC 105
(ENG protein inhibitor)
TRACON Pharmaceuticals
San Diego, CA
(see also ovarian, prostate, other) P|ase l/ll
(858) 550-0Z80
trebananib
(AMG386)
Amgen
Tnousano Daks, 0/
ovarian, stomach, other)
P|ase ll
(800) ZZ2-13
Tykerb
lapatinib
GlaxoSmithKline
|rlarralory oreasl carcer
(see also colorectal, head/neck,
stomach)
--------------------------------------------------
adjuvarl oreasl carcer, lrsl-||re
--------------------------------------------------
(888) 825-5219
-------------------------------------------
P|ase lll
(888) 825-5219
-------------------------------------------
P|ase ll
(888) 825-5219
upamostat
(wX-Z1)
w||ex
Munich, Germany
P|ase ll
www.wilex.de
17
BREAST CANCER
varlitinib ASLAN Pharmaceuticals
Singapore
P|ase ll
www.aslanpharma.com
VeriStrat
companion diagnostic test

E0FR-TKl
Biodesix
Boulder, CO
advanced breast cancer
(diagnosis-outcome test in
HER2-overexpressing tumors)
P|ase lll
(303) 11Z-0500
YV155
(sepantronium)
Astellas Pharma US
0eerle|o, lL
(800) 95-1321
Zolinza
vorinostat
Merck
multiple myeloma, other)
P|ase ll
(800) 672-6273
Zytiga
abiraterone
Janssen Biotech
Horsham, PA
(see also prostate)
P|ase ll
(800) 52-ZZ3
CERVICAL CANCER
ADXS-HPV Advaxis
Princeton, NJ
cervical cancer, cervical
intraepithelial neoplasia
P|ase ll
(09) 152-9813
PV-00101 PharmaMar
Madrid, Spain
(see also sarcoma, other) P|ase ll
www.pharmamar.com
PV701
(replication-competent oncolytic
virus)
we||slal 8|o|o|cs
Gaithersburg, MD
(see also colorectal) P|ase ll
(210) 83-2500
lousron, TX
cervical intraepithelial neoplasia
(intravaginal)
(see also brain, head/neck, solid
tumors, other)
P|ase ll
(Z13) 511-2000
v503
(HPV virus-like particle (VLP)
vaccine)
Merck
prevention of cervical cancer,
prevention of vulvovaginal cancer
P|ase lll
(800) 672-6372
v505
(HPV vaccine)
Merck
prevention of cervical cancer P|ase ll corp|eled
(800) 672-6372
18
CERVICAL CANCER
verpasep caltespen
(cancer vaccine)
Akela Pharma
/usr|n, TX
cervical intraepithelial neoplasia P|ase l corp|eled
(512) 831-0119
VGX-3100
(DNA cancer vaccine)
lrov|o P|arraceul|ca|s
Blue Bell, PA
cervical intraepithelial neoplasia P|ase ll
(8ZZ) 11-81
COLORECTAL CANCER
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
(see also brain, breast, lung,
other)
P|ase ll
(81Z) 93Z-100
Aptocine
la|aporlr
Light Sciences Oncology
Bellevue, WA
metastatic colorectal cancer P|ase lll
(125) 95Z-8900
AUY922
(Hsp90 inhibitor)
East Hanover, NJ
second-line colorectal cancer
(see also breast, lung, multiple
myeloma, stomach)
P|ase l
(888) 669-6682
Avastin
bevacizumab
Genentech
metastatic colorectal cancer
(treatment beyond progression)
(see also brain, breast, lung, ovarian,
other)
P|ase lll
(800) 2-3553
AVX701
(CEA cancer immunotherapy)
AlphaVax
colorectal cancer prevention in
patients with advanced or metastatic
CEA-expressing malignancies
P|ase l/ll
(919) 595-0100
belinostat Spectrum Pharmaceuticals
Henderson, NV
colorectal cancer (combination
therapy)
(see also leukemia, liver, lung,
lymphoma, ovarian, other)
P|ase l/ll
(Z02) 835-300
brivanib
(VEGFR/FGFR kinase inhibitor)
Princeton, NJ
(see also liver, sarcoma)
P|ase ll
(800) 332-205
CPX-1
(|r|rolecar/loxur|d|re)
Celator Pharmaceuticals
Princeton, NJ
P|ase ll corp|eled
(09) 213-0123
CT-011 CureTech
Yavne, Israel
lrsl-||re relaslal|c co|orecla| carcer
(see also leukemia, lymphoma)
P|ase ll
www.curetechbio.com
E7820 Eisai
Woodcliff Lake, NJ
P|ase ll
(888) 122-1Z13
19
COLORECTAL CANCER
efatutazone Daiichi Sankyo
Parsippany, NJ
(see also lung, other)
P|ase ll
(9Z3) 911-200
EGEN-001 EGEN
Huntsville, AL
(see also ovarian, other) P|ase l/ll
(25) 512-00ZZ
EGFR antagonist
0lA0EN
Valencia, CA
colorectal cancer (diagnosis) application submitted
www.qiagen.com
encapsulated cell therapy
(macrobeads)
Roos|r lrsl|lule
New York, NY
refractory metastatic colorectal
cancer
(see also pancreatic, prostate)
P|ase ll
(212) Z1-15
Waltham, MA
(see also breast, kidney, leukemia,
lung, lymphoma)
P|ase ll
(Z81) 119-1100
ERBITUX
cetuximab
Princeton, NJ
Eli Lilly
Indianapolis, IN
lrsl-||re co|orecla| carcer
(see also stomach)
in clinical trials
(800) 332-205
(800) 515-59Z9
etirinotecan pegol
(NKTR-102)
Nektar Therapeutics
San Francisco, CA
(see also breast, ovarian, solid
tumors)
P|ase ll/lll
(855) 182-58Z
EZN-2208
Piscataway, NJ
(see also breast, solid tumors)
P|ase ll
(9Z3) 980-1500
FANG Vaccine
autologous tumor cell vaccine
Gradalis
0arro||ron, TX
(see also ovarian, skin) P|ase ll
(211) 112-8100
ganetespib
(Hsp90i)
Lexington, MA
refractory, metastatic colorectal
cancer
(see also breast, leukemia, liver,
P|ase ll
(Z81) 2Z1-8200
ganitumab
(AV0 1Z9)
Amgen
Tnousano Daks, 0/
second-line metastatic colorectal
cancer (combination therapy)
(see also breast, lung, pancreatic,
sarcoma)
P|ase ll
(800) ZZ2-13
0l-1000
(cancer vaccine)
0|ooelrrure
Louisville, CO
(see also lung, pancreatic) P|ase ll
(303) 25-2Z00
20
COLORECTAL CANCER
GM-CT-01 Galectin Therapeutics
Newton, MA
colorectal cancer
P|ase ll
(1Z) 559-0033
03-21
(monoclonal antibody)
Gilead Sciences
Foster City, CA
(see also pancreatic) P|ase ll
(800) 115-3235
GVAX
Colorectal
cancer vaccine
Lincolnshire, IL
P|ase l
(81Z) 1Z8-0500
icrucumab
(LY3012212/lVC-18F1)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
(see also bladder, breast) P|ase ll
(800) 515-59Z9
lV0-2055
(TLR9 agonist)
ldera P|arraceul|ca|s
Cambridge, MA
(see also head/neck, lung) P|ase l
(1Z) Z9-5000
Imprime PGG
Biothera
Eagan, MN
(see also leukemia, lung, skin) P|ase lll
(51) Z5-0300
JX-591
(pexastimogene devacirepvec)
Jennerex Biotherapeutics
San Francisco, CA
(see also liver) P|ase l/ll
(115) 281-888
KRN-330 Kyowa Hakko Kirin Pharma
Princeton, NJ
colorectal cancer
--------------------------------------------------
colorectal cancer (monotherapy)
P|ase l/ll
(609) 919-1100
-------------------------------------------
P|ase l
(609) 919-1100
|aoeluzurao l-131
(lVVu-111)
lrrurored|cs
Morris Plains, NJ
P|ase ll
(9Z3) 05-8200
labetuzumab-SN-38
(lVVu-130)
lrrurored|cs
Morris Plains, NJ
P|ase l
(9Z3) 05-8200
LGX818
(RAF inhibitor)
East Hanover, NJ
(see also skin)
P|ase l
(888) 669-6682
Abbott Park, IL
(see also breast, kidney, liver, lung)
P|ase ll
(81Z) 93Z-100
Toronro, 0anaoa
(see also breast, kidney, leukemia,
prostate)
P|ase ll
(11) Z98-1200
motesanib Amgen
Tnousano Daks, 0/
(see also breast, lung, other) P|ase l
(800) ZZ2-13
21
COLORECTAL CANCER
Nexavar
sorafenib
Wayne, NJ
(see also breast, head/neck, kidney,
leukemia, liver, lung, multiple
P|ase ll
(888) 812-293Z
NPC-1C
(ensituximab)
Neogenix Oncology
Rockville, MD
(see also pancreatic)
P|ase l
(301) 917-6893
(see also breast, lung) P|ase ll
(800) 2-3553
OncoVAX
acl|ve spec|lc |rrurol|erapy

Vaccinogen
Frederick, MD
(Fast Track) P|ase l/ll
(301) 8-8100
Basking Ridge, NJ
refractory metastatic colorectal
(Fast Track)
(see also brain, kidney, leukemia,
lung, lymphoma, multiple myeloma,
sarcoma, solid tumors, stomach)
P|ase lll
(908) 2-5128
PHY906 PhytoCeutica
heu laven, 0T
(see also liver, pancreatic,
cancer-related)
P|ase l/ll
(203) ZZZ-312
picoplatin Ponaird Pharmaceuticals
Seattle, WA
(see also lung, ovarian, prostate) P|ase ll
(206) 281-7001
polyclonal antibody stimulator Cancer Advances
Durham, NC
(see also pancreatic, stomach) P|ase ll
(919) 361-2162
PV701
(replication-competent oncolytic
virus)
we||slal 8|o|o|cs
Gaithersburg, MD
(see also cervical) P|ase ll
(210) 83-2500
ramucirumab
(lVC-11218)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
(see also breast, stomach) P|ase lll
(800) 515-59Z9
regorafenib Bayer HealthCare Pharmaceuticals
Wayne, NJ
(Fast Track)
(see also kidney, lung, solid tumors,
stomach)
P|ase lll
(888) 812-283Z
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
(see also brain, head/neck, lung,
ovarian, pancreatic, sarcoma,
skin, solid tumors)
P|ase l
(103) Z0-Z3ZZ
22
COLORECTAL CANCER
RG7160
(EGFR inhibitor)
Roche
Nutley, NJ
P|ase ll
(9Z3) 235-5000
R0Z111
(EGFL7 inhibitor)
Genentech
(800) 2-3553
RIGScan
luror-spec|lc, rad|o-|aoe|ed
monoclonal antibody targeting
agent
Navidea Biopharmaceuticals
Dublin, OH
(diagnosis)
(800) 793-0079
robatumumab Merck
(see also sarcoma, solid tumors) P|ase ll corp|eled
(800) 672-6372
3yr001 Symphogen
Lyngby, Denmark
metastatic colorectal cancer P|ase ll
www.symphogen.com
TAS-102 Taiho Pharma U.S.A.
Princeton, NJ
P|ase l
(09) Z50-5300
telatinib ACT Biotech
San Francisco, CA
(see also stomach) P|ase l
(115) 230-3900
TF2
(pretargeted radioimmuno-
therapy)
lrrurored|cs
Morris Plains, NJ
colorectal cancer P|ase l
(9Z3) 05-8200
ThermoDox
Celsion
Lawrenceville, NJ
adjuvant inoperable/unresectable,
(see also breast, liver)
P|ase ll
(609) 896-9100
tigatuzumab
(arl|-0R5 arl|oody)
Daiichi Sankyo
Parsippany, NJ
(see also breast, liver, lymphoma,
P|ase l
(9Z3) 911-200
tivantinib
(ARQ 197)
ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
(see also kidney, liver, lung,
pancreatic, sarcoma, other)
P|ase l/ll
(Z81) 991-0300
(9Z3) 911-200
tivozanib
(A3P1130/Av-951)
Astellas Pharma US
0eerle|o, lL
Cambridge, MA
colorectal cancer
(see also breast, kidney)
P|ase ll
(800) 95-1321
(1Z) 299-5000
trebananib
(AMG386)
Amgen
Tnousano Daks, 0/
(see also breast, kidney, liver,
P|ase ll
(800) ZZ2-13
Tykerb
lapatinib
GlaxoSmithKline
(see also breast, head/neck,
stomach)
P|ase ll
(888) 825-5219
23
COLORECTAL CANCER
Vectibix
panitumumab
Amgen
Tnousano Daks, 0/
lrsl-||re ard secord-||re co|orecla|
cancer
(see also head/neck)
(800) ZZ2-13
Xeloda
capecitabine
Genentech
lrsl-||re ard secord-||re relaslal|c
colorectal cancer
(see also brain, liver, stomach)
(800) 2-3553
Zaltrap
al|oercepl
Regeneron Pharmaceuticals
Tarryroun, hY
3arol u3
Bridgewater, NJ
cancer
(see also prostate)
(911) 315-Z100
(800) 981-2191
Zelboraf
vemurafenib
Genentech
Plexxikon
Berkeley, CA
(see also brain, other) P|ase l
(800) 2-3553
HEAD/NECK CANCER
ACE-011
(dalantercept)
Acceleron Pharma
Cambridge, MA
(see also multiple myeloma) P|ase ll
(1Z) 19-9200
afatinib
(8l8w2992)
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
second-line head/neck cancer
(see also breast, brain, lung)
P|ase ll
(800) 213-012Z
AP531 Access Pharmaceuticals
0a||as, TX
P|ase ll
(211) 905-5100
EZ050 Eisai
Woodcliff Lake, NJ
(see also brain, liver, skin, solid
tumors, stomach)
P|ase l/ll
(888) 122-1Z13
foretinib
(GSK1363089)
GlaxoSmithKline
(see also kidney, liver, lung) P|ase ll corp|eled
(888) 825-5219
GL-0810
(Orphan Drug)
Gliknik
Baltimore, MD
P|ase l
www.gliknik.com
GL-0817
(Orphan Drug)
Gliknik
Baltimore, MD
(see also multiple myeloma) P|ase l
www.gliknik.com
HF-10 Takara Bio
Shiga, Japan
P|ase l
www.takara-bio.com
24
HEAD/NECK CANCER
lV0-2055
(TLR9 agonist)
Cambridge, MA
second-line head and neck cancer
P|ase ll
(1Z) Z9-5000
lRX-2 lRX T|erapeul|cs
New York, NY
(Fast Track) P|ase ll
(212) 582-1199
Lymphoseek
Tc-99m tilmanocept
Dublin, OH
head and neck cancer (diagnosis)
(see also breast, skin)
P|ase lll
(11) Z93-Z500
Multikine
leukocyte interleukin
(Orphan Drug)
CEL-3Cl
Vienna, VA
lrsl-||re |ead ard rec| carcer P|ase lll
(Z03) 50-910
Nexavar
sorafenib
Wayne, NJ
(see also breast, colorectal, kidney,
P|ase ll
(888) 812-293Z
Tokyo, Jaan
(see also breast, liver, lung) P|ase l
www.oncolys.com
PX-866 Oncothyreon
Seattle, WA
head and neck cancer (combination
therapy)
(see also brain, lung, prostate)
P|ase ll
(206) 801-2100
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
metastatic head and neck cancer
ovarian, pancreatic, sarcoma, skin,
solid tumors)
P|ase lll
(103) Z0-Z3ZZ
R0Z59Z
(EGFR antagonist)
Genentech
P|ase ll
(800) 2-3553
seliciclib
(CYC202)
Cyclacel Pharmaceuticals
nasopharyngeal cancer
P|ase ll
(908) 51Z-Z330
Tarceva
erlotinib
Genentech
03l P|arraceul|ca|s
Farmingdale, NY
lrsl-||re |ead/rec| carcer
(see also brain, breast, leukemia,
liver, lung, other)
P|ase ll
(800) 2-3553
(631) 962-0600
TAS-106 Taiho Pharma U.S.A.
Princeton, NJ
P|ase ll
(09) Z50-5300
25
HEAD/NECK CANCER
lousron, TX
head and neck cancer (intratumoral)
(see also brain, cervical, solid
tumors, other)
P|ase l
(Z13) 511-2000
TNFerade
golnerminogene pradenovec
GenVec
Gaithersburg, MD
(see also prostate, skin, stomach) P|ase l/ll corp|eled
(8ZZ) 913-832
Tykerb
lapatinib
GlaxoSmithKline
head and neck squamous cell
carcinoma (resectable disease)
(see also breast, colorectal, stomach)
P|ase lll
(888) 825-5219
v81-815
(Orphan Drug)
Viventia Biotechnologies
Mississauga, Canada
(Fast Track)
(see also bladder)
P|ase ll
(905) 32-29Z3
Vectibix
panitumumab
Amgen
Tnousano Daks, 0/
lrsl-||re |ead ard rec| carcer
(see also colorectal)
--------------------------------------------------
second-line head and neck cancer
P|ase lll
(800) ZZ2-13
-------------------------------------------
P|ase ll
(800) ZZ2-13
KIDNEY CANCER
$QLWRU
everolimus
East Hanover, NJ
hepatocellular carcinoma
(see also breast, lymphoma)
P|ase ll
(888) 669-6682
AGS-003
(personalized dendritic cell
vaccine)
Argos Therapeutics
Durham, NC
renal cancer (combination therapy)
(Fast Track)
--------------------------------------------------
metastatic renal cancer
(monotherapy)
P|ase ll
(919) 287-6300
-------------------------------------------
P|ase ll
(919) 287-6300
AMG 172 Amgen
Tnousano Daks, 0/
P|ase l
(800) ZZ2-13
anti-PD1
(8V3-93558)
Princeton, NJ
renal cell carcinoma
P|ase ll
(800) 332-205
8NC105 Bionomics
Tneoarron, /usrra||a
P|ase ll
www.bionomics.com.au
cabozantinib
(XL181)
Exelixis
(see also breast, lung, ovarian,
prostate, other)
P|ase l
(50) 83Z-Z000
26
KIDNEY CANCER
CVX 060
(PF-0185881)
(Ang2 antagonist)
Plzer
New York, NY
P|ase ll
(80) Z32-515
CYT107
(interleukin-7)
Cytheris
Rockville, MD
(see also skin) P|ase l
(301) 231-0151
Waltham, MA
(see also breast, colorectal,
leukemia, lung, lymphoma)
P|ase l/ll
(Z81) 119-1100
foretinib
(GSK1363089)
GlaxoSmithKline
(see also head/neck, liver, lung) P|ase ll
(888) 825-5219
lVA901
(cancer vaccine)
immatics biotechnologies
Tueo|ngen, Sermany
renal cancer P|ase lll
www.immatics.com
Inlyta
axitinib
(Orphan Drug)
Plzer
New York, NY
advanced renal cell carcinoma in
treatment-naive patients
(see also liver, other)
P|ase lll
(80) Z32-515
Istodax
romidepsin
Celgene
Summit, NJ
renal cancer
(see also pancreatic, prostate, other)
P|ase ll
(908) 673-9000
L8l589
(panobinostat)
East Hanover, NJ
renal cancer
myeloma, prostate, solid tumors)
P|ase ll
(888) 669-6682
Abbott Park, IL
renal cancer
(see also breast, colorectal, liver,
lung)
P|ase ll
(81Z) 93Z-100
L0R-2010
(Orphan Drug)
Lorus Therapeutics
Toronro, 0anaoa
leukemia, prostate)
P|ase ll
(11) Z98-1200
naptumomab estafenatox Active Biotech
Lund, Sweden
(see also lung, pancreatic) P|ase l corp|eled
www.activebiotech.com
Nexavar
sorafenib
Wayne, NJ
(adjuvant therapy)
head/neck, leukemia, liver, lung,
multiple myeloma, ovarian, other)
P|ase lll
(888) 812-293Z
Oncophage
vitespen
(Orphan Drug)
Agenus
Lexington, MA
renal cell carcinoma (Fast Track) P|ase ll
(Z81) Z1-1100
03l-02Z
(TORC1/TORC2 inhibitor)
03l P|arraceul|ca|s
Farmingdale, NY
renal cancer
(see also lymphoma)
P|ase ll
(631) 962-0600
27
KIDNEY CANCER
Basking Ridge, NJ
(see also brain, colorectal, leukemia,
P|ase ll
(908) 2-5128
Redectane
|rerlux|rao l-121
w||ex
Munich, Germany
renal cancer (diagnosis) P|ase lll corp|eled
www.wilex.de
Wayne, NJ
renal cancer
(see also colorectal, lung,
P|ase ll
(888) 812-283Z
Rencarex
girentuximab
(Orphan Drug)
w||ex
Munich, Germany
clear cell renal cell carcinoma
(Fast Track)
P|ase lll
www.wilex.de
Cambridge, MA
Merck
(see also breast, lung, prostate,
sarcoma, other)
P|ase l
(800) 672-6372
30N-Z5
(vorsetuzumab mafodotin)
Seattle Genetics
Bothell, WA
renal cancer
(see also lymphoma)
P|ase l
(125) 52Z-1000
Sutent
sunitinib
(Orphan Drug)
Plzer
New York, NY
(adjuvant therapy)
P|ase lll
(80) Z32-515
tivantinib
(ARQ 197)
ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
(see also colorectal, liver, lung,
P|ase ll
(Z81) 991-0300
(9Z3) 911-200
tivozanib
(A3P1130/Av-951)
Astellas Pharma US
0eerle|o, lL
Cambridge, MA
lrsl-||re rera| carcer
(see also breast, colorectal)
--------------------------------------------------
renal cancer
P|ase lll
(800) 95-1321
(1Z) 299-5000
-------------------------------------------
P|ase l
(800) 95-1321
(1Z) 299-5000
TKl258
(dovitinib)
East Hanover, NJ
(see also breast, multiple myeloma,
prostate, skin, other)
P|ase lll
(888) 669-6682
Torisel
temsirolimus
(Orphan Drug)
Plzer
New York, NY
renal cell carcinoma P|ase lll
(80) Z32-515
trebananib
(AMG386)
Amgen
Tnousano Daks, 0/
renal cancer
P|ase ll
(800) ZZ2-13
28
KIDNEY CANCER
Tvl-K|drey-1
(cellular immunotherapy
vaccine)
TVAX Biomedical
Lenexa, KS
renal cell carcinoma P|ase ll corp|eled
(913) 192-2221
veglin
(VEGF antisense)
VasGene Therapeutics
Los Angeles, CA
(see also lung, skin) P|ase l
(323) 221-7818
Votrient
pazopanib
GlaxoSmithKline
(see also ovarian, other) P|ase lll
(888) 825-5219
LEUKEMIA
A8l0-0501
(TALL101)
Abiogen Pharma
Pisa, Italy
chronic myeloid leukemia (CML) P|ase ll
www.abiogen.it
AC220
(quizartinib)
Ambit Biosciences
San Diego, CA
Astellas Pharma US
0eerle|o, lL
second-line and third-line acute
myeloid leukemia (AML)
(monotherapy)
--------------------------------------------------
acute lymphocytic leukemia (ALL)
(coro|ral|or l|erapy), lrsl-||re AVL
P|ase ll
(858) 331-2100
(800) 95-1321
-------------------------------------------
P|ase l
(858) 331-2100
(800) 95-1321
AC130
(JAK2 inhibitor)
Ambit Biosciences
San Diego, CA
P|ase l
(858) 331-2100
Adcetris
brentuximab vedotin
Millennium Pharmaceuticals
Cambridge, MA
Seattle Genetics
Bothell, WA
(800) 390-53
(125) 52Z-1000
AE03515
(XlAP |r||o|lor)
Aegera Therapeutics
Montreal, Canada
AML
(see also lymphoma)
--------------------------------------------------
chronic lymphocytic leukemia (CLL)
P|ase ll
(511) 288-5532
-------------------------------------------
P|ase l/ll
(511) 288-5532
AFX-9151 Afecta Pharmaceuticals
Irvine, CA
in clinical trials
(919) 253-188
29
LEUKEMIA
A03-005 Argos Therapeutics
Durham, NC
CLL P|ase l/ll
(919) 287-6300
AL0-151 Aldagen
Durham, NC
P|ase l
(919) 181-25Z1
ALXN6000
(samalizumab)
Alexion Pharmaceuticals
0nesn|re, 0T
CLL
(see also multiple myeloma)
P|ase l/ll corp|eled
(203) 2Z2-259
aminopterin Syntrix Biosystems
Auburn, WA
ALL P|ase ll corp|eled
(253) 833-8009
anti-CD22/CD19 mAb-toxin
conjugate
Abiogen Pharma
Pisa, Italy
ALL P|ase l
www.abiogen.com
Flemington, NJ
CLL
(see also lymphoma, multiple
myeloma)
P|ase l/ll
(862) 703-7170
Flemington, NJ
myelodysplastic syndromes
(see also brain, solid tumors)
P|ase ll
(862) 703-7170
Arranon
nelarabine
(Orphan Drug)
GlaxoSmithKline
lrsl-||re ALL
(see also lymphoma)
--------------------------------------------------
second-line ALL
P|ase lll
(888) 669-6682
-------------------------------------------
P|ase l/ll
(888) 669-6682
ARRY-520
(KSP inhibitor)
Array BioPharma
Boulder, CO
AML
(see also multiple myeloma,
solid tumors)
P|ase ll
(8ZZ) 33-213
Arzerra
ofatumumab
(Orphan Drug)
GlaxoSmithKline
lrsl-||re CLL (coro|ral|or l|erapy)
(see also lymphoma)
P|ase lll
(888) 825-5219
AT-101
Malvern, PA
CLL
(see also brain, lung, lymphoma,
prostate, stomach)
P|ase ll
(10) 108-0301
AT-10/0eo|o-1113 Ascenta Therapeutics
Malvern, PA
Debiopharm
Lausanne, Switzerland
AML
(see also lymphoma)
P|ase l
(10) 108-0301
www.debiopharm.com
30
LEUKEMIA
ATZ519
(CDK inhibitor)
Astex Pharmaceuticals
Dublin, CA
CLL
myeloma, solid tumors)
P|ase ll
(925) 50-0100
AT9283
(aurora/Jak2 inhibitor)
(Orphan Drug)
Dublin, CA
AML
P|ase l/ll
(925) 50-0100
AVL-292
(Btk inhibitor)
Celgene
Summit, NJ
second-line CLL
(see a|so |yrp|ora, urspec|led)
P|ase l
(908) 673-9000
AZD1208
(Pim kinase inhibitor)
AstraZeneca
Wilmington, DE
AML P|ase l
(800) 236-9933
bafetinib
(Orphan Drug)
CytRx
Los Angeles, CA
second-line CLL
(see also brain, prostate)
--------------------------------------------------
ALL, CML
P|ase ll
(310) 82-518
-------------------------------------------
P|ase l
(310) 82-518
Bcl-2 inhibitor
(ABT-199/GDC-0199)
Abbott Laboratories
Abbott Park, IL
Genentech
CLL
(see also lymphoma)
P|ase l
(81Z) 93Z-100
(800) 2-3553
Henderson, NV
AML
(see also colorectal, liver, lung,
P|ase l/ll
(Z02) 835-300
8l-811283
(aurora kinase B inhibitor)
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
AML
P|ase l/ll
(800) 213-012Z
8l-8382 8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
CLL P|ase l
(800) 213-012Z
bosutinib Plzer
New York, NY
previously treated CML application submitted
(80) Z32-515
cenersen
(Orphan Drug)
Eleos
Omaha, NE
AML P|ase ll corp|eled
(102) 393-3031
Ceplene
histamine dihydrochloride
injection
(Orphan Drug)
EpiCept
Tarryroun, hY
AML application submitted
(911) 0-3500
31
LEUKEMIA
CLL immunotherapeutic vaccine MaxCyte
Gaithersburg, MD
CLL P|ase l/ll
(301) 911-1Z00
Clolar
clofarabine injection
(Orphan Drug)
Genzyme
Cambridge, MA
AML (adults) P|ase lll
(1Z) 252-Z500
CNDO-109
(tumor activated NK cells)
Coronado Biosciences
Burlington, MA
AML P|ase l
(781) 238-6621
CPX-351
(cytarabine/daunorubicin)
(Orphan Drug)
Celator Pharmaceuticals
Princeton, NJ
AML P|ase ll
(09) 213-0123
CT-011 CureTech
Yavne, Israel
second-line AML
(see also colorectal, lymphoma)
P|ase ll
www.curetechbio.com
CwP232291 Jw P|arraceul|ca|
Seoul, South Korea
