The Global Harmonised System (GHS) within the EU

The new classification and labelling system according to CLP regulation (EC) No 1272/2008
Hazard class Category Unstable Explosive Div 1.1 Pictogram Signal word Danger Danger Code H200 H201 Hazard statements Unstable Explosive Explosive; mass explosion hazard Explosive; severe projection hazard Explosive; fire, blast or projection hazard Fire or projection hazard May mass explode in fire P-Codes P201, P202, P281, P372, P373, P380, P401, P501 P210, P230, P240, P250, P280, P370+P380, P372, P373, P401, P501 P210, P230, P240, P250, P280, P370+P380, P372, P373, P401, P501 P210, P230, P240, P250, P280, P370+P380, P372, P373, P401, P501 P210, P240, P250, P280, P370+P380, P372, P373, P374, P401, P501 P210, P230, P240, P250, P280, P370+P380, P372, P373, P401, P501 Sensitisation, Skin Category 1 GHS07 Skin corrosion/ irritation Category 2 GHS07 P261, P272, P280, P302+P352, P333+P313, P321, P363, P501 Category 1A, B, C GHS05 Danger H314 Causes severe skin burns and eye damage Hazard class Category Pictogram Signal word Code Hazard statements P-Codes P260,P264, P280, P301+P330+ P331, P303+P361+P353, P363, P304+P340, P310, P321, P305+ P351+P338, P405, P501

Div 1.2 Explosives

Danger

H202

Div 1.3

GSH01

Danger

H203

Warning

H315

Causes skin irritation

P264, P280, P302+P352, P321, P332+P313, P362

Div 1.4

Warning

H204

Div 1.5 Div 1.6

No Pictogram No Pictogram

Danger

H205

Warning

H317

May cause an allergic skin reaction

Flammable gases

Category 1 GHS02 Category 2 No Pictogram

Danger

H220

Extremely flammable gas

P210, P377, P381, P403 Serious eye damage/ eye irritation

Category 1 GHS05

Danger

H318

Causes serious eye damage

P280, P305+P351+P338, P310

Warning Danger Warning Danger Danger

H221 H222 H223 H224 H225 H226 H228 H228

Flammable gas Extremely flammable aerosol Flammable aerosol Extremely flammable liquid and vapour Highly Flammable liquid and vapour Flammable liquid and vapour Flammable solid Flammable solid

P210, P377, P381, P403 P210, P211, P251, P410+P412 P210, P211, P251, P410+P412 P210,P233, P240, P241, P242, P243, P280, P303+ P361+P353, P370+P378, P403+P235, P501 P210, P240,P241, P280, P370+P378 P210, P220, P234, P280, P370+ P378, P370+ P380+P375, P403+P235, P411, P420, P501 P210, P220, P234, P280, P370+P378, P370+ P380+P375, P403+P235, P411, P420, P501 P210, P220, P234, P280, P370+P378, P403+P235, P411, P420, P501 P210, P220, P234, P280, P370+P378, P403+P235, P411, P420, P501 P210, P222, P280, P302+P334, P370+P378, P422 P235+P410, P280, P407, P413, P420

Flammable aerosols

Category 1 Category 2 Category 1

Category 2 GHS07 Category 1, 2

Warning

H319

Causes serious eye irritation

P264, P280, P305+P351+P338, P337+P313 P260, P271, P284, P304+P340, P310, P320, P403+P233, P405, P501 P261, P271, P304+P340, P311, P321, P403+P233, P405, P501

Danger

H330

Fatal if inhaled

Flammable liquids

Category 2 Category 3 GHS02

Warning Danger Warning

Category 3 Acute toxicity, inhalation Category 4 GHS07 GHS06

Danger

H331

Toxic if inhaled

Flammable solids

Category 1 Category 2

Warning

H332

Harmful if inhaled

Type A GSH01 Self-reactive substances and mixtures; and Organic peroxides

Danger

H240

Heating may cause an explosion

P261, P271, P304+P340, P312

Type B
GHS01 GHS02

Danger

H241

Heating may cause a fire or explosion

Sensitisation, respiratory

Category 1 GHS08

Danger

H334

May cause allergy or asthma symptoms or breathing difficulties if inhaled

P261, P285, P304+P341, P342+P311, P501

Type C, D,

Danger

H242

Heating may cause a fire Heating may cause a fire

Type E, F GHS02 Type G Pyrophoric liquids; Pyrorophoric solids Self-heating substances and mixtures Category 1 Category 1 Category 2 No Pictogram

Warning

H242

Specific target organ toxicity, single exposure; Respiratory tract irritation Specific target organ toxicity, single exposure; Narcotic effects Germ cell mutagenicity

Category 3

Warning

H335

May cause respiratory irritation

P261, P271, P304+P340, P312, P403+P233, P405, P501

Category 3

GHS07

Warning

H336

May cause drowsiness or dizziness May cause genetic defects Suspected of causing genetic defects May cause cancer Suspected of causing cancer May damage fertility or the unborn child Suspected of damaging fertility or the unborn child May cause harm to breast-fed children Causes damage to organs May cause damage to organs Causes damage to organs through prolonged or repeated exposure Causes damage to organs through prolonged or repeated exposure

