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1: Int J Vitam Nutr Res. 1989;59(2):161-6. Links

Vitamin C lowers mutagenic and toxic effect of hexavalent chromium in guinea pigs. Related Articles

Effect of vitamins C and E on toxicity and mutagenicity of hexavalent chromium

Ginter E, Chorvatovicová D, Kosinová A. in rat and guinea pig. [Mutat Res. 1991]

Research Institute of Human Nutrition, Bratislava, Czechoslovakia. Clastogenicity and mutagenicity of hexavalent chromium in lacZ transgenic mice.
[Tox ico lLett. 1997]
The mutagenic effect of intraperitoneally injected K2Cr2O7 was significantly higher in vitamin C-deficient guinea
NTP Toxicity Studies of Sodium Dichromate Dihydrate (CAS No. 7789-12-0)
pigs than in animals fed diet with high vitamin C content. Mutagenic and toxic effects of hexavalent chromium Administered in Drinking Water to Male and Female F344/N Rats and B6C3F1
[T oxic Rep Ser. 2007]
were more expressed in vitamin C-deficient guinea pigs administered K2Cr2O7 in drinking water: the number of
micronuclei in polychromatic erythrocytes of bone marrow was increased, and the activity of O-demethylase Review Ascorbic acid and atherosclerotic cardiovascular disease.
and the levels of cytochromes P-450 and b5 in liver microsomes were decreased. In guinea pigs fed high vitamin [Subcel lBiochem. 1996]

C diet the same doses of bichromate in drinking water evoked no mutagenic changes in the bone marrow and no Review Therapeutic review: is ascorbic acid of value in chromium poisoning
changes in microsomal enzymes in the liver. These results indicate that high intake of ascorbic acid in the diet and chromium dermatitis? [J To xicol ClinT oxicol. 1999]
reduces mutagenic effects of K2Cr2O7 and its toxic influence on drug metabolizing enzymes in hepatocytes. The
protective effect ascorbic acid consists most probably in the enhanced extracellular and intracellular reduction » See Reviews... | » See All...
of hexavalent chromium to the less toxic and less mutagenic trivalent chromium.
Patient Drug Information
PMID: 2777501 [PubMed - indexed for MEDLINE]
Potassium (Glu-K® , K+ 10® , K+ 8® , ...) Potassium is essential for the proper
functioning of the heart, kidneys, muscles, nerves, and digestive system. Usually
the food you eat supplies all of the potassium you need. However, certain diseases

Ascorbic Acid (Cecon® Drops, Cenolate® , Cevi-Bid® , ...) Ascorbic acid is used
to prevent and treat scurvy, a disease caused by a lack of vitamin C in the body.

Source: AHFS Consumer Medication Information

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