AML P|ase l
Dacogen
decitabine
Eisai
Woodcliff Lake, NJ
AML
--------------------------------------------------
pediatric AML
(888) 122-1Z13
-------------------------------------------
P|ase ll
(888) 122-1Z13
danusertib Nerviano Medical Sciences
Nerviano, Italy
CML P|ase ll
www.nervianoms.com
DCC-2036 Deciphera Pharmaceuticals
Lawrence, KS
ALL, CML
--------------------------------------------------
AML
P|ase l/ll
(Z85) 830-2100
-------------------------------------------
P|ase l
(Z85) 830-2100
0C03-1501A Genentech
CLL
(see also lymphoma)
P|ase l
(800) 2-3553
DCDT-2980S Genentech
recurrent CLL
(see also lymphoma)
P|ase l
(800) 2-3553
Elacyt
elacytarabine
(Orphan Drug)
Clavis Pharma
Oslo, Norway
late-stage AML
(Fast Track)
--------------------------------------------------
early-stage AML
P|ase lll
www.clavispharma.com
-------------------------------------------
P|ase ll
www.clavispharma.com
32
LEUKEMIA
elesclomol Synta Pharmaceuticals
Lexington, MA
AML
P|ase l
(Z81) 2Z1-8200
Waltham, MA
lung, lymphoma)
P|ase ll
(Z81) 119-1100
epratuzumab
(Orphan Drug)
lrrurored|cs
Morris Plains, NJ
UCB
Atlanta, GA
ALL in children (combination therapy)
(see also lymphoma)
P|ase ll
(9Z3) 05-8200
forodesine
(Orphan Drug)
BioCryst Pharmaceuticals
Durham, NC
CLL
(see also lymphoma)
P|ase ll
(919) 859-1302
ganetespib
(Hsp90i)
Lexington, MA
ALL, AML, CML
--------------------------------------------------
P|ase l/ll
(Z81) 2Z1-8200
-------------------------------------------
P|ase l
(Z81) 2Z1-8200
GNKG-168 38l 8|olec|
Tokyo, Jaan
CLL P|ase l
www.sbibiotech.jp
GRNVAC1
Argos Therapeutics
Durham, NC
Geron
Menlo Park, CA
AML
(see also prostate)
P|ase ll
(50) 1Z3-ZZ00
GS-1101
(Pl3K de|la |r||o|lor)
Gilead Sciences
Foster City, CA
second-line CLL
(see also lymphoma)
P|ase lll
(800) 115-3235
GSK2110183
(protein kinase B inhibitor)
GlaxoSmithKline
(888) 825-5219
03K21305Z9A
(wT1 arl|er-spec|lc carcer
immunotherapeutic)
GlaxoSmithKline
AML P|ase ll
(888) 825-5219
GVAX
Leukemia
cancer vaccine
(Orphan Drug)
Lincolnshire, IL
AML, CML P|ase ll
(81Z) 1Z8-0500
luV195-Ac-225
(||rluzurao Ac-225)
Actinium Pharmaceuticals
Newark, NJ
AML P|ase l
(9Z3) 311-500
33
LEUKEMIA
luV195-8|-213
(lintuzumab Bi-213)
Actinium Pharmaceuticals
Newark, NJ
AML P|ase l/ll
(9Z3) 311-500
luV195/r0e|
(lintuzumab-gelonin conjugate)
Targa Therapeutics
San Diego, CA
AML, CML, myelodysplastic
syndromes
P|ase l
(858) 183-00
ibrutinib
(PCl-32Z5)
Janssen Biotech
Horsham, PA
Pharmacyclics
Sunnyvale, CA
CLL
myeloma)
P|ase l/ll
(800) 52-ZZ3
(108) ZZ1-0330
imatinib sublingual Kedem Pharmaceuticals
Mesa, AZ
CML in clinical trials
(01) 321-1211
imetelstat Geron
Menlo Park, CA
CLL
(see also breast, lung, multiple
myeloma)
P|ase l/ll
(50) 1Z3-ZZ00
Imprime PGG
Biothera
Eagan, MN
CLL
(see also colorectal, lung, skin)
P|ase l/ll
(51) Z5-0300
lNN0-305
(wT-1 vacc|re)
CytRx
Los Angeles, CA
AML, myelodysplastic syndromes
P|ase l
(310) 82-518
inotuzumab ozogamicin Plzer
New York, NY
ALL
(see also lymphoma)
P|ase l
(80) Z32-515
l3F35
(recombinant
immunotherapeutic vaccine)
Memgen
San Diego, CA
CLL (monotherapy)
(see also lymphoma)
--------------------------------------------------
refractory metastatic CLL
P|ase ll
(858) 521-5100
-------------------------------------------
P|ase l
(858) 521-5100
JNJ-2181585
(quisinostat)
Johnson & Johnson Pharmaceutical
Raritan, NJ
myelodysplastic syndromes,
metastatic leukemia
(see also lymphoma)
P|ase l
(800) 81Z-528
JVRS-100
(lipid-DNA complex vaccine)
Colby Pharmaceutical
San Jose, CA
P|ase l
(50) 333-3152
KX2-391 Kinex Pharmaceuticals
Buffalo, NY
AML in the elderly
(see also prostate)
P|ase l
(716) 898-8626
34
LEUKEMIA
L8l589
(panobinostat)
East Hanover, NJ
ALL, AML, myelodysplastic
syndromes
(see also kidney, multiple myeloma,
prostate, solid tumors)
P|ase ll
(888) 669-6682
L0E225
(erismodegib)
East Hanover, NJ
CML (combination therapy)
(see also pancreatic, solid tumors,
skin)
P|ase l
(888) 669-6682
lestaurtinib
(Orphan Drug)
Cephalon
Frazer, PA
AML P|ase ll
(10) 311-0200
leukemia DNA vaccine lrov|o P|arraceul|ca|s
Blue Bell, PA
University of Southampton
Southampton, United Kingdom
AML, CML P|ase ll
(8ZZ) 11-81
L0Z10
(activated T-cells)
Lentigen
Gaithersburg, MD
University of Pennsylvania
Philadelphia, PA
ALL, B-cell prolymphocytic leukemia,
CLL
(see also lymphoma)
P|ase l
(301) 52Z-1200
L0R-2010
(Orphan Drug)
Lorus Therapeutics
Toronro, 0anaoa
AML (combination therapy)
prostate)
--------------------------------------------------
CML, myelodysplastic syndromes
P|ase ll
(11) Z98-1200
-------------------------------------------
P|ase l
(11) Z98-1Z01
lurbinectedin PharmaMar
Madrid, Spain
(see also solid tumors) P|ase l
www.pharmamar.com
Marqibo
vincristine liposomal
(Orphan Drug)
Talon Therapeutics
San Mateo, CA
relapsed or refractory Philadelphia
chromosome-negative ALL
(Fast Track)
(see also lymphoma, skin, other)
--------------------------------------------------
ALL in the elderly (Fast Track)
(50) 588-101
-------------------------------------------
P|ase lll
(50) 588-101
milatuzumab lrrurored|cs
Morris Plains, NJ
CLL (monotherapy)
myeloma)
P|ase l/ll
(9Z3) 05-8200
VK-Z95
(dinaciclib)
(Orphan Drug)
Merck
CLL
(see also lymphoma)
P|ase ll
(800) 672-6372
35
LEUKEMIA
VK-8212 Merck
AML
P|ase l
(800) 672-6372
mocetinostat
(MGCD0103, HDAC inhibitor)
MethylGene
Montreal, Canada
CLL
P|ase ll corp|eled
(511) 33Z-3333
Mozobil
plerixafor
Genzyme
Cambridge, MA
AML P|ase l
(1Z) 252-Z500
navitoclax
(ABT-263)
Abbott Laboratories
Abbott Park, IL
(see also lung, lymphoma)
--------------------------------------------------
CLL, lymphoid leukemia
P|ase ll
(81Z) 93Z-100
-------------------------------------------
P|ase l
(81Z) 93Z-100
Nexavar
sorafenib
Wayne, NJ
head/neck, kidney, liver, lung,
P|ase l/ll
(888) 812-293Z
obatoclax
(Orphan Drug)
Cephalon
Frazer, PA
CLL
(see also lung, lymphoma, multiple
myeloma)
(10) 311-0200
obinutuzumab
(0A101/R0Z159)
8|oer ldec
Weston, MA
Genentech
(see also lymphoma)
P|ase lll
(Z81) 11-2000
(800) 2-3553
Omapro
omacetaxine
(Orphan Drug)
Cephalon
Frazer, PA
second-line CML
--------------------------------------------------
(10) 311-0200
-------------------------------------------
P|ase ll
(10) 311-0200
0N 013105 Onconova Therapeutics
Newtown, PA
ALL
(see also lymphoma)
P|ase l
(2Z) Z59-380
oral azacitidine
(Orphan Drug)
Celgene
Summit, NJ
(Fast Track)
(see also lung, lymphoma,
solid tumors)
--------------------------------------------------
AML, CML
P|ase ll
(908) 673-9000
-------------------------------------------
P|ase l
(908) 673-9000
36
LEUKEMIA
oral clofaribine Genzyme
Cambridge, MA
myelodysplastic syndromes P|ase l
(1Z) 252-Z500
0vl-123
(Orphan Drug)
0rcov|sla lrroval|ve T|erap|es
$an /nron|o, TX
TdT-positive leukemia P|ase l
(210) 677-6000
0X|1503 OXiGENE
AML, myelodysplastic syndromes P|ase l
(50) 35-Z000
Basking Ridge, NJ
refractory metastatic CLL
(see also brain, colorectal, kidney,
P|ase ll
(908) 2-5128
PKC112
(midostaurin)
East Hanover, NJ
AML P|ase lll
(888) 669-6682
PLX3397
Plexxikon
Berkeley, CA
recurrent or refractory AML
(see also brain, lymphoma,
solid tumors)
P|ase l/ll
(510) 1Z-1000
ponatinib
(Orphan Drug)
ARlA0 P|arraceul|ca|s
Cambridge, MA
Philadelphia-positive ALL, CML
--------------------------------------------------
AML
P|ase ll
(1Z) 191-0100
-------------------------------------------
P|ase l
(1Z) 191-0100
PR101 Proacta
La Jolla, CA
AML P|ase l/ll
(858) 12-038
Revlimid
lenalidomide
(Orphan Drug)
Celgene
Summit, NJ
CLL, myelodysplastic syndromes
(see also lymphoma)
P|ase lll
(908) 673-9000
rigosertib
(Orphan Drug)
Onconova Therapeutics
Newtown, PA
(intravenous)
(see also lymphoma, ovarian,
pancreatic)
--------------------------------------------------
CLL
--------------------------------------------------
AML
--------------------------------------------------
myelodysplastic syndromes (oral)
P|ase lll
(2Z) Z59-380
-------------------------------------------
P|ase ll
(2Z) Z59-380
-------------------------------------------
P|ase l/ll
(2Z) Z59-380
-------------------------------------------
P|ase l
(2Z) Z59-380
37
LEUKEMIA
sapacitabine
(CYC682)
(Orphan Drug)
lrsl-||re AVL
(see also lung, solid tumors)
--------------------------------------------------
CLL (combination therapy),
P|ase lll
(908) 51Z-Z330
-------------------------------------------
P|ase ll
(908) 51Z-Z330
SB989
(pracinostat)
38l0
Oakland, CA
(see also solid tumors, other)
P|ase l
(50) Z30-280
381518
(pacritinib)
38l0
Oakland, CA
--------------------------------------------------
myeloid leukemia
P|ase ll
(50) Z30-280
-------------------------------------------
P|ase l/ll
(50) Z30-280
SF1126
(Orphan Drug)
Semafore Pharmaceuticals
Indianapolis, IN
CLL
solid tumors)
P|ase l
(31Z) 8Z-30Z5
30l110
(DNMT inhibitor)
Dublin, CA
AML, myelodysplastic syndromes P|ase l/ll
(925) 50-0100
3L-101
(recombinant fusion protein)
(Orphan Drug)
Stemline Therapeutics
New York, NY
AML, myelodysplastic syndromes P|ase l/ll
(1) 502-2310
tamibarotene
(Orphan Drug)
CytRx
Los Angeles, CA
acute promyelocytic leukemia (APL)
(Fast Track)
(see also lung)
--------------------------------------------------
APL (combination therapy)
P|ase ll
(310) 82-518
-------------------------------------------
P|ase l
(310) 82-518
Tarceva
erlotinib
Genentech
03l 0rco|oy
Farmingdale, NY
(see also brain, breast, head/neck,
liver, lung, other)
P|ase ll
(800) 2-3553
(631) 962-0600
Tasigna
nilotinib
(Orphan Drug)
East Hanover, NJ
CML (adolescents and children),
ALL (adolescents and children)
(see also skin, stomach)
P|ase ll
(888) 669-6682
Temodar
temozolomide
Merck
AML
(see also lung)
P|ase ll
(800) 672-6372
(see also brain, multiple myeloma,
pancreatic, sarcoma)
P|ase l
(50) 1Z1-8200
thiarabine Access Pharmaceuticals
0a||as, TX
(see also lymphoma) P|ase l/ll
(215) 901-5100
38
LEUKEMIA
TL-32711
(birinapant)
TetraLogic Pharmaceuticals
Malvern, PA
AML
P|ase l/ll
(610) 889-9900
tosedostat
(Orphan Drug)
Chroma Therapeutics
Oxon, United Kingdom
AML P|ase ll
www.chromatherapeutics.com
trametinib GlaxoSmithKline
relapsed or refractory leukemia
(see also brain, lung, lymphoma,
multiple myeloma, pancreatic, skin)
P|ase lll
(888) 825-5219
Treanda
bendamustine
Cephalon
Frazer, PA
ALL in children, AML in children
myeloma)
P|ase l/ll
(10) 311-0200
treosulfan Medac
Wedel, Germany
ALL, AML, myelodysplastic
syndromes
P|ase ll
www.medac.de
TRU-016
(humanized anti-CD37
therapeutic)
Emergent BioSolutions
Rockville, MD
CLL
(see also lymphoma)
P|ase ll
(301) Z95-1800
Velcade
bortezomib
Cambridge, MA
second-line T-cell prolymphocytic
leukemia
(see also lymphoma, other,
cancer-related)
P|ase ll
(800) 390-53
veltuzumab
(Orphan Drug)
lrrurored|cs
Morris Plains, NJ
CLL
(see also lymphoma)
P|ase l/ll
(9Z3) 05-8200
Vidaza
azacitidine
(Orphan Drug)
Celgene
Summit, NJ
AML in the elderly
(see also lymphoma)
P|ase lll
(908) 673-9000
vosaroxin
(Orphan Drug)
Sunesis Pharmaceuticals
second-line AML
(Fast Track)
(see also ovarian)
--------------------------------------------------
AML in the elderly
P|ase lll
(50) 2-3Z39
-------------------------------------------
P|ase ll
(50) 2-3Z39
XmAb
5574
(MOR208, anti-CD19 mAb)
MorphoSys
Planegg, Germany
Xencor
Monrovia, CA
recurrent CLL P|ase l
www.morphosys.com
(2) 305-5900
Zolinza
vorinostat
Merck
(see also breast, lung, lymphoma,
P|ase ll
(800) 672-6273
39
LIVER CANCER
ALN-VSP Alnylam Pharmaceuticals
Cambridge, MA
P|ase l
(1Z) 551-8200
bavituximab Peregrine Pharmaceuticals
Tusr|n, 0/
(see also lung, pancreatic) P|ase l/ll
(Z15) 508-000
BAY 86-9766
(MEK inhibitor)
Ardea Biosciences
San Diego, CA
Wayne, NJ
lrsl-||re ||ver carcer
P|ase ll
(888) 812-293Z
Henderson, NV
inoperable/unresectable liver cancer
(see also colorectal, leukemia, lung,
P|ase l/ll
(Z02) 835-300
8ll8 022 8|oer ldec
Cambridge, MA
(see also lung) P|ase l corp|eled
(617) 679-2000
brivanib
Princeton, NJ
lrsl-||re ||ver carcer,
liver cancer (TACE)
(see also colorectal, sarcoma)
P|ase lll
(800) 332-205
cixutumumab
(LY301221Z/lVC-A12)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
(800) 515-59Z9
darinaparsin
(Zl0-101)
Zl0PlARV 0rco|oy
New York, NY
P|ase ll
(1) 211-0Z00
DC Bead
doxorubicin-eluting beads
Wayne, NJ
Biocompatibles
Surrey, United Kingdom
P|ase ll
(888) 812-293Z
EZ050 Eisai
Woodcliff Lake, NJ
(see also brain, head/neck, skin,
P|ase l/ll
(888) 122-1Z13
foretinib
(GSK1363089)
GlaxoSmithKline
(see also head/neck, kidney, lung) P|ase l
(888) 825-5219
ganetespib
(Hsp90i)
Lexington, MA
leukemia, lung, multiple myeloma,
pancreatic, prostate, skin, stomach)
P|ase ll
(Z81) 2Z1-8200
Inlyta
axitinib
Plzer
New York, NY
(see also kidney, other) P|ase ll
(80) Z32-515
irinotecan eluting beads 8|ocorpal|o|es lrlerral|ora|
Surrey, United Kingdom
liver metastases from colorectal
cancer
P|ase ll
www.biocompatibles.com
40
LIVER CANCER
JX-591
(pexastimogene devacirepvec)
(Orphan Drug)
Jennerex Biotherapeutics
San Francisco, CA
(115) 281-888
lansoprazole
(Orphan Drug)
Apricus Biosciences
San Diego, CA
lrsl-||re ||ver carcer P|ase ll
(858) 220-8011
Abbott Park, IL
lrsl-||re ||ver carcer (rorol|erapy)
lung)
P|ase lll
(81Z) 93Z-100
mapatumumab Human Genome Sciences
Rockville, MD
liver cancer (combination therapy)
(see also lung, multiple myeloma)
P|ase ll
(301) 309-8501
MB07133
(HepDirect HepB inhibitor)
Ligand Pharmaceuticals
La Jolla, CA
inoperable/unresectable liver cancer P|ase l/ll corp|eled
(858) 550-Z500
melphalan drug delivery system Delcath Systems
New York, NY
inoperable/unresectable liver cancer application submitted
(212) 189-2100
ruparloslal (Pl-88) Progen Pharmaceuticals
Queensland, Australia
liver cancer (Fast Track)
(see also skin)
P|ase lll
www.progen.com.au
Nexavar
sorafenib
(Orphan Drug)
Wayne, NJ
heptocellular carcinoma
(adjuvant therapy)
head/neck, kidney, leukemia, lung,
P|ase lll
(888) 812-293Z
NV-1020 Catherex
Philadelphia, PA
Tokyo, Jaan
(see also breast, head/neck, lung) P|ase l
www.oncolys.com
PEG arginine deiminase
(A0l-PE0 20)
Polaris Pharmaceuticals
San Diego, CA
hepatocellular carcinoma
(see also prostate, skin, other)
P|ase lll
(858) 152-88
PHY906 PhytoCeutica
heu laven, 0T
(see also colorectal, pancreatic,
cancer-related)
(203) ZZZ-312
PV-10
(rose bengal sodium)
(Orphan Drug)
Provectus Pharmaceuticals
rnoxv|||e, Th
liver cancer, liver metastases
(see also skin)
P|ase l
(8) 591-5999
RG7686 Roche
Nutley, NJ
metastatic liver cancer
P|ase ll
(9Z3) 235-5000
41
LIVER CANCER
Tarceva
erlotinib
Genentech
03l P|arraceul|ca|s
Farmingdale, NY
lrsl-||re |roperao|e/urreseclao|e ||ver
leukemia, lung, other)
--------------------------------------------------
second-line liver cancer
P|ase lll
(800) 2-3553
(631) 962-0600
-------------------------------------------
P|ase ll
(800) 2-3553
(631) 962-0600
TGF- R1 inhibitor
(LY215Z299)
Eli Lilly
Indianapolis, IN
(see also brain) P|ase ll
(800) 515-59Z9
ThermoDox
(Orphan Drug)
Celsion
Lawrenceville, NJ
lrsl-||re |roperao|e/urreseclao|e ||ver
cancer (Fast Track)
P|ase lll
(609) 896-9100
tigatuzumab
(arl|-0R5 arl|oody)
Daiichi Sankyo
Parsippany, NJ
lymphoma, ovarian, pancreatic)
P|ase ll
(9Z3) 911-200
tivantinib (ARQ 197) ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
second-line liver cancer
(see also colorectal, kidney, lung,
--------------------------------------------------
liver cancer (combination therapy)
P|ase ll
(Z81) 991-0300
(9Z3) 911-200
------------------------------------------
P|ase l
(Z81) 991-0300
(9Z3) 911-200
trebananib
(AMG386)
Amgen
Tnousano Daks, 0/
P|ase ll
(800) ZZ2-13
Xeloda
capecitabine
Genentech
biliary cancer (combination therapy)
(see also brain, colorectal, stomach)
P|ase ll
(800) 2-3553
Zadaxin
thymalfasin alfa 1
(Orphan Drug)
SciClone Pharmaceuticals
Foster City, CA
(see also skin) P|ase ll/lll
(50) 358-315
42
LUNG CANCER
Abraxane
Celgene
Summit, NJ
lrsl-||re ror-sra||-ce|| |ur carcer
(NSCLC)
(see also bladder, breast, ovarian,
pancreatic, skin)
(908) 673-9000
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
NSCLC
(see also brain, breast, colorectal,
other)
P|ase ll
(81Z) 93Z-100
AC180
(pan-HER inhibitor)
Ambit Biosciences
San Diego, CA
NCSLC
(see also brain, breast)
P|ase l
(858) 331-2100
Actimid
pomalidomide
Celgene
Summit, NJ
small-cell lung cancer (SCLC)
myeloma, pancreatic)
P|ase l/ll
(908) 673-9000
afatinib
(8l8w2992)
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
lrsl-||re N3CLC
(see also brain, breast, head/neck)
--------------------------------------------------
second-line NSCLC (Fast Track)
P|ase lll
(800) 213-012Z
-------------------------------------------
P|ase ll/lll
(800) 213-012Z
Alimta
pemetrexed
Eli Lilly
Indianapolis, IN
lrsl-||re ard ra|rlerarce N3CLC P|ase lll
(800) 515-59Z9
AMG888/U3-1287
(anti-HER3 antibody)
Amgen
Tnousano Daks, 0/
Daiichi Sankyo
Parsippany, NJ
NSCLC P|ase ll
(800) ZZ2-13
(9Z3) 911-200
amrubicin
(Orphan Drug)
Celgene
Summit, NJ
SCLC (Fast Track)
(see also breast)
--------------------------------------------------
lrsl-||re 3CLC
P|ase lll
(908) 673-9000
-------------------------------------------
P|ase ll
(908) 673-9000
amuvatinib
(VP1Z0)
Dublin, CA
SCLC (combination therapy)
(see also lymphoma)
P|ase ll
(925) 50-0100
anti-PD1
(8V3-93558)
Princeton, NJ
(see also kidney, skin) P|ase ll
(800) 332-205
AP26113 ARlA0 P|arraceul|ca|s
Cambridge, MA
NSCLC P|ase l
(1Z) 191-0100
apricoxib
(TG01)
Tragara Pharmaceuticals
San Diego, CA
second-line NSCLC
P|ase ll
(858) 350-900
43
LUNG CANCER
astuprotimut-R
(VA0E-A3 arl|er-spec|lc
cancer immunotherapeutic)
GlaxoSmithKline
adjuvant NSCLC
(see also skin)
P|ase lll
(888) 825-5219
AT-101
Malvern, PA
NSCLC (combination therapy),
SCLC (combination therapy)
(see also brain, leukemia, lymphoma,
prostate, stomach)
P|ase ll
(10) 108-0301
AUY922
(Hsp90 inhibitor)
East Hanover, NJ
third-line NSCLC
(see also breast, colorectal, multiple
myeloma, stomach)
--------------------------------------------------
second-line late-stage NSCLC
P|ase ll
(888) 669-6682
-------------------------------------------
P|ase l/ll
(888) 669-6682
Avastin
bevacizumab
Genentech
adjuvant NSCLC
ovarian, other)
P|ase lll
(800) 2-3553
Tusr|n, 0/
lrsl-||re N3CLC,
second-line NSCLC
(see also liver, pancreatic)
P|ase ll
(Z15) 508-000
Henderson, NV
mesothelioma
--------------------------------------------------
NSCLC
--------------------------------------------------
SCLC
P|ase ll corp|eled
(Z02) 835-300
-------------------------------------------
P|ase l/ll
(Z02) 835-300
-------------------------------------------
P|ase l
(Z02) 835-300
8ll8 022 8|oer ldec
Cambridge, MA
NSCLC
(see also liver)
P|ase l corp|eled
(617) 679-2000
BKM120
(Pl3K |r||o|lor)
East Hanover, NJ
late-stage NSCLC
(see also brain, breast, other)
P|ase ll
(888) 669-6682
cabozantinib
(XL181)
Exelixis
NSCLC
(see also breast, kidney, ovarian,
prostate, other)
P|ase l/ll
(50) 83Z-Z000
C8P-501
(peptide mimetic)
CanBas
Shizouka, Japan
mesothelioma (combination therapy),
lrsl-||re N3CLC (coro|ral|or
therapy)
P|ase ll
www.canbas.co.jp
44
LUNG CANCER
CC-223
(mTOR inhibitor)
Celgene
Summit, NJ
NSCLC
myeloma)
P|ase l
(908) 673-9000
CEP-9722
(PARP inhibitor)
Cephalon
Frazer, PA
NSCLC (combination therapy)
(see also lymphoma)
P|ase ll
(10) 311-0200
Chk1 inhibitor
(LY2603618)
Eli Lilly
Indianapolis, IN
NSCLC
P|ase ll
(800) 515-59Z9
cixutumumab
(LY301221Z/lVC-A12)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
NSCLC
(see also liver)
P|ase ll
(800) 515-59Z9
CLR1101-l-121 Novelos Therapeutics
Madison, WI
NSCLC (diagnosis) P|ase l/ll
(08) 111-8120
CLR1101-l-131 Novelos Therapeutics
Madison, WI
NSCLC (diagnosis) P|ase l/ll
(08) 111-8120
CO-1686
(EGFR inhibitor)
Clovis Oncology
Boulder, CO
second-line NSCLC P|ase l/ll
(303) 25-5000
custirsen
(OGX-001/TV-1011)
OncoGenex Pharmaceuticals
Bothell, WA
Teva Pharmaceuticals
T|kva, lsrae|
lrsl-||re N3CLC
(see also prostate)
P|ase ll
(125) 8-1500
dacomitinib
(PF-00299801)
Plzer
New York, NY
NSCLC
P|ase lll
(80) Z32-515
dalotuzumab
(VK-01)
Merck
recurrent NSCLC (combination
therapy)
(see also breast, pancreatic, other)
P|ase ll
(800) 672-6372
EC20
(technetium Tc-99m etarfolatide)
Endocyte
West Lafayette, IN
NSCLC (diagnosis)
(see also ovarian)
P|ase ll
www.endocyte.com
EC115
(vintafolide)
Endocyte
West Lafayette, IN
Merck
NSCLC
(see also ovarian)
P|ase ll
www.endocyte.com
(800) 672-6372
Parsippany, NJ
NSCLC
(see also colorectal, other)
P|ase ll
(9Z3) 911-200
Lexington, MA
NSCLC
(see also leukemia, ovarian)
P|ase l/ll
(Z81) 2Z1-8200
45
LUNG CANCER
emepepimut-S EMD Serono
Rockland, MA
Oncothyreon
Seattle, WA
NSCLC (Fast Track)
(see also prostate)
P|ase lll
(800) 283-8088
Waltham, MA
leukemia, lymphoma)
P|ase ll
(Z81) 119-1100
lc|aluzurao
(AV-299)
Cambridge, MA
P|ase ll
(1Z) 299-5000
Folotyn
pralatrexate
Allos Therapeutics
Westminster, CO
NSCLC
(see also bladder, breast, lymphoma)
P|ase ll
(303) 12-22
foretinib
(GSK1363089)
GlaxoSmithKline
NSCLC
(see also head/neck, kidney, liver)
P|ase l/ll
(888) 825-5219
ganetespib
(Hsp90i)
Lexington, MA
second-line NSCLC (combination
therapy)
leukemia, liver, multiple myeloma,
pancreatic, prostate, skin, stomach)
--------------------------------------------------
