McDonald, Kayla Period 5 Article Due: 09/27/12

Critique
Bentley, William E., and David N. Quan. "Gene network homology in prokaryotes using a similarity search approach: queries of quorum sensing signal transduction." PLoS Computational Biology 8.8 (2012). General Science Collection. Web. 25 Sept. 2012.

The Article was about gene networking in prokaryotes (bacteria cells) using similarity search approaches and queries of quorum sensing signal transduction. Bentley and Quans report defines genome sequences in prokaryotes. The genetic modularity of signal transduction processing is also clearly explained by the works of the two scientists. The Local Modular Network Alignment Similarity Tool (LMNAST) was used in this research. LMNAST applies a BLAST-like heuristic to gene order arrangement. The LMNAST evaluated nucleotide records for similarity to the inquiry using the BLAST-like heuristic. Queries are therefore not necessarily restricted to defined networks insofar as any gene ordering may be a query. The Input consisted of an ordered list of gene elements and later on the Nucleotide records were investigated farther. The results found by conducting this experiment had many important results that later in time could result in finding cures for infectious diseases and bacteria. The stringent criteria search yielded fewer hits that the corresponding weak criteria search (189 vs. 236). The results showed that lac systems were found in 26 unique E. coli strains The bacteria E. coli is linked to Salmonella. False positives were represented by the truncated systems. As many new facts were found in this research further testing of LMNAST was conducted with weak, stringent, and expanded window searched of E. Coli Lsr system. This experiment showed how

bacteria combine to become a stronger force. Bacteria grow and grow until eventually diseases are products of the combination. With the research gathered in this experiment scientist may be able to find cures for bacteria causing infections. Scientists may be able to find a cure for bacteria causing infections because they have a fuller understanding as to how bacteria link and expand. The Authors, Bentley and Quan, expanded the base for bacteria focused scientists. The scientist became more clear on the signaling molecule, AI2, and began to understand that it is synthesized by many bacteria so that in a natural ecosystem compromised of many secreting cells of different species, the molecule may be present in an appreciable concentration. This article could one day help me to become a famously known scientist because it begins the basis for finding cures for several infectious diseases just by beginning to understand how prokaryotic cells link and expand. This article can be the basis for any scientist! This article helps society understand that this hope to find cures for even the most infectious diseases. Overall the data and conclusion match up, there are no contradictions. There is sufficient data to support the authors generalizations as well. Bentley and Quan showed great amounts of data to support their generalizations. Future studies will be able to expand upon this study to create a better and healthier society. The question left to understand is, where can this study take us and how can we control the spread of bacteria and creation of infectious diseases? The answer to this question is left up to the scientists in the world, now that the synthesizing and combining of prokaryotic cells is understood.