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From Pilot to Industrial Computarizated Bioreactors (Biorreactores computarizados de escala piloto a industria.l)
FERMENTADORES PILOTO
Caractersticas Generales
La serie SIFERM SIF 10/200 es una lnea de fermentadores multiproposito que posee control microprocesado de todos los parmetros del proceso en un diseo compacto, que est construdo para la fermentacin de un amplio rango de microorganismos. El proceso puede ser para cultivo en batch o continuo, el sistema esta equipado con un control propio RTX 10/20 que controla Ph, OD, antiespuma, agitacin y temperatura. Incluye bombas para acido, base, antiespuma y adicin de nutrientes, y todo elemento accesorio para el control del proceso. El fermentador es facilmente desarmado para el autoclavado , teniendo una rpida intercambiabilidad de los distintos recipientes para facilitar el escalado. La agitacin es diseada para altos valores de OTR y incorpora un motor de AC para producir la agitacin . Adems 2 ports RS 232 1 485 permiten las comunicaciones remotas o control supervisor con PC
BENCHOP FERMENTORS
General Characteristics
The Serie SIFERM SIF 10/200 is a PC ready multi purpose fermentar that provides microprocessor control of all process parameters in one compact package Designed for a wide range of microbial fermentations. Process, can be employed for booth batch and continuous culture The system is equipped with built in controls for pH, D.O., foam level, agitation, temperature another no standard instruments and includes pumps for acid, base, antifoam and nutrient addition. The reactor is easily removed for autoclaving and for rapid interchangeability of different vessels to facilitate escale - up. The agitation system is designed for high OTR values, and incorporates a AC motor to drive all system , in adition an two RS 232/485 integral serial port permit remote communications or supervisory computer control.
Fermentar Vessel: A Thick-Walled, flanged glass tu be and toroidal bottom glass is anchored toa stanley steel AISI 316 head plate and botton plate. The glass tube is considerably stronger than conventional hars, and provides superior resistance to high temperatures and rugh handline. Eight autoclave ports are mounted in the head plate for the addition of anti foam nutrient, as well as for vessel accesories in-out port, aireation etc. The port have and externa! compression ring for aseptic sealing, and may be plugegg when not in use
FERMENTADORES INDUSTRIALES
Caractersticas Generales
La serie SIFERM SIF 100/5000 es una lnea de fermentadores ' industriales.controlados por microprocesador con la posibilidad de la esterilizacin in situ por medio de un generador externo o una fuente propia. Posee un sistema de control de alta tecnologa RTX 10/20 y la posibilidad de supervisin con P.C.
INDUSTRIAL FERMENTORS
General Characteristics
SIFERM SIF 100/5000 combines the efficiency of microprocessor controled industrial fermentar with the convenience of in place sterilization a bu lit - in steam generator or externa! steam suply. With vessels are from 100 to 5000 achieving reproducible oxygen transfer rates of 350 mM . Utilizing microcomputer tecnology a built-in alfa - numeric display guides you through sterelization, prove and pump calibration, as well as control of process parameters with two build - in RS232/485 -time monitiring data interfase, SIFEM can provide real. adquisition and computer control in batch , fedbatch and continous culture studies
Caractersticas Tcnicas
Recipiente del fermentador: El equipo es autoesterilizable con
un recipiente de acero inoxidable tipo AISI 316 , presurizable segn el cdigo ASME para 40 psig (2 ,8 kg cm2) y vacio total. Agitadores de dimetro adecuado y bafles ayudan a obtener altas transferencias de oxigeno. Nuestros reactores de acero inoxidable standard vienen en medidas de 100 a 5000 lts, con cabezal y fondo toriesfrico de AISI316. Camisa: Convencional o media caa de acero inoxidable con uno o varios puntos de entrada, puede suministrarse con serpentina interior . Terminacion superficial: Las unidades pueden ser adaptadas a los requerimientos para cada necesidad industrial Aislacion: Las unidades pueden ser suministradas con aislacin fro, calor o ambas. La terminacin puede ser de acero inoxidable o aluminio. Agitador: Puede suminitrarse con los siguientes tipos , axial ,
Technical Characteristics
Fermentor Vessel: The self-sterilizable SIFERM equipped with a type Al SI 316 stainless steel pressure vessel that is A.S.M.E. Coded for 40 psig (2.8 Kg/cm) and full vaccum . Agitator of adecuate diameter and wide baffles help two achieve high oxigen transfer rates. Our standard stainless steel reactors are available in several standard size, rangind from 100 through 5000 liters.