SCLC
P|ase ll/lll
(Z81) 2Z1-8200
-------------------------------------------
P|ase ll
(Z81) 2Z1-8200
ganitumab
(AV0 1Z9)
Amgen
Tnousano Daks, 0/
lrsl-||re 3CLC (coro|ral|or l|erapy)
pancreatic, sarcoma)
P|ase l/ll
(800) ZZ2-13
0l-1000
(cancer vaccine)
0|ooelrrure
Louisville, CO
NSCLC
(see also colorectal, pancreatic)
P|ase l
(303) 25-2Z00
Gleevec
imatinib
East Hanover, NJ
(see also prostate, skin, other)
P|ase ll
(888) 669-6682
03K211813
GlaxoSmithKline
BRAF mutation-positive disease
NSCLC
(see also brain, skin)
P|ase ll
(888) 825-5219
Halaven
eribulin
Eisai
Woodcliff Lake, NJ
NSCLC
(see also prostate, sarcoma)
P|ase lll
(888) 122-1Z13
HS-110
(cancer vaccine)
Heat Biologics
Chapel Hill, NC
late-stage NSCLC (combination
therapy)
P|ase l
(919) 210-Z133
46
LUNG CANCER
HyperAcute
Lung
lung cancer immunotherapy
NewLink Genetics
Ames, IA
metastatic NSCLC P|ase ll
(515) 29-5555
l0V-2101
(multi-epitope cancer vaccine)
Biotech Synergy
San Diego, CA
NSCLC P|ase ll
(858) 159-89
imetelstat Geron
Menlo Park, CA
late-stage NSCLC
(see also breast, leukemia,
multiple myeloma)
P|ase ll
(50) 1Z3-ZZ00
lV0-2055
(TLR9 agonist)
Cambridge, MA
(see also colorectal, head/neck) P|ase l
(1Z) Z9-5000
Imprime PGG
Biothera
Eagan, MN
NSCLC
(see also colorectal, leukemia, skin)
P|ase ll
(51) Z5-0300
iniparib
(83l-201)
3arol u3
Bridgewater, NJ
squamous NSCLC
(see also breast, ovarian)
--------------------------------------------------
non-squamous NSCLC
P|ase lll
(800) 981-2191
-------------------------------------------
P|ase ll
(800) 981-2191
Iressa
ell|r|o
AstraZeneca
Wilmington, DE
lrsl-||re E0FR rulal|or-pos|l|ve
NSCLC
P|ase lll
(800) 236-9933
l3l3-ElF1E
Rx
ls|s P|arraceul|ca|s
Carlsbad, CA
late-stage NSCLC (combination
therapy)
(see also prostate)
P|ase ll
(800) Z9-1Z1Z
JNJ-285115
(Hdm2 inhibitor)
Raritan, NJ
NSCLC
(see also prostate, solid tumors)
P|ase l
(800) 81Z-528
Karenitecin
8NP1350
BioNumerik Pharmaceuticals
$an /nron|o, TX
NSCLC
(see also ovarian, solid tumors)
P|ase ll
(210) 11-1Z01
KD019
(33Kl |r||o|lor)
Kadmon Pharmaceuticals
Warrendale, PA
late-stage NSCLC P|ase lll
(Z21) ZZ8-100
KD032
(ras/mTOR inhibitor)
Warrendale, PA
NSCLC
P|ase ll corp|eled
(Z21) ZZ8-100
Abbott Park, IL
NSCLC
liver)
P|ase ll
(81Z) 93Z-100
litronesib
(LY2523355)
Eli Lilly
Indianapolis, IN
NSCLC
(see also breast)
P|ase ll
(800) 515-59Z9
47
LUNG CANCER
lorvotuzumab mertansine
(lV0N901)
(Orphan Drug)
lrruro0er
Waltham, MA
SCLC
(see also multiple myeloma)
P|ase ll
(Z81) 895-000
Lucanix
belagenpumatucel-L
NovaRx
San Diego, CA
NSCLC (Fast Track)
(see also brain)
P|ase lll
(858) 522-800
Rockville, MD
(see also liver, multiple myeloma)
P|ase ll
(301) 309-8501
VE0l-5Z5
(anti-PDGFR-alpha mAb)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
NSCLC
(see also brain)
P|ase ll
(800) 236-9933
(301) 398-0000
V0C025
(multi-kinase inhibitor)
MethylGene
Montreal, Canada
NSCLC (combination therapy) P|ase l/ll
(511) 33Z-3333
MORAb-003
(farletuzumab)
Eisai
Woodcliff Lake, NJ
NSCLC
(see also ovarian)
P|ase ll
(888) 122-1Z13
MORAb-009
(amatuximab)
Eisai
Woodcliff Lake, NJ
mesothelioma P|ase ll
(888) 122-1Z13
motesanib Amgen
Tnousano Daks, 0/
NSCLC
(see also breast, colorectal, other)
P|ase lll
(800) ZZ2-13
Lund, Sweden
NSCLC (Fast Track)
(see also kidney, pancreatic)
P|ase l corp|eled
navitoclax
(ABT-263)
Abbott Laboratories
Abbott Park, IL
NSCLC, SCLC
P|ase ll
(81Z) 93Z-100
necitumumab
(lVC-11F8)
Princeton, NJ
Eli Lilly
Indianapolis, IN
lrC|ore 3yslers
Bridgewater, NJ
NSCLC P|ase lll
(800) 332-205
(800) 515-59Z9
Nexavar
sorafenib
Wayne, NJ
NSCLC
head/neck, kidney, leukemia, liver,
P|ase lll
(888) 812-293Z
48
LUNG CANCER
NGR-hTNF
(Orphan Drug)
MolMed
Milan, Italy
second-line mesothelioma P|ase lll
www.molmed.com
NK-012 Nippon Kayaku
Tokyo, Jaan
SCLC
(see also breast)
P|ase ll
www.nipponkayaku.co.jp
NTX-010 Neotropix
Malvern, PA
SCLC
(see also other)
P|ase ll
www.neotropix.com
obatoclax Cephalon
Frazer, PA
lrsl-||re 3CLC
multiple myeloma)
P|ase ll
(10) 311-0200
Tokyo, Jaan
mesothelioma
(see also breast, head/neck, liver)
P|ase l
www.oncolys.com
Bothell, WA
NSCLC
P|ase l
(125) 8-1500
ombrabulin
(AVE8062)
3arol u3
Bridgewater, NJ
lrsl-||re N3CLC
(see also ovarian, sarcoma)
P|ase ll
(800) 981-2191
metastatic NSCLC
P|ase lll
(800) 2-3553
Oncoprex
(TUSC2/FUS1 gene therapy)
Genprex
/usr|n, TX
NSCLC P|ase l
(512) 59Z-5900
Opaxio
Cell Therapeutics
Seattle, WA
NSCLC
(see also brain, ovarian, stomach,
other)
P|ase lll
(800) 215-2355
oral azacitidine Celgene
Summit, NJ
NSCLC
solid tumors)
P|ase l
(908) 673-9000
03l-90
(l0F-1R/1R lyros|rase ||rase
inhibitor)
03l P|arraceul|ca|s
Farmingdale, NY
NSCLC
(see also ovarian, other)
P|ase ll
(631) 962-0600
P2015 Bryan Oncor
Somerville, MA
NSCLC, SCLC P|ase l corp|eled
palifosfamide
(Zl0-201)
Zl0PlARV 0rco|oy
New York, NY
SCLC
(see also sarcoma, solid tumors)
P|ase l
(1) 211-0Z00
49
LUNG CANCER
pegdinetanib
(VEGFR-2 adnectin)
(8V3-811203)
Princeton, NJ
NSCLC P|ase ll
(800) 332-205
Basking Ridge, NJ
NSCLC
leukemia, lymphoma, multiple
myeloma, sarcoma, solid tumors,
stomach)
P|ase l/ll
(908) 2-5128
picoplatin
(Orphan Drug)
Ponaird Pharmaceuticals
Seattle, WA
second-line SCLC
(Fast Track)
(see also colorectal, ovarian,
prostate)
P|ase ll
(206) 281-7001
plinabulin
(NPl-2358)
Nereus Pharmaceuticals
San Diego, CA
NSCLC P|ase ll
(858) 58Z-1090
PRAVE arl|er-spec|lc carcer
immunotherapeutic
(recombinant)
GlaxoSmithKline
NSCLC
(see also skin)
P|ase l
(888) 825-5319
PT107
(allogeneic tumor cell vaccine)
Pique Therapeutics
Durham, NC
NSCLC P|ase ll
(919) 80-1395
PX-866 Oncothyreon
Seattle, WA
(see also brain, head/neck, prostate)
P|ase ll
(206) 801-2100
ranpirnase Tamir Biotechnology
Monmouth Junction, NJ
NSCLC P|ase ll
(732) 823-1003
Wayne, NJ
NSCLC
P|ase l
(888) 812-283Z
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
(see also brain, colorectal,
head/neck, ovarian, pancreatic,
sarcoma, skin, solid tumors)
P|ase ll
(103) Z0-Z3ZZ
retaspimycin lrlr|ly P|arraceul|ca|s
Cambridge, MA
NSCLC P|ase ll
(1Z) 153-1000
R0Z111
(EGFL7 inhibitor)
Genentech
NSCLC
P|ase ll
(800) 2-3553
50
LUNG CANCER
R0Z599
(antibody drug conjugate)
Genentech
NSCLC
(see also ovarian)
P|ase l
(800) 2-3553
Cambridge, MA
Merck
NSCLC
(see also breast, kidney, prostate,
sarcoma, other)
P|ase ll
(800) 672-6372
sapacitabine
(CYC682)
NSCLC
P|ase ll
(908) 51Z-Z330
3AR25212 (VV-121)
(anti-ErbB3 mAb)
Cambridge, MA
3arol u3
Bridgewater, NJ
NSCLC
P|ase ll
(800) 981-2191
talactoferrin alfa (oral)
(Orphan Drug)
Agennix
Princeton, NJ
NSCLC
(Fast Track)
P|ase lll
(09) 521-1000
tamibarotene CytRx
Los Angeles, CA
NSCLC
(see also leukemia)
P|ase ll
(310) 82-518
Tarceva
erlotinib
Genentech
03l P|arraceul|ca|s
Farmingdale, NY
adjuvant NSCLC
leukemia, liver, other)
P|ase lll
(800) 2-3553
(631) 962-0600
Tavocept
dimesna
$an /nron|o, TX
(see also cancer-related) P|ase lll
(210) 11-1Z01
Tc-99m ethylenedicysteine
glucosamine
(EC-G)
Cell Point
Centennial, CO
NSCLC (diagnosis) P|ase ll/lll
(303) 689-9693
Telcyta
canfosfamide
Telik
Palo Alto, CA
third-line NSCLC
(see also lymphoma, ovarian)
P|ase lll corp|eled
(50) 815-ZZ00
Temodar
temozolomide
Merck
SCLC
(see also leukemia)
P|ase ll
(800) 672-6372
tivantinib
(ARQ 197)
ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
NSCLC
P|ase lll
(Z81) 991-0300
(9Z3) 911-200
51
LUNG CANCER
topotecan liposomes injection Talon Therapeutics
San Mateo, CA
SCLC
(see also ovarian)
P|ase l
(50) 599-101
second-line NSCLC
multiple myeloma, pancreatic, skin)
P|ase ll
(888) 825-5219
Vargatef
intedanib
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
second-line late-stage NSCLC
(see also ovarian)
P|ase lll
(800) 213-012Z
veglin
(VEGF antisense)
Los Angeles, CA
mesothelioma
(see also kidney, skin)
P|ase l
(323) 221-7818
volociximab Abbott Laboratories
Abbott Park, IL
8|oer ldec
Weston, MA
NSCLC P|ase ll
(81Z) 93Z-100
(Z81) 11-2000
Xalkori
crizotinib
(Orphan Drug)
Plzer
New York, NY
lrsl-||re ALK-pos|l|ve N3CLC,
second-line ALK-positive NSCLC
--------------------------------------------------
P|ase lll
(80) Z32-515
-------------------------------------------
P|ase l/ll
(80) Z32-515
YERVOY
ipilimumab
Princeton, NJ
NSCLC, SCLC
(see also prostate, skin)
in clinical trials
(800) 332-205
Zolinza
vorinostat
(Orphan Drug)
Merck
mesothelioma
(see also breast, leukemia,
lymphoma, multiple myeloma, other)
P|ase lll
(800) 672-6273
Zybrestat
fosbretabulin
OXiGENE
lrsl-||re N3CLC
(see also ovarian)
P|ase ll
(50) 35-Z000
52
LYMPHOMA
abexinostat
(HDAC inhibitor)
Pharmacyclics
Sunnyvale, CA
lymphoma
(see also sarcoma)
P|ase l/ll
(108) ZZ1-0330
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
lung, ovarian, prostate, skin, other)
P|ase l/ll
(81Z) 93Z-100
Actimid
pomalidomide
Celgene
Summit, NJ
wa|derslror's racro|oou||rer|a
(see also lung, multiple myeloma,
pancreatic)
P|ase l
(908) 673-9000
Adcetris
brentuximab vedotin
Cambridge, MA
Seattle Genetics
Bothell, WA
post-transplant Hodgkins lymphoma
relapse prevention
(see also leukemia)
--------------------------------------------------
relapsed/refractory CD30-positive
non-Hodgkins lymphoma, relapsed/
refractory anaplastic large-cell
lymphoma
--------------------------------------------------
lrsl-||re arap|asl|c |are-ce||
|yrp|ora, lrsl-||re lod||r's
lymphoma
P|ase lll
(800) 390-53
(125) 52Z-1000
-------------------------------------------
P|ase ll
(800) 390-53
(125) 52Z-1000
-------------------------------------------
P|ase l
(800) 390-53
(125) 52Z-1000
Adcetris
Companion Diagnostic
brentuximab vedotin companion
diagnostic
Cambridge, MA
Seattle Genetics
Bothell, WA
Ventana Medical Systems
Tuoson, /Z
cutaneous T-cell lymphoma
(diagnosis), T-cell lymphoma
(diagnosis)
in clinical trials
(617) 679-7000
(125) 52Z-1000
(800) 22Z-2155
AE03515
(XlAP |r||o|lor)
Aegera Therapeutics
Montreal, Canada
B-cell lymphoma
(see also leukemia)
P|ase l/ll
(511) 288-5532
Basking Ridge, NJ
(908) 2-5128
$QLWRU
everolimus
East Hanover, NJ
mantle cell lymphoma
(see also breast, kidney)
P|ase ll
(888) 669-6682
AFM13 Allred T|erapeul|cs
Heidelberg, Germany
second-line Hodgkins disease P|ase l
WWW.allred.cor
Alocrest
vinorelbine liposomal
Talon Therapeutics
San Mateo, CA
non-Hodgkins lymphoma
P|ase l
(50) 588-101
53
LYMPHOMA
AME-133v
(ocaratuzumab)
VENTRlK 8|olec|
0a||as, TX
non-Hodgkins lymphoma P|ase ll corp|eled
(211) 593-0500
Amplimexon
imexon
AmpliMed
Tuoson, /Z
second-line non-Hodgkins lymphoma P|ase ll
(520) 529-1000
amuvatinib
(VP1Z0)
Dublin, OH
(see also lung) P|ase l
(925) 50-0100
anti-CD22 mAb Abiogen Pharma
Pisa, Italy
B-cell lymphoma P|ase l
www.abiogen.com
Aplidin
plitidepsin
PharmaMar
Madrid, Spain
solid tumors)
P|ase l
www.pharmamar.com
Flemington, NJ
(862) 703-7170
Flemington, NJ
myeloma)
P|ase l/ll
(862) 703-7170
Arranon
nelarabine
(Orphan Drug)
GlaxoSmithKline
lrsl-||re T-ce|| |yrp|ora
(see also leukemia)
--------------------------------------------------
second-line T-cell lymphoma
P|ase lll
(888) 669-6682
-------------------------------------------
P|ase l/ll
(888) 669-6682
Arzerra
ofatumumab
GlaxoSmithKline
second-line diffuse large B-cell
lymphoma, second-line follicular
lymphoma
(see also leukemia)
--------------------------------------------------
P|ase lll
(888) 825-5219
-------------------------------------------
P|ase ll
(888) 825-5219
ASP3026 Astellas Pharma US
0eerle|o, lL
late-stage B-cell lymphoma
P|ase l
(800) 95-1321
AT-101
Malvern, PA
(see also brain, leukemia, lung,
prostate, stomach)
P|ase ll
(10) 108-0301
AT-10/0eo|o-1113 Ascenta Therapeutics
Malvern, PA
Debiopharm
Lausanne, Switzerland
lymphoma
(see also leukemia)
P|ase l
(10) 108-0301
www.debiopharm.com
54
LYMPHOMA
ATZ519
(CDK inhibitor)
Dublin, CA
P|ase ll
(925) 50-0100
AT9283
Dublin, CA
P|ase l
(925) 50-0100
autologous cancer vaccine 8ayer lrroval|or
Dusseldorf, Germany
Stellar Biotechnologies
Port Hueneme, CA
follicular lymphoma
(prevention of relapse)
P|ase l
(888) 812-293Z
(805) 188-2800
AVL-292
(Btk inhibitor)
Celgene
Summit, NJ
second-line non-Hodgkins
|yrp|ora, secord-||re wa|der-
slror's racro|oou||rer|a
(see a|so |eu|er|a, urspec|led)
P|ase l
(908) 673-9000
Bcl-2 inhibitor
(ABT-199/GDC-0199)
Abbott Laboratories
Abbott Park, IL
Genentech
(see also leukemia)
P|ase l
(81Z) 93Z-100
(800) 2-3553
belinostat
(Orphan Drug)
Henderson, NV
peripheral T-cell lymphoma (PTCL)
(Fast Track)
lung, ovarian, other)
P|ase ll
(Z02) 835-300
Bexxar
tositumomab and iodine

l-131 los|lurorao
GlaxoSmithKline
P|ase ll
(888) 825-5219
BiovaxID
B-cell lymphoma vaccine

(personalized lymphoma
vaccine)
8|ovesl lrlerral|ora|
Tama, FL
indolent follicular lymphoma
(Fast Track)
--------------------------------------------------
P|ase lll
(813) 81-2551
-------------------------------------------
P|ase ll
(813) 81-2551
CC-115
(kinase inhibitor)
Celgene
Summit, NJ
solid tumors)
P|ase l
(908) 673-9000
CC-122 Celgene
Summit, NJ
solid tumors)
P|ase l
(908) 673-9000
CC-223
(mTOR inhibitor)
Celgene
Summit, NJ
(see also lung, multiple myeloma)
P|ase l
(908) 673-9000
CEP-9722
(PARP inhibitor)
Cephalon
Frazer, PA
mantle cell lymphoma (combination
therapy)
(see also lung)
P|ase l
(10) 311-0200
55
LYMPHOMA
Clearazide
mechlorethamine gel
(Orphan Drug)
Ceptaris Therapeutics
Malvern, PA
(Fast Track)
(10) 9Z5-9290
CT-011 CureTech
Yavne, Israel
diffuse large B-cell lymphoma,
second-line follicular lymphoma
(see also colorectal, leukemia)
P|ase ll
www.curetechbio.com
darinaparsin
(Zl0-101)
(Orphan Drug)
Zl0PlARV 0rco|oy
New York, NY
second-line peripheral T-cell
lymphoma
(see also liver, multiple myeloma,
solid tumors)
--------------------------------------------------
lrsl-||re per|p|era| T-ce|| |yrp|ora
(combination therapy), non-Hodgkins
lymphoma
P|ase ll
(1) 211-0Z00
-------------------------------------------
P|ase l
(1) 211-0Z00
0C03-1501A Genentech
(see also leukemia)
P|ase l
(800) 2-3553
DCDT-2980S Genentech
recurrent non-Hodgkins lymphoma
(see also leukemia)
P|ase l
(800) 2-3553
0l-Leu1-lL2 Alopexx Oncology
Waltham, MA
non-Hodgkins lymphoma P|ase l
(Z81) 19Z-9888
Waltham, MA
Hodgkins disease
leukemia, lung)
P|ase ll
(Z81) 119-1100
enzastaurin Eli Lilly
Indianapolis, IN
diffuse large B-cell lymphoma P|ase lll
(800) 515-59Z9
epratuzumab
(Orphan Drug)
lrrurored|cs
Morris Plains, NJ
UCB
Atlanta, GA
diffuse large B-cell lymphoma
(combination therapy), follicular
lymphoma (combination therapy)
(see also leukemia)
P|ase ll
(9Z3) 05-8200
epratuzumab Y-90 lrrurored|cs
Morris Plains, NJ
--------------------------------------------------
recurrent non-Hodgkins lymphoma
P|ase ll
(9Z3) 05-8200
-------------------------------------------
P|ase l/ll
(9Z3) 05-8200
56
LYMPHOMA
EZN-2968
(llF1-a|p|a |r||o|lor)
Piscataway, NJ
(9Z3) 980-1500
Folotyn
pralatrexate
(Orphan Drug)
Allos Therapeutics
Westminster, CO
peripheral T-cell lymphoma
(lrsl-||re l|erapy)
(see also bladder, breast, lung)
--------------------------------------------------
B-cell non-Hodgkins lymphoma,
--------------------------------------------------
P|ase lll
(303) 12-22
-------------------------------------------
P|ase ll
(303) 12-22
-------------------------------------------
P|ase l
(303) 12-22
forodesine
(Orphan Drug)
BioCryst Pharmaceuticals
Durham, NC
(see also leukemia)
P|ase ll
(919) 859-1302
galiximab 8|oer ldec
Cambridge, MA
--------------------------------------------------
lrsl-||re ror-lod||r's |yrp|ora
(monotherapy)
P|ase ll corp|eled
(617) 679-2000
-------------------------------------------
P|ase l corp|eled
(617) 679-2000
00C-0319
(small molecule)
Genentech
P|ase l
(800) 2-3553
00C-0125
(ChK1 inhibitor)
Genentech
(800) 2-3553
00C-05Z5 Genentech
(800) 2-3553
GDC-0917
(lAP arlaor|sl)
Genentech
(800) 2-3553
GDC-0980
inhibitor)
Genentech
P|ase l
(800) 2-3553
GS-1101
(Pl3K de|la |r||o|lor)
Gilead Sciences
Foster City, CA
indolent non-Hodgkins lymphoma
(see also leukemia)
P|ase ll
(800) 115-3235
03K1131
(polio-like kinase inhibitor)
GlaxoSmithKline
P|ase l
(888) 825-5219
GSK690693
(AKT kinase inhibitor)
GlaxoSmithKline
(888) 825-5219
57
LYMPHOMA
03K212158
GlaxoSmithKline
(888) 825-5219
03K2111Z95
GlaxoSmithKline
(888) 825-5219
iboctadekin GlaxoSmithKline
(see also ovarian)
P|ase l corp|eled
(888) 825-5219
ibrutinib
(PCl-32Z5)
Janssen Biotech
Horsham, PA
Pharmacyclics
Sunnyvale, CA
myeloma)
P|ase ll
(800) 52-ZZ3
(108) ZZ1-0330
lV0N529 lrruro0er
Waltham, MA
metastatic non-Hodgkins lymphoma P|ase l
(Z81) 895-000
lNK128
(mTOR inhibitor)
lrle|||||re
La Jolla, CA
(see also multiple myeloma, solid
tumors)
P|ase l
(858) Z8-500
inotuzumab ozogamicin Plzer
New York, NY
aggressive non-Hodgkins lymphoma
(see also leukemia)
--------------------------------------------------
indolent non-Hodgkins lymphoma
P|ase lll
(80) Z32-515
-------------------------------------------
P|ase ll
(80) Z32-515
interleukin-12 gene therapy OncoSec Medical
San Diego, CA
(see also skin)
P|ase ll
www.oncosec.com
l3F35 Memgen
San Diego, CA
follicular lymphoma, diffuse large cell
lymphoma, mantle cell lymphoma,
small lymphocytic lymphoma
(see also leukemia)
P|ase ll
(858) 521-5100
JNJ-2181585
(quisinostat)
Raritan, NJ
(see also leukemia)
P|ase ll
(800) 81Z-528
LEE011
(C0K1/ |r||o|lor)
East Hanover, NJ
(888) 669-6682
L0Z10
(activated T-cells)
Lentigen
Gaithersburg, MD
University of Pennsylvania
Philadelphia, PA
follicular lymphoma, mantle-cell
lymphoma
(see also leukemia)
P|ase l
(301) 52Z-1200
58
LYMPHOMA
lucatumumab
(HDC122)
East Hanover, NJ
XOMA
Berkeley, CA
lymphoma
--------------------------------------------------
follicular lymphoma
P|ase l/ll
(888) 669-6682
-------------------------------------------
P|ase l
(888) 669-6682
Marqibo
Talon Therapeutics
San Mateo, CA
(see also leukemia, skin, other)
P|ase ll
(50) 588-101
Morris Plains, NJ
myeloma)
P|ase l/ll
(9Z3) 05-8200
VK-Z95
(dinaciclib)
Merck
(see also leukemia)
P|ase ll
(800) 672-6372
MK-8808 Merck
late-stage follicular lymphoma
P|ase l
(800) 672-6372
MLN8237
(alisertib)
Cambridge, MA
P|ase lll
(800) 390-53
MLN9708
(ixazomib)
Cambridge, MA
|yrp|ora, wa|derslror's
macroglobulinemia
(see also multiple myeloma, solid
tumors)
P|ase l
(800) 390-53
mocetinostat
(Orphan Drug)
MethylGene
Montreal, Canada
follicular lymphoma
P|ase ll
(511) 33Z-3333
mogamulizumab
(Orphan Drug)
Amgen
Tnousano Daks, 0/
cutaneous T-cell lymphoma,
P|ase ll
(800) ZZ2-13
navitoclax
(ABT-263)
Abbott Laboratories
Abbott Park, IL
(see also leukemia, lung) P|ase l/ll
(81Z) 93Z-100
NPl-0052
(marizomib)
San Diego, CA
solid tumors)
P|ase l
(858) 58Z-1090
obatoclax
(Orphan Drug)
Cephalon
Frazer, PA
lrsl-||re lo|||cu|ar |yrp|ora
(see also leukemia, lung, multiple
myeloma)
--------------------------------------------------
P|ase ll corp|eled
(10) 311-0200
-------------------------------------------
(10) 311-0200
59
LYMPHOMA
obinutuzumab
(0A101/R0Z159)
8|oer ldec
Weston, MA
Genentech
(combination therapy), second-line
non-Hodgkins lymphoma (com-
o|ral|or l|erapy), lrsl-||re 8-ce||
(see also leukemia)
--------------------------------------------------
second-line non-Hodgkins lymphoma
(monotherapy)
P|ase lll
(Z81) 11-2000
(800) 2-3553
-------------------------------------------
P|ase ll
(Z81) 11-2000
(800) 2-3553
0N 013105 Onconova Therapeutics
Newtown, PA
(see also leukemia) P|ase l
(2Z) Z59-380
0N0-1059 ONO Pharmaceutical
Osaka, Japan
B-cell lymphoma P|ase l
www.ono.co.jp
Summit, NJ
(see also leukemia, lung,
solid tumors)
P|ase l
(908) 673-9000
03l-02Z
(TORC1/TORC2 inhibitor)
03l P|arraceul|ca|s
Farmingdale, NY
(see also kidney) P|ase l
(631) 962-0600
P 27600 Piramal Life Sciences
Mumbai, India
mantle cell lymphoma P|ase ll
www.piramallifesciences.com
Basking Ridge, NJ
lymphoma (combination therapy),
leukemia, lung, multiple myeloma,
P|ase ll
(908) 2-5128
P01101Z Progen Pharmaceuticals
www.progen-pharma.com
pixantrone Cell Therapeutics
Seattle, WA
(see also breast)
P|ase lll
(800) 215-2355
PLX3397
Plexxikon
Berkeley, CA
recurrent or refractory Hodgkins
disease
(see also brain, leukemia, solid
tumors)
P|ase ll
(510) 1Z-1000
60
LYMPHOMA
Revlimid
lenalidomide
Celgene
Summit, NJ
(see also leukemia)
P|ase lll
(908) 673-9000
RG7602 Genentech
(800) 2-3553
rigosertib Onconova Therapeutics
Newtown, PA
(see also leukemia, ovarian,
pancreatic)
P|ase ll
(2Z) Z59-380
Rituxan
rituxumab
(fast infusion)
8|oer ldec
Weston, MA
Genentech
non-Hodgkins lymphoma application submitted
(Z81) 11-2000
(800) 2-3553
3AR215109
(XLZ5)
3arol u3
Bridgewater, NJ
Exelixis
(see also breast)
P|ase ll
(800) 981-2191
(50) 83Z-Z000
30N-Z5
(vorsetuzumab mafodotin)
Seattle Genetics
Bothell, WA
(see also kidney)
P|ase l
(125) 52Z-1000
3lP-111 Shape Pharmaceuticals
Cambridge, MA
cutaneous T-cell lymphoma P|ase l
www.shapepharma.com
sotrastaurin
(AEB071)
East Hanover, NJ
diffuse large B-cell lymphoma P|ase l
(888) 669-6682
stem cell therapy Benitec Biopharma
Sydney, Australia
City of Hope National Medical Center
Duarte, CA
Al03-re|aled |yrp|ora P|ase l
www.benitec.com
teglarinad Cephalon
Frazer, PA
(10) 311-0200
Telcyta
canfosfamide
Telik
Palo Alto, CA
mantle cell lymphoma, non-Hodgkins
lymphoma
P|ase ll
(50) 815-ZZ00
thiarabine Access Pharmaceuticals
0a||as, TX
(see also leukemia) P|ase l/ll
