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INSTRUCTIONS TO CANDIDATES
There are two (2) short answer questions in part A of the paper. Each question carries 10
marks.
There are thirty (30) questions in this paper. Each question consists of a stem followed by
five possible responses, identified as A, B, C, D, E, which are either true or false. One
mark is given for a correct answer and one minus mark for a wrong answer, but a
minimum mark for each question is zero.
There is no restriction on the number of true or false items in a question. It is possible for
all the items in a question to be true, or for all to be false.
Mark the answer with a 2B pencil by shading the spaces provided in the answer sheet.
Candidates are not allowed to take away the question papers from the Examination Hall.
All papers are to be returned.
Part A
Short answer questions:
Question 1.
A) Briefly describe the structure of skeletal muscle cell. (3)
B) Describe the processes of excitation and contraction within smooth muscle cells. (7)
Question 2.
Briefly outline the differences between the pulmonary circulation and the systemic
circulation. (10)
Part B
Multiple choice questions
3. All the following statements related to respiration and its control is correct
a. involuntary breathing is controlled by the brain stem
b. the control level of PaCO2 is set around 40 mmHg
c .the central chemoreceptors are the principal site of CO2 determined regulation of
respiration
d. afferent impulses from the thoracic mechanoreceptors run to the brain via vagus nerve
e. Pa O2 is more important than Pa CO2 in the control of respiration
15. The following statements(s) related to the endothelium and arterial tone is/are
correct:
a. thromboxane causes vasoconstriction
b. nitric oxide causes vasodilatation
c. nitric oxide causes proliferation of smooth muscles
d. acetylcholine acts directly on the arteriolar smooth muscles to cause relaxation
e. the artery wall consists, going outwards, of endothelium, intima, media and adventitia
16. Regarding the ventricular action potential
a. The rapid phase of depolarization is due to sodium influx
b. the plateau phase is due to sustained increase in membrane sodium permeability
c. repolarisation is associated with an increase in membrane permeability to potassium
d. The absolute refractory period last for approximately 1 millisecond
e. the refractory period is almost as long as the muscle twitch which it elicits
21. The following statement(s) is/ are true regarding the kidneys
a. there are approximately 1.3 billion nephrons in each kidney
b. they produce aldosterone
c. in a resting state, the kidneys receive 12% of the cardiac output
d. The blood flow in renal cortex is greater than that in the medulla
e. Autoregulation of renal blood flow occurs
22. A person aged 48, weight 70 kg, has the following values measures in their plasma
and urine. An infusion of PAH and Inulin has been given to achieve constant blood levels,
100 mls of urine was collected over 2 hours. The patient’s haematocrit is 40%.
Plasma comcentration Urine concentration
Creatinine 0.10 mmol/L 10.8 mmol/L
Urea 4 mmol/L 240 mmol/L
PAH 0.05 mmol/L 30 mmol/L
Inulin 0.05 mmol/L 6 mmol/L
Drug A 1 µmol/L 360 µmol/L
Drug B 10 µmol/L 120 µmol/L
25. The following statement(s) related to skeletal muscle and its contraction is/are true
a. the basic contractile unit is the sarcomere
b. at each end of the sarcomere is a Z disc
c. thin filaments are attached to the Z disc
d. myofibrils contain myosin in the thin filament
e. hydrolysis of ATP reduces affinity of myosin for actin
26. Foetal haemoglobin:
a. forms approximately 80% of haemoglobin at birth
b. is made up of 2 alpha and 2 delta chains
c. forms approximately 20% of haemoglobin at the age of 6 months
d. has a low affinity for oxygen than adult haemoglobin (HbA)
e. is present in β-Thalassaemia major
30. Bicarbonate
a. when the standard bicarbonate is lower than actual bicarbonate it indicates respiratory
acidosis
b. in metabolic acidosis standard bicarbonate is high
c. an uncompensated metabolic acidosis both actual and standard bicarbonate are high
and equal
d. the actual and standard bicarbonate values can vary by + 2 mEq/L
e. actual and standard bicarbonate values can be derived from Siggard-Andersen
normogram
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Answers:
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9. F F F T T
10. T T T F T
11. F F T F T
12. T T F F T
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14. F F F T T
15. T T F F T
16. T F T F T
17. T T T F F
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19. T T F F T
20. T T T T F
21. F F F T T
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23. T F T T F
24. T T T F T
25. T T T F F
26. T F F F T
27. F T F T T
28. T T T F T
29. F T T T T
30. T F F T T