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I. N o 1
Complete the following tables with suitable answer Drug Action Endocitocidal Broad spectrum anthelmentic Mechanism of action GABA agonist GABA : "inhibitory neuro chemical transmmitor" bind to chloride channles in parasite nerve and muscle fiber .cause paralysis Neuro muscular blocker -curare like action -:block ach at myoneural junction cause paralysis
Ivermectin
Piprazine citrate
Antiascaris
Live worm expelled by peistalsis 2-GABA agoinst GABA : "inhibitory neuro chemical transmmitor" bind to chloride channles in parasite nerve and muscle fiber .cause 3 paralysis inhibit mitochondrial reaction: inhibit fumerate reductase inhibit transformation of
Albendazole
Levamisole HCl
Pyrental tartarate
Ganglionic stimulant :Mimice action of ACH stimulate nicotonic raceptor at neuromuscular junction of
Praziquantel
Anticestodal, antischistosomal
,cause paralysis. increase permeability to Ca. - damage to tegument lead to paralysis of the
Mebendazole
worm. Anti adult Fasciola 1-inhibit glucose -Broad spectrum anthlemintic transport and utilization by the worm . 2-inhibit microtubulin formation. Inhibit egg and
Niclosamise
Anticestodal antischistosomal
Nitroxinil
Antinematodal
1 0
Clorsulon
1 1
Thiabendazol e
Antinematodal
Inhibit egg and larva production 2-inhibit tubulin polymerization to microtubule 3-inhibit mitochondrial reaction.
1 2
Closantel
1 3
Dichlorofos
Antinematodal Endocitocidal
Diamphenati de
increase permeability to Ca. - damage to tegument lead to paralysis of the worm. inhibit mitochondrial reaction: inhibit fumerate reductase inhibit transformation of fumerate to succinate inhibit tubulin polymerization
1 5
Triclabendaz ole
Rafoxanide
1 7
Fenbendazol e
inhibit mitochondrial reaction: inhibit fumerate reductase inhibit transformation of fumerate to succinate inhibit tubulin polymerization Inhibit egg and larva
1 8
Aricholine HCl
anticestodal
Choleinergic agonist stimulate adult nervous system cause paralysis of the worm. GABA agonist GABA : "inhibitory neuro chemical transmmitor" bind to chloride channles in parasite nerve and muscle fiber .cause paralysis Uncoupling of oxidative phosphorylaton
1 9
Doramectin
Endocitocidal antinematodal
2 0
Clioxanide
Anti trematodal
N o 1
Drug
Adverse effects Embryotoxic in animal. Teratogenic effect not used during pregnancy Increase active ach neurotoxicity in host Narrow range of safety Not used in heart worm positive dogs
Albendazol e Fenchlorof os
4 5
tartarate
II.
Write only 1 word for each of the following sentence Simple heterocyclic compound of choice for treatment of Parascaris equarum in donkey. (Piperazine
citrate)
Parasympathomimetic cesticide.
(Arecholine
HCL)
Faciolicide could be combined with ivermectin in order to broaden its spectrum. (clorsulon) (GABA)
(Levamezol)
sulfoxide)
III. How to use subject index to search about albendazole in Veterinary Drug Therapy
Look at index at the back of the book Search for albendazole : for example: anti nematodal >page:300 anti cestodal > page :500