E-Cigarette ENSP Athen 2013 Press Conf PDF

E-cigarette : Lessons from 31 may French report Bertrand Dautzenberg,
Professor of pneumology University Pierre et Maris Curie Paris, Piti-salptire hospital and OFT (Office franais de prvention du tabagisme). bdautz@gmail.com
Mai 2013
Rapport et avis dexperts sur
le-cigarette
Avec le soutien de la Direction gnrale de la sant
No conflicts of interest on the topic
ENSP e-cigarettes 2013
www.ofta-asso.fr/docatel/Rapport_e-cigarette_VF_1.pdf
E-cigarettes is in 2013 a very small part of the tobacco control problem in 2013. In 2016 we may anticipate a signifiant part
Tobacco control
Tobacco
e-cigarette
We have the certitude than tobacco smoke kill 700 000 EU citizens each year e_cigarette is much less toxic than regular cigarette but need precautions.
First patent 1965
Kon Lik 2006 Brevet 2006 de Hon Lik patent
Applicant(s): Classification: - international: - cooperative:
+ HON LIK [CN] +

HON LIK [CN] A24B15/16; A24D1/00; A24F47/00; A61K9/00; (IPC17): A24B15/16
A24F47/002; A61K9/007 WO2004CN00182 20040308 ; CN20031011582 20030429 EP1618803 (A4) EP1618803 (B1) US201227358 9 (A1) US2012090630 (A1) US2006196518 (A1) more
Application number: EP20040718242 20040308 Priority number(s):
Also published as:
The invention relates to a non-smokable electronic spray cigarette which only comprises nicotine without harmful tar. The cigarette includes a smoke mouth integer comprised with a shell, a cell, a high frequency ionizer, nicotine solution storage and its container, control circuit, a display screen, a human contact sensor, a piezoelectric supersound atomizer, a high temperature vaporization nozzle and attachments, an electro-thermal vaporization nozzle installed in the air suction end of the shell goes through an electric control pump or a valve with a measuring chamber and a liquid storage container which contains nicotine solution and is connected to the electric control pump or a valve with a one-way flow valve, the control circuit plate has four export ends individually connected with the high frequency ionizer, electric heater, pump or valve and the display screen,; a human resistence sensor and an air flow sensor are connected to the input end of the control circuit. The advantages of the present invention are smoking without tar, reducing the cancerogenic risk, the user still feel smoking and experiercing the excitement, the cigarette is no need to be lit and is no fire danger.
The market of e-cigarettes will be more important than the market of smoking cessation in 2013
US market of e-cigarettes millions $
1200 1000 800 600 400 510
1000
260
200
30
0 2008
60 2009
120
2010
2011
2012
2013*
According to 2012 eurobarometer, Greck population is more heavy user than other Eu citizen with 8% experimentation 1% occasionnal use 2% regular use
2013 data are expected soon
e-cigarette & e-liquide ?

Single use e-cigarette look like cigarettes, but where usually less attractive
cartridge
Mouth piece
atomizer

batterie
diode
New e-refilling e-cigarette dont look like cigarettes but are more attractives
Same chemical content

E.liquide
vapor
Different chemical content Tabacco

smoke
Formation of artificial fume

1
e.cigarette
2
e-liquide in cartridge.
Electric shock heath e-liquide produce vapor
3
4
Condensation of gaze in small liquid particules

Smoker inhale particules gaz and liquid
User air
inhalation. Half life of liquid particule is short (11 sec with PG)
Dissipation of gazes
Aerosol characteristic are not the same with vegetal glycerin and propylene glycol
180 000 Propylne glycol CMAD Immdiate 10 secondes 40 secondes Glycrine vgtale 20 000
CMAD
Immdiate 10 secondes 40 secondes
100 000
10 000
0 10 100 1000
0 10 100 1000
E cig 78
Vansickel AR, Cobb CO, Weaver MF, Eissenberg TE.A clinical laboratory model for evaluating the acute effects of electronic "cigarettes": nicotine delivery profile and cardiovascular and subjective effects. Cancer Epidemiol Biomarkers Prev. 2010 Aug;19(8):1945-53.
2010 5 <1ng/ml
cigarette Old (2009) e-cigarette dont delivered significant amont of nicotine
E-cigarette Hydro
E-cigarette NPRO
No nicotine
Product Electronic Cigarette

Nicotine Gum
NNN
3.87 2
NNK
1.46 ND
NAT
2.16 ND
NAB
0.69 ND
Total
8.18 2
No more NNK than in NRT medication
Nicotine Patch Swedish Snus