(215) 901-5100
61
LYMPHOMA
tigatuzumab
(arl|-0R5 arl|oody)
Daiichi Sankyo
Parsippany, NJ
P|ase l corp|eled
(9Z3) 911-200
TKM-PLK1
(RNAi)
Tekmira Pharmaceuticals
Burnaby, Canada
(01) 119-3200
(see also leukemia, lung, multiple
myeloma, pancreatic, skin)
P|ase l
(888) 825-5219
Treanda
bendamustine
Cephalon
Frazer, PA
myeloma)
--------------------------------------------------
second-line mantle cell lymphoma
(10) 311-0200
-------------------------------------------
P|ase ll
(10) 311-0200
TRU-016
(humanized anti-CD37
therapeutic)
Rockville, MD
(see also leukemia)
P|ase l/ll
(301) Z95-1800
uN83-512 Drais Pharmaceuticals
Bridgewater, NJ
(908) 895-1200
Velcade
bortezomib
Cambridge, MA
lrsl-||re rarl|e ce|| |yrp|ora
(see also leukemia, cancer-related,
other)
--------------------------------------------------
non-Hodgkins B-cell lymphoma
--------------------------------------------------
P|ase lll
(800) 390-53
-------------------------------------------
P|ase lll
(800) 390-53
-------------------------------------------
P|ase ll
(800) 390-53
veltuzumab lrrurored|cs
Morris Plains, NJ
(see also leukemia)
P|ase l/ll
(9Z3) 05-8200
Vidaza
azacitidine
Celgene
Summit, NJ
(see also leukemia) P|ase lll
(908) 673-9000
VTX-2337 VentiRx Pharmaceuticals
Seattle, WA
B-cell lymphoma
--------------------------------------------------
lymphoma
P|ase l/ll
(20) 89-2259
-------------------------------------------
P|ase l
(20) 89-2259
62
LYMPHOMA
XmAb
2513
(CD30-antigen inhibitor)
Xencor
Monrovia, CA
Hodgkins disease, T-cell lymphoma P|ase l
(2) 305-5900
YV155
(sepantronium)
Astellas Pharma US
0eerle|o, lL
(see also breast)
P|ase ll
(800) 95-1321
zanolimumab
(Orphan Drug)
Rockville, MD
--------------------------------------------------
P|ase ll
(301) Z95-1800
-------------------------------------------
P|ase l
(301) Z95-1800
Zevalin
ibritumomab tiuxetan
Henderson, NV
second-line diffuse large B-cell
lymphoma
--------------------------------------------------
P|ase lll
(Z02) 835-300
-------------------------------------------
P|ase ll
(Z02) 835-300
Zolinza
vorinostat
Merck
B-cell lymphoma
(see also breast, leukemia, lung,
P|ase ll
(800) 672-6273
MULTIPLE MYELOMA
ACE-011
(dalantercept)
Acceleron Pharma
Cambridge, MA
(see also head/neck) P|ase l
(1Z) 19-9200
Actimid
pomalidomide
(Orphan Drug)
Celgene
Summit, NJ
recurrent multiple myeloma
pancreatic)
(908) 673-9000
ACY-1215
(HDAC6 inhibitor)
Acetylon Pharmaceuticals
Boston, MA
P|ase l/ll
(1Z) 215-1300
ALXN6000
(samalizumab)
Alexion Pharmaceuticals
0nesn|re, 0T
(see also leukemia) P|ase l/ll corp|eled
(203) 2Z2-259
63
MULTIPLE MYELOMA
Aplidin
plitidepsin
(Orphan Drug)
PharmaMar
Madrid, Spain
(see also lymphoma, solid tumors) P|ase lll
www.pharmamar.com
Flemington, NJ
(see also leukemia, lymphoma) P|ase l/ll
(862) 703-7170
ARRY-520
(KSP inhibitor)
Array BioPharma
Boulder, CO
multiple myeloma
--------------------------------------------------
multiple myeloma (combination
therapy)
P|ase ll
(8ZZ) 33-213
-------------------------------------------
P|ase l
(8ZZ) 33-213
ATZ519
(CDK inhibitor)
Dublin, CA
second-line multiple myeloma
solid tumors)
P|ase l/ll
(925) 50-0100
AT9283
Dublin, CA
solid tumors)
P|ase ll
(925) 50-0100
AUY922
(Hsp90 inhibitor)
East Hanover, NJ
stomach)
P|ase l/ll
(888) 669-6682
BHQ880
(mAb)
East Hanover, NJ
(see also solid tumors) P|ase ll
(888) 669-6682
8l-505
(Orphan Drug)
8|olrverl lrlerral|ora|
Lund, Sweden
second-line late-stage multiple
myeloma
P|ase l
www.bioinvent.com
8lw-892 Kyowa Hakko Kirin Pharma
Princeton, NJ
P|ase l/ll
(609) 919-1100
carl|zor|o
(Orphan Drug)
Onyx Pharmaceuticals
third-line multiple myeloma
(Fast Track)
--------------------------------------------------
therapy)
(50) 2-0000
-------------------------------------------
P|ase l/ll
(50) 2-0000
C83301
(noscapine)
Cougar Biotechnology
Raritan, NJ
P|ase l/ll
www.cougarbiotechnology.com
CC-115
(kinase inhibitor)
Celgene
Summit, NJ
(see also lymphoma, solid tumors) P|ase l
(908) 673-9000
CC-122 Celgene
Summit, NJ
(908) 673-9000
CC-223
(mTOR inhibitor)
Celgene
Summit, NJ
(see also lung, lymphoma) P|ase l
(908) 673-9000
64
MULTIPLE MYELOMA
CP-18770
(delanzomib)
Cephalon
Frazer, PA
P|ase ll
(10) 311-0200
CX-1915
(CK2 inhibitor)
Cylene Pharmaceuticals
San Diego, CA
(858) 8Z5-5100
daratumumab Genmab
Princeton, NJ
P|ase l/ll
(09) 130-2181
darinaparsin
(Zl0-101)
Zl0PlARV 0rco|oy
New York, NY
(see also liver, lymphoma,
solid tumors)
P|ase ll
(1) 211-0Z00
0FRF-1539A Genentech
refractory metastatic multiple
myeloma
P|ase l
(800) 2-3553
elotuzumab
(BMS-901608)
Princeton, NJ
P|ase lll
(800) 332-205
ENMD-2076
(Orphan Drug)
EntreMed
Rockville, MD
relapsed or refractory multiple
myeloma
P|ase l
(210) 81-200
ganetespib
(Hsp90i)
Lexington, MA
leukemia, liver, lung, pancreatic,
P|ase l
(Z81) 2Z1-8200
GL-0817 Gliknik
Baltimore, MD
(see also head/neck) P|ase ll
www.gliknik.com
GSK2110183
GlaxoSmithKline
(888) 825-5219
GVAX
Myeloma
cancer vaccine
Lincolnshire, IL
P|ase ll
(81Z) 1Z8-0500
ibrutinib
(PCl-32Z5)
Janssen Biotech
Horsham, PA
Pharmacyclics
Sunnyvale, CA
(see also leukemia, lymphoma) P|ase ll
(800) 52-ZZ3
(108) ZZ1-0330
imetelstat Geron
Menlo Park, CA
(monotherapy)
(see also breast, leukemia, lung)
P|ase ll
(50) 1Z3-ZZ00
indatuximab ravtansine
(Orphan Drug)
Biotest
Dreieich, Germany
relapsed or refractory multiple
myeloma
P|ase l/ll
www.biotest.de
65
MULTIPLE MYELOMA
lNK128
(mTOR inhibitor)
lrle|||||re
La Jolla, CA
(858) Z8-500
lPl-2101
(arl|-KlR rAo)
lrrale P|arra
Marseille, France
multiple myeloma (monotherapy)
--------------------------------------------------
therapy)
P|ase ll
www.innate-pharma.com
-------------------------------------------
P|ase l/ll
www.innate-pharma.com
Kw-21Z8 Kyowa Hakko Kirin Pharma
Princeton, NJ
therapy)
P|ase l/ll
(609) 919-1100
L8l589
(panobinostat)
East Hanover, NJ
(see also kidney, leukemia, prostate,
solid tumors)
P|ase lll
(888) 669-6682
lorvotuzumab mertansine
(lV0N901)
lrruro0er
Waltham, MA
(Z81) 895-000
Rockville, MD
therapy)
(see also liver, lung)
P|ase ll
(301) 309-8501
melphalan intravenous
(captisol-enabled)
(Orphan Drug)
CyDex Pharmaceuticals
Lenexa, KS
P|ase ll
www.ligand.com/cydex
Morris Plains, NJ
P|ase l/ll
(9Z3) 05-8200
MLN9708
(ixazomib)
Cambridge, MA
newly diagnosed multiple myeloma
multiple myeloma
P|ase l/ll
(800) 390-53
Nexavar
sorafenib
Wayne, NJ
(see also breast, colorectal, head/
neck, kidney, leukemia, liver, lung,
ovarian, other)
P|ase l/ll
(888) 812-293Z
NPl-0052
(marizomib)
San Diego, CA
(858) 58Z-1090
obatoclax Cephalon
Frazer, PA
(see also leukemia, lung, lymphoma) P|ase l corp|eled
(10) 311-0200
66
MULTIPLE MYELOMA
perifosine
(Orphan Drug)
AEterna Zentaris
Basking Ridge, NJ
(Fast Track)
leukemia, lung, lymphoma, sarcoma,
P|ase lll
(908) 2-5128
R0Z111
(MFGR-1877S)
Genentech
refractory metastatic multiple
myeloma
P|ase l
(800) 2-3553
R0Z598
Genentech
P|ase l
(800) 2-3553
injection
EUSA Pharma
Langhorne, PA
(see also breast, prostate, sarcoma,
other)
P|ase l/ll
(800) 833-3533
SF1126 Semafore Pharmaceuticals
Indianapolis, IN
(see also leukemia, solid tumors) P|ase l
(31Z) 8Z-30Z5
siltuximab Janssen Biotech
Horsham, PA
(see also prostate, other) P|ase ll
(800) 52-ZZ3
SNS01-T
(nano-encapsulated gene
therapy)
(Orphan Drug)
Senesco Technologies
Bridgewater, NJ
second-line multiple myeloma P|ase l/ll
(908) 81-1111
(see also brain, leukemia, pancreatic,
sarcoma)
P|ase l/ll
(50) 1Z1-8200
TKl258
(dovitinib)
East Hanover, NJ
(see also breast, kidney, prostate,
skin, other)
P|ase ll
(888) 669-6682
multiple myeloma
pancreatic, skin)
P|ase l/ll
(888) 825-5219
Treanda
bendamustine
Cephalon
Frazer, PA
P|ase l/ll
(10) 311-0200
Xgeva
denosumab
Amgen
Tnousano Daks, 0/
(see also cancer-related, other) P|ase ll
(800) ZZ2-13
Zolinza
vorinostat
(Orphan Drug)
Merck
metastatic multiple myeloma
lymphoma, other)
P|ase lll
(800) 672-6273
67
OVARIAN CANCER
6 Angstrom Pharmaceuticals
Solana Beach, CA
(858) 311-235
abagovomab
(anti-idiotype mAb vaccine)
(Orphan Drug)
Menarini
Florence, Italy
P|ase lll
www.menarini.com
Abraxane
Celgene
Summit, NJ
(see also bladder, breast, lung,
pancreatic, skin)
P|ase ll
(908) 673-9000
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
lung, lymphoma, prostate, skin,
other)
P|ase ll
(81Z) 93Z-100
AE37 peptide vaccine Antigen Express
Worcester, MA
(see also breast) P|ase l
(508) 852-8Z83
AEZS-108
(Orphan Drug)
AEterna Zentaris
Basking Ridge, NJ
(see also bladder, prostate, other) P|ase ll
(908) 2-5128
Avastin
bevacizumab
(Orphan Drug)
Genentech
relapsed, platinum-sensitive ovarian
cancer
lung, other)
--------------------------------------------------
lrsl-||re relaslal|c ovar|ar carcer
(800) 2-3553
-------------------------------------------
P|ase lll
(800) 2-3553
BC-819
(gene therapy)
(Orphan Drug)
Jerusalem, Israel
late-stage ovarian cancer
(see also bladder, pancreatic)
P|ase l/ll
www.biocancell.com
Henderson, NV
late-stage ovarian cancer
lung, lymphoma, other)
P|ase ll corp|eled
(Z02) 835-300
cabozantinib
(XL181)
Exelixis
(see also breast, kidney, lung,
prostate, other)
P|ase ll
(50) 83Z-Z000
catumaxomab Fresenius Biotech North America
Waltham, MA
www.fresenius-biotech.com
CVac
MUC-1 cancer vaccine
Prima BioMed
Sydney, Australia
P|ase ll/lll
www.primabiomed.com.au
68
OVARIAN CANCER
DCVax
-Ovarian
dendritic cell-based vaccine
Northwest Biotherapeutics
Bethesda, MD
P|ase l
(210) 19Z-9021
0VuC-5Z51A Genentech
second-line ovarian cancer
(see also other)
P|ase l
(800) 2-3553
Halifax, Canada
(see also breast, prostate) P|ase l
(902) 192-1819
DPX-survivac cancer vaccine lrrurovacc|re
Halifax, Canada
P|ase l
(902) 192-1819
EZ850
(irofulven)
Eisai
Woodcliff Lake, NJ
(see also prostate, other) P|ase ll
(888) 122-1Z13
EC20
(technetium Tc-99m etarfolatide)
Endocyte
West Lafayette, IN
ovarian cancer (diagnosis)
(see also lung)
P|ase lll
www.endocyte.com
EC115
(vintafolide)
Endocyte
West Lafayette, IN
Merck
platinum-resistant ovarian cancer
(see also lung)
P|ase lll
www.endocyte.com
(800) 672-6372
EGEN-001
(Orphan Drug)
EGEN
Huntsville, AL
(see also colorectal, other) P|ase ll
(25) 512-00ZZ
Lexington, MA
(see also leukemia, lung) P|ase ll
(Z81) 2Z1-8200
ENMD-2076
(Orphan Drug)
EntreMed
Rockville, MD
(see also multiple myeloma, other)
P|ase ll
(210) 81-200
etirinotecan pegol
(NKTR-102)
(Orphan Drug)
Nektar Therapeutics
San Francisco, CA
(see also breast, colorectal, solid
tumors)
P|ase ll
(855) 182-58Z
FANG Vaccine
Gradalis
0arro||ron, TX
adjuvant ovarian cancer
(see also colorectal, skin)
P|ase ll
(211) 112-8100
vaccine
Galena Biopharma
Lake Oswego, OR
(see also breast, other) P|ase l/ll
(855) 855-1253
iboctadekin GlaxoSmithKline
(see also lymphoma) P|ase l corp|eled
(888) 825-5219
69
OVARIAN CANCER
lVT-1012 |rrurol|erapeul|c
vaccine
lrrurolope
Doylestown, PA
(215) 253-1180
iniparib
(83l-201)
3arol u3
Bridgewater, NJ
(see also breast, lung) P|ase ll
(800) 981-2191
Karenitecin
cositecan
$an /nron|o, TX
advanced ovarian cancer
P|ase lll
(210) 11-1Z01
KHK-2866 Kyowa Hakko Kirin Pharma
Princeton, NJ
ovarian cancer (combination therapy)
P|ase l
(609) 919-1100
VK-1ZZ5
(wee1 |r||o|lor)
Merck
second-line ovarian cancer P|ase ll
(800) 672-6372
MORAb-003
(farletuzumab)
Eisai
Woodcliff Lake, NJ
platinum-sensitive ovarian cancer
(see also lung)
P|ase lll
(888) 122-1Z13
Nexavar
sorafenib
Wayne, NJ
lrsl-||re ovar|ar carcer
lung, multiple myeloma, other)
P|ase ll
(888) 812-293Z
Bothell, WA
(see also breast, lung) P|ase l
(125) 8-1500
olaratumab
(LY3012207)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
(800) 515-59Z9
ombrabulin
(AVE8062)
3arol u3
Bridgewater, NJ
(see also lung, sarcoma)
P|ase ll
(800) 981-2191
Opaxio
Cell Therapeutics
Seattle, WA
(see also brain, lung, stomach, other) P|ase lll
(800) 215-2355
oregovomab
(Orphan Drug)
Quest PharmaTech
Edmonton, Canada
P|ase l/ll
(Z80) 118-1100
03l-90
inhibitor)
03l P|arraceul|ca|s
Farmingdale, NY
(see also lung, other) P|ase ll
(631) 962-0600
OVax
autologous cell vaccine

(Orphan Drug)
AVAX Technologies
Philadelphia, PA
P|ase l/ll
(215) 211-9Z0
70
OVARIAN CANCER
phenoxodiol Marshall Edwards
San Diego, CA
second-line late-stage ovarian cancer
(Fast Track)
(see also prostate, other)
P|ase lll
(858) Z92-300
Seattle, WA
(see also colorectal, lung, prostate) P|ase ll
(206) 281-7001
Quinamed
aroralde
Cephalon
Frazer, PA
(see also breast, prostate) P|ase ll
(10) 311-0200
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
ovarian cancer (combination therapy)
head/neck, lung, pancreatic,
sarcoma, skin, solid tumors)
--------------------------------------------------
ovarian cancer (monotherapy)
P|ase ll
(103) Z0-Z3ZZ
-------------------------------------------
P|ase l
(103) Z0-Z3ZZ
R0Z158 Genentech
P|ase l
(800) 2-3553
R0Z599
Genentech
(800) 2-3553
RG7600
Genentech
P|ase l
(800) 2-3553
Newtown, PA
pancreatic)
P|ase ll
(2Z) Z59-380
rucaparib Clovis Oncology
Boulder, CO
(see also breast) P|ase ll
(303) 25-5000
Wayne, NJ
(see also breast, prostate) P|ase ll corp|eled
(888) 812-293Z
3AR25212 (VV-121)
(anti-ErbB3 mAb)
Cambridge, MA
3arol u3
Bridgewater, NJ
(see also breast, lung) P|ase l
(800) 981-2191
SG2000 Spirogen
London, United Kingdom
P|ase ll
www.spirogen.com
squalamine
(Orphan Drug)
OHR Pharmaceutical
New York, NY
resistant ovarian cancer P|ase ll
(212) 82-8152
Telcyta
canfosfamide
Telik
Palo Alto, CA
(see also lung, lymphoma) P|ase lll corp|eled
(50) 815-ZZ00
71
OVARIAN CANCER
tigatuzumab
(arl|-0R5 arl|oody)
Daiichi Sankyo
Parsippany, NJ
lymphoma, pancreatic)
P|ase ll
(9Z3) 911-200
topotecan liposomes injection Talon Therapeutics
San Mateo, CA
(50) 588-101
trabectedin
(Orphan Drug)
Raritan, NJ
(see also breast, prostate, sarcoma)
P|ase lll
(800) 81Z-528
TRC 105
San Diego, CA
(see also breast, prostate, other) P|ase ll
(858) 550-0Z80
trebananib
(AMG386)
Amgen
Tnousano Daks, 0/
liver, stomach, other)
P|ase lll
(800) ZZ2-13
Vargatef
intedanib
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
lrsl-||re |ale-slae ovar|ar carcer
(see also lung)
P|ase lll
(800) 213-012Z
vosaroxin Sunesis Pharmaceuticals
(see also leukemia) P|ase ll
(50) 2-3Z39
Votrient
pazopanib
GlaxoSmithKline
(see also kidney, other) P|ase lll
(888) 825-5219
Zybrestat
fosbretabulin
(Orphan Drug)
OXiGENE
(50) 35-Z000
PANCREATIC CANCER
Abraxane
(Orphan Drug)
Celgene
Summit, NJ
ovarian, skin)
P|ase lll
(908) 673-9000
Actimid
pomalidomide
Celgene
Summit, NJ
multiple myeloma)
P|ase l/ll
(908) 673-9000
72
PANCREATIC CANCER
anti-MUC1 mAb Quest PharmaTech
Edmonton, Canada
P|ase l/ll
(Z80) 118-1100
anti-PSCA mAb Agensys
Santa Monica, CA
Astellas Pharma US
0eerle|o, lL
metastatic pancreatic cancer
P|ase ll
(800) 95-1321
apricoxib
(TG01)
San Diego, CA
pancreatic (combination therapy)
(see also lung)
P|ase ll
(858) 350-900
Archexin
RX-0201
(Orphan Drug)
Rexahn Pharmaceuticals
Rockville, MD
P|ase ll
(210) 28-5300
A30-5VE Agensys
Santa Monica, CA
Seattle Genetics
Bothell, WA
(see also prostate)
P|ase l
(800) 95-1321
(125) 52Z-1000
Tusr|n, 0/
lrsl-||re parcreal|c carcer
(see also liver, lung)
P|ase ll
(Z15) 508-000
BAY 86-9766
(MEK inhibitor)
Ardea Biosciences
San Diego, CA
Wayne, NJ
(see also liver)
P|ase l/ll
(888) 812-293Z
BC-819
(gene therapy)
(Orphan Drug)
Jerusalem, Israel
lrsl-||re |ale-slae parcreal|c carcer
(Fast Track)
(see also bladder, ovarian)
P|ase ll
www.biocancell.com
Chk1 inhibitor
(LY2603618)
Eli Lilly
Indianapolis, IN
(800) 515-59Z9
CO-101
(lipid drug conjugate of
gemcitabine)
(Orphan Drug)
Clovis Oncology
Boulder, CO
lrsl-||re relaslal|c parcreal|c
cancer, second-line metastatic
pancreatic cancer
P|ase ll
(303) 25-5000
CO-101
(|ENT1 llC assay)
Clovis Oncology
Boulder, CO
Ventana Medical Systems
Tuoson, /Z
pancreatic cancer (diagnosis) in clinical trials
(303) 25-5000
CPl-13
(Orphan Drug)
Cornerstone Pharmaceuticals
Cranbury, NJ
combination therapy
(see also other)
P|ase l/ll
(09) 109-Z050
73
PANCREATIC CANCER
CRS-207
(cancer vaccine)
Aduro BioTech
Berkeley, CA
P|ase ll
(510) 818-1100
dalotuzumab
(VK-01)
Merck
(see also breast, lung, other) P|ase l/ll
(800) 672-6372
(macrobeads)
Roos|r lrsl|lule
New York, NY
refractory metastatic pancreatic
cancer
(see also colorectal, prostate)
P|ase ll
(212) Z1-15
FG-3019
(connective tissue growth
factor)
FibroGen
San Francisco, CA
P|ase ll
(115) 9Z8-1200
ganetespib
(Hsp90i)
Lexington, MA
myeloma, prostate, skin, stomach)
P|ase ll
(Z81) 2Z1-8200
ganitumab
(AV0 1Z9)
Amgen
Tnousano Daks, 0/
lrsl-||re relaslal|c parcreal|c carcer
sarcoma)
P|ase lll
(800) ZZ2-13
0l-1000 0|ooelrrure
Louisville, CO
(see also colorectal, lung) P|ase ll
(303) 25-2Z00
glufosfamide
(Orphan Drug)
Eleison Pharmaceuticals
Princeton, NJ
pancreatic cancer (Fast Track) P|ase lll corp|eled
(215) 551-3530
03-21
(monoclonal antibody)
Gilead Sciences
Foster City, CA
(800) 115-3235
GV1001
(hTERT RNA vaccine)
KAEL-GemVax
Seoul, South Korea
P|ase l
www.kaelgemvax.com
GVAX
Pancreatic
cancer vaccine
(Orphan Drug)
Lincolnshire, IL
Aduro BioTech
Berkeley, CA
P|ase ll
(81Z) 1Z8-0500
(510) 818-1100
HyperAcute
Pancreas
algenpantucel-L
(Orphan Drug)
NewLink Genetics
Ames, IA
P|ase lll
(515) 29-5555
lVP321 lrrulep
Chtenay-Malabry, France
P|ase l
www.immutep.org
lNN0-20
(Orphan Drug)
CytRx
Los Angeles, CA
pancreatic ductal adenocarcinoma
(see also sarcoma, solid tumors)
P|ase ll
(310) 82-518
74
PANCREATIC CANCER
Istodax
romidepsin
Celgene
Summit, NJ
(see also kidney, prostate, other) P|ase l/ll
(908) 673-9000
-DND
ruxolitinib
lrcyle
Wilmington, DE
(855) 11-2983
KD032
(ras/mTOR inhibitor)
Warrendale, PA
(see also lung) P|ase l/ll corp|eled
(Z21) ZZ8-100
L0E225
(erismodegib)
East Hanover, NJ
neoadjuvant pancreatic cancer
(see also leukemia, solid tumors,
skin)
P|ase l/ll
(888) 669-6682
LE-DT
(liposomal docetaxel)
lrsys T|erapeul|cs
Phoenix, AZ
lrsl-||re parcreal|c carcer P|ase ll
(602) 910-2617
V102
(low molecular weight heparin)
Momenta Pharmaceuticals
Cambridge, MA
metastatic pancreatic cancer P|ase l/ll
(1Z) 191-9Z00
masitinib AB Science USA
Short Hills, NJ
(see also stomach) P|ase lll
(9Z3) 218-213Z
MM-398
(nanotherapeutic)
(Orphan Drug)
Cambridge, MA
metastatic pancreatic cancer P|ase ll
(1Z) 111-1000
Lund, Sweden
(see also kidney, lung) P|ase l corp|eled
NPC-1C
(ensituximab)
(Orphan Drug)
Neogenix Oncology
Rockville, MD
late-stage, metastatic pancreatic
cancer
P|ase l
(301) 917-6893
paclitaxel polymeric micelle
formulation
Samyang Biopharmaceuticals
Seoul, South Korea
late-stage pancreatic cancer P|ase ll
www.samyangpharm.com
PancAtak
gene therapy
Advantagene
Auburndale, MA
P|ase l
(1Z) 91-5115
PCl-2Z183
(laclor vlla |r||o|lor)
Pharmacyclics
Sunnyvale, CA
P|ase ll
(108) ZZ1-0330
PEGPH20
(pegylated recombinant
human hyaluronidase)
Halozyme Therapeutics
San Diego, CA
P|ase l/ll
(858) Z91-8889
75
PANCREATIC CANCER
PHY906 PhytoCeutica
heu laven, 0T
(see also colorectal, liver,
cancer-related)
P|ase l/ll
(203) ZZZ-312
polyclonal antibody stimulator
(Orphan Drug)
Cancer Advances
Durham, NC
(see also colorectal, stomach) P|ase lll
(919) 361-2162
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
pancreatic cancer (combination
therapy)
(see also brain, colorectal, head/
neck, lung, ovarian, sarcoma, skin,
solid tumors)
P|ase ll
(103) Z0-Z3ZZ
Rexin-G
(Orphan Drug)
San Marino, CA
(Fast Track)
(see also breast, sarcoma)
P|ase l/ll
(2) 111-95
RG7600
Genentech
platinum-resistant pancreatic cancer
(see also ovarian)
P|ase l
(800) 2-3553
Newtown, PA
ovarian)
P|ase ll/lll
(2Z) Z59-380
RP101 RESprotect
Dresden, Germany
P|ase ll/lll
www.resprotect.de
SecreFlo
synthetic human secretin
Repligen
Waltham, MA
pancreatic cancer (diagnosis) Phase 0
(Z81) 250-0111
SPRYCEL
dasatinib
Princeton, NJ
(see also brain, breast, prostate,
other)
in clinical trials
(800) 332-205
(see also brain, leukemia, multiple
myeloma, sarcoma)
P|ase ll
(50) 1Z1-8200
tigatuzumab
(arl|-0R5 arl|oody)
Daiichi Sankyo
Parsippany, NJ
lymphoma, ovarian)
P|ase ll corp|eled
(9Z3) 911-200
tivantinib
(ARQ 197)
ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
lung, sarcoma, other)
P|ase l
(Z81) 991-0300
(9Z3) 911-200
multiple myeloma, skin)
P|ase ll
(888) 825-5219
uridine triacetate
(PN101)
we||slal T|erapeul|cs
Gaithersburg, MD
(see also stomach) P|ase lll
(210) 31-2500
76
PANCREATIC CANCER
Virulizin
Lorus Therapeutics
Toronro, 0anaoa
P|ase lll
(11) Z98-1200
Y-90 clivatuzumab
(Orphan Drug)
lrrurored|cs
Morris Plains, NJ
(Fast Track)
P|ase l/ll
(9Z3) 05-8200
PROSTATE CANCER
99rTc-VlP-1105 Vo|ecu|ar lrs||l P|arraceul|ca|s
Cambridge, MA
prostate cancer (diagnosis) P|ase l
(1Z) 192-5551
A8l-008
(nab
-docetaxel)
Celgene
Summit, NJ
lrsl-||re |orrore-relraclory proslale
cancer
P|ase l/ll
(908) 673-9000
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
lung, lymphoma, ovarian, skin, other)
P|ase l
(81Z) 93Z-100
Basking Ridge, NJ
(see also bladder, ovarian, other) P|ase ll
(908) 2-5128
arl|-0X10 rAo AgonOx
Portland, OR
P|ase l
(800) 979-7202
AP1903 Bellicum Pharmaceuticals
lousron, TX
(see also cancer-related) P|ase l/ll
(Z13) 311-1Z2
Apatone
ascorbic acid/menadione
lC-VedTec|
San Diego, CA
P|ase l/ll
(19) Z19-500
APC-100 Adamis Pharmaceuticals
San Diego, CA
P|ase l/ll
www.adamispharmaceuticals.
