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1: Carcinogenesis. 1994 Feb;15(2):291-5.

Effect of vitamin C supplementation on gastric mucosal DNA damage. Related Articles

Effect of vitamin C upon gastric mucosal O6-alkyltransferase

Dyke GW, Craven JL, Hall R, Garner RC.
activity and on gastric vitamin C levels. [Cancer Lett.1994]
Jack Birch Unit for Environmental Carcinogenesis, Department of Biology, University of York, UK. Ascorbic acid and total vitamin C concentrations in plasma,
[Gut.1996]
gastric juice, and gastrointestinal mucosa: effects of gastritis
The effect of oral vitamin C supplementation on intragastric ascorbate levels and gastric mucosal
DNA damage as measured by the 32P-postlabelling assay was assessed in 43 patients. In Effects of antioxidant vitamin supplements on Helicobacter
patients with normal gastric mucosa, treatment with vitamin C resulted in elevation of pylori-induced gastritis in Mongolian gerbils. [Helicobacter.2005]
intragastric ascorbate levels in all cases. In the presence of chronic atrophic gastritis, however, Review Ascorbic acid metabolism and cancer in the human
the effect was variable. Gastric mucosal DNA damage was decreased in 28 of the 43 patients stomach. [ActaGastroenterol Belg.1997]
after vitamin C supplementation (P = 0.01; Wilcoxon sign rank test). This supports Review Vitamin C and genomic stability.
epidemiological evidence that suggests vitamin C may exert a protective effect against the [Mutat Res .2001]
development of gastric cancer.
» See Reviews... | » See All...
PMID: 8313520 [PubMed - indexed for MEDLINE]

Cited by PubMed Central articles

Oxidative DNA damage accumulation in gastric carcinogenesis.

[Gut.1998]

Review Damage to DNA by reactive oxygen and nitrogen

species: role in inflammatory disease and progression to cancer.
[Biochem J.1996]

Patient Drug Information

Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...)

Ascorbic acid is used to prevent and treat scurvy, a disease
caused by a lack of vitamin C in the body.

Source: AHFS Consumer Medication Information

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