Canadian Mild Ultra Du Maurier Regular Export A Ultra Light King
ND
ND
ND
8 2400
445 308 794
540 523 848
552 448 752
NQ NQ 122
1537 1277 2516
Gitanes Kings
Benson & Hedges Ultra Mild Winston Newport Camel Skoal Marlboro
6369 522
2200 1100 3100 4500 4300
1477 733
580 830 1400 470 1800
2965 629
560 1900 2800 4100 4900
354 NQ
25 55 150 220 190
11165 1884
3365 3885 7450 9290 11190
http://smoke-vsvapor.webs.com/nitrosa minelevels.htm
12
Some chemical substances in cigarette smoke and e-cigarette aerosol

Composs 1,2-Propandiol 1-Hydroxy-2Propanone 2,3-Butandione 2,5-Dimethylfurane 2-Butanone (MEK) 2-Furaldhyde 2-Methylfurane 3-Ethenylpyridine Acide actique Actone Benzne Isoprne Limonne m,p-Xylne Phnol Pyrrole Tolune Formaldhyde b Actaldhyde b Propanal b N CAS 57-55-6 116-09-6 431-03-8 625-86-5 78-93-3 98-01-1 534-22-5 1121-55-7 64-19-7 67-64-1 71-43-2 78-79-5 5989-27-5 1330-20-7 108-95-2 109-97-7 108-88-3 50-00-0 75-07-0 123-38-6
e-cigarette e-cigarette e-cigarette background 1 2 3 cigarette <1 <1 <1 <1 112
<1 <1 <1 <1 <1 <1 <1 <1 <1 <1 8 <1 <1 <1 <1 <1 <1 <1 <0.2 <1 <1 <1 2 <1 <1 <1 11 17 <1 6 <1 <1 <1 <1 <1 8 2 <0.2 <1 <1 <1 2 <1 <1 <1 13 18 <1 7 <1 <1 <1 <1 <1 11 2 <0.2 <1 <1 <1 2 <1 <1 <1 14 25 <1 10 <1 <1 <1 <1 <1 16 3 <0.2 62 21 5 19 21 19 24 68 64 22 135 21 18 15 61 44 86 119 12
13
Cancerogen in e-liquide and in cigarette smoke

Substance Anthracne Phnanthrne 1-Mthyl phnanthrne Pyrne Benz(a) anthracne Chrysne Benzo(b) fluoranthne Benzo(k) fluoranthne Benzo(a) pyrne Benzo(e) pyrne Perylne Indeno(1,2,3-cd)pyrne Dibenz(ah) anthracne UK ecigarette 7 48 5 36 Under limit Under limit Under limit Under limit Under limit Under limit Under limit Under limit Under limit Groupe IARC UK cigarette cancrognes 130 350 30 130 45 50 30 9 35 16 4 12 4 3 3 3 3 2A 3 2B 2B 2A 3 3 2B 2A % (e.cig/20 cig) 0,27% 0,69% 0,83% 1,38% 0% 0% 0% 0% 0% 0% 0% 0% 0%
Benzo(ghi) prylne
Under limit
60
0%
14
tar
Cancer
tar
CO
cardio vascular risk COPD

Upper airway
CO
PM
PM
irritants
irritants
nicotine
addiction
nicotine
In 2013 Electronic cigarettes: effective nicotine delivery after acute administration.
5 11ng/ml
Vansickel AR, Eissenberg T. ENSP e-cigarettes 2013
Nicotine Tob Res. 2013 Jan;15(1):267-70 www.ofta-asso.fr/docatel/Rapport_e-cigarette_VF_1.pdf
New devices are good delivery system
nicotine ng/ml
20 15
10
5
0 2010 2010 2012 2013 pic cigarette
Cotinine in serum (ng/ml) in active and passive user of e-cigarette and cigarette
70 60 50 40 60,6 61,3
e.cigarette cigarette
30 20 10 0
Actif Passif 2,4 2,6
http://informahealthcare.com/doi/abs/10.3109/08958378.2012.758197 Flouris 2013

Effect on cigarette and e-cigarette on lung mesured by FEV(1)

decrease FEV1/VC
8% 7% 6% 5% 4% 3% 2% 1% 0% e-cigarette cigarette
7,20%
3% 2,30%
3,40%
Actif
Passif
http://informahealthcare.com/doi/abs/10.3109/08958378.2012.758197
19
Time to decrease desir to smoke
E-cig 0 mg
14 E-cig 16 mg
25
inhaleur
Cigarette
e-cigarette to go in and out nicotine dependence

Tabacco
e.cigarette
Persistance addiction
Nicotine dependance
?
Decrease of addiction
E.cigarette
E-cigarette : Product of initiation of Tobacco dependance
tobacco
Nicotine depedance
What we want to see in France