com
New York, NY
hormone-refractory prostate cancer
(see also brain, breast, skin)
P|ase ll
(1) Z1Z-9090
ARN-509 Aragon Pharmaceuticals
San Diego, CA
hormone-refractory prostate cancer P|ase l/ll
(858) 39-Z00
77
PROSTATE CANCER
A30-5VE Agensys
Santa Monica, CA
Seattle Genetics
Bothell, WA
castration-resistant prostate cancer
P|ase l
(800) 95-1321
(125) 52Z-1000
AT-101
Malvern, PA
lymphoma, stomach)
--------------------------------------------------
hormone-sensitive prostate cancer
P|ase ll
(10) 108-0301
-------------------------------------------
P|ase l
(10) 108-0301
AZ03511
(androgen receptor
down-regulator)
AstraZeneca
Wilmington, DE
P|ase l
(800) 236-9933
bafetinib CytRx
Los Angeles, CA
second-line metastatic hormone-
refractory prostate cancer
(see also brain, leukemia)
P|ase ll
(310) 82-518
BPX-101
Bellicum Pharmaceuticals
lousron, TX
P|ase l/ll
(Z13) 311-1Z2
cabozantinib
(XL181)
Exelixis
ovarian, other)
P|ase lll
(50) 83Z-Z000
CBLC102
(mepacrine)
Cleveland BioLabs
Buffalo, NY
lrcuror
Moscow, Russia
hormone-refractory prostate cancer P|ase ll corp|eled
(Z1) 819-810
CD1089
(seocalcitol)
Cougar Biotechnology
Raritan, NJ
P|ase l
www.cougarbiotechnology.com
cilengitide EMD Serono
Rockland, MA
(see also brain) P|ase lll
(800) 283-8088
custirsen
(OGX-011/TV-1011)
OncoGenex Pharmaceuticals
Bothell, WA
Teva Pharmaceuticals
T|kva, lsrae|
lrsl-||re proslale carcer (coro|ra-
tion therapy), second-line hormone-
refractory prostate cancer (combina-
tion therapy) (Fast Track)
(see also lung)
P|ase lll
(125) 8-1500
CYT-500 EUSA Pharma
Langhorne, PA
P|ase l
(800) 833-3533
Halifax, Canada
(see also breast, ovarian) P|ase l
(902) 192-1819
78
PROSTATE CANCER
DSTP-3086S Genentech
metastatic hormone-refractory
prostate cancer
P|ase l
(800) 2-3553
EZ850
(irofulven)
Eisai
Woodcliff Lake, NJ
P|ase ll
(888) 122-1Z13
EV0-525Z9Z
(anti-integrin mAb)
EMD Serono
Rockland, MA
metastatic castration-resistant
prostate cancer
P|ase ll/lll
(800) 283-8088
emepepimut-S EMD Serono
Rockland, MA
Oncothyreon
Seattle, WA
newly-diagnosed prostate cancer
(see also lung)
P|ase ll
(800) 283-8088
(macrobeads)
Roos|r lrsl|lule
New York, NY
refractory metastatic prostate cancer
P|ase ll
(212) Z1-15
enzalutamide
(MDV3100)
Astellas Pharma
Tokyo, Jaan
Medivation
San Francisco, CA
(Fast Track)
P|ase lll
(115) 513-31Z0
EPO-806
(patupilone)
East Hanover, NJ
(888) 669-6682
EZN-11Z
(antisense oligonucleotide)
Piscataway, NJ
P|ase l
(9Z3) 980-1500
Firmagon
degarelix
Ferring Pharmaceuticals
Parsippany, NJ
3-month formulation
--------------------------------------------------
neoadjuvant therapy
P|ase lll
(973) 796-1600
-------------------------------------------
P|ase lll
(973) 796-1600
ganetespib
(Hsp90i)
Lexington, MA
second-line hormone-refractory
prostate cancer
myeloma, pancreatic, skin, stomach)
P|ase ll
(Z81) 2Z1-8200
Gleevec
imatinib
East Hanover, NJ
(see also lung, skin, other)
P|ase ll
(888) 669-6682
GRNVAC1
Argos Therapeutics
Durham, NC
Geron
Menlo Park, CA
(50) 1Z3-ZZ00
79
PROSTATE CANCER
0Tx-Z58
(selective estrogen receptor
alpha agonist)
GTx
Vemn|s, Th
lrsl-||re advarced proslale carcer,
second-line advanced prostate
cancer
P|ase ll
(901) 523-9Z00
GVAX
Prostate
cancer vaccine
Lincolnshire, IL
Aduro BioTech
Berkeley, CA
(Fast Track) P|ase lll
(81Z) 1Z8-0500
(510) 818-1100
Halaven
eribulin
Eisai
Woodcliff Lake, NJ
(see also lung, sarcoma) P|ase ll
(888) 122-1Z13
lE3235 Harbor Therapeutics
San Diego, CA
hormone-refractory prostate cancer P|ase l/ll
(858) 58Z-9333
intetumumab Janssen Biotech
Horsham, PA
(see also skin) P|ase ll corp|eled
(800) 52-ZZ3
lRX1201 lo T|erapeul|cs
Santa Ana, CA
P|ase ll
www.io-therapeutics.com
l3l3-ElF1E
Rx
Carlsbad, CA
prostate cancer (combination
therapy)
(see also lung)
P|ase ll
(800) Z9-1Z1Z
Istodax
romidepsin
Celgene
Summit, NJ
(see also kidney, pancreatic, other) P|ase ll
(908) 673-9000
J 591 Lu-1ZZ
(anti-PMSA mAb)
BZL Biologics
New York, NY
metastatic prostate cancer,
non-metastatic prostate cancer
P|ase ll
(212) 315-55Z5
JNJ-285115
(Hdm2 inhibitor)
Raritan, NJ
(see also lung, solid tumors) P|ase l
(800) 81Z-528
KX2-391 Kinex Pharmaceuticals
Buffalo, NY
(716) 898-8626
L8l589
(panobinostat)
East Hanover, NJ
(see also kidney, leukemia, multiple
P|ase ll
(888) 669-6682
LFA102
(anti-prolactin receptor
antibody)
East Hanover, NJ
XOMA
Berkeley, CA
(888) 669-6682
Toronro, 0anaoa
metastatic prostate cancer
leukemia)
P|ase ll
(11) Z98-1200
80
PROSTATE CANCER
VER-101
(GnRH antagonist)
Merrion Pharmaceuticals
Wilmington, DE
P|ase l
(910) Z99-181Z
MVA-BN
PRO
antigen cancer vaccine
Mountain View, CA
P|ase l/ll
(50) 81-10
NeuVax
carcer vacc|re EZ5
Galena Biopharma
Lake Oswego, OR
(see also breast) P|ase l/ll
(855) 855-1253
nimotuzumab YM Biosciences USA
Lehigh Valley, PA
(see also brain, breast) P|ase ll
(10) 50-000
NX-1207 Nymox Pharmaceutical
Quebec, Canada
P|ase ll
(800) 936-9669
ODM-201
(androgen receptor antagonist)
Endo Pharmaceuticals
Chadds Ford, PA
Orion
Espoo, Finland
castration-resistant prostate cancer P|ase ll
(800) 12-33
oncolytic virus CZ BioMed
Tama, FL
P|ase l
(813) 00-1088
0ryvax-105
anti-idiotype cancer vaccine
105A0Z
VaxOnco
Seoul, South Korea
P|ase ll
www.vaxonco.com
Onyvax-P
(prostate cancer vaccine)
VaxOnco
Seoul, South Korea
P|ase ll
ozarelix Spectrum Pharmaceuticals
Henderson, NV
hormone-dependent prostate cancer P|ase ll
(Z02) 835-300
(A0l-PE0 20)
San Diego, CA
prostate cancer
(see also liver, skin, other)
P|ase l
(858) 152-88
San Diego, CA
prostate cancer (Fast Track)
P|ase ll corp|eled
(858) Z92-300
Seattle, WA
(see also colorectal, lung, prostate) P|ase ll
(206) 281-7001
ProstAtak
gene therapy
Advantagene
Auburndale, MA
adjuvant prostate cancer
(Fast Track)
P|ase lll
(1Z) 91-5115
81
PROSTATE CANCER
prostate cancer vaccine
(anti-GnRH)
Novartis Vaccines & Diagnostics
Cambridge, MA
Pepscan Therapeutics
Lelystad, Netherlands
P|ase l/ll
(617) 871-7000
Prostvac
rilimogene galvacirepvec
8V lrruroT|erapeul|cs
Mountain View, CA
(Fast Track)
P|ase lll
(50) 81-10
Provenge
sipuleucel-T
Dendreon
Seattle, WA
recurrent early-stage prostate cancer
--------------------------------------------------
neoadjuvant early-stage prostate
cancer
P|ase lll
(8ZZ) 25-1515
-------------------------------------------
P|ase ll
(8ZZ) 25-1515
PRX-302 Sophiris Bio
La Jolla, CA
P|ase ll
(858) ZZZ-1Z0
PSMA ADC
(anti-drug conjugate)
Progenics Pharmaceuticals
Tarryroun, hY
P|ase l
(911) Z89-2800
PSMA protein vaccine
(recombinant soluble)
Progenics Pharmaceuticals
Tarryroun, hY
P|ase l
(911) Z89-2800
PSMA VRP therapeutic vaccine Progenics Pharmaceuticals
Tarryroun, hY
P|ase l
(911) Z89-2800
PX-866 Oncothyreon
Seattle, WA
(see also brain, head/neck, lung)
P|ase ll
(206) 801-2100
Quinamed
aroralde
Cephalon
Frazer, PA
(see also breast, ovarian) P|ase ll
(10) 311-0200
RElC ere l|erapy Momotaro-Gene
Okayama, Japan
P|ase l
www.mt-gene.com
Cambridge, MA
Merck
sarcoma, other)
P|ase ll
(800) 672-6372
Wayne, NJ
(see also breast, ovarian) P|ase ll corp|eled
(888) 812-293Z
injection
EUSA Pharma
Langhorne, PA
sarcoma, other)
P|ase ll
(800) 833-3533
Horsham, PA
P|ase l
(800) 52-ZZ3
82
PROSTATE CANCER
SPRYCEL
dasatinib
Princeton, NJ
(see also brain, breast, pancreatic,
other)
in clinical trials
(800) 332-205
TAK-118
(Kl331R prole|r aor|sl)
Cambridge, MA
P|ase l
(800) 390-53
TAK-700
(orteronel)
Cambridge, MA
lrsl-||re relaslal|c proslale carcer
--------------------------------------------------
prostate cancer
P|ase lll
(800) 390-53
-------------------------------------------
P|ase ll
(800) 390-53
tasquinimod
(TASQ)
Active Biotech
Lund, Sweden
--------------------------------------------------
second-line metastatic prostate
cancer
P|ase lll
-------------------------------------------
P|ase l
TeloB-Vax
telomerase cancer vaccine
Adamis Pharmaceuticals
San Diego, CA
P|ase l
www.adamispharmaceuticals.
com
tesetaxel Genta
(see also bladder, breast, skin,
stomach)
P|ase ll
(908) 286-9800
tigapotide Kotinos Pharmaceuticals
New York, NY
hormone-refractory prostate cancer P|ase ll
(212) 935-3000
TKl258
(dovitinib)
East Hanover, NJ
(see also breast, kidney, multiple
myeloma, skin, other)
P|ase ll
(888) 669-6682
TNFerade
GenVec
Gaithersburg, MD
(see also head/neck, skin, stomach) P|ase l
(8ZZ) 913-832
TOK-001 Tokai Pharmaceuticals
Cambridge, MA
castration-resistant prostate cancer P|ase l
(1Z) 225-1305
trabectedin Johnson & Johnson Pharmaceutical
Raritan, NJ
(see also breast, ovarian, sarcoma) P|ase ll
(800) 81Z-528
TRC 105
San Diego, CA
(see also breast, ovarian, other) P|ase l/ll
(858) 550-0Z80
83
PROSTATE CANCER
Trofex
|olo|aslal l-121
Vo|ecu|ar lrs||l P|arraceul|ca|s
Cambridge, MA
prostate cancer (diagnosis) P|ase l
(1Z) 191-5551
TroVax
tumor-associated antigen
vaccine
Oxford BioMedica
Oxford, United Kingdom
P|ase ll
www.oxfordbiomedica.co.uk
vT-11 Viamet Pharmaceuticals
Morrisville, NC
P|ase l/ll
(919) 1Z-8539
YERVOY
ipilimumab
Princeton, NJ
prostate cancer (post-hormonal
therapy), prostate cancer
(post-chemotherapy)
in clinical trials
(800) 332-205
Zaltrap
al|oercepl
Tarryroun, hY
3arol u3
Bridgewater, NJ
lrsl-||re ardroer-|rdeperderl
prostate cancer
P|ase lll
(911) 315-Z100
(800) 981-2191
Zytiga
abiraterone
Janssen Biotech
Horsham, PA
lrsl-||re relaslal|c proslale carcer
(see also breast)
--------------------------------------------------
neoadjuvant prostate cancer
P|ase lll
(800) 52-ZZ3
-------------------------------------------
P|ase ll
(800) 52-ZZ3
SARCOMA
Silver Spring, MD
soft tissue sarcoma
(see also brain, other)
P|ase l
(301) 608-9292
abexinostat
(HDAC inhibitor)
Pharmacyclics
Sunnyvale, CA
sarcoma
(see also lymphoma)
P|ase l/ll
(108) ZZ1-0330
brivanib
Princeton, NJ
(see also colorectal, liver) P|ase ll
(800) 332-205
cancer vaccine MabVax Therapeutics
San Diego, CA
(858) 259-9105
ganitumab
(AV0 1Z9)
Amgen
Tnousano Daks, 0/
pancreatic)
P|ase ll
(800) ZZ2-13
Halaven
eribulin
Eisai
Woodcliff Lake, NJ
(see also lung, prostate) P|ase lll
(888) 122-1Z13
84
SARCOMA
lNN0-20
(Orphan Drug)
CytRx
Los Angeles, CA
soft tissue sarcoma
(see also pancreatic, solid tumors)
P|ase ll
(310) 82-518
Junovan
mifamurtide
(Orphan Drug)
Cambridge, MA
osteosarcoma P|ase lll
(800) 390-53
ombrabulin
(AVE8062)
3arol u3
Bridgewater, NJ
(see also lung, ovarian) P|ase lll
(800) 981-2191
palifosfamide
(Zl0-201)
(Orphan Drug)
Zl0PlARV 0rco|oy
New York, NY
lrsl-||re soll l|ssue sarcora
--------------------------------------------------
second-line soft tissue sarcoma
--------------------------------------------------
soft tissue sarcoma (monotherapy)
P|ase lll
(1) 211-0Z00
-------------------------------------------
P|ase ll
(1) 211-0Z00
-------------------------------------------
P|ase l/ll
(1) 211-0Z00
Basking Ridge, NJ
myeloma, solid tumors, stomach)
P|ase ll
(908) 2-5128
PV-00101 PharmaMar
Madrid, Spain
Ewings sarcoma
(see also cervical, other)
P|ase ll
www.pharmamar.com
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
(see also brain, colorectal, head/
neck, lung, ovarian, pancreatic, skin,
solid tumors)
P|ase ll
(103) Z0-Z3ZZ
Rexin-G
(Orphan Drug)
San Marino, CA
osteosarcoma
(see also breast, pancreatic)
--------------------------------------------------
soft tissue sarcoma
P|ase ll
(2) 111-95
-------------------------------------------
P|ase l/ll
(2) 111-95
ridaforolimus
(Orphan Drug)
ARlA0 P|arraceul|ca|s
Cambridge, MA
Merck
metastatic sarcoma (Fast Track)
prostate, other)
--------------------------------------------------
sarcoma
(800) 672-6372
(2) 111-95
-------------------------------------------
P|ase ll
(800) 672-6372
(2) 111-95
robatumumab Merck
osteosarcoma, sarcoma
(see also colorectal, solid tumors)
P|ase ll
(800) 672-6372
85
SARCOMA
injection
EUSA Pharma
Langhorne, PA
osteosarcoma
prostate, other)
P|ase l/ll
(800) 833-3533
saridegib
(Orphan Drug)
lrlr|ly P|arraceul|ca|s
Cambridge, MA
chondrosarcoma
(inoperable/unresectable)
P|ase ll
(1Z) 153-1000
TH-302
(Orphan Drug)
Threshold Pharmaceuticals
soft tissue sarcoma
(see also brain, leukemia, multiple
myeloma, pancreatic)
P|ase lll
(50) 1Z1-8200
tivantinib
(ARQ 197)
(Orphan Drug)
ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
soft tissue sarcoma
lung, pancreatic, other)
P|ase ll
(Z81) 991-0300
(9Z3) 911-200
trabectedin
(Orphan Drug)
Raritan, NJ
soft tissue sarcoma
(see also breast, ovarian, prostate)
--------------------------------------------------
soft tissue sarcoma (adolescents and
children)
P|ase lll
(800) 81Z-528
-------------------------------------------
P|ase ll
(800) 81Z-528
SKIN CANCER
Abraxane
(Orphan Drug)
Celgene
Summit, NJ
malignant melanoma
P|ase lll
(908) 673-9000
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
malignant melanoma
lung, lymphoma, ovarian, prostate,
other)
P|ase ll
(81Z) 93Z-100
Ad-lL-12 0NA l|erapeul|c
(lNXN-2001)
Zl0PlARV 0rco|oy
New York, NY
malignant melanoma P|ase l
(1) 211-0Z00
Allovectin
velimogene aliplasmid
(Orphan Drug)
Vical
San Diego, CA
lrsl-||re ra||rarl re|arora P|ase lll
(858) 1-1100
86
SKIN CANCER
ALT-801 Altor BioScience
Miramar, FL
malignant melanoma
(see also other)
P|ase l/ll
(951) 113-800
anti-PD1
(8V3-93558)
Princeton, NJ
melanoma
(see also kidney, lung)
P|ase ll
(800) 332-205
APN301
(c|11.18 rAo/|rler|eu||r-2
fusion protein)
Apeiron Biologics
Vienna, Austria
malignant melanoma
(see also brain)
P|ase ll
www.apeiron-biologics.com
New York, NY
malignant melanoma (combination
therapy)
(see also brain, breast, prostate)
P|ase ll
(1) Z1Z-9090
ARRY-162
(MEK inhibitor)
Array BioPharma
Boulder, CO
malignant melanoma (BRAFV600E
or NRAS mutations)
P|ase ll
(8ZZ) 33-213
astuprotimut-R
(VA0E-A3 arl|er-spec|lc
cancer immunotherapeutic)
GlaxoSmithKline
malignant melanoma
(see also lung)
--------------------------------------------------
inoperable/unresectable malignant
melanoma
P|ase lll
(888) 825-5219
-------------------------------------------
P|ase ll
(888) 825-5219
autologous stem cell therapy California Stem Cells
Irvine, CA
malignant melanoma P|ase ll
(919) 531-9119
c31510 Cytotech
Natick, MA
basal cell cancer, squamous call
cancer
P|ase ll
(15) 515-5138
Cavatak
coxsackievirus A21
(Orphan Drug)
Viralytics
Pymble, Australia
www.viralytics.com
CB-10-01
cancer vaccine
Cosmo Pharmaceuticals
Lainate, Italy
www.cosmopharmaceuticals.
com
CDX-011
(glembatumumab vedotin)
Needham, MA
malignant melanoma
(see also breast)
P|ase ll
(Z81) 133-0ZZ1
CYT107
(interleukin-7)
Cytheris
Rockville, MD
malignant melanoma
(see also kidney)
P|ase l
(301) 231-0151
0C-lL-12 0NA l|erapeul|c
(lNXN-3001)
Zl0PlARV 0rco|oy
New York, NY
(1) 211-0Z00
0E0N-52A Genentech
(800) 2-3553
87
SKIN CANCER
dendritic cancer cell vaccine EMD Millipore
Billerica, MA
(Z81) 533-000
EZ050 Eisai
Woodcliff Lake, NJ
late-stage malignant melanoma
(see also brain, head/neck, liver,
P|ase l/ll
(888) 122-1Z13
E7080
(lenvatinib)
Eisai
Woodcliff Lake, NJ
melanoma
(see also brain, other)
P|ase ll
(888) 122-1Z13
ecromeximab Life Science Pharmaceuticals
0ar|en, 0T
therapy)
P|ase ll
(203) 5-2500
Erivedge
vismodegib
Genentech
early-stage basal cell cancer
(resectable)
P|ase ll
(800) 2-3553
FANG Vaccine
Gradalis
0arro||ron, TX
malignant melanoma
(see also colorectal, ovarian)
P|ase ll
(211) 112-8100
ganetespib
(Hsp90i)
Lexington, MA
malignant melanoma
myeloma, pancreatic, prostate,
stomach)
P|ase ll
(Z81) 2Z1-8200
GDC-0973
(MEK inhibitor)
Genentech
second-line metastatic malignant
melanoma (combination therapy)
P|ase l
(800) 2-3553
Gleevec
imatinib
East Hanover, NJ
malignant melanoma
(see also lung, prostate, other)
P|ase ll
(888) 669-6682
03K211813
GlaxoSmithKline
lrsl-||re 8RAF rulal|or-pos|l|ve |ale-
stage malignant melanoma
(see also brain, lung)
--------------------------------------------------
BRAF mutation-positive metastatic
therapy)
P|ase lll
(888) 825-5219
-------------------------------------------
P|ase ll
(888) 825-5219
03K221158A
(cancer vaccine)
GlaxoSmithKline
metastatic malignant melanoma P|ase l
(888) 825-5219
03K2302025A
(cancer vaccine)
GlaxoSmithKline
lrsl-||re relaslal|c ra||rarl
melanoma
P|ase l
(888) 825-5219
88
SKIN CANCER
HyperAcute
Melanoma
melanoma vaccine
NewLink Genetics
Ames, IA
(515) 29-5555
lVC-p100
(cancer vaccine)
lrrurocore
Oxon, United Kingdom
malignant melanoma Phase 0
www.immunocore.com
Imprime PGG
Biothera
Eagan, MN
malignant melanoma
(see also colorectal, leukemia, lung)
P|ase l
(51) Z5-0300
lNC82130 lrcyle
Wilmington, DE
malignant melanoma
P|ase ll
(855) 11-2983
interleukin-12 gene therapy OncoSec Medical
San Diego, CA
malignant melanoma, merkel cell
carcinoma
(see also lymphoma)
P|ase ll
www.oncosec.com
intetumumab Janssen Biotech
Horsham, PA
malignant melanoma
(see also prostate)
P|ase l/ll
(800) 52-ZZ3
L0E225
(erismodegib)
East Hanover, NJ
basal cell cancer
(see also leukemia, pancreatic,
solid tumors)
P|ase ll
(888) 669-6682
L0K9Z1
(wNT s|ra||r pal|Way
inhibitor)
East Hanover, NJ
malignant melanoma
(see also breast)
P|ase l
(888) 669-6682
LGX818
(RAF inhibitor)
East Hanover, NJ
metastatic malignant melanoma
P|ase l
(888) 669-6682
Lymphoseek
Tc-99m tilmanocept
Dublin, OH
malignant melanoma (diagnosis)
(see also breast, head/neck)
(11) Z93-Z500
M-200 prophage cancer vaccine
(vitespen)
(Orphan Drug)
Agenus
Lexington, MA
metastatic melanoma
(Fast Track)
P|ase lll
(Z81) Z1-1100
Marqibo
(Orphan Drug)
Talon Therapeutics
San Mateo, CA
malignant melanoma
other)
P|ase ll
(50) 588-101
melanoma DNA vaccine lc|or Ved|ca| 3yslers
San Diego, CA
Memorial Sloan-Kettering
Cancer Center
New York, NY
(858) 550-2022
V0RAo-001 Eisai
Woodcliff Lake, NJ
(888) 122-1Z13
89
SKIN CANCER
ruparloslal (Pl-88)
(Orphan Drug)
Progen Pharmaceuticals
malignant melanoma
(see also liver)
P|ase ll
www.progen.com.au
MVax
melanoma vaccine
AVAX Technologies
Philadelphia, PA
malignant melanoma P|ase lll
(215) 211-9Z0
NX-101 NexGenix
New York, NY
derra| reurolororaloses P|ase ll
(212) 9Z1-300
Ontak
denileukin diftitox
Eisai
Woodcliff Lake, NJ
(888) 122-1Z13
(A0l-PE0 20)
San Diego, CA
(see also liver, prostate, other)
P|ase ll
(858) 152-88
Picato
ingenol mebutate
LEO Pharma
Parsippany, NJ
basal cell cancer P|ase ll
(8ZZ) 191-153
POL-103A
(melanoma vaccine)
(Orphan Drug)
Polynoma
San Diego, CA
(858) 205-2501
PRAVE arl|er-spec|lc carcer
immunotherapeutic
(recombinant)
GlaxoSmithKline
(see also lung)
P|ase l
(888) 825-5319
PTl-188 Pain Therapeutics
/usr|n, TX
malignant melanoma P|ase l corp|eled
(512) 501-2111
PV-10
(rose bengal sodium)
(Orphan Drug)
Provectus Pharmaceuticals
rnoxv|||e, Th
malignant melanoma
(see also liver)
P|ase ll corp|eled
(8) 591-5999
RAF25
(raf kinase inhibitor)
East Hanover, NJ
malignant melanoma
P|ase l
(888) 669-6682
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
malignant melanoma
head/neck, lung, ovarian, pancreatic,
sarcoma, solid tumors)
P|ase ll
(103) Z0-Z3ZZ
R0Z25
(BRAF kinase inhibitor)
Roche
Nutley, NJ
(9Z3) 235-5000
RG7636
Roche
Nutley, NJ
(800) 2-3553
90
SKIN CANCER
talminogene laherparepvec Amgen
Tnousano Daks, 0/
(800) ZZ2-13
Tasigna
nilotinib
East Hanover, NJ
malignant melanoma (c-Kit mutation)
(see also leukemia, stomach)
P|ase lll
(888) 669-6682
tesetaxel
(Orphan Drug)
Genta
malignant melanoma
(see also bladder, breast, prostate,
stomach)
P|ase ll
(908) 286-9800
TKl258
(dovitinib)
East Hanover, NJ
malignant melanoma
myeloma, prostate, other)
P|ase l/ll
(888) 669-6682
TNFerade
GenVec
Gaithersburg, MD
malignant melanoma
(see also head/neck, prostate,
stomach)
P|ase ll
(8ZZ) 913-832
malignant melanoma (monotherapy)
multiple myeloma, pancreatic)
--------------------------------------------------
therapy)
P|ase lll
(888) 825-5219
-------------------------------------------
P|ase ll
(888) 825-5219
veglin
(VEGF antisense)
Los Angeles, CA
Kaposis sarcoma
(see also lung, kidney)
P|ase l
(323) 221-7818
YERVOY
ipilimumab
Princeton, NJ
melanoma (adjuvant therapy),
melanoma brain metastases
(see also lung, prostate)
in clinical trials
(800) 332-205
Zadaxin
thymalfasin alfa 1
(Orphan Drug)
SciClone Pharmaceuticals
Foster City, CA
malignant melanoma
(see also liver)
P|ase ll/lll
(50) 358-315
SOLID TUMORS
AbGn-7 AbGenomics
Los Altos, CA
P|ase l
(50) 988-9912
A8l-009
(sirolimus albumin bound)
Celgene
Summit, NJ
P|ase l
(908) 673-9000
91
SOLID TUMORS
A8T-318
(aurora kinase inhibitor)
Abbott Laboratories
Abbott Park, IL
late-stage solid tumors
(see also other)
P|ase l
(81Z) 93Z-100
ABT-700
(c-Met inhibitor)
Abbott Laboratories
Abbott Park, IL
P|ase l
(81Z) 93Z-100
ABT-767
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
P|ase l
(81Z) 93Z-100
ABT-806
(EGFR inhibitor)
Abbott Laboratories
Abbott Park, IL
P|ase l
(81Z) 93Z-100
AC220
(quizartinib)
Ambit Biosciences
San Diego, CA
Astellas Pharma US
0eerle|o, lL
(858) 331-2100
(800) 95-1321
Basking Ridge, NJ
(see also lymphoma) P|ase l
(908) 2-5128
Al-850 Acusphere
Lexington, MA
P|ase l
(1Z) 18-8800
AL8-10951(a)
(tubulin inhibitor)
AVRl
Albany, NY
Bessor Pharma
Framingham, MA
P|ase l
www.amriglobal.com
AlloStim lrruroval|ve T|erap|es
Shoham, Israel
(see also other) P|ase l/ll
www.immunovative.co.il
Alocrest
vinorelbine liposomal
Talon Therapeutics
San Mateo, CA
(50) 588-101
AMG 208
(c-Met inhibitor)
Amgen
Tnousano Daks, 0/
P|ase l
(800) ZZ2-13
AMG 337
(c-Met inhibitor)
Amgen
Tnousano Daks, 0/
P|ase l
(800) ZZ2-13
AMG 780
(angioprotein inhibitor)
Amgen
Tnousano Daks, 0/
P|ase l
(800) ZZ2-13
AMG 820
(c-fms antagonist)
Amgen
Tnousano Daks, 0/
P|ase l
(800) ZZ2-13
92
SOLID TUMORS
AMG 900
Amgen
Tnousano Daks, 0/
(see also other) P|ase l
(800) ZZ2-13
AVP-221 Amplimmune
Gaithersburg, MD
P|ase l
(301) 309-9800
anti-CD137
(8V3-3513)
Princeton, NJ
P|ase l
(800) 332-205
arl|-l0F-1R rAo Genentech
P|ase l
(800) 2-3553
anti-PD-L1
(8V3-93559)
Princeton, NJ
P|ase l
(800) 332-205
Aplidin
plitidepsin
PharmaMar
Madrid, Spain
myeloma)
P|ase l
www.pharmamar.com
Flemington, NJ
(862) 703-7170
Flemington, NJ
(see also brain, leukemia) P|ase l
(862) 703-7170
