Pilot Talk

Brookes Pharma (Pvt) Limited

Promotional Objectives
o To established the MUCOACTIVE TETRADYNAMIC effect of Dostin. Muco-Modulatory Anti-Oxidant Bacterial Anti-Adhesion Bronchial Anti- Inflammatory effects

o To establish that Dostin is the potent mucolytic agent belonging to one of the latest generation of Mucolytic. o To established Dostin as the first line mucolytic treatment in the Respiratory Tract Diseases. o To establish the concept that Dostin restores the natural rheology. o To further establish the therapeutic superiority over N- Acetylcysteine & Ambroxel. o To established the safety profile of Dostin both in: Adults Children

Call Objectives of Specialities

Chest Specialist: o The Oxidative stress is the most important aspect in the Lungs structure destruction in patients with COPD and Emphysema. Dostin prevents the further destruction of Lungs
structure in long term use in patients with COPD and Emphysema by:

Decreasing the Level of Reactive Oxygen Species (ROS) Increasing the level of Glutathione (GSH)

Dostin reduce sputum viscosity that increases the Antibiotic concentration in sputum and potentiate its effect in patients with Exacerbation of Chronic Bronchitis.

General Practioners
o o o Dostin is an effective mucolytic agent for the patients of Sinusitis, Pharyngitis, Laryngitis, and Tracheitis. Beside mucolytic effect Dostin offers Bacterial Anti-Adhesion and prevents relapses in patients with Acute Exacerbation of Chronic Bronchitis. Dostin reduce sputum viscosity that increases the Antibiotic concentration in sputum and potentiate its effect in patients with Exacerbation of Chronic Bronchitis.

ENT Specialist
o Being the latest generation of its kind Dostin is an effective mucolytic agent for the patients of Sinusitis, Pharyngitis, Laryngitis, and Tracheitis.

Pediatrician
Dostin is a valuable drug for your pediatric patients with acute lower respiratory tract diseases and in these patients along with antibiotics. Dostin offers synergistic effects in reducing the symptoms of Cough, Ronchi, Rales and Polypnoea.

Physician
o The Oxidative stress is the most important aspect in the Lungs structure destruction in patients with COPD and Emphysema. Dostin prevents the further destruction of Lungs in long term use in patients with COPD and Emphysema by: o o o Decreasing the Level of Reactive Oxygen Species (ROS) Increasing the level of Glutathione (GSH)

Dostin reduce sputum viscosity that increases the Antibiotic concentration in sputum and potentiate its effect in patients with Exacerbation of Chronic Bronchitis. Dostin offers bronchial anti-inflammatory effect by reducing the level of bronchial inflammatory markers like total protein, DNA and Albumin in patients with COPD. Beside mucolytic effect Dostin offers Bacterial Anti-Adhesion and prevents relapses in patients with Acute Exacerbation of Chronic Bronchitis.

General for All

o Dostin is an amino acid derivative compound. Therefore, as compare to conventional Mucolytic Dostin has: No drug interaction No unpleasant odor No G.I. side effect

Pilot - Talk
Doctor! Start with opening statement but do not take out the folder yet!

Opening Statement...

Doctor

As you know that due to pollution, dust and smoking there is noticeable increase respiratory disorders, whereas the relapse case of asthma, bronchitis & COPD are also on increase. This is the result of deposition of sputum in bronchi that does not let the exchange of oxygen and CO2 to take place in the alveoli. Doctor! As you know that due to the complex structure of SPUTUM most of the medications fail to act or take elongated time to act. By then the patient remain in lack of oxygen supply to the whole body that can result in to other physiological complications. Doctor! As you know there are different therapeutic approaches available e.g. cough & cold preparations, expectorants, bronchodilators and other medications with the targets to reduce the dyspnoea & exacerbation by moving the sputum out of lungs as to let the oxygen and CO2 to exchange properly. Doctor! A mucolytic agent that can modulate the sputum for easy movement out of lungs, with AntiOxidant properties, have the Bacterial anti-adhesive and have the Anti- Inflammatory effects on bronchi.

Show the front page (Page 1):

Doctor! Brookes Pharma is proud to present: Dostin A Mucoactive Tetradynimic product which has: o Muco-Modulatory o Anti-Oxidant o Bacterial Anti-Adhesion o Bronchial Anti- Inflammatory effects
Note : While showing and talking keep pointing with pen on the product and its above mentioned properties.

Take a pause; if any quarry reply and move forward Turn to page No. 2 and page No. 3

Doctor! Point to the caption

Dostin . a Mucoactive Tetradynimic

that Restores the Natural Rheology

Show the comparative graph of sputum viscosity and frequency of cough (Upper half of page No. 2) Doctor! Doctor! Dostin significantly reduces sputum viscosity and volume faster than N-Acetylcysteine and also reduces the frequency of cough. Dostin also increases concentration of antibiotics in sputum to potentiate the effect of antibiotics in patients with Exacerbation of chronic Bronchitis.

Show the comparative graph and inhibition of bacteria with Dostin and N-Acetylcysteine. (Lower half of page No. 2) Doctor! The initiating factor in bacterial colonization of the respiratory tract is bacterial adhesion with the help of bacterial fimbria, made up of single protein called pillin, containing disulphide bond. Dostin acts on the disulphide bond of Pillin and brings morphological changes In its structure thus makes bacteria in capable of getting adhesion on mucosal surface of respiratory tract and prevents relapses in patients with Acute Exacerbation of chronic bronchitis.