Danger Danger Warning

H250 H251 H252

Catches fire spontaneously if exposed to air Self-heating; may catch fire Self-heating in large quantities; may catch fire In contact with water releases flammable gases which may ignite spontaneously In contact with water releases flammable gas In contact with water releases flammable gas May cause or intensify fire; oxidizer May cause fire or explosion; strong oxidiser May intensify fire; oxidizer May intensify fire; oxidizer Contains gas under pressure; may explode if heated Contains refrigerated gas; may cause cryogenic burns or injury

Category 1A, 1B Category 2 Category 1A, 1B

Danger Warning Danger Warning GHS08 Danger Warning

H340 H341 H350 H351 H360 H361

P201,P202, P281, P308+P313, P405, P501

Carcinogenicity

Category 2 Category 1A, 1B

P201, P202, P281, P308+P313, P405, P501

Substances And Mixtures Which, In Contact With Water, Emit Flammable Gases

Category 1 GHS02 Category 2 Category 3

Danger

H260

P223, P231+P232, P280, P335+ P334, P370+P378, P402+P404, P501 P231+P232, P280, P370+P378, P402+P404, P501 P220, P244, P370+P376, P403 P210, P220, P221, P280, P283, P306+P360, P371+P380+P375, P370+P378, P501 P210, P220, P221, P280, P370+P378, P501

Reproductive toxicity Reproductive toxicity, effects on or via lactation Specific target organ toxicity, single exposure

Category 2

P201, P202, P281, P308+P313, P405, P501

Danger Warning Danger

H261 H261 H270

Additional category

No Pictogram

H362

P201, P260, P263, P264, P270, P308+P313 P260, P264, P270, P307+P311, P321, P405, P501 P260, P264, P270, P309+P311, P405, P501 P260, P264, P270, P314, P501

Oxidising gases

Category 1

Category 1 Category 2

Danger Warning

H370 H371

Category 1 Oxidising liquids; Oxidising solids

Danger

H271

Category 2 Category 3 Compressed gas Liquefied gas Dissolved gas Refrigerated liquefied gas

GHS03

Danger Warning Warning

H272 H272 H280

Category 1 Specific target organ toxicity, repeated exposure Category 2 P410+P403 Hazardous to the aquatic environment, acute hazard Category 1 GHS08

Danger

H372

Warning

H373

P260, P314, P501

Gases under pressure

Warning GHS04

H281

P282, P336, P315, P403

Warning

H400

Very toxic to aquatic life P273, P391, P501 Very toxic to aquatic life with long lasting effects Toxic to aquatic life with long lasting effects Harmful to aquatic life with long lasting effects May cause long lasting harmful effects to aquatic life P273, P501

Category 1 Hazardous to the aquatic environment, long-term hazard Category 2 Category 3 Category 4 GHS09 No Pictogram No Pictogram

Warning

H410 H411 H412 H413

P273, P391, P501

Corrosive to Metals

Category 1 GHS05 Category 1, 2

Warning

H290

May be corrosive to metals

P234, P390, P404

Danger

H300

Fatal if swallowed

P264, P270, P301+P310, P321, P330, P405, P501 P264, P270, P301+P310, P321, P330, P405, P501

Category 3 Acute toxicity, oral GHS06

Danger

H301

Toxic if swalloed

Additional EU Hazard Class

Explosive when dry EUH001 EUH006 EUH014 EUH018 EUH019 EUH029 EUH031 EUH032 EUH044 EUH059 EUH066 EUH070 EUH071
Warning H302 Harmful if swallowed P264, P270, P301+P312, P330, P501

Category 4 GHS07

Explosive with or without contact with air Reacts violently with water In use may form flammable/explosive vapour-air mixture

Aspiration hazard

Category 1 GHS08 Category 1, 2

Danger

H304

May be fatal if swallowed and enters airways

May form explosive peroxides

P301+P310, P331, P405, P501

Contact with water liberates toxic gas Contact with acids liberates toxic gas Contact with acids liberates very toxic gas Risk of explosion if heated under confinement Hazardous to the ozone layer Repeated exposure may cause skin dryness or cracking Toxic by eye contact Corrosive to the respiratory tract

Danger

H310

Fatal in contact with skin Toxic in contact with skin

P262, P264, P270, P280, P302+P350, P310, P322, P361, P363, P405, P501 P280, P302+P352, P312, P322, P361, P363, P405, P501

Category 3 Acute toxicity, dermal Category 4 GHS07 GHS06

Danger

H311

Warning

H312

Harmful in contact with skin

P280,P302+P352, P312, P322, P363, P501

For more information, please visit the online Safety Center: sigma-aldrich.com/safety-center.html
NBO 30334_1 1060

