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5006
Edexcel GCSE
Science
Biology B1b
Topic 3: Electrical and Chemical Signals
Topic 4: Use, Misuse and Abuse
Foundation and Higher Tiers
Monday 25 June 2007 – Morning
Time: 20 minutes
Materials required for examination Items included with question papers
Multiple Choice Answer Sheet Nil
HB pencil, eraser and calculator
Instructions to Candidates
Use an HB pencil. Do not open this booklet until you are told to do so.
Mark your answers on the separate answer sheet.
This publication may be reproduced only in accordance with Edexcel Limited copyright policy. ©2007 Edexcel Limited.
Questions 1 to 16 must be answered by Foundation tier candidates only.
Higher tier candidates start at question 17.
Boiled egg
The picture shows Jane removing her hand quickly after she touched an egg that had just been boiled.
A a voluntary response
B an involuntary response
C a stimulus
D an impulse
A relay
B sensory
C motor
D effector
3. Jane wants to find out if cold hands react differently from warm hands when touching a hot
egg.
The best way to do this would be to measure how long it took for
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4. Which should Jane use to measure the reaction time?
A ice
B clock
C thermometer
D egg
The most popular drug in the world is one you probably have
every day. This is caffeine. Caffeine is found in tea, coffee and
cola.
5. Caffeine is a
A painkiller
B sedative
C stimulant
D antibiotic
A brain
B lungs
C liver
D stomach
TAURINE 1000 mg
GLUCURONOLACTONE 600 mg
CAFFEINE 80 mg
NIACIN 20 mg
VITAMIN B6 5 mg
PANTOTHENIC ACID 5 mg
VITAMIN B12 0.005 mg
SUCROSE 21.5 g
GLUCOSE 5.25 g
A 80 mg
B 160 mg
C 250 mg
D 500 mg
Peter’s illness
Peter was worried because he began to lose weight and became very tired. He went to see his doctor.
His doctor took a blood sample from Peter. The pie chart shows the four main parts of Peter’s blood.
key
plasma
platelets
red blood cells
white blood cells
A plasma
B platelets
C red blood cells
D white blood cells
A plasma
B platelets
C red blood cells
D white blood cells
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The doctor showed Peter a graph showing normal blood glucose concentration and the blood glucose
concentration found in Peter’s blood.
28 ±
blood glucose
concentration 24 ±
in mmol
per litre 20 ±
16 ±
12 ±
8±
4±
A 4
B 16
C 20
D 24
12. Peter’s blood glucose concentration was much higher than normal.
His doctor told him he had
A diabetes
B fatigue
C inflammation
D an addiction
13. The doctor said that Peter had the illness because an organ in his body was not making
enough
A enzymes
B insulin
C red blood cells
D stimulants
A intestine
B brain
C liver
D pancreas
A more reliable
B averaged
C safer
D more ethical
16. The doctor told Peter he would feel better if he had a hormone injection.
Which row of the table is correct for hormones?
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Higher tier candidates start at question 17 and answer questions 17 to 40.
Questions 17 to 24 must be answered by all candidates: Foundation tier and Higher tier.
Salmonella poisoning
A foreign bodies
B microbes
C pathogens
D viruses
19. Salmonella bacteria can be found in raw chicken. They grow very quickly in the correct
conditions.
What are the best conditions to store raw chicken to reduce the growth of Salmonella
bacteria?
20. Salmonella bacteria can affect the body when eaten in infected food.
What is this type of transmission called?
A vector borne
B vehicle borne
C vertical contact
D horizontal contact
Paracetamol is a drug for pain relief that can be bought in supermarkets. It is the most used painkiller
in Britain.
21. Which part of the body may be seriously damaged by taking an overdose of paracetamol?
A heart
B kidney
C liver
D lungs
23. Which is not a reason for paracetamol being the most used painkiller in Britain?
Foundation tier candidates do not answer any more questions after question 24.
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Questions 25 to 40 must be answered by Higher tier candidates only.
Foundation tier candidates do not answer questions 25 to 40.
Tuberculosis
A patient was suffering from TB. Samples from their breath, saliva and fingers were taken and cultured
in Petri dishes in the laboratory. The Petri dishes were covered, sealed and incubated. The results are
shown below.
colony of colony of
TB bacteria TB bacteria
25. Based on the results of the experiment, what would you conclude was the most likely way for
TB to be spread?
A by animal vector
B by hand to hand contact
C through droplets in the air
D in drinking water
26. Before the experiment the Petri dishes were irradiated to sterilise them.
Why was this important?
A bacterium
B antigen
C fungus
D virus
The graph shows the number of deaths from TB in Britain since 1840.
4500
number of 4000
deaths per million
3500
3000
2500
2000
1500
1000
500
0
1820 1840 1860 1880 1900 1920 1940 1960 1980
year
A 600
B 4000
C 6000
D 7200
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31. What would be the effect in Britain of the emergence of drug resistant TB?
A The number of cases of TB would increase and they would be easier to treat
B The number of cases of TB would increase and they would be more difficult to treat
C The number of cases of TB would be unaffected but they would be easier to treat
D The number of cases of TB would be unaffected but the drugs would have the same
effect
32. These two statements are about conditions and the spread of TB.
A 1 only
B 2 only
C both 1 and 2
D neither
Contraception
Julie wanted to avoid getting pregnant. She read the passage below in a newspaper.
33. Julie calculated that if one million women used the pill, the number who could get pregnant in
the first year of use would be
A 25
B 250
C 2 500
D 25 000
A uterus
B brain
C liver
D lung
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Development of drugs to fight cancer
According to research in America the number of deaths from most types of cancer is falling due to the
development of new and improved drugs.
The graph shows the number of drugs in development for cancer as of April 30, 1999.
bladder cancer 13
brain cancer 23
breast cancer 63
cervical cancer 11
colon cancer 46
head/neck cancer 23
kidney cancer 18
leukemia 38
liver cancer 8
lung cancer 58
lymphoma 37
multiple myeloma 5
neuroblastoma 2
ovarian cancer 41
pancreatic cancer 22
prostate cancer 47
sarcoma 6
skin cancer 58
solid tumors 49
stomach cancer 12
cancer-related conditions 37
other cancers 20
unspecified cancers 21
0 10 20 30 40 50 60 70
Source: www.ncpa.org
37. In 1999 according to the graph which two types of cancer had the most drugs in
development?
38. The highest number of cancer deaths in America is due to lung cancer but more drugs are being
developed for breast cancer.
The most likely reason for this is that
A Nicotine causes mutations of cells in the lungs and tar can clog up the cilia
B Nicotine is addictive and tar binds to red blood cells instead of oxygen
C Chemicals in tar cause cell mutations and nicotine is addictive
D Chemicals in tar block goblet cells and nicotine damages alveoli
40. These three statements are about the use of opiates in the treatment of terminally ill patients.
1 Opiates are addictive and are not prescribed to terminally ill patients.
2 Opiates offer very strong pain relief.
3 Opiates can prolong the life of terminally ill patients.
A 2 only
B 1 and 2 only
C 2 and 3 only
D 1, 2 and 3
END
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