Papilloma. The lesion consists of thickened fingers of epithelium.

Slender vascular cores of connective tissue support each frond

Papilloma arising at the commissure

Keratoacanthoma

Keratoacanthoma of the upper lip

Keratoacanthoma. Note the cup-shaped symmetry and verruciform surface.

Squamous cell carcinoma, floor of mouth

Squamous cell carcinoma, gingiva

Squamous cell carcinoma of the lip.

Exophytic squamous cell carcinoma of the lip.

Advanced squamous cell carcinoma of the posterior-lateral tongue

Squamous cell carcinoma of the lateral tongue in a 34-year-old man

Squamous cell carcinoma of the lateral tongue.

Squamous cell carcinoma of the ventral surface of the tongue.

Early squamous cell carcinoma of the floor of the mouth

Early squamous cell carcinoma of the floor of the mouth.

Squamous cell carcinoma of the floor of the mouth

Squamous cell carcinoma of the floor of the mouth.

Squamous cell carcinoma of the gingiva.

Metastasis of squamous cell carcinoma of the tongue to a submandibular lymph node.

Metastatic squamous cell carcinoma (right) in a lymph node.

A and B, Squamous cell carcinoma of the tongue.

Squamous cell carcinoma showing tumor nest invading skeletal muscle.

A, Spindle cell squamous cell carcinoma. B, Immunohistochemical stain for keratins showing positive staining of tumor cells.

Postradiation scar in the floor of the mouth, the site of the patient's primary squamous cell carcinoma.

TNM Clinical Staging System for Oral Squamous Cell Carcinoma TTumor T1: tumor <2cm T2: tumor 24cm T3: tumor >4cm T4: tumor invades deep subjacent structures NNodes

N0: no palpable nodes N1: single ipsilateral node 3cm N2A: single ipsilateral node 36cm N2B: multiple ipsilateral nodes 6cm N2C: contralateral or bilateral nodes 6cm N3: node >6cm MMetastasis M0: no distant metastasis M1: distant metastasis

Lymph nodes in TNM staging Stage TNM Designation I T1, N0, M0 II T2, N0, M0 III T3, N0, M0 T13, N1, M0

IV T4, N0, M0 T4, N1, M0 Tany, N2-3, M0 Tany, Nany, M1 TNM Clinical Staging of Oral Squamous Cell Carcinoma

Idiopathic leukoplakia of the lateral tongue. The microscopic diagnosis was squamous cell carcinoma.

Exophytic well differentiated papillary squamous cell carcinoma in the buccal sulcus in a 54-year-old woman.

A and B, Basal cell carcinoma.

Basal cell carcinoma.

Basal cell carcinoma. Note solid tumor (left) and nested tumor (right

Nevoid basal cell carcinoma syndrome patient. Note bifid (arrow).

Verrucous carcinoma of the maxillary alveolar ridge.

Verrucous carcinoma of the mandibular vestibule.

Verrucous carcinoma of the tongue.

Verrucous carcinoma of the lingual gingival,

Verrucous carcinoma showing broad, pushing, well-differentiated rete ridges.

Verrucous carcinoma showing well-differentiated epithelium in a verruciform profile.

Proliferative verrucous leukoplakia.

Verrucous carcinoma developed from persistent proliferative verrucous leukoplakia.