ARQ 092
(AKT inhibitor)
ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
inoperable/unresectable late-stage
solid tumors
P|ase l
(Z81) 991-0300
(9Z3) 911-200
ARQ 621
(E5 |r||o|lor)
ArQule
Woburn, MA
(see also other)
P|ase l
(Z81) 991-0300
ARQ 736
(BRAF inhibitor)
ArQule
Woburn, MA
late-stage solid tumors P|ase l
(Z81) 991-0300
ARQ 761
(E2F1 stimulant)
ArQule
Woburn, MA
P|ase l
(Z81) 991-0300
ARRY-162
(MEK inhibitor)
Array BioPharma
Boulder, CO
(see also skin)
P|ase l
(8ZZ) 33-213
ARRY-520
(KSP inhibitor)
Array BioPharma
Boulder, CO
(see also leukemia,
multiple myeloma)
P|ase l
(8ZZ) 33-213
93
SOLID TUMORS
ASG-22ME Agensys
Santa Monica, CA
Seattle Genetics
Bothell, WA
P|ase l
(800) 95-1321
(125) 52Z-1000
ASP3026 Astellas Pharma US
0eerle|o, lL
(see also lymphoma)
P|ase l
(800) 95-1321
ATZ519
(CDK inhibitor)
Dublin, CA
multiple myeloma)
P|ase l
(925) 50-0100
AT9283
Dublin, CA
multiple myeloma)
P|ase l
(925) 50-0100
AT13387
(Hsp90 inhibitor)
Dublin, CA
refractory solid tumors
(see also stomach)
P|ase l
(925) 50-0100
ATl-1123
(docetaxel liposomal)
Azaya Therapeutics
$an /nron|o, TX
P|ase l
(210) 311-00
AZ01180
(JAK1/JAK2 inhibitor)
AstraZeneca
Wilmington, DE
P|ase l
(800) 236-9933
AZ02011
(TOR kinase inhibitor)
AstraZeneca
Wilmington, DE
P|ase l
(800) 236-9933
AZ0151Z
(FGFR tyrosine kinase inhibitor)
AstraZeneca
Wilmington, DE
P|ase ll
(800) 236-9933
AZ0533
(AKT inhibitor)
Dublin, CA
AstraZeneca
Wilmington, DE
P|ase l
(800) 236-9933
AZD8330
(ARRY-121Z01)
(MEK inhibitor)
Array BioPharma
Boulder, CO
AstraZeneca
Wilmington, DE
P|ase l
(800) 236-9933
AZD8931
(erbB kinase inhibitor)
AstraZeneca
Wilmington, DE
(800) 236-9933
8AY 10-00391
(Pan-CDK inhibitor)
Wayne, NJ
(888) 812-293Z
8AY Z9-120
(antibody-drug conjugate)
Wayne, NJ
P|ase l
(888) 812-293Z
94
SOLID TUMORS
8AY 80-91 Bayer HealthCare Pharmaceuticals
Wayne, NJ
P|ase l
(888) 812-293Z
8AY 8Z-2213
(llF-1 pathway inhibitor)
Wayne, NJ
P|ase l
(888) 812-293Z
8AY 91-9313
Wayne, NJ
P|ase l
(888) 812-293Z
88l503
(stemness kinase inhibitor)
Boston Biomedical
Norwood, MA
(781) 278-0900
88l08
(stemness inhibitor)
Boston Biomedical
Norwood, MA
(781) 278-0900
belotecan OnKor Pharmaceuticals
Seattle, WA
P|ase ll
(20) 91-1121
8EZ235
(kinase inhibitor)
East Hanover, NJ
P|ase l/ll
(888) 669-6682
BGJ398
(FGF-R kinase inhibitor)
East Hanover, NJ
P|ase l
(888) 669-6682
BGT226
(VT0R/Pl3K |r||o|lor)
East Hanover, NJ
P|ase l/ll
(888) 669-6682
BHQ880
(mAb)
East Hanover, NJ
(888) 669-6682
8l-811283
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
(800) 213-012Z
8l-8312 8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
P|ase l
(800) 213-012Z
8l-83815
(l01-|aroda)
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
P|ase l
(800) 213-012Z
8l-81Z325 8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
P|ase l
(800) 213-012Z
95
SOLID TUMORS
8l-853520
(TYK2 inhibitor)
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
P|ase l
(800) 213-012Z
8ll8 015 8|oer ldec
Cambridge, MA
P|ase l corp|eled
(617) 679-2000
8ll8 028 8|oer ldec
Cambridge, MA
P|ase l corp|eled
(617) 679-2000
8lN0-011
(docetaxel nanopharmaceutical)
8lN0 8|osc|erces
Cambridge, MA
P|ase l
(1Z) 191-3100
BMN-673
(PARP inhibitor)
BioMarin Pharmaceuticals
Novato, CA
(see also other) P|ase l/ll
(115) 50-Z00
803181
(E5 |r||o|lor)
East Hanover, NJ
P|ase l
(888) 669-6682
BYL719
(Pl3K-a|p|a |r||o|lor)
East Hanover, NJ
(888) 669-6682
CA-18C3 XBiotech
/usr|n, TX
(see also cancer-related, other) P|ase l/ll
(512) 38-2900
CALAA 01
(siRNA)
Calando Pharmaceuticals
Pasadena, CA
P|ase l
(626) 683-7200
carl|zor|o Onyx Pharmaceuticals
(50) 2-0000
C8P-501
(peptide mimetic)
CanBas
Shizouka, Japan
www.canbas.co.jp
CC-115
(kinase inhibitor)
Celgene
Summit, NJ
myeloma)
P|ase l
(908) 673-9000
CC-122 Celgene
Summit, NJ
myeloma)
P|ase l
(908) 673-9000
CDX-1127 Celldex Therapeutics
Needham, MA
(Z81) 133-0ZZ1
C0X-1101
(cancer vaccine)
Needham, MA
solid tumors expressing the
NY-ESO-1 protein
P|ase l/ll
(Z81) 133-0ZZ1
CEP-11981
(vE0F-R/TlE2 ||rase |r||o|lor)
Cephalon
Frazer, PA
P|ase l corp|eled
(10) 311-0200
96
SOLID TUMORS
CG201
(cancer vaccine)
CG Therapeutics
Seattle, WA
P|ase ll
(20) 33-501
CRLX101 Cerulean Pharma
Cambridge, MA
late-stage solid tumors P|ase l/ll
(1Z) 551-900
crolibulin EpiCept
Tarryroun, hY
P|ase l/ll
(911) 0-3500
CUDC-101 Curis
Lexington, MA
P|ase l
(1Z) 503-500
CVX 060
(PF-0185881)
(Ang2 antagonist)
Plzer
New York, NY
(see also kidney) P|ase l
(80) Z32-515
CX-1915
(CK2 inhibitor)
Cylene Pharmaceuticals
San Diego, CA
(858) 8Z5-5100
CYC116
(aurora kinase/VEGFR2
inhibitor)
P|ase l
(908) 51Z-Z330
CYT-6091
(Aurimune)
Cyllrrure 3c|erces
Rockville, MD
P|ase l
(301) 825-3011
D-1MT NewLink Genetics
Ames, IA
(515) 29-5555
D-3263
(TRPM8 protein stimulant)
Dendreon
Seattle, WA
P|ase l
(8ZZ) 25-1515
dacomitinib
(PF-00299801)
Plzer
New York, NY
(80) Z32-515
darinaparsin
(Zl0-101)
Zl0PlARV 0rco|oy
New York, NY
(see also liver, lymphoma,
multiple myeloma)
P|ase l
(1) 211-0Z00
03-2218 Daiichi Sankyo
Parsippany, NJ
P|ase l
(9Z3) 911-200
03-Z123 Daiichi Sankyo
Parsippany, NJ
P|ase l
(9Z3) 911-200
97
SOLID TUMORS
EZ050 Eisai
Woodcliff Lake, NJ
metastatic solid tumors
skin, stomach)
P|ase l/ll
(888) 122-1Z13
EC17 Endocyte
West Lafayette, IN
P|ase l
www.endocyte.com
EC0189 Endocyte
West Lafayette, IN
P|ase l
www.endocyte.com
elsamitrucin Spectrum Pharmaceuticals
Henderson, NV
(Z02) 835-300
EV0-121103
(c-Met kinase inhibitor)
EMD Serono
Rockland, MA
P|ase l
(800) 283-8088
enavatuzumab Abbott Laboratories
Abbott Park, IL
P|ase l
(81Z) 93Z-100
EP-100 Esperance Pharmaceuticals
Baton Rouge, LA
P|ase l
(225) 15-8911
ETBX-011
cancer vaccine
Etubics
Seattle, WA
late-stage metastatic solid tumors P|ase l
(20) 838-5110
etirinotecan pegol
(NKTR-102)
Nektar Therapeutics
San Francisco, CA
combination therapy
(see also breast, colorectal, ovarian)
P|ase l
(855) 182-58Z
EZN-2208
Piscataway, NJ
solid tumors (pediatric)
--------------------------------------------------
combination therapy
P|ase l/ll
(9Z3) 980-1500
-------------------------------------------
P|ase l
(9Z3) 980-1500
EZN-2968
(llF1-a|p|a |r||o|lor)
Piscataway, NJ
(9Z3) 980-1500
lc|aluzurao
(AV-299)
Cambridge, MA
(1Z) 299-5000
luc|c|al|de F-18 GE Healthcare
Waukesha, WI
Nal|ora| Carcer lrsl|lule
Bethesda, MD
solid tumors (diagnosis) P|ase ll
(22) 513-1000
FP-1039/HGS1036 Five Prime Therapeutics
Human Genome Sciences
Rockville, MD
(115) 35-500
(301) 309-8501
98
SOLID TUMORS
G-202 GenSpera
$an /nron|o, TX
P|ase l
(210) 1Z9-8112
GC1008
(fresolimumab)
Genzyme
Cambridge, MA
P|ase l
(1Z) 252-Z500
GDC-0032
(Pl3 ||rase |r||o|lor)
Genentech
metastatic solid tumors P|ase l
(800) 2-3553
GDC-0068
(Akt inhibitor)
Genentech
P|ase l/ll
(800) 2-3553
00C-0319
(small molecule)
Genentech
(800) 2-3553
00C-0125
(ChK1 inhibitor)
Genentech
(800) 2-3553
00C-05Z5 Genentech
(800) 2-3553
GDC-0623
(MEK inhibitor)
Genentech
(800) 2-3553
GDC-0917
(lAP arlaor|sl)
Genentech
(800) 2-3553
GDC-0973
(MEK inhibitor)
Genentech
(see also skin cancer) P|ase l
(800) 2-3553
GDC-0980
inhibitor)
Genentech
(see also breast, lymphoma) P|ase l
(800) 2-3553
0erz11282
(toposisomerase-1 inhibitor)
Genzyme
Cambridge, MA
P|ase l
(800) 981-2191
00Tl-2118 Kirax
Bonita Springs, FL
P|ase l
(239) 111-5100
0l-301
(brachyury peptide vaccine)
0|ooelrrure
Louisville, CO
P|ase l
(303) 25-2Z00
GL-ONC1 Genelux
San Diego, CA
P|ase l
(858) 183-0021
GO-203-2c Genus Oncology
Vernon Hills, IL
(81Z) 519-500
99
SOLID TUMORS
03K1131
(polio-like kinase inhibitor)
GlaxoSmithKline
(888) 825-5219
GSK690693
(AKT kinase inhibitor)
GlaxoSmithKline
(888) 825-5219
GSK1070916A
(selective aurora kinase B/C
inhibitor)
GlaxoSmithKline
P|ase l
(888) 825-5219
03K212158
GlaxoSmithKline
(888) 825-5219
03K2111Z95
GlaxoSmithKline
(888) 825-5219
03K225098
(FAK inhibitor)
GlaxoSmithKline
P|ase l
(888) 825-5219
GSK2636771
(Pl3K oela-se|ecl|ve |r||o|lor)
GlaxoSmithKline
P|ase l
(888) 825-5219
HSP990
(heat shock protein)
East Hanover, NJ
P|ase l
(888) 669-6682
l0F-1R arlaor|sl
(8V3-Z5180Z)
Princeton, NJ
P|ase ll
(800) 332-205
lVF-001
(cancer vaccine)
lrruroFrorl|er
Tokyo, Jaan
NY-ESO-1 antigen-expressing solid
tumors
P|ase l
www.immunofrontier.com
lV0N388 lrruro0er
Waltham, MA
P|ase l
(Z81) 895-000
lNC280
(c-Met inhibitor)
East Hanover, NJ
P|ase l/ll
(888) 669-6682
lNC82130 lrcyle
Wilmington, DE
(see also skin) P|ase l/ll
(855) 11-2983
indium-111 (ABT-806) Abbott Laboratories
Abbott Park, IL
solid tumors (diagnosis) P|ase l
(81Z) 93Z-100
lNK128
(mTOR inhibitor)
lrle|||||re
La Jolla, CA
myeloma)
P|ase l
(858) Z8-500
lNK111Z
(Pl3K |r||o|lor)
lrle|||||re
La Jolla, CA
P|ase l
(858) Z8-500
100
SOLID TUMORS
lNN0-20 CytRx
Los Angeles, CA
(see also pancreatic, sarcoma) P|ase l/ll
(310) 82-518
lNN0-305
(wT-1 vacc|re)
CytRx
Los Angeles, CA
(310) 82-518
Jl-101
(angiogenesis inhibitor)
Jubilant Biosys
Malvern, PA
P|ase l/ll
(10) 210-890
JNJ-285115
(Hdm2 inhibitor)
Raritan, NJ
(see also lung, prostate)
P|ase l
(800) 81Z-528
JX-929 Jennerex Biotherapeutics
San Francisco, CA
P|ase l
(115) 281-888
Karenitecin
8NP1350
$an /nron|o, TX
solid tumors (adults and pediatric)
P|ase l
(210) 11-1Z01
KHK-2866 Kyowa Hakko Kirin Pharma
Princeton, NJ
advanced solid tumors
(see also ovarian)
P|ase l
(609) 919-1100
L8l589
(panobinostat)
East Hanover, NJ
(see also kidney, leukemia, multiple
myeloma, prostate)
P|ase l
(888) 669-6682
LCl99
(aldosterone synthase inhibitor)
East Hanover, NJ
P|ase ll
(888) 669-6682
LCL161
(lAP |r||o|lor)
East Hanover, NJ
P|ase l
(888) 669-6682
L0E225
(erismodegib)
East Hanover, NJ
solid tumors (adults and pediatric)
(see also leukemia, pancreatic, skin)
P|ase l
(888) 669-6682
LDK378
(ALK inhibitor)
East Hanover, NJ
P|ase l
(888) 669-6682
LEE011
(C0K1/ |r||o|lor)
East Hanover, NJ
(888) 669-6682
LE050
(Smo antagonist)
East Hanover, NJ
P|ase l
(888) 669-6682
L-MDAM BioNumerik Pharmaceuticals
$an /nron|o, TX
P|ase l
(210) 11-1Z01
L0R 253
(MTF-1 inhibitor)
Lorus Therapeutics
Toronro, 0anaoa
(11) Z98-1200
101
SOLID TUMORS
LP-261 Locus Pharmaceuticals
Blue Bell, PA
P|ase l
(215) 358-2000
lurbinectedin PharmaMar
Madrid, Spain
www.pharmamar.com
VE-113
(NADH oxidase inhibitor)
Marshall Edwards
San Diego, CA
refractory solid tumors P|ase l
(858) Z92-300
VE0l-55
(anti-CEA BiTE)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
P|ase l
(800) 236-9933
(301) 398-0000
VE0l-5Z3
(arl|-l0F rAo)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
P|ase l
(800) 236-9933
(301) 398-0000
VE0l-039
(arl|-de|la-|||e 1 rAo)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
P|ase l
(800) 236-9933
(301) 398-0000
VE0l-31Z
(anti-ANG-2 mAb)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
P|ase l
(800) 236-9933
(301) 398-0000
MG-1102 Green Cross
Yongin, South Korea
Mogam Biotechnology Research
lrsl|lule
Yongin, South Korea
second-line solid tumors P|ase l
www.eng.greencross.com
MGA271
(anti-B7-H3)
MacroGenics
Rockville, MD
refractory metastatic solid tumors P|ase l
(301) 251-51Z2
MGAH22 (anti-HER2 mAb) MacroGenics
Rockville, MD
P|ase l
(301) 251-51Z2
VlNT152A Genentech
P|ase l
(800) 2-3553
VK-119 Merck
P|ase l corp|eled
(800) 672-6372
102
SOLID TUMORS
VK-31Z5 Merck
metastatic late-stage solid tumors P|ase l
(800) 672-6372
VK-182Z
(PARP inhibitor)
Merck
P|ase l
(800) 672-6372
VK-5108/vX-89
(aurora kinase A inhibitor)
Merck
Vertex Pharmaceuticals
Cambridge, MA
P|ase l
(800) 672-6372
(1Z) 111-100
VK-8212 Merck
(800) 672-6372
MLN0128 Millennium Pharmaceuticals
Cambridge, MA
(800) 390-53
VLN0518
(tandutinib)
Cambridge, MA
P|ase l
(800) 390-53
Cambridge, MA
P|ase l
(800) 390-53
VLN2180
Cambridge, MA
P|ase l
(800) 390-53
VLN1921
(NEDD8 inhibitor)
Cambridge, MA
(800) 390-53
MLN8237
(alisertib)
Cambridge, MA
(800) 390-53
MLN9708
(ixazomib)
Cambridge, MA
myeloma)
P|ase l
(800) 390-53
VV-151
(EGFR antagonist)
Cambridge, MA
P|ase l
(1Z) 111-1000
mocetinostat
MethylGene
Montreal, Canada
(see also leukemia, lymphoma) P|ase l/ll
(511) 33Z-3333
MPDL-3280A Genentech
P|ase l
(800) 2-3553
103
SOLID TUMORS
V3C20151038
(MEK inhibitor)
EMD Serono
Rockland, MA
P|ase l
(800) 283-8088
MTKi-328 BeiGene
Beijing, China
P|ase l
www.beigene.com
MTRN-2696 Spectrum Pharmaceuticals
Henderson, NV
P|ase l
(Z02) 835-300
NKP-1339 Niiki Pharma
Hoboken, NJ
P|ase l
(201) Z10-5512
NKTR-105
(pegylated docetaxel)
Nektar Therapeutics
San Francisco, CA
P|ase l
(115) 182-5300
NV3-111351
(CDC7 protein kinase inhibitor)
Nerviano Medical Services
Nerviano, Italy
P|ase l
www.nervianoms.com
NMS-1286937
(PlK-1 |r||o|lor)
Nerviano Medical Services
Nerviano, Italy
P|ase l
www.nervianoms.com
NPl-0052
(marizomib)
San Diego, CA
myeloma)
P|ase l
(858) 58Z-1090
olaparib
(PARP inhibitor)
AstraZeneca
Wilmington, DE
P|ase l
(800) 236-9933
Omapro
omacetaxine
Cephalon
Frazer, PA
(10) 311-0200
0VP-18R5
(wrl pal|Way)
Wayne, NJ
OncoMed Pharmaceuticals
Redwood City, CA
P|ase l
(888) 812-283Z
(50) 995-8200
OMP-21M18
(0LL1 |r||o|lor)
GlaxoSmithKline
Redwood City, CA
P|ase l
(888) 825-5219
(50) 995-8200
0VP-59R5
(notch pathway)
GlaxoSmithKline
Redwood City, CA
P|ase l
(888) 825-5219
(50) 995-8200
omtriptolide Pharmagenesis
Redwood City, CA
Pierre Fabre Pharmaceuticals
Parsippany, NJ
P|ase l
(50) 812-Z00
www.pierre-fabre.com
104
SOLID TUMORS
ONT-10
(cancer vaccine)
Oncothyreon
Seattle, WA
P|ase l
(206) 769-9219
ONX-0801 Onyx Pharmaceuticals
P|ase l
(50) 2-0000
0P8-5102 Otsuka America Pharmaceutical
Rockville, MD
P|ase l
(800) 52-39Z1
oprozomib Onyx Pharmaceuticals
P|ase l
(50) 2-0000
Summit, NJ
(see also leukemia, lung, lymphoma) P|ase ll
(908) 673-9000
ortataxel Spectrum Pharmaceuticals
Henderson, NV
taxane-refractory solid tumors P|ase ll
(Z02) 835-300
03l-930
(c-kit/VEGFR-2)
03l P|arraceul|ca|s
Farmingdale, NY
P|ase l
(631) 962-0600
p28 peptide CDG Therapeutics
Chicago, IL
P|ase l
www.cdgti.com
paclitaxel liposomal Sun Pharma
Mumbai, India
P|ase l
www.sunpharma.com
palifosfamide
(Zl0-201)
Zl0PlARV 0rco|oy
New York, NY
(see also lung, sarcoma) P|ase l
(1) 211-0Z00
pbi-shRNA STMN1 LP
(anti-stathim gene therapy)
Gradalis
0arro||ron, TX
P|ase l
(211) 112-8100
Basking Ridge, NJ
myeloma, sarcoma, stomach)
P|ase l
(908) 2-5128
PF-00337210
(VEGFR2 antagonist)
Plzer
New York, NY
P|ase l corp|eled
(80) Z32-515
PF-031192
(ALK-1 mAb)
Plzer
New York, NY
P|ase l
(80) Z32-515
105
SOLID TUMORS
PF-0105112
(arl|-51 |rler|r rAo)
Plzer
New York, NY
P|ase l
(80) Z32-515
PF-0191502
Plzer
New York, NY
(80) Z32-515
PF-05212381
(rT0R/Pl3K |r||o|lor)
Plzer
New York, NY
(80) Z32-515
P01101Z Progen Pharmaceuticals
www.progen-pharma.com
PLX3397
Plexxikon
Berkeley, CA
metastatic solid tumors
(see also brain, leukemia, lymphoma)
P|ase l
(510) 1Z-1000
PV-00181 PharmaMar
Madrid, Spain
P|ase l
www.pharmamar.com
PNT2258
(bcl-2 oncogene inhibitor)
ProNAi Therapeutics
Ann Arbor, MI
P|ase l
(29) 815-8098
PRl-Z21
(CBP/catenin inhibitor)
PRl3V 8|oLao
Yokohama, Japan
P|ase l
www.prismbiolab.com
PRLX93936 Prolexys Pharmaceuticals
$a|r Lake 0|ry, uT
P|ase l
$ourn P|a|nle|o, hJ
(see also breast, other) P|ase ll
(908) 222-7000
purine nucleoside
phosphorylase
gene therapy
PNP Therapeutics
Birmingham, AL
P|ase l
www.pnptherapeutics.com
PwT3359Z
(Pl3K a|p|a/rT0R ||rase)
Pathway Therapeutics
San Francisco, CA
P|ase l
www.pathwaytx.com
08l-139 Quintessence Biosciences
Madison, WI
P|ase l
(08) 111-2950
RAF25
East Hanover, NJ
(see also skin) P|ase l/ll
(888) 669-6682
106
SOLID TUMORS
Wayne, NJ
stomach)
P|ase l
(888) 812-283Z
Reolysin
reovirus
Oncolytics Biotech
Calgary, Canada
head/neck, lung, ovarian, pancreatic,
sarcoma, skin)
P|ase l
(103) Z0-Z3ZZ
RG7112
(MDM2 antagonist)
Roche
Nutley, NJ
(9Z3) 235-5000
RG7116
(ErbB-3 receptor antagonist)
Roche
Nutley, NJ
P|ase l
(9Z3) 235-5000
R0Z155
(anti-CSF-1R mAb)
Roche
Nutley, NJ
P|ase l
(9Z3) 235-5000
RG7167
(ClF/VEK |r||o|lor)
Roche
Nutley, NJ
P|ase l
(9Z3) 235-5000
R0Z301
(MAP/raf inhibitor)
Roche
Nutley, NJ
P|ase l
(9Z3) 235-5000
RG7321
(Pl3K |r||o|lor)
Genentech
Roche
Nutley, NJ
P|ase ll
(800) 2-3553
(9Z3) 235-5000
R0Z31Z
(NRP1 antagonist)
Genentech
Roche
Nutley, NJ
P|ase l
(800) 2-3553
(9Z3) 235-5000
R0Z35
(C011 arl|er |r||o|lor)
Roche
Nutley, NJ
P|ase l
(9Z3) 235-5000
RG7388
(MDM2 inhibitor)
Roche
Nutley, NJ
(9Z3) 235-5000
R0Z111
(HFGR-1877S)
Genentech
(800) 2-3553
R0Z11
(mAb)
Genentech
P|ase l
(800) 2-3553
R0Z591
(mAb)
Genentech
advanced solid tumors P|ase l
(800) 2-3553
107
SOLID TUMORS
RG7602 Genentech
(800) 2-3553
robatumumab Merck
solid tumors (combination therapy)
(see also colorectal, sarcoma)
--------------------------------------------------
P|ase ll
(800) 672-6372
-------------------------------------------
P|ase l
(800) 672-6372
RRx-001 RadioRx
Mountain View, CA
P|ase l
(50) 81-9885
sapacitabine
(CYC682)
(see also leukemia, lung) P|ase l
(908) 51Z-Z330
3AR125811
(Met kinase inhibitor)
3arol u3
Bridgewater, NJ
P|ase l
(800) 981-2191
3AR153192
(arl|-0LL1 rAo)
3arol u3
Bridgewater, NJ
P|ase l
(800) 981-2191
3AR215108/V3C193398
combination therapy
(Pl3K |r||o|lor/VEK |r||o|lor)
Merck Serono
Geneva, Switzerland
3arol u3
Bridgewater, NJ
P|ase l
(800) 981-2191
3AR215109/V3C193398
combination therapy
(Pl3K-rT0R |r||o|lor/VEK
inhibitor)
Merck Serono
Geneva, Switzerland
3arol u3
Bridgewater, NJ
P|ase l
(800) 981-2191
3AR25212
(MM-121)
Cambridge, MA
3arol u3
Bridgewater, NJ
solid tumors (diagnosis) P|ase ll
(800) 981-2191
3AR30ZZ1
(REGN910)
(anti-Ang2 mAb)
Tarryroun, hY
3arol u3
Bridgewater, NJ
P|ase l
(911) 31Z-Z000
(800) 981-2191
3AR558
(maytansin-loaded anti-DS6)
3arol u3
Bridgewater, NJ
DS6-positive solid tumors P|ase l
(800) 981-2191
SB989
(pracinostat)
38l0
Oakland, CA
(see also leukemia, other)
P|ase l
(50) Z30-280
108
SOLID TUMORS
3Cl-900353 Merck
P|ase l
(800) 672-6372
seliciclib
(CYC202)
(see also head/neck) P|ase l
(908) 51Z-Z330
selumetinib
(AZ0211/ARRY-11288)
(MEK inhibitor)
AstraZeneca
Wilmington, DE
P|ase ll
(800) 236-9933
selumetinib
(AZ0211/ARRY-11288)/
MK2206 combination
(MEK/AKT inhibitor)
AstraZeneca
Wilmington, DE
Merck
P|ase l
(800) 236-9933
(800) 672-6372
SF1126 Semafore Pharmaceuticals
Indianapolis, IN
myeloma)
P|ase l
(31Z) 8Z-30Z5
s|rolaxe| lv Taxolog
Fa|rle|o, hJ
P|ase l
(8) 829-51
solid tumor immunotherapy
(mAb)
Genentech
P|ase l
(800) 2-3553
sonepcizumab Lpath
San Diego, CA
P|ase l
(858) Z8-0800
3Pl-120
(endothelin B receptor agonist)
Henderson, NV
P|ase l
(Z02) 835-300
TAG vaccine Gradalis
0arro||ron, TX
P|ase l
(211) 112-8100
TAK-385
(gonadotrophin
hormone-releasing hormone
receptor antagonist)
Cambridge, MA
P|ase l
(800) 390-53
TAK-111
(hedgehog signaling pathway
inhibitor)
Cambridge, MA
P|ase l
(800) 390-53
TAK-701
(HGF inhibitor)
Cambridge, MA
P|ase l
(800) 390-53
TAK-733
(MEK inhibitor)
Cambridge, MA
P|ase l
(800) 390-53
109
SOLID TUMORS
TAK-960
(Plk1 inhibitor)
Cambridge, MA
P|ase l
(800) 390-53
teglarinad Cephalon
Frazer, PA
(10) 311-0200
lousron, TX
so||d lurors (lv-|rlus|or)
(see also brain, cervical, head/neck,
other)
P|ase l
(Z13) 511-2000
TKM-PLK1
(RNAi)
Tekmira Pharmaceuticals
Burnaby, Canada
(01) 119-3200
TL-32711
(birinapant)
TetraLogic Pharmaceuticals
Malvern, PA
(610) 889-9900
TLC-388 TLC Biopharmaceuticals
P|ase l
(50) 8Z2-881
TRC093
(l01 rAo)
San Diego, CA
P|ase l corp|eled
(858) 550-0Z80
TRC102
(DNA repair inhibitor)
San Diego, CA
P|ase l
(858) 550-0Z80
tremelimumab
(arl|-CTLA1 rAo)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
P|ase ll
(800) 236-9933
(301) 398-0000
TST-10088 Cangene
Winnipeg, Canada
P|ase l
(201) 2Z5-1200
u3-155
(anti-HB-EGF antibody)
Amgen
Tnousano Daks, 0/
Daiichi Sankyo US
Parsippany, NJ
P|ase l
(800) ZZ2-13
(9Z3) 911-200
uN83-512 Drais Pharmaceuticals
Bridgewater, NJ
(908) 895-1200
v931/v935 Merck
P|ase l corp|eled
(800) 672-6372
v935
(telomerase inhibitor vaccine)
Geron
Menlo Park, CA
Merck
P|ase l
(50) 1Z3-ZZ00
(800) 672-6372
110
SOLID TUMORS
VGX-100
(VEGF-C mAb)
Circadian Technologies
Victoria, Australia
P|ase l
www.circadian.com.au
VTX-2337 VentiRx Pharmaceuticals
Seattle, WA
(20) 89-2259
vX15 Vaccinex
Rochester, NY
P|ase l
(585) 2Z1-2Z00
wX-uK1 w||ex
Munich, Germany
P|ase l
www.wilex.de
X-82
(dual VEGFR/PDGFR inhibitor)
Tyrogenex
West Palm Beach, FL
advanced solid tumors P|ase l
(51) 835-935
Xalkori
crizotinib
Plzer
New York, NY
(80) Z32-515
XMT-1001 Mersana Therapeutics
Cambridge, MA
P|ase l
(1Z) 198-0020
XMT-1107 Mersana Therapeutics
Cambridge, MA
P|ase l
(1Z) 198-0020
STOMACH CANCER
AT-101
Malvern, PA
late-stage esophageal cancer
lymphoma, prostate)
P|ase l/ll
(10) 108-0301
AT13387
(Hsp90 inhibitor)
Dublin, CA
late-stage gastrointestinal stromal
lurors (0l3T) (secord-||re l|erapy)
P|ase ll
(925) 50-0100
AUY922
(Hsp90 inhibitor)
East Hanover, NJ
secord-||re 0l3T
multiple myeloma)
P|ase ll
(888) 669-6682
8ll8 2021 8|oer ldec
Cambridge, MA
0l3T
(see also breast)
P|ase ll corp|eled
(617) 679-2000
111
STOMACH CANCER
crenolanib
(CP-88-59)
AROG Pharmaceuticals
0a||as, TX
0l3T
(see also brain)
P|ase ll
(211) 591-0002
EZ050 Eisai
Woodcliff Lake, NJ
gastric cancer (combination therapy)
skin, solid tumors)
P|ase l/ll
(888) 122-1Z13
ERBITUX

cetuximab
Princeton, NJ
Eli Lilly
Indianapolis, IN
gastric cancer
in clinical trials
(800) 332-205
(800) 515-59Z9
ganetespib
(Hsp90i)
Lexington, MA
esophageal cancer, gastric cancer,
0l3T
myeloma, pancreatic, prostate, skin)
P|ase ll
(Z81) 2Z1-8200
masitinib
(Orphan Drug)
AB Science USA
Short Hills, NJ
0l3T
P|ase lll
(9Z3) 218-213Z
Opaxio
Cell Therapeutics
Seattle, WA
esophageal cancer
(see also brain, lung, ovarian, other)
P|ase ll
(800) 215-2355
Basking Ridge, NJ
0l3T
myeloma, sarcoma, solid tumors)
P|ase ll
(908) 2-5128
polyclonal antibody stimulator
(Orphan Drug)
Cancer Advances
Durham, NC
gastric cancer
P|ase lll
(919) 361-2162
ramucirumab
(lVC-11218)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
gastric cancer
P|ase lll
(800) 515-59Z9
regorafenib
(Orphan Drug)
Wayne, NJ
0l3T (Fasl Trac|)
solid tumors)
P|ase lll
(888) 812-283Z
S-1 Taiho Pharma U.S.A.