1- A product to help smokers to quit tobacco risk reduction : cigarettee-cigarette out of tobacco and nicotine
2- NOT a product for non smokers Risk of initiation to nicotine dependence Use to re-normalize-cigarette (non smoking place) Use as promotion as cigarette
22
Yes
Decrease of tobacco market (and use)
Official datas
-8%
extrapolation
1M e-cig
Sail of cigarettes
Sail of cigarettes
13,5M
12,5M ?
13,5 millions user
14/ 2012
14/ 2013
2012
2013
23
Yes
First page of a French new paper 31 may 2013
24
No
First page of a French new paper early 2013
Promotion of use e-cigarette every where including non smoking place
Some advertising is clearly for teenagers
No
26
No
Placement of e-cigarette in fim : Johnny Depp explain to Angelina Jollie how to use e-cigarette
http://www.wat.tv/embedframe/198477chuPP3r5586959
27
No A product to dont stop to smoke
28
Rapport et avis dexperts sur
le-cigarette
Avec le soutien de la Direction gnrale de la sant
Use by non smoke increase

Mai 2013
No
Non-fumeurs exprimentant l'e-cigarette

9,0% 8,0% 7,0% 6,0% 5,0% 4,0%
8,40%
3,0%
2,0% 3,2% 0,8% 1,1% 3,8%
6,0%
4,0%
1,0%
0,0%
1,4%
France PST France OFT France 12-14 ans Mdecine W PST12-19ans (2012) (2013)
USA Pearson Core jeunes Pologne 15- Pologne 15- USA Regan (2012) (2012) 19 ans filles 19 ans (2013) (2011) garons (2011) ENSP e-cigarettes 2013
29
To achieve the end tobacco, the first preventable cause of death, e-cigarette may play a positive and a negative role
+ How to facilitate access to e-cigarette to all smoker who dont plane to quit by usual way for cessation or reduction ?
- How to prevent :
Use by non smokers and adolescents tobacco industry lobbying and indirect promotion Renormalization of tobacco use
30

E-Cigarette ENSP Athen 2013 Press Conf PDF

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E-Cigarette ENSP Athen 2013 Press Conf PDF

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Авторское право:

Доступные форматы

E-cigarette : Lessons from 31 may French report Bertrand Dautzenberg,

Rapport et avis dexperts sur

No conflicts of interest on the topic

ENSP e-cigarettes 2013

ENSP e-cigarettes 2013

First patent 1965

ENSP e-cigarettes 2013

Kon Lik 2006 Brevet 2006 de Hon Lik patent

Applicant(s): Classification: - international: - cooperative:

+ HON LIK [CN] +

Application number: EP20040718242 20040308 Priority number(s):

Also published as:

ENSP e-cigarettes 2013

2013 data are expected soon

ENSP e-cigarettes 2013

e-cigarette & e-liquide ?

Same chemical content

Different chemical content Tabacco

ENSP e-cigarettes 2013

Formation of artificial fume

Electric shock heath e-liquide produce vapor

Condensation of gaze in small liquid particules

ENSP e-cigarettes 2013

Immdiate 10 secondes 40 secondes

Product Electronic Cigarette

No more NNK than in NRT medication

Nicotine Patch Swedish Snus

445 308 794

540 523 848

552 448 752

1537 1277 2516

ENSP e-cigarettes 2013

Some chemical substances in cigarette smoke and e-cigarette aerosol

ENSP e-cigarettes 2013

Cancerogen in e-liquide and in cigarette smoke

ENSP e-cigarettes 2013

cardio vascular risk COPD

In 2013 Electronic cigarettes: effective nicotine delivery after acute administration.

Vansickel AR, Eissenberg T. ENSP e-cigarettes 2013

Nicotine Tob Res. 2013 Jan;15(1):267-70 www.ofta-asso.fr/docatel/Rapport_e-cigarette_VF_1.pdf

New devices are good delivery system

ENSP e-cigarettes 2013

http://informahealthcare.com/doi/abs/10.3109/08958378.2012.758197 Flouris 2013

Effect on cigarette and e-cigarette on lung mesured by FEV(1)

Time to decrease desir to smoke

ENSP e-cigarettes 2013

e-cigarette to go in and out nicotine dependence

ENSP e-cigarettes 2013

What we want to see in France

Decrease of tobacco market (and use)

13,5 millions user

ENSP e-cigarettes 2013

First page of a French new paper 31 may 2013

ENSP e-cigarettes 2013

First page of a French new paper early 2013

Promotion of use e-cigarette every where including non smoking place

ENSP e-cigarettes 2013

Some advertising is clearly for teenagers

ENSP e-cigarettes 2013

ENSP e-cigarettes 2013

No A product to dont stop to smoke

ENSP e-cigarettes 2013

Rapport et avis dexperts sur

Use by non smoke increase