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The infection can cause a wide spectrum of symptoms in birds, ranging from mild illness, which may pass unnoticed, to a rapidly fatal disease that can cause severe epidemics. Avian influenza viruses do not normally infect humans. However, there have been instances of certain highly pathogenic strains causing severe respiratory disease in humans. In most cases, the people infected had been in close contact with infected poultry or with objects contaminated by their faeces. Nevertheless, there is concern that the virus could mutate to become more easily transmissible between humans, raising the possibility of an influenza pandemic. -Who antigenic drift. These are small changes in the virus that happen continually over time. Antigenic drift produces new virus strains that may not be recognized by the body's immune system. This process works as follows: a person infected with a particular flu virus strain develops antibody against that virus. As newer virus strains appear, the antibodies against the older strains no longer recognize the newer virus, and reinfection can occur. This is one of the main reasons why people can get the flu more than one time. In most years, one or two of the three virus strains in the influenza vaccine are updated to keep up with the changes in the circulating flu viruses. So, people who want to be protected from flu need to get a flu shot every year. The other type of change is called antigenic shift. Antigenic shift is an abrupt, major change in the influenza A viruses, resulting in new hemagglutinin and/or new hemagglutinin and neuraminidase proteins in influenza viruses that infect humans. Shift results in a new influenza A subtype or a virus with a hemagglutinin or a hemagglutinin and neuraminidase combination that has emerged from an animal population that is so different from the same subtype in humans that most people do not have immunity to the new (e.g. novel) virus. Such a shift occurred in the spring of 2009, when a new H1N1 virus with a new combination of genes emerged to infect people and quickly spread, causing a pandemic. When shift happens, most people have little or no protection against the new virus. While influenza viruses are changing by antigenic drift all the time, antigenic shift happens only occasionally. Type A viruses undergo both kinds of changes; influenza type B viruses change only by the more gradual process of antigenic drift. cdc Vaccination is the administration of antigenic material (a vaccine) to stimulate an individual's immune system to develop adaptive immunity to apathogen. Vaccines can prevent or ameliorate morbidity from infection.
A pandemic is an epidemic of infectious disease that has spread through human populations across a large region; for instance multiplecontinents, or even worldwide. Morbidity refers to the state of being diseased or unhealthy. It is an incidence of ill health in a population. It reprted by: World Health Statistics (compiled by WHO), MMWR (Morbidity and Mortality Weekly Report, by Center for Disease Control and Prevention, USA), EMDB (European hospital Morbidity Database, Europe), NHMD (National hospital morbidity Database, Australia). Mortality is the term used for the number of people who died within a population. It refers to the incidence of death or the number of deaths in a population. The Human Mortality Database developed by for example: the Department of Demography at the University of California, Berkeley and the Max Planck Institute for Demographic Research in Rostock Germany.
Tanya? how to overcome the outbreaks of avian influenza? How Influenza Viruses Change: Drift and Shift