Jacket: conventional or half pipe stainless steel, one or several entry points We can al so suply an additional inner coil. Surfase finishing: l.t varies and can be adapted to the particular requeriments of each industrial need. lnsulation: The uits can be supplied with insulation to cold , heat or both conditionds. The fishining or such insulation can be stainless steel, aluminim . Agitator: Can be supplied the folowing types, axial or radial turbines
Control delantiespuma por medio de la regulacin precisa de la bomba de adicin de antiespuma. Control de alimentacin de nutriente con bomba de adicin. Control del flujo de aire con vlvula proporcional (opcional) .
lntrumentation and Control: Can be programmed to monitor and control all process variables through built-in microprocessor-controlled intrumentation pH-PID control via acid and base aditions from pumps Agitation speed via ~O control D.O. by PID regulation of agitator speed, air flow and others Temperature-PID control through dual mode adjustment of heater out put andwather recirculation rate for precise temperature control Foaming - by means of an adjustable conductivity leve! probe coupled to a chemical the foamer adition pump Nutrient feed - via a medium adition pump for precise regulation of the dilution rate in continuous culture. The nutrient feed pump can be regulated via front - panel Flow air via a masic sensor and control valve proportional (optional)
CARACTERSTICAS AVANZADAS
Alto OTR Control PID (proporcional integral , derivativo de velocidad desde 20 a 1000 rpm Control temperatura PID desde 4 C hasta 80 C Filtros entrada salida reemplazables Control de OD con lazo PID, sensor polarogrfico o galvanice rango 10 a 90% Control de PH con lazo PID , sensor de rango 2-12 pH Interfase a computadora con RS 232 /485 Display alfanumrico - grfico Backup con batera, que previene perdidas de informacin ante falla de alimentacin
ADVANCED FEATURES
High OTR Proportional , integral and derivative control of speed, from 20 to 1000 rpm . Temperatura control PID from 4C to 80 11C. Replace inlet and exhaust gas filters. OD control PID with polarogrfic (or galvanic) sensors from 10to90%. Ph control PID from 2 to 12 pH.
omputer interfase with RS/232 or RS/485 pha numeric graphic display attery backup avoid loss of set point in event of power failure.
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TECHNICAL CHARACTERISTIC
BENCHOP FERMENTATOR
Total Capacity VESSEL Design Pressure Window STEAM STERILIZATION Range TEMPERATURE Sensor Control Range Control AGITATION Orive lmpelier Range AIR FLOW Filler, lnlet Filler, Exhaust COMMUNICATIONS PORT FOAM/LEVEL CONTROL pH CONTROL HIGH FOAM CONTROL D.O. CONTROL Standard Standard Standard From 1 Lis lo 25 Lis VESSEL retorced glass Not presurizable Allows observation of culture above and liquid level Autoclave From 4C lo 80C Platinum RTD Microprocesor TEMPERATURE 20 lo 1000 rpm PID AC motor Two turbine of six blades Olo 20 Lts./min u others EXHAUST Cartridge of 0.2 micrones Cartridge of 0.2 micrones RS 232/485 Addition pump D.O. Via peristaltic pump Via peristaltic pump Via agitation o air flow Graphic display 220/110 VAC monofasic pH AIR FLOW Filler lnlet Filler Outlet Condenser Range Control Probe Range Control Pro be PUMPS Ph CONTROL FOAM CONTROL DISPLAYS SCREEN COMMUNICATONS PORT RECORDER PORT ELECTRICAL SERVICE ELECTRICAL DATA Cartridge of 0.2 micrones Cartridge of 0.2 micrones Optional 2to 12 Ph PID Presurisable sensor 10 to 100% PID Polarographic Sensor Peristaltic Pump Peristaltic Pump Alphanumeric - Graphic Two RS 232/485 Optional 3 x 220 or 3 x 110 Trifasic
STERILIZATION Volume
INDUSTRIAL FERMENTATOR
100 Lis to 5000 Lis
Trifasic AC motor 50- 1000 rpm In control PID 2 or 3 six blade turbine impellers 4 to 80 C Microprocessor Pt100 In situ
Range
Fabricante:
MC
bGEMERIA
Distribudo por:
Timoteo Gordillo 371 (1408) Capital Federal- Rep. Argentina Tel.: (54) 4-642-8565 Fax: (54) 4-642-8565 web www.mcingenieria.com