Princeton, NJ
gastric cancer P|ase lll
(09) Z50-5300
Tasigna
nilotinib
(Orphan Drug)
East Hanover, NJ
0l3T
(see also leukemia, skin)
P|ase lll
(888) 669-6682
112
STOMACH CANCER
telatinib
(Orphan Drug)
ACT Biotech
San Francisco, CA
gastric cancer (combination therapy)
P|ase ll
(115) 230-3900
tesetaxel
(Orphan Drug)
Genta
gastric cancer
(see also bladder, breast, prostate,
skin)
P|ase ll
(908) 286-9800
TNFerade
golnerminogene pradenovac
GenVec
Gaithersburg, MD
esophageal cancer
(see also head/neck, prostate, skin)
P|ase ll
(8ZZ) 913-832
trebananib
(AMG386)
Amgen
Tnousano Daks, 0/
esophageal cancer, gastric cancer
liver, ovarian, other)
P|ase ll
(800) ZZ2-13
Tykerb
lapatinib
GlaxoSmithKline
gastric cancer
(see also breast, head/neck)
P|ase lll
(888) 825-5219
uridine triacetate
(PN101)
we||slal T|erapeul|cs
Gaithersburg, MD
gastric cancer
P|ase ll
(210) 31-2500
Xeloda
capecitabine
Genentech
esophageal cancer
(see also brain, colorectal, liver)
P|ase ll
(800) 2-3553
CANCER/CHEMOTHERAPY-RELATED CONDITIONS
AG103 ActoGenix
Zwijnaarde, Belgium
oral mucositis associated with cancer
treatment
P|ase l
www.actogenix.com
AP1903 Bellicum Pharmaceuticals
lousron, TX
graft-versus-host disease
(see also prostate)
P|ase l
(Z13) 311-1Z2
ARX-02
(sufentanil sublingual)
AcelRx Pharmaceuticals
Redwood City, CA
breakthrough cancer pain P|ase ll
(50) 21-3500
CA-18C3 XBiotech
/usr|n, TX
cancer-related cachexia
(see also other, solid tumors)
P|ase l/ll
(512) 38-2900
113
C01100
(oltipraz)
Canopus BioPharma
Studio City, CA
chemotherapy- and radiation-induced
mucositis
P|ase ll
www.canopusbiopharma.com
CLT-008 Cellerant Therapeutics
San Carlos, CA
chemotherapy-related neutropenia
(see also other)
P|ase l/ll
(50) 232-2122
dronabinol oral solution lN3Y3 T|erapeul|cs
Phoenix, AZ
chemotherapy-induced nausea and
vomiting
P|ase lll
(602) 910-2617
E011 Eisai
Woodcliff Lake, NJ
oral mucositis P|ase lll
(888) 122-1Z13
Emend
aprepitant
Merck
vomiting (pediatric)
P|ase lll
(800) 672-6372
Emend
IV
aprepitant
Merck
vomiting (pediatric)
P|ase l
(800) 672-6372
fentanyl inhalation Akela Pharma
/usr|n, TX
cancer pain P|ase ll/lll
(512 831-0119
ferroportin mAb Eli Lilly
Indianapolis, IN
anemia associated with cancer P|ase l
(800) 515-59Z9
fulranumab Johnson & Johnson Pharmaceutical
Raritan, NJ
cancer pain (adjunctive treatment) P|ase ll
(800) 81Z-528
hepcidin mAb Eli Lilly
Indianapolis, IN
anemia associated with cancer P|ase l
(800) 515-59Z9
LG631 Lentigen
Gaithersburg, MD
chemoprotection in patients
undergoing treatment for
glioblastoma
P|ase l
(301) 52Z-1200
mesenchymal stem cell therapy
(Orphan Drug)
Mesoblast
New York, NY
for bone marrow regeneration in
patients undergoing bone marrow
transplantation
P|ase lll
(212) 880-2060
morphine intranasal Marina Biotech
Bothell, WA
cancer pain P|ase ll
(125) 908-300
MultiStem
stem cell therapy

(Orphan Drug)
Athersys
Cleveland, OH
graft-versus-host disease in patients
undergoing bone marrow transplant
P|ase l
(21) 131-9900
114
nabiximols Otsuka America Pharmaceutical
Rockville, MD
cancer pain (adjunctive treatment) P|ase lll
(800) 52-39Z1
netupitant/palonosetron Helsinn Therapeutics
Bridgewater, NJ
vomiting
P|ase lll
(908) 231-1135
NP-2 gene therapy
(intradermal)
Diamyd Medical
Pittsburgh, PA
(112) ZZ0-1310
Nplate
romiplostim
Amgen
Tnousano Daks, 0/
chemotherapy-associated
thrombocytopenia
P|ase ll
(800) ZZ2-13
PHY906 PhytoCeutica
heu laven, 0T
chemotherapy-induced
gastrointestinal disorders
(see also colorectal, liver, pancreatic)
P|ase l/ll
(203) ZZZ-312
Prochymal
remestemcel-L
(Orphan Drug)
Osiris Therapeutics
Columbia, MD
graft-versus-host disease P|ase lll
(113) 515-1800
ProDermaCel
norepinephrine topical
ProCertus BioPharm
Madison, WI
prevention of oral mucositis,
prevention of radiation-induced skin
damage
P|ase l/ll
(608) 273-8862
Promacta
eltrombopag
GlaxoSmithKline
thrombocytopenia
P|ase ll
(888) 669-6682
R0l-2001 REGiMMUNE
Santa Clara, CA
graft-versus-host disease P|ase l/ll
www.regimmune.com
rolapitant TESARO
Waltham, MA
vomiting
P|ase lll
(339) 970-0900
SGX201 Soligenix
Princeton, NJ
acute radiation enteritis in patients
with cancer
P|ase l/ll
(09) 538-8200
sotatercept
(ACE-011)
Celgene
Summit, NJ
chemotherapy-induced anemia
(see also other)
P|ase ll/lll
(908) 673-9000
tanezumab Plzer
New York, NY
cancer pain (adjunctive treatment) P|ase ll
(80) Z32-515
Tavocept
dimesna
$an /nron|o, TX
chemoprotection
(see also lung)
P|ase lll
(210) 11-1Z01
115
T-cell replacement therapy Bellicum Pharmaceuticals
lousron, TX
graft-versus-host disease in patients
with late-stage cancer undergoing
bone marrow transplantation
P|ase l
(Z13) 311-1Z2
Tl-9102
(Orphan Drug)
Kiadis Pharma
Amsterdam, Netherlands
graft-versus-host disease P|ase l/ll
www.kiadis.com
TXA127 Tarix Pharmaceuticals
Cambridge, MA
thrombocytopenia
P|ase ll
www.tarixpharma.com
Velcade
bortezomib
Cambridge, MA
steroid-refractory graft-versus-host
disease
other)
P|ase ll
(800) 390-53
XEN-21Z1 Xenome
www.xenome.com
Xgeva
denosumab
Amgen
Tnousano Daks, 0/
prevention of cancer-related bone
damage or malignant hypercalcemia
P|ase lll
(800) ZZ2-13
OTHER CANCERS
Silver Spring, MD
peritoneal cancer
(see also brain, sarcoma)
P|ase l
(301) 608-9292
6 Angstrom Pharmaceuticals
Solana Beach, CA
gynecologic cancer
(see also ovarian)
P|ase l
(858) 311-235
A8T-318
Abbott Laboratories
Abbott Park, IL
hematological malignancies
P|ase l
(81Z) 93Z-100
ABT-888
(veliparib)
(PARP inhibitor)
Abbott Laboratories
Abbott Park, IL
fallopian tube cancer
lung, lymphoma, ovarian, prostate,
skin)
P|ase ll
(81Z) 93Z-100
Basking Ridge, NJ
late-stage endometrial cancer
(see also bladder, ovarian, prostate)
P|ase ll
(908) 2-5128
AlloStim lrruroval|ve T|erap|es
Shoham, Israel
P|ase l/ll
www.immunovative.co.il
116
OTHER CANCERS
Alpharadin
radium-223 chloride
Wayne, NJ
bone metastases from
(888) 812-283Z
Miramar, FL
urogenital cancer
(see also skin)
P|ase l/ll
(951) 113-800
AMG 319
(Pl3K-de|la |r||o|lor)
Amgen
Tnousano Daks, 0/
hematological malignancies P|ase l
(800) ZZ2-13
AMG 900
Amgen
Tnousano Daks, 0/
P|ase l
(800) ZZ2-13
anti-CD70 ADC
(8V3-9351)
Princeton, NJ
(800) 332-205
arl|-CXCR1
(8V3-9351)
Princeton, NJ
(800) 332-205
ARQ 621
(E5 |r||o|lor)
ArQule
Woburn, MA
P|ase l
(Z81) 991-0300
Avastin
bevacizumab
Genentech
high-risk carcinoid tumor
lung, ovarian)
P|ase lll
(800) 2-3553
BAY 10-02670 Bayer HealthCare Pharmaceuticals
Wayne, NJ
uterine leiomyoma P|ase l
(888) 812-293Z
Henderson, NV
peritoneal cancer, thymoma
lung, lymphoma, ovarian)
--------------------------------------------------
lrsl-||re l|yrora
--------------------------------------------------
recurrent hematological malignancies
P|ase ll
(Z02) 835-300
-------------------------------------------
P|ase l/ll
(Z02) 835-300
-------------------------------------------
P|ase l
(Z02) 835-300
BKM120
(Pl3K |r||o|lor)
East Hanover, NJ
second-line endometrial cancer,
second-line urogenital cancer
(see also brain, breast, lung)
P|ase ll
(888) 669-6682
BMN-673
(PARP inhibitor)
BioMarin Pharmaceuticals
Novato, CA
(115) 50-Z00
117
OTHER CANCERS
BP-100-1-01 Bio-Path
Ogden, Utah
(801) 580-232
CA-18C3 XBiotech
/usr|n, TX
(see also cancer-related, solid
tumors)
P|ase l
(512) 38-2900
cabozantinib
(XL181)
(Orphan Drug)
Exelixis
medullary thyroid cancer
ovarian, prostate)
P|ase lll
(50) 83Z-Z000
catumaxomab Fresenius Biotech North America
Waltham, MA
malignant ascites
(see also ovarian)
P|ase ll
www.fresenius-biotech.com
CDX-1127 Celldex Therapeutics
Needham, MA
P|ase l
(Z81) 133-0ZZ1
clodronic acid Bayer HealthCare Pharmaceuticals
Wayne, NJ
bone metastases P|ase lll
(888) 812-293Z
CLT-008 Cellerant Therapeutics
San Carlos, CA
(see also cancer-related)
P|ase l
(50) 232-2122
CPl-13
(Orphan Drug)
Cornerstone Pharmaceuticals
Cranbury, NJ
P|ase l
(09) 109-Z050
dalotuzumab
(VK-01)
Merck
neuroendocrine tumors
(see also breast, lung, pancreatic)
P|ase ll
(800) 672-6372
0VuC-5Z51A Genentech
lrsl-||re la||op|ar luoe carcer,
second-line peritoneal cancer
(see also ovarian)
P|ase l
(800) 2-3553
0N21-02
(lapuleucel-T)
dendritic cell vaccine
Dendreon
Seattle, WA
high-risk, HER2-positive urogenital
cancer (adjuvant therapy)
P|ase ll
(8ZZ) 25-1515
E7080
(lenvatinib)
Eisai
Woodcliff Lake, NJ
thyroid cancer
(see also brain, skin)
--------------------------------------------------
endometrial cancer
P|ase lll
(888) 122-1Z13
-------------------------------------------
P|ase ll
(888) 122-1Z13
EZ850
(irofulven)
Eisai
Woodcliff Lake, NJ
thyroid cancer
(see also ovarian, prostate)
P|ase ll
(888) 122-1Z13
Parsippany, NJ
thyroid cancer
P|ase l/ll
(9Z3) 911-200
118
OTHER CANCERS
EGEN-001 EGEN
Huntsville, AL
fallopian tube cancer,
peritoneal cancer
(see also colorectal, ovarian)
P|ase ll
(25) 512-00ZZ
elagolix Abbott Laboratories
Abbott Park, IL
Neurocrine Biosciences
San Diego, CA
uterine leiomyoma P|ase ll
(81Z) 938-100
(858) 1Z-Z00
ENMD-2076 EntreMed
Rockville, MD
late-stage cancer
(see also multiple myeloma, ovarian)
P|ase l
(210) 81-200
Femara
letrozole
East Hanover, NJ
recurrent, metastatic endometrial
P|ase ll
(888) 669-6682
vaccine
Galena Biopharma
Lake Oswego, OR
endometrial cancer
P|ase l/ll
(855) 855-1253
fostamatinib
(SYK inhibitor)
AstraZeneca
Wilmington, DE
Rigel Pharmaceuticals
hematological malignancies P|ase ll
(800) 236-9933
(50) 21-1100
Gleevec
imatinib
East Hanover, NJ
lorora
(see also lung, prostate, skin)
P|ase ll
(888) 669-6682
Inlyta
axitinib
Plzer
New York, NY
thyroid cancer
(see also kidney, liver)
P|ase ll
(80) Z32-515
lPl-115 lrlr|ly P|arraceul|ca|s
Cambridge, MA
(1Z) 153-1000
Istodax
romidepsin
Celgene
Summit, NJ
(see also kidney, pancreatic,
prostate)
P|ase l
(908) 673-9000
IXEMPRA

ixabepilone
Princeton, NJ
endometrial cancer in clinical trials
(800) 332-205
-DND
ruxolitinib
lrcyle
Wilmington, DE
P|ase ll
(855) 11-2983
K8001 KaloBios Pharmaceuticals
(50) 213-3100
Marqibo
Talon Therapeutics
San Mateo, CA
pediatric cancers
(see also leukemia, lymphoma, skin)
P|ase l/ll
(50) 588-101
119
OTHER CANCERS
VE0l-551
(anti-CD19 mAb)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
(800) 236-9933
(301) 398-0000
MER-101
(zoledronic acid oral)
Merrion Pharmaceuticals
Wilmington, NC
bone metastases P|ase ll
www/merrionpharma.com
Mirena
levonorgestrel-releasing
intrauterine system
Wayne, PA
endometrial cancer,
endometrial hyperplasia
P|ase ll
(888) 812-293Z
VK-0Z52
(notch signaling pathway
inhibitor)
Merck
central nervous system (CNS) cancer
in patients ages 3-21
(see also breast)
P|ase l
(800) 672-6372
MK-2206
(c-akt inhibitor)
Merck
inoperable/unresectable
(see also breast)
P|ase ll
(800) 672-6372
Cambridge, MA
P|ase l
(800) 390-53
VLN1921
(NEDD8 inhibitor)
Cambridge, MA
(see aslo solid tumors)
P|ase l
(800) 390-53
motesanib Amgen
Tnousano Daks, 0/
thyroid cancer
(see also breast, colorectal, lung)
P|ase ll
(800) ZZ2-13
moxetumomab pasudotox
(CAT-8015)
AstraZeneca
Wilmington, DE
Vedlrrure
Gaithersburg, MD
(800) 236-9933
(301) 398-0000
MSC1936369B EMD Serono
Rockland, MA
hematological malignancies P|ase l/ll
(800) 283-8088
Nexavar
sorafenib
Wayne, NJ
thyroid cancer
lung, multiple myeloma, ovarian)
--------------------------------------------------
P|ase lll
(888) 812-293Z
-------------------------------------------
P|ase l
(888) 812-293Z
NiCord
umbilical cord blood stem cell

therapy
Gamida Cell
Jerusalem, Israel
hematological malignancies P|ase l/ll
www.gamida-cell.com
120
OTHER CANCERS
NTX-010 Neotropix
Malvern, PA
(see also lung)
P|ase l
www.neotropix.com
Opaxio
Cell Therapeutics
Seattle, WA
peritoneal cancer
(see also brain, lung, ovarian,
stomach)
P|ase lll
(800) 215-2355
OPR-003 EUSA Pharma
Langhorne, PA
Vaccinex
Rochester, NY
(800) 833-3533
(585) 2Z1-2Z00
03l-90
inhibitor)
03l P|arraceul|ca|s
Farmingdale, NY
adrenocortical carcinoma
P|ase lll
(631) 962-0600
(A0l-PE0 20)
San Diego, CA
pediatric cancer
(see also liver, prostate, skin)
P|ase l
(858) 152-88
PF-0191502
Plzer
New York, NY
endometrial cancer
P|ase ll
(80) Z32-515
PF-05212381
(rT0R/Pl3K |r||o|lor)
Plzer
New York, NY
endometrial cancer
P|ase ll
(80) Z32-515
PlA818125 Nerviano Medical Services
Nerviano, Italy
thymoma P|ase ll
www.nervianoms.com
San Diego, CA
fallopian tube cancer (combination
therapy)
(see also ovarian, prostate)
P|ase l/ll
(858) Z92-300
PV-00101 PharmaMar
Madrid, Spain
endometrial cancer
(see also cervical, sarcoma)
P|ase ll
www.pharmamar.com
$ourn P|a|nle|o, hJ
central nervous system (CNS) cancer
in children
P|ase ll
(908) 222-7000
RG7112
(MDM2 antagonist)
Roche
Nutley, NJ
P|ase l
(9Z3) 235-5000
RG7388
(MDM2 inhibitor)
Roche
Nutley, NJ
P|ase l
(9Z3) 235-5000
R0Z593
(mAb)
Roche
Nutley, NJ
(9Z3) 235-5000
121
OTHER CANCERS
R0Z59
Genentech
(800) 2-3553
Cambridge, MA
Merck
endometrial cancer
prostate, sarcoma)
P|ase ll
(800) 672-6372
rintatolimod Hemispherx Biopharma
Philadelphia, PA
cancer vaccine adjuvant P|ase l/ll
(215) 988-0080
injection
EUSA Pharma
Langhorne, PA
bone metastases
prostate, sarcoma)
P|ase lll
(800) 833-3533
3AR3119
(maytansin-loaded anti-CD19
mAb)
3arol u3
Bridgewater, NJ
lrruro0er
Needham, MA
B-cell malignancies P|ase ll
(800) 981-2191
(Z81) 895-000
3AR215108
(XL11Z)
(ora| Pl3K |r||o|lor)
3arol u3
Bridgewater, NJ
Exelixis
endometrial cancer
(see also breast)
P|ase ll
(800) 981-2191
(50) 83Z-Z000
3AR50981
(anti-CD38 naked mAb)
3arol u3
Bridgewater, NJ
(800) 981-2191
SB989
(pracinostat)
38l0
Oakland, CA
P|ase l
(50) Z30-280
Horsham, PA
giant lymph node hyperplasia
(see also multiple myeloma, prostate)
P|ase ll
(800) 52-ZZ3
SOM230
(pasireotide)
East Hanover, NJ
carcinoid tumors
--------------------------------------------------
meningioma, neuroendocrine tumors
P|ase lll
(888) 669-6682
-------------------------------------------
P|ase ll
(888) 669-6682
sotatercept
(ACE-011)
Celgene
Summit, NJ
cancer metastases
(see also cancer-related)
P|ase ll
(908) 673-9000
SPRYCEL
dasatinib
Princeton, NJ
pediatric cancer
(see also brain, breast, pancreatic,
prostate)
in clinical trials
(800) 332-205
122
OTHER CANCERS
StemEx
carlecortemcel-L
(Orphan Drug)
Gamida Cell
Jerusalem, Israel
Teva North America
North Wales, PA
(Fast Track)
P|ase lll
(888) 838-2872
TAK-901
Cambridge, MA
(800) 390-53
Tarceva
erlotinib
Genentech
03l P|arraceul|ca|s
Farmingdale, NY
gynecological cancer
leukemia, liver, lung)
P|ase ll
(800) 2-3553
(631) 962-0600
telapristone Repros Therapeutics
Tne wooo|anos, TX
uterine leiomyoma P|ase l/ll
(281) Z19-3100
lousron, TX
(intravenous)
(see also brain, cervical, head/neck,
solid tumors)
P|ase l
(Z13) 511-2000
TG02 38l0
Oakland, CA
San Diego, CA
(50) 235-5539
(858) 350-900
tivantinib
(ARQ 197)
ArQule
Woburn, MA
Daiichi Sankyo
Parsippany, NJ
germ cell and embryonal neoplasms
lung, pancreatic, sarcoma)
P|ase ll
(Z81) 991-0300
(9Z3) 911-200
TKl258
(dovitinib)
East Hanover, NJ
second-line endometrial cancer,
urothelial carcinoma
myeloma, prostate, skin)
P|ase ll
(888) 669-6682
TRC 105
San Diego, CA
fallopian tube cancer, peritoneal
cancer
(see also breast, ovarian, prostate)
P|ase ll
(858) 550-0Z80
trebananib (AMG386) Amgen
Tnousano Daks, 0/
fallopian tube cancer, peritoneal
cancer
liver, stomach)
P|ase lll
(800) ZZ2-13
123
OTHER CANCERS
ulipristal walsor P|arraceul|ca|s
Parsippany, NJ
uterine leiomyoma P|ase lll
(800) 900-111
VB-111 VBL Therapeutics
Or Yehuda, Israel
thyroid cancer
(see also brain)
P|ase l/ll
www.vblrx.com
Velcade
bortezomib
Cambridge, MA
adenocarcinoma (combination
therapy)
cancer-related)
P|ase ll
(800) 390-53
volasertib 8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
urogenital cancer P|ase ll
(800) 213-012Z
Votrient
pazopanib
GlaxoSmithKline
peritoneal cancer
(see also kidney, ovarian)
P|ase lll
(888) 825-5219
Xgeva
denosumab
Amgen
Tnousano Daks, 0/
prevention of bone metastases in
men with castrate-resistant prostate
cancer
(see also cancer-related, multiple
myeloma)
--------------------------------------------------
prevention of bone metastases
in women with early-stage breast
cancer
--------------------------------------------------
giant cell tumor of bone
(800) ZZ2-13
-------------------------------------------
P|ase lll
(800) ZZ2-13
-------------------------------------------
P|ase ll
(800) ZZ2-13
Zelboraf
vemurafenib
Genentech
Plexxikon
Berkeley, CA
inoperable/unresectable thyroid
cancer
(see also brain, colorectal)
P|ase ll
(800) 2-3553
(510) 1Z-1000
Zolinza
vorinostat
Merck
gynecological cancer, peritoneal
cancer
lymphoma, multiple myeloma)
P|ase l/ll
(800) 672-6273
124
UNSPECIFIED CANCER
A8C29110 Apogee Biotechnology
Hummelstown, PA
late-stage disease P|ase l
(813) Z92-3120
A8l-011
(nab
-5101)
Celgene
Summit, NJ
P|ase l
(908) 673-9000
AFX-9901 Afecta Pharmaceuticals
Irvine, CA
in clinical trials
(919) 253-188
AGS-6MF Agensys
Santa Monica, CA
Astellas Pharma US
0eerle|o, lL
P|ase l
(800) 95-1321
AGS-16M8F Agensys
Santa Monica, CA
Astellas Pharma US
0eerle|o, lL
P|ase l
(800) 95-1321
Miramar, FL
P|ase l/ll
(951) 113-800
arl|-KlR
(8V3-98015)
Princeton, NJ
P|ase l
(800) 332-205
anti-LAG3
(BMS-986016)
Princeton, NJ
P|ase l
(800) 332-205
ANX-511
(docetaxel for injectable
emulsion)
ADVENTRX Pharmaceuticals
San Diego, CA
P|ase l
(858) 552-08
ARRY-300
(MEK inhibitor)
Array BioPharma
Boulder, CO
East Hanover, NJ
P|ase l
(8ZZ) 33-213
(888) 669-6682
ARRY-382
(c-fms antagonist)
Array BioPharma
Boulder, CO
Celgene
Summit, NJ
metastatic cancer P|ase l
(8ZZ) 33-213
(908) 673-9000
AVL-292
(Btk inhibitor)
Celgene
Summit, NJ
(see also leukemia, lymphoma) P|ase l
(908) 673-9000
B7-2/GM-CSF
cancer gene therapy vaccine
NuVax Therapeutics
Tusr|n, 0/
P|ase l
(Z11) 505-111
8AY 91-9392
(PET imaging)
Wayne, NJ
cancer (diagnosis) P|ase l
(888) 812-293Z
125
UNSPECIFIED CANCER
cancer vaccine lrrur|lor u3A
Vancouver, Canada
P|ase l/ll
www.immunitor.com
cancer vaccine
(lorocyle vacc|re)
Cytokine PharmaSciences
King of Prussia, PA
P|ase l
(610) 687-1776
carboxyamidotriazole orotate
(CTO)
Tactical Therapeutics
New York, NY
P|ase l
(212) 51-953
C8L8502 Cleveland BioLabs
Buffalo, NY
P|ase l
(Z1) 819-810
C0K 1/ |r||o|lor
(LY2835219)
Eli Lilly
Indianapolis, IN
P|ase ll
(800) 515-59Z9
CDX-301
(Fms-like tyrosine kinase 3
ligand)
Needham, MA
P|ase l
(Z81) 133-0ZZ1
cell therapy Cell Medica
London, United Kingdom
Center for Cell and Gene Therapy
lousron, TX
P|ase ll
www.cellmedica.co.uk
CEN-109 Centella Therapeutics
Palo Alto, CA
cancer (diagnosis) P|ase ll
www.centellatx.com
Chk1 inhibitor Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
c-Met inhibitor Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
c-Met mAb
(LY28Z5358)
Eli Lilly
Indianapolis, IN
P|ase ll
(800) 515-59Z9
CSF-1R mAb
(lVC-C31)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
P|ase l
(800) 515-59Z9
curmucin Signpath Pharma
Quakertown, PA
P|ase l
(267) 772-0107
CXCR1 pepl|de |r||o|lor
(LY2510921)
Eli Lilly
Indianapolis, IN
P|ase ll
(800) 515-59Z9
126
UNSPECIFIED CANCER
cytotropic heterogeneous
molecular lipids
(CHML)
Glory Pharmaceuticals
Vienna, VA
P|ase l
(Z03) 201-1Z03
DM-CHOC-PEN Dekk-Tec
New Orleans, LA
P|ase l
(501) 583-135
EC0225 Endocyte
West Lafayette, IN
P|ase l
www.endocyte.com
E0FR/l0FR larder adrecl|r
(8V3-91210)
Princeton, NJ
P|ase l
(800) 332-205
elF-1E A30
(LY22Z5Z9)
Eli Lilly
Indianapolis, IN
P|ase ll
(800) 515-59Z9
fenretinide intravenous CerRx
Luooook, TX
P|ase l
www.cerrx.com
FGF receptor inhibitor Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
luorapac|r ACEA Biosciences
San Diego, CA
P|ase l
(866) 308-2232
gemcitabine prodrug Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
0l-20Z
(cancer vaccine)
0|ooelrrure
Louisville, CO
P|ase l
(303) 25-2Z00
GSK3 inhibitor
(LY2090311)
Eli Lilly
Indianapolis, IN
P|ase ll
(800) 515-59Z9
l8l-8000 luYA 8|osc|erce lrlerral|ora|
San Diego, CA
Quintiles
P|ase l
www.huyabio.com
hedgehog antagonist
(LY291080)
Eli Lilly
Indianapolis, IN
P|ase ll
(800) 515-59Z9
hTERT plasmid DNA cancer
vaccine
Merck
Vical
San Diego, CA
P|ase l
(800) 672-6372
127
UNSPECIFIED CANCER
lL-21
(8V3-9821Z0)
Princeton, NJ
P|ase l
(800) 332-205
lr-111-0AC
imaging agent
Mayo Clinic
Rochester, MN
Naviscan
San Diego, CA
cancer (diagnosis) P|ase l
www.mayoclinic.org
l3l3-3TAT3
Rx
Carlsbad, CA
P|ase l
(800) Z9-1Z1Z
JAK2 inhibitor Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
masoprocol TriAct Therapeutics
San Francisco, CA
P|ase ll
(115) 02-Z19Z
MK-8033
(c-Met/RON protein inhibitor)
Merck
P|ase l
(800) 672-6372
new molecular entity Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
notch inhibitor Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
notch inhibitor
(8V3-90021)
Princeton, NJ
P|ase l
(800) 332-205
OPB-31121 Otsuka America Pharmaceutical
Rockville, MD
P|ase l
(800) 52-39Z1
p38 MAP inhibitor (1) Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
p38 MAP inhibitor (2) Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
p70/AKT inhibitor Eli Lilly
Indianapolis, IN
P|ase l
(800) 515-59Z9
P8-35Z Puma Biotechnology
Los Angeles, CA
P|ase l
(121) 218-500
128
UNSPECIFIED CANCER
P8l-05201 Phoenix Biotechnology
$an /nron|o, TX
P|ase l
(210) 828-13Z3
P0-0325901 Plzer
New York, NY
P|ase l
(80) Z32-515
PD-0332991 Plzer
New York, NY
P|ase ll
(80) Z32-515
PF-03081011
(gamma-secretase inhibitor)
Plzer
New York, NY
P|ase l
(80) Z32-515
PF-01119913
(sonic hedgehog pathway
inhibitor)
Plzer
New York, NY
P|ase l
(80) Z32-515
PF-050825
(CD137 antigen agonist mAb)
Plzer
New York, NY
P|ase l
(80) Z32-515
Proleukin
aldesleukin
(subcutaneous)
Prometheus Laboratories
San Diego, CA
P|ase ll
(888) 892-8391
PRT6207
(3y|-spec|lc |r||o|lor)
8|oer ldec
Cambridge, MA
Portola Pharmaceuticals
P|ase l
(Z81) 11-2000
(50) 21-Z000
RON mAb
(lVC-R0N8)
Eli Lilly
Indianapolis, IN
lrC|ore 3yslers
Bridgewater, NJ
P|ase l
(800) 515-59Z9
3815Z8
(JAK2 inhibitor)
38l0
Oakland, CA
P|ase l
(50) 235-5539
SCH-900776 Merck
P|ase ll
(800) 672-6372
SMO antagonist
(BMS-833923)
Princeton, NJ
P|ase l
(800) 332-205
SR13668 3Rl lrlerral|ora|
Menlo Park, CA
cancer (prevention) Phase 0
(50) 859-2000
V930/V932
(plasmid DNA vaccine)
Merck
Vical
San Diego, CA
P|ase l
(800) 672-6372
(858) 1-1100
129
UNSPECIFIED CANCER
VEGFR3 mAb
(lVC-3C5)
Eli Lilly
Indianapolis, IN
lrC|ore
Bridgewater, NJ
P|ase l
(800) 515-59Z9
XmAb

anti-cancer mAb
8oe|r|rer lre||e|r
Pharmaceuticals
P|ogele|o, 0T
Xencor
Monrovia, CA
P|ase l
(800) 213-012Z
(2) 305-5900
Tne oonrenr ol rn|s reorr nas oeen oora|neo rnrougn |nousrry souroes ano rne /o|s "P&0 lns|gnr oaraoase oaseo on rne |aresr |nlormar|on. Report
current as of May 16, 2012. Tne |nlormar|on may nor oe oomrenens|ve. For more seo|lo |nlormar|on aoour a arr|ou|ar roouor, oonraor rne |no|-
v|oua| oomany o|reor|y or go ro uuu.o||n|oa|rr|a|s.gov. Tne enr|re ser|es ol Veo|o|nes |n 0eve|omenr |s ava||ao|e on PnPV/s ueo s|re.