Move to Page No. 3

(Upper half of page No. 3)

Doctor! Point to the caption Doctor! Dostin also offers bronchial Anti-Oxidant effect because oxidative stress is the main characteristics of Chronic Bronchitis and COPD. Dostin has a direct scavenging activity on ROS (Reactive Oxygen Species) and significantly increases the level of Glutathione which is a natural anti-oxidant in plasma and Bronchoalveolar Lavage

(Point to the graph and show the free radical scavenging activity of Dostin)
(Lower half of page No. 3) Doctor! Doctor; Dostin also offers bronchial Anti-Inflammatory activity by reducing the concentration of bronchial inflammatory markers in sputum like Total proteins, DNA and Albumin in patients with COPD.

Take a pause; if any quarry reply and move forward Turn to page No. 4 and

by pointing

Show page No. 4

Doctor! (Point to the upper portion of page no. 4 Dostin also offers excellent efficacy in children. A double blind placebo controlled multicenter trial conducted in pediatric patients suffering from Acute Lower Respiratory tract Diseases. Dostin demonstrates synergetic effect with anti-biotic in improving the symptoms of Cough, Rhonchi, Rales and Polypnoea within one week.

Now it is time to start the closing, point to the USPs of Dostin and

by pointing

Dostin . a Mucoactive Tetradynimic

o o o o o o

that Restores the Natural Rheology

Dostin! Exerts its potent mucolytic effect within 2 days. Dostin! Provides synergistic activity with Antibiotic therapy. Dostin! Offers No unpleasant Odor, No G.I side effects. Dostin! Has placebo like tolerability profile for excellent patients compliance. Dostin! Has superior therapeutic efficacy compared to Ambroxol. Dostin! Shows significant improvement over N-Acetylcysteine.

(Now show the Dosage schedule) Discuss the Dosage Schedule by pointing the dosage area

Adults
In patients with Sinusitis, Pharyngitis, Laryngitis, Tracheitis Dostin Capsules 300mg: twice daily for 7 to 10 days. In patients with Acute Exacerbation of chronic bronchitis Dostin Capsules 300mg: twice daily for 4 to 6 weeks. In patients with COPD and Emphysema Dostin Capsules 300mg: twice daily OR Dostin Sachet 225mg twice daily for 3 to 6 months and Dostin Capsules 150 mg twice daily as maintenance therapy for 2 to 3 months.

Children
In patients With Acute Bronchitis, Asthmatic Bronchitis, Tracheobronchitis and Broncho alveolitis. o Age : 2 to 6 years Dostin Suspension : One TSF twice daily for 1 -2 weeks o o Age : 7 to 13 years Dostin Suspension : One & half TSF twice daily for 1 -2 weeks OR Dostin Sachet 225 mg : twice daily for 1 to 2 weeks

Closing & Commitment

For every specialty you may close your calls with the following remarks for taking the commitment. Chest Specialist/ Physician
Doctor! Considering its tetradynamic properties of Dostin, look forward for prescriptions for long term use to the patients with chronic Respiratory disorders, COPD and emphysema. Would you kindly prescribe Dostin in your next patient?

General Practioner
Doctor! You can see from the clinical studies the results of Dostin within 2-3 days, therefore Dostin will be your drug of choice to prescribe in such patients.

Pediatrics
Doctor! To avoid recurrence and relapse in pediatric ptients with respiratory disease Dostin is Drug of Choice in such patients due to it safty & eeicay for your next few patients prescribe Dostin Suspension.

ENT Specialist Doctor! In need of a mucolytic agent for the most of your patientsDostin being the latest generation of mucolytic serves your purpose effectively, therefore, in next patients prescribe Dostin.

GLOSSARY
Mucoactive Tetradynamic Rheology Viscosity N-Acetylcysteine Exacerbations Adhesion Colonization Fimbraie Pillin Oxidant COPD COAD GSH Synergetic Cough Rhonch obstruction Rales Polypnoea Odor Reflux Ambroxol Emphysema : Pertaining to mucus activity. : Four mechanisms of actions. : The science of the flow of matter. : Resistance to flow, a physical property of a substance. : The generic of Abbott,s mucolytic drug Mucolator. : Increase the severity of a disease or any of its symptoms. : The property of remaining in close proximity. : The foundation and growth of a new group of microorganisms on a host. : Access structure developed by certain bacteria help in adhesion : The protein that composes bacterial Pili. : The electron acceptor also known as ROS. (Reactive Oxygen Species). : Chronic Obstructive Pulmonary Disease in some countries known as COLD, Chronic Obstructive Lung disease. : Chronic Obstructive Air Way Disease. : Glutathione a natural anti-oxidant present in the respiratory tract. : Acting together or in harmony. : A sudden noisy expulsion of air from the lungs. : A continuous sound produced in the throat or bronchial tube due to partial. : A discontinuous sound heard primarily during inhalation. : Abnormal increase in the depth and rate of breathing. : A smell. : A backward or return flow. : The generics name of mucolytic drug (e.g. Mercks Mucosolvan). : The permanent enlargement of the air spaces of the lung.