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Hydrates Skin

Cools & Soothes Irritated Skin

is a moisturizing face / body cream, which enhances the regeneration and care the dry, irritated and sensitive skin. contains a combination of ingredients known for their healing and moisturizing qualities:
Panthenol Chamomile extract Allantoin Urea 2% Moisturizing / Regenerating/ Mild anti-in ammatory action Mild anti-in ammatory action Regenerating action Moisturizing action

PANTHENOL AND SKIN REGENERATION

Panthenol
Epithelium regeneration

Cell proliferation Co-enzyme A

Collagen synthesis

Acetyl Co-enzyme A Fibroblast proliferation


Citric Acid cycle

ATP ATP

ATP ATP

ATP

Serious Skin Care

Serious Skin Care


Healing / Hydrating qualities
properties.

Moisturizing: Panthenol and 2% Urea moisturize the skin due to their hygroscopic

Regenerating: Allantoin and Panthenol increase the mitotic index and stimulates the epidermal regeneration, as well as activates broblast proliferation and collagen synthesis. Mild anti-in ammatory: Clinical trials showed that Panthenol and Chamomile extract have mild anti-in ammatory action. The action of 5% Panthenol, as well as Chamomile extract is comparable with that of hydrocortisone 0,25%.
U. Wollina et al: Anti-Inammatory Eects of Dexpanthenol: Akt Dermatol: 2004:30:pp 478-482 Patzelt-Wenczler R. et al: Proof of ecacy of Kamillosan cream in atopic eczema: Eur J Med Res: 2000 April: 19: 5(4)

topical application of Panthenol 5% (twice daily for 7 days) increases the synthesis of fatty acids, improves the skins barrier function and decreases TEWL.
F.Ebner: Topical Use of Dexpanthenol in Skin disorders: Am. J. Clin. Dermatology: 2002: 3(6): pp 427-433

Restoration of the Natural Barrier Fuction: Clinical trials have shown that

Rapid Resolution: The bene cial e ects are visible within 2 weeks.
EFFICACY OF PANTHENOL 3%
Xerosis Roughness Scaling Pruritus Erythema Skin Fissure
0,0 0,5 1,0 1,5 2,0 2,5 3,0 3,5

Before After

In a multicenter study 3% Panthenol was applied topically in 483 patients with Atopic Dermatitis, Psoriasis, Ichthyosis and Contact Dermatitis. Within 3 4 weeks the symptoms improved by > 80 90%.
[ F. Ebner: Topical Use of Dexpanthenol in Skin disorders: Am. J. Clin. Dermatology: 2002:3 (6):pp.427 433 ]

is a non-sticky, non-staining cream that is rapidly absorbed. It leaves the skin feeling smooth, hydrated and non-greasy.

Excellent Tolerability:

is an enhanced moisturizing body cream with regenerating and calming action. is reinforced with 10% urea and presents a high degree of moisturizing power.
NMF Composition
Amino acids Pyrrolidone carboxylic acid Lactate Urea Sodium, calcium, potassium, and magnesium phosphates and chlorides Ammonia, uric acid, glucosamine, creatinine Unidenti ed 40.0% 12.0% 12.0% 7.0% 18.5% 1.5% 9.0%

Urea constitutes 7% of the NMF and plays a vital role in epidermis hydration

Urea levels in healthy and atopic skin


25 20

mg / 2,5 cm2

In cases of severe xerosis (psoriasis, atopic dermatitis, diabetes mellitus, etc) Urea level is reduced by up to 90%.

15 10 5 0

16 - 20 years
Healthy skin

21 - 30 years
Symptom - free atopic skin

31 - 40 years
Diseased atopic skin

Hydration of the Stratum Corneum by Urea 10%


90 80 Nonlesional skin Urea 10% Placebo Psoriatic skin (untreated)

Hydration (capacitance)

70 60 50 40 30 20 10 0 0 2 4 5 8

Topical application of Urea 10% increases the water holding capacity of the stratum corneum by 100%.

10

12

14

The table depicts the daily progress of SC hydration in 10 patients with psoriasis over 14 days. A signi cant increase in skin hydration was observed in areas where Urea 10% was applied (In 2 weeks +73%, p<0.025). Even after 2 days following the start of treatment, Urea 10% was signi cantly better than placebo.
I.Hagemann and E. Proksch: Topical treatment by Urea Reduces Epidermal Hyperproliferation and Induces Dierentiation in Psoriasis: Acta Derm Venereol (Stockh): 1996: 76: pp 353-356

ENHANCED MOISTURIZING

Indications:
a moisturizing cream with regenerating and calming action for the daily care of the face and body, is ideal for the management of mild skin irritations, as well as for dry skin conditions:
Sunburn Tattoo aftercare Mild burns Chapped hands Protection from environmental factors (wind, cold etc) Irritation / dryness after shaving Dry skin and irritation after laser depilation Dry skin caused by the use of soap Dry and atopic skin (symptom-free atopic skin) Mild senile xerosis Dry skin caused by the administration of anti-acne medicines*

R.Romiti et al: Dexpanthenol cream signicantly improves mucocutaneous side eects associated with isotretinoin therapy: Pediatric Dermatology: Vol. 19: 4: 2002: Correspondence: p 368

an extra moisturizing cream with regenerating and calming action for the daily care of skin, is ideal for the management of moderate dry skin conditions and mild irritations, as found in:
End-stage Renal Disease Diabetes Mellitus Hypothyroidism Autoimmune Diseases (Scleroderma, Lupus Erythematosus, Sjogren Syndrome, etc) Chronic Venous Insu ciency Adverse drug reactions (e.g. diuretics, statins, etc) Menopause Moderate endogenous or acquired Dry skin (Atopic Dermatitis, Contact Dermatitis, Winter Xerosis, Psoriasis, Ichthyosis, Feet Xerosis, Senile Xerosis, etc.)

Serious Skin Care Enhanced Moisturizing


Hydrates skin til n un i k s to Soothes and cools skin lly in ed. Use bside. a r e b su li orb pply tely abs mptoms A Aids the skins healing process sy ple com rly until la regu Restores the Skins Natural Barrier Function Reduces the Transepidermal Water Loss (TEWL) Acts quickly on the skin Rapidly absorbed Very well tolerated Non-sticky, non-staining 150 ml Corticosteroid free Parabens free Compatible with all skin types

150 ml
NOTE The ingredients of are very well tolerated by the human skin. It has been reported that, in a few cases, Urea might cause a transient burning or stinging sensation in individuals with sensitive or irritated skin or with small abrasions (e.g. atopic dermatitis, irritation after scratching or shaving the legs etc). The sensation is mild. If in spite of this the sensation causes discomfort, may be used alternately with (morning evening).

28-30 Hansen str., 111 44 Athens, Greece el.: (++30) 210 2110614 info@cheironpharma.com www.cheironpharma.com