A publication of PhRMAs Communications & Public Affairs Department. (202) 835-3460
www.phrma.org | www.innovation.org | www.pparx.org | www.buysafedrugs.info
Prov|ded as a Puo||c 3erv|ce oy P|RVA. Fourded |r 1958 as l|e P|arraceul|ca| Varulaclurers Assoc|al|or.
Copyright 2012 by the Pharmaceutical Research and Manufacturers of America. Permission to reprint is awarded if proper credit is given.
3KDUPDFHXWLFDO5HVHDUFKDQG0DQXIDFWXUHUVRI$PHULFD950 F 3lreel, Nw, was||rlor, 0C 20001
130
Glossary
actinic keratosesRoughness and thicken-
ing of the skin caused by overexposure to the
sur's u|lrav|o|el rays. ll car deererale |rlo a
skin cancer called squamous cell carcinoma.
adenocarcinomaMalignant tumor derived
from a gland or glandular tissue.
adjunctive treatmentAn auxiliary treatment
that is secondary to the main treatment.
adjuvantA substance or drug that aids
another substance in its action.
allogeneicRefers to having cell types that
are distinct and cause reactions in the immune
system.
application submittedAn application for
marketing has been submitted by the company
to the Food and Drug Administration (FDA).
ascitesExcess lu|d |r l|e space oelWeer
the tissues lining the abdomen and abdominal
organs (the peritoneal cavity).
basal cell cancerCancer of the lower layers
of the skin.
B-cellA class of white blood cells important
to the bodys immune system.
biliaryRelating to bile.
carcinomaA malignant tumor that arises
from epithelial tissues, such as skin.
cervicalRelating to the neck of the uterus.
chemoprotectionA therapeutic technique in
which bone marrow cells are removed from an
individual with cancer and are genetically modi-
led lo W|l|slard |||er doses ol c|erol|erapy
before being returned to the donor.
cholangiocarcinomaA malignancy of the
biliary duct system that may originate in the
liver and extrahepatic bile ducts. More than 90
percent are adenocarcinomas, and the remain-
der are squamous cell tumors. Cholangiocarci-
roras lerd lo roW s|oW|y ard lo |rl|lrale l|e
walls of the ducts. Each year, approximately
2,500 cases occur, ard l|e averae |rc|derce
is 1 case per 100,000 people per year.
cutaneousPertaining to the skin.
dysplasiaAbnormal tissue development.
gastricOf or relating to the stomach.
GIST0aslro|rlesl|ra| (0l) slrora| carcer
|s ar urcorror luror ol l|e 0l lracl. Nol
a|| 0l3Ts are carcerous, sore are oer|r.
Although these cancers can arise anywhere
|r l|e 0l lracl, l|ey occur rosl oller |r l|e
stomach (60% to 70%) and less commonly
in the small intestine (20% to 30%). The rest
are found in the esophagus, large intestine,
rectum, and anus. About 80% of people diag-
rosed W|l| 0l3T are o|der l|ar 50. ll |s s|||l|y
more common in men. Blacks are more likely
lo deve|op 0l3Ts l|ar W||les.
glioblastomaA fast growing and highly
malignant type of brain tumor arising from glial
(supporting) cells within the brain. There are
aooul lve lo 10 reW cases per r||||or popu|a-
tion per year in the United States.
gliomaA type of brain tumor arising from the
supporting glial cells within the brain. Gliomas
make up about 60 percent of all primary brain
tumors and are frequently malignant.
graft-versus-host disease (GVHD)A
complication in bone marrow transplants where
immune system cells attack the transplant
recipients tissues.
head and neck cancerThe term given to a
variety of malignant tumors that develop in the
mouth, throat, paranasal sinuses, nasal cavity,
larynx, and salivary glands. Many authorities
also include skin tumors of the face and neck
and tumors of the cervical lymph nodes. There
are more than half a million survivors of oral,
head, and neck cancer living in the United
States today.
hematological malignanciesCancers of the
blood or blood-forming tissues, such as leuke-
mia, Hodgkins and non-Hodgkins lympho-
mas, Al03-re|aled ra||rarc|es, multiple
myeloma, myelodysplasia and myeloprolifera-
tive disorders.
hepatocellular cancer/carcinomaA cancer
that begins in the liver cells.
hyperuricemiaAn abnormally high uric acid
level in the blood.
imaging agentA substance used to enhance
x-ray images of organs and spaces in the body.
intraepithelial neoplasia, anal (AIN) & cervi-
cal (CIN)AlN |s a corsequerce ol c|ror|c
human papillomavirus infection in the anal
canal and appears to be driven by high viral
|oads ol |urar pap|||orav|rus. w|al |s |roWr
of its natural history resembles that of cervical
intraepithelial neoplasia. Dysplasia and cervi-
ca| |rlraep|l|e||a| reop|as|a (ClN) are d|llererl
terms or names for the same conditionit is
a precursor to cervical cancer. ClN ray oe
mild, moderate or severe.
Kaposis sarcomaA rare, malignant skin
luror l|al occurs |r sore Al03 pal|erls. ll
can be accompanied by fever, enlarged lymph
nodes and gastrointestinal problems.
LeiomyomaA benign neoplasm derived from
smooth muscle.
leukemiaA form of cancer in which abnor-
mally growing white blood cells are scattered
throughout the body and bone marrow. They
can take over the marrow and prevent it from
making enough normal blood cells (white,
red and platelets), leaving the patient highly
susceptible to serious infections, anemia and
bleeding episodes. The cells can also spill into
l|e o|ood, |rl|lral|r ard |rlerler|r W|l| l|e
function of other organs. The four main types
ol |eu|er|a are: acute lympho blastic leuke-
mia (ALL), acute myeloid leukemia (AML),
chronic lymphocytic leukemia (CLL), and
chronic myeloid leukemia (CML). The acute
types have a rapid onset, and overwhelming
infection or blood loss can cause death. The
chronic forms progress much more slowly.
lung cancerThe leading cause of cancer
deaths in both men and women. There are
several types of lung cancer, the most common
being squamous cell carcinoma, small (oat)
cell carcinoma, adenocarcinoma and large cell
131
Glossary
carcinoma. Each has a different growth pattern
and response to treatment. The squamous cell,
small cell and large cell types are all strongly
associated with tobacco abuse.
lymphomaCancers in which the cells of lym-
phoid tissue, found mainly in the lymph nodes
and spleen, multiply unchecked. Lymphomas
la|| |rlo lWo caleor|es: lod||r d|sease, c|ar-
acterized by a particular kind of abnormal cell,
and non-Hodgkin lymphomas, which vary in
their malignancy according to the nature and
activity of the abnormal cells. Mantle cell lym-
phoma is a type of non-Hodgkin lymphoma.
macroglobulinemiaA disorder in which
plasma cells produce an excessive quantity
of macroglobulins (large antibodies) that ac-
curu|ale |r l|e o|ood. ll resu|ls lror a roup
of abnormal, cancerous lymphocytes and
plasma cells. Men are affected more often than
Worer, ard l|e averae ae al orsel |s 5.
mastocytosisA condition characterized by
|rl|lral|or ol rasl ce||s |rlo l|e l|ssues ol l|e
body. Mast cells are connective tissue cells
which release chemicals including histamine
that are very irritating and cause itching, swell-
|r, ard lu|d |ea|ae lror ce||s.
medullaryRelating to the medulla (any soft
marrow-like structure, especially the innermost
part) or marrow.
melanomaA cancer made up of pigmented
(usually brown-colored) skin cells anywhere in
the body.
mesotheliomaA tumor of the lining of the
lung and chest cavity (the pleura).
metastases/metastaticAreas of secondary
cancer that have spread from the primary or
original cancer site.
mucositisThe swelling, irritation, and ulcer-
ation of the mucosal cells that line the digestive
tract. Mucositis can occur anywhere along the
d|esl|ve lracl lror l|e roul| lo l|e arus. ll
can be a very troublesome and painful side
effect of chemotherapy.
multiple myelomaA malignant condition of
middle to old age, characterized by the uncon-
trolled proliferation and disordered function of
plasma cells in the bone marrow. The condi-
tion, which makes the patient particularly prone
to infection, is rare, with about three new cases
annually per 100,000 population.
myeloablationA severe form of myelosup-
pression, a condition in which bone marrow
activity is decreased, resulting in fewer red
o|ood ce||s, W||le o|ood ce||s, ard p|ale|els. ll |s
a side effect of some cancer treatments.
myelodysplastic syndromes (MDS)Blood
disorders that ultimately are fatal. Patients
usually succumb to infections or bleeding. The
term preleukemia has been used to describe
these disorders.
neoadjuvant therapyChemotherapy, radia-
tion therapy, or hormone therapy given before
the primary or main treatment. Neo-adjuvant
therapy, like chemotherapy and radiation
therapy, is often given before surgery to reduce
the size of a tumor or to make surgery less
complicated.
neuroblastomaA tumor of the adrenal
glands or sympathetic nervous system (the
part of the nervous system responsible for
certain automatic body functions, such as the
control of heart rate). Neuroblastomas are the
most common extracranial (outside the skull)
solid tumors of childhood.
osteosarcomaCancer of the bone that oc-
curs predominantly in adolescents and young
adu|ls. ll accourls lor 5 percerl ol carcer |r
children.
peritonealRelating to the peritoneum, the
membrane that lines the abdominal cavity and
covers most of the abdominal organs.
Phase 0First-in-human trials conducted
in accordance with FDAs 2006 guidance on
exp|oralory lrvesl|al|ora| NeW 0ru (lN0)
studies designed to speed up development of
promising drugs by establishing very early on
whether the agent behaves in human subjects
as was anticipated from preclinical studies.
Phase ISafety testing and pharmacologi-
ca| prol||r ol reW drus |r sra|| ruroers ol
humans.
Phase IIEllecl|veress lesl|r ard |derl|lca-
tion of side effects of new drugs in humans.
Phase IIIExtensive clinical trials in humans
to verify effectiveness and monitor adverse
reactions of new drugs.
prolactinomaA noncancerous pituitary
tumor that produces a hormone called prolac-
tin, which results in too much prolactin in the
blood.
refractoryResistant to treatment or cure.
sarcomaA malignant tumor that arises from
deep body tissues, such as muscle, bone or
lorous l|ssue.
T-cellOne of two main classes of white blood
cells called lymphocytes, which are important
lo l|e oody's d|sease-l|l|r |rrure sysler.
thrombocytopeniaA reduction in the
number of platelet cells in the blood, which
causes a tendency to bleed, especially from
the smaller blood vessels.
thymomaAlthough rare, thymomas are the
most common tumor of the thymus, a small
organ located in the upper chest just below
the neck that produces certain types of white
blood cells (lymphocytes) before birth and
during childhood. Thymomas arise from thymic
epithelial cells, which make up the covering of
l|e l|yrus. up lo 10 percerl ol l|yroras are
invasive. They affect men and women equally
and are usually diagnosed between the ages
ol 10 ard 0. T|yroras are urcorror |r
children.
unresectableUnable to be removed (re-
sected) by surgery.
132
Selected Facts about Cancer in the United States
Carcer |s l|e secord |ead|r cause ol deal| oy d|seaserear|y 1 ol every 1 deal|s|r l|e ur|led 3lales, exceeded or|y oy |earl d|sease.
Ver |ave s|||l|y |ess l|ar a 1 |r 2 ||lel|re r|s| ol deve|op|r carcer, lor Worer, l|e r|s| |s a ||ll|e rore l|ar 1 |r 3. Aooul ZZ percerl ol a||
carcers are d|arosed |r peop|e aes 55 ard o|der.
T||s year a|ore, rore l|ar 1. r||||or reW carcer cases are expecled lo oe d|arosed, ard ar esl|raled 5ZZ,190 peop|e are expecled lo d|e ol
carcer. T|al's rore l|ar 1,500 peop|e a day.
3c|erl|lc ev|derce suesls l|al aooul ore-l||rd ol l|e carcer deal|s expecled l||s year W||| oe re|aled lo overWe||l or ooes|ly, p|ys|ca| |racl|v-
ity, and poor nutrition, and thus could be prevented.
T|e Nal|ora| Carcer lrsl|lule esl|rales l|al rear|y 12 r||||or Arer|cars W|l| a ||slory ol carcer Were a||ve |r Jaruary 2008. T|e 5-year re|al|ve
surv|va| rale lor a|| carcers d|arosed oelWeer 2001 ard 200Z |s Z percerl, up lror 19 percerl |r l|e r|d-Z0s.
Studies have shown that pain occurs in 30 percent of all cancer patients, regardless of the stage of the disease, and 90 percent of patients with
advanced cancer experience severe pain. Half of patients may be undertreated for cancer pain.
2
The most common cause of cancer-related pain is from metastases to the bone. Up to 80 percent of cancer patients with bone metastases
exper|erce pa|r. T|e secord rosl corror cause ol carcer pa|r |s re|aled lo lurors |rl|lral|r l|e rerve ard |o||oW v|scus. Turors rear reura|
structures may cause the most severe pain. The third most common cause of pain associated with cancer result from chemotherapy, radiation,
or surgery.
2

Breakthrough painpain that occurs even when taking regular pain medicationis common in cancer patients. Breakthrough cancer pain
occurs |r 50 percerl lo 90 percerl ol orco|oy |rpal|erl sell|rs, 89 percerl ol |ore care ard |rpal|erl |osp|ce sell|rs, ard 35 percerl ol
corrur|ly-oased orco|oy pracl|ces. Peop|e W|l| orea|l|rou| pa|r |ave a s|r|lcarl|y |||er rale ol |osp|la||zal|or l|ar l|ose W|l|oul orea|-
l|rou| pa|r (3.9 percerl vs. 22.5 percerl, respecl|ve|y) ard draral|ca||y |||er esl|raled arrua| cosls ol care (S1.Z r||||or corpared W|l|
S192,000).
3
T|e Nal|ora| lrsl|lules ol lea|l| esl|rales overa|| cosls lor carcer |r 200Z al S22.8 o||||or: S103.8 o||||or lor d|recl red|ca| cosls (lola| ol a||
|ea|l| experd|lures) ard S123 o||||or lor |rd|recl rorla||ly cosls (cosl ol |osl producl|v|ly due lo preralure deal|).
Overview
1
Pain
Costs
1
133
New Cancer Cases/Deaths
1
Cancer Type Estimated 2012 New Cases Estimated 2012 Deaths
All Sites .................................................................................. 1,638,910 ..................................................................................... 5ZZ,190
Male ............................................................................. 818,1Z0 ..................................................................................... 301,820
Female ......................................................................... Z90,Z10 ..................................................................................... 2Z5,3Z0
Acute Lymphocytic Leukemia .......................................................... ,050 ......................................................................................... 1,110
Male ................................................................................. 3,150 ............................................................................................ 820
Female ............................................................................. 2,600 ............................................................................................ 620
Acute Myeloid Leukemia ............................................................... 13,780 ....................................................................................... 10,200
Male ................................................................................. Z,350 ......................................................................................... 5,Z90
Female ............................................................................. ,130 ......................................................................................... 1,110
Bladder Cancer .............................................................................. Z3,510 ....................................................................................... 11,880
Male ............................................................................... 55,00 ....................................................................................... 10,510
Female ........................................................................... 17,910 ......................................................................................... 1,3Z0
Bone Cancer (and joints) ................................................................. 2,890 ......................................................................................... 1,110
Male ................................................................................. 1,600 ............................................................................................ 790
Female ............................................................................. 1,290 ............................................................................................ 620
Brain Cancer (and other nervous system) ..................................... 22,910 ....................................................................................... 13,700
Male ............................................................................... 12,630 ......................................................................................... 7,720
Female ........................................................................... 10,280 ......................................................................................... 5,980
Breast Cancer .............................................................................. 229,060 ....................................................................................... 39,920
Male ................................................................................. 2,190 ............................................................................................ 110
Female ......................................................................... 226,870 ....................................................................................... 39,510
Cervical and Uterine Cancers ........................................................ 59,300 ....................................................................................... 12,230
Male ....................................................................................... ...............................................................................................
Female ........................................................................... 59,300 ....................................................................................... 12,230
Chronic Lymphocytic Leukemia ..................................................... 16,060 ......................................................................................... 1,580
Male ................................................................................. 9,190 ......................................................................................... 2,730
Female ............................................................................. ,5Z0 ......................................................................................... 1,850
Chronic Myeloid Leukemia .............................................................. 5,130 ............................................................................................ 610
Male ................................................................................. 3,210 ............................................................................................ 370
Female ............................................................................. 2,220 ............................................................................................ 210
Colorectal Cancer ........................................................................ 113,10 ....................................................................................... 51,90
Male ............................................................................... Z3,120 ....................................................................................... 2,1Z0
Female ........................................................................... Z0,010 ....................................................................................... 25,220
134
Esophageal Cancer ....................................................................... 1Z,10 ....................................................................................... 15,0Z0
Male ............................................................................... 13,950 ....................................................................................... 12,010
Female ............................................................................. 3,510 ......................................................................................... 3,030
Kidney Cancer (and renal pelvis) .................................................. 1,ZZ0 ....................................................................................... 13,5Z0
Male ............................................................................... 10,250 ......................................................................................... 8,50
Female ........................................................................... 21,520 ......................................................................................... 1,920
Leukemia (all types) ...................................................................... 1Z,150 ....................................................................................... 23,510
Male ............................................................................... 26,830 ....................................................................................... 13,500
Female ........................................................................... 20,320 ....................................................................................... 10,010
Liver Cancer .................................................................................. 28,720 ....................................................................................... 20,550
Male ............................................................................... 21,370 ....................................................................................... 13,980
Female ............................................................................. Z,350 ......................................................................................... ,5Z0
Lung Cancer (and bronchus) ....................................................... 226,160 ..................................................................................... 10,310
Male ..............................................................................11,1Z0 ....................................................................................... 8Z,Z50
Female ......................................................................... 109,690 ....................................................................................... Z2,590
Lymphoma (all types) .................................................................... 79,190 ....................................................................................... 20,130
Male ............................................................................... 13,120 ....................................................................................... 10,990
Female ........................................................................... 36,070 ......................................................................................... 9,110
Lymphoma (non-Hodgkins) ........................................................... 70,130 ....................................................................................... 18,910
Male ............................................................................... 38,160 ....................................................................................... 10,320
Female ........................................................................... 31,970 ......................................................................................... 8,620
Melanoma-Skin Cancer ................................................................. Z,250 ......................................................................................... 9,180
Male ............................................................................... 11,250 ......................................................................................... 6,060
Female ........................................................................... 32,000 ......................................................................................... 3,120
Multiple Myeloma ........................................................................... 21,700 ....................................................................................... 10,710
Male ............................................................................... 12,190 ......................................................................................... 6,020
Female ............................................................................. 9,510 ......................................................................................... 1,90
Ovarian Cancer ............................................................................. 22,280 ....................................................................................... 15,500
Male ....................................................................................... ...............................................................................................
Female ........................................................................... 22,280 ....................................................................................... 15,500
Pancreatic Cancer ......................................................................... 13,920 ....................................................................................... 37,390
Male ............................................................................... 22,090 ....................................................................................... 18,850
Female ........................................................................... 21,830 ....................................................................................... 18,510
1
continued
135
1
continued
Sources:
1. 0anoer Faors & F|gures 2012, American Cancer Society (www.cancer.org)
2. Remedy Health Media, LLC (www.healthcommunities.com)
3. American Pain Foundation (www.painfoundation.org)

Prostate Cancer ........................................................................... 211,Z10 ....................................................................................... 28,170
Male ............................................................................. 211,Z10 ....................................................................................... 28,170
Female ................................................................................... ...............................................................................................
Stomach Cancer ............................................................................ 21,320 ....................................................................................... 10,510
Male ............................................................................... 13,020 ......................................................................................... 6,190
Female ............................................................................. 8,300 ......................................................................................... 1,350
The U.S. system of new drug approvals is
perhaps the most rigorous in the world.
ll la|es 10-15 years, or averae, lor ar
experimental drug to travel from lab to U.S.
patients, according to the Tufts Center for the
3ludy ol 0ru 0eve|oprerl. 0r|y lve |r 5,000
compounds that enter preclinical testing make
|l lo |urar lesl|r. Ard or|y ore ol l|ose lve
is approved for sale.
0r averae, |l cosls a corpary S1.2 o||||or,
including the cost of failures, to get one new
medicine from the laboratory to U.S. patients,
according to a 2007 study by the Tufts Center
for the Study of Drug Development.
0rce a reW corpourd |as oeer |derl|led |r
the laboratory, medicines are usually devel-
oped as lo||oWs:
Preclinical Testing. A pharmaceutical com-
pany conducts laboratory and animal studies
to show biological activity of the compound
against the targeted disease, and the com-
pound is evaluated for safety.
Investigational New Drug Application (IND).
After completing preclinical testing, a company
l|es ar lN0 W|l| l|e u.3. Food ard 0ru
Administration (FDA) to begin to test the drug
|r peop|e. T|e lN0 s|oWs resu|ls ol prev|ous
exper|rerls, |oW, W|ere ard oy W|or l|e
reW slud|es W||| oe corducled, l|e c|er|ca|
slruclure ol l|e corpourd, |oW |l |s l|ou|l
lo Wor| |r l|e oody, ary lox|c ellecls lourd |r
l|e ar|ra| slud|es, ard |oW l|e corpourd
is manufactured. All clinical trials must be
rev|eWed ard approved oy l|e lrsl|lul|ora|
Rev|eW 8oard (lR8) W|ere l|e lr|a|s W||| oe
conducted. Progress reports on clinical trials
must be submitted at least annually to FDA and
l|e lR8.
Clinical Trials, Phase I. These tests usually
involve about 20 to 100 healthy volunteers. The
lesls sludy a dru's salely prol|e, |rc|ud|r l|e
safe dosage range. The studies also determine
how a drug is absorbed, distributed, metabo-
lized, and excreted as well as the duration of
its action.
Clinical Trials, Phase II. lr l||s p|ase,
corlro||ed lr|a|s ol approx|rale|y 100 lo 500
volunteer patients (people with the disease)
assess a drugs effectiveness and determine
l|e ear|y s|de ellecl prol|e.
Clinical Trials, Phase III. This phase usually
|rvo|ves 1,000 lo 5,000 pal|erls |r c||r|cs ard
hospitals. Physicians monitor patients closely to
corlrr ellcacy ard |derl|ly adverse everls.
New Drug Application (NDA)/Biologic
License Application (BLA). Following the
completion of all three phases of clinical trials,
a corpary ara|yzes a|| ol l|e dala ard l|es ar
NDA or BLA with FDA if the data successfully
demonstrate both safety and effectiveness.
T|e app||cal|ors corla|r a|| ol l|e sc|erl|lc
information that the company has gathered.
Applications typically run 100,000 pages or
more.
Approval. Once FDA approves an NDA or
BLA, the new medicine becomes available
for physicians to prescribe. A company must
continue to submit periodic reports to FDA,
including any cases of adverse reactions and
appropriate quality-control records. For some
medicines, FDA requires additional trials
(P|ase lv) lo eva|uale |or-lerr ellecls.
Discovering and developing safe and effective
reW red|c|res |s a |or, d|llcu|l, ard expers|ve
process. PhRMA member companies invested
ar esl|raled S19.5 o||||or |r researc| ard
development in 2011.
The Drug Discovery, Development and Approval Process
Developing a new medicine takes an average of 10-15 years;
For every 5,000-10,000 compounds in the pipeline, only 1 is approved.
The Drug Development and Approval Process

Ancer: 1.6 Million

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