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1: Anticancer Res. 1994 Jan-Feb;14(1A):221-7.

Uptake and cytotoxicity of ascorbic acid and dehydroascorbic acid in neuroblastoma Related Articles
(SK-N-SH) and neuroectodermal (SK-N-LO) cells.
Ascorbic acid induces lipid peroxidation on neuroectodermal
[Anticancer
SK-N-LO cells with high endogenous ferritin content Res .1994]
and loaded
Baader SL, Bruchelt G, Trautner MC, Boschert H, Niethammer D.
Cerebral astrocytes transport ascorbic acid and dehydroascorbic
Children's Hospital, Department of Hematology and Oncology, University of Tuebingen, Germany. [JNeuAMP.
acid through distinct mechanisms regulated by cyclic rochem.1997]

The uptake of ascorbic acid into human umbilical vein

Ascorbic acid (AA) was found to be cytotoxic to neuroblastoma cells in vitro and in vivo. In the
[BiochemPharmacol.1995]
endothelial cells and its effect on oxidant insult.
present, study we investigated whether the reduced--(AA) or oxidized form (dehydroascorbic
acid, DhAA) and its rapidly formed metabolites were the main cytotoxic agents. In Ascorbic-acid-mediated iron release from cellular ferritin and its
neuroblastoma SK-N-SH cells, AA was found to be more cytotoxic than DhAA, although [JCanin
relation to the formation of DNA strand breaks cerneuroblastoma
ResClinOncol.1994]
considerably higher amounts of [14C]DhAA than of [14C]AA were incorporated. In contrast, Review Final report of the safety assessment of L-Ascorbic
SK-N-LO cells derived from neuroectodermal tissue in fact showed a similar uptake but were [Int J Toxicol.2005]
Acid, Calcium Ascorbate, Magnesium Ascorbate, Magnesium
much less injured by both substances. We observed that uptake of [14C]AA and [14C]DhAA was
impaired in the presence of dithiothreitol and glutathione. Once inside the cell, [14C]DhAA was » See Reviews... | » See All...
partially reduced to [14C]AA. From these data we conclude first that at least part of AA is
oxidized prior to its uptake, and second that the reduced form of AA and perhaps ascorbyl Cited by PubMed Central article
radicals but not DhAA or its metabolites are the most important forms in mediating cytotoxic
reactions in neuroblastoma cells. Furthermore, the results strengthen the previous assumption Ascorbate enhances the toxicity of the photodynamic action of
that AA acts as a pro-oxidant in neuroblastoma cells and supports its use in the treatment of Verteporfin in HL-60 cells. [FreeRadic Biol Med.2006]
neuroblastoma, especially in combination with existing chemotherapeutics.

PMID: 8166453 [PubMed - indexed for MEDLINE] Patient Drug Information

Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...)

Ascorbic acid is used to prevent and treat scurvy, a disease
caused by a lack of vitamin C in the body.

Source: AHFS Consumer Medication Information

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