The Global Harmonised System (GHS) within the EU

The new classification and labelling system according to CLP regulation (EC) No 1272/2008
H-CODES
Physical Hazards
H200 H201 H202 H203 H204 H205 H220 H221 H222 H223 H224 H225 H226 H228 H240 H241 H242 H250 H251 H252 H260 H261 H270 H271 H272 H280 H281 H290 Unstable Explosive Explosive; mass explosion hazard Explosive; severe projection hazard Explosive; fire, blast or projection hazard Fire or projection hazard May mass explode in fire Extremely flammable gas Flammable gas Extremely flammable aerosol Flammable aerosol Extremely flammable liquid and vapour Highly Flammable liquid and vapour Flammable liquid and vapour Flammable solid Heating may cause an explosion Heating may cause a fire or explosion Heating may cause a fire Catches fire spontaneously if exposed to air Self-heating; may catch fire Self-heating in large quantities; may catch fire In contact with water releases flammable gases which may ignite spontaneously In contact with water releases flammable gas May cause or intensify fire; oxidizer May cause fire or explosion; strong oxidiser May intensify fire; oxidizer Contains gas under pressure; may explode if heated Contains refrigerated gas; may cause cryogenic burns or injury May be corrosive to metals
GHS hazard notes codification system is discussed more in the UN Expert Committee; therefore, changes may be necessary.

P-CODES
General
P101 P102 P103 If medical advice is needed,have product container or label at hand. Keep out of reach of children. Read label before use P377 P378 P380 P381 P390 P391 P301 + P310 P301 + P312 P301 + P330 + P331 P302 + P334 P302 + P350 P302 + P352 P303 + P361 + P353 P304 + P312 P304 + P340 P304 + P341 P305 + P351 + P338 P306 + P360 P307 + P311 P308 + P313 P309 + P311 P332 + P313 P333 + P313 P335 + P334 P337 + P313 P342 + P311 P370 + P376 P370 + P378 P370 + P380 P370 + P380 + P375 P371 + P380 + P375 Leaking gas fire: Do not extinguish, unless leak can be stopped safely. Use for extinction. Evacuate area. Eliminate all ignition sources if safe to do so. Absorb spillage to prevent material damage. Collect spillage. Hazardous to the aquatic environment IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. IF ON SKIN: Immerse in cool water/wrap in wet bandages. IF ON SKIN: Gently wash with plenty of soap and water. IF ON SKIN: wash with plenty of soap and water. IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. IF exposed: call a POISON CENTER or doctor/physician. IF exposed or concerned: Get medical advice/attention. IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. IF SKIN irritation occurs: Get medical advice/attention. IF SKIN irritation or rash occurs: Get medical advice/attention. Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. IF eye irritation persists: Get medical advice/attention. IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. In case of fire: Stop leak if safe to do so. In case of fire: Use for extinction. In case of fire: Evacuate area. In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. In case of major fire and large quantities: evacuate area. Fight fire remotely due to the risk of explosion.

H361 H362 H370 H371 H372 H373

Suspected of damaging fertility or the unborn child May cause harm to breast-fed children Causes damage to organs May cause damage to organs Causes damage to organs through prolonged or repeated exposure May cause damage to organs through prolonged or repeated exposure

Prevention
P201 P202 P210 P211 P220 P221 P222 P223 P230 P231 P232 P233 P234 P235 P240 P241 P242 P243 P244 P250 P251 Obtain special instructions before use. Do not handle until all safety precautions have been read and understood. Keep away from heat/sparks/open flames/hot surfaces. No smoking. Do not spray on an open flame or other ignition source. Keep/Store away from clothing// combustible materials. Take any precaution to avoid mixing with combustibles/ Do not allow contact with air. Keep away from any possible contact with water, because of violent reaction and possible flash fire. Keep wetted with Handle under inert gas. Protect from moisture. Keep container tightly closed. Keep only in original container. Keep cool. Ground/bond container and receiving equipment. Use explosion-proof electrical/ventilating/lighting/ /equipment. Use only non-sparking tools. Take precautionary measures against static discharge. Keep reduction valves free from grease and oil. Do not subject to grinding/shock//friction. Pressurized container: Do not pierce or burn, even after use. Do not breathe dust/fume/gas/mist/vapours/spray. Avoid breathing dust/fume/gas/mist/vapours/spray. Do not get in eyes, on skin, or on clothing. Avoid contact during pregnancy/while nursing. Wash hands thoroughly after handling. Do not eat, drink or smoke when using this product. Use only outdoors or in a well-ventilated area. Contaminated work clothing should not be allowed out of the workplace. Avoid release to the environment. Wear protective gloves/protective clothing/eye protection/face protection. Use personal protective equipment as required. Wear cold insulating gloves/face shield/eye protection. Wear fire/flame resistant/retardant clothing. Wear respiratory protection. In case of inadequate ventilation wear respiratory protection. Handle under inert gas. Protect from moisture. Keep cool. Protect from sunlight.

Environmental Hazards
H400 H410 H411 H412 H413 Very toxic to aquatic life Very toxic to aquatic life with long lasting effects Toxic to aquatic life with long lasting effects Harmful to aquatic life with long lasting effects May cause long lasting harmful effects to aquatic life

Combination of H-Codes
H300 + H310 H300 + H330 H310 + H330 H300 + H310 + H330 H301 + H311 H311 + H331 H301 + H311 + H331 H302 + H312 H302 + H312 H312 + H332 H302 + H312 + H332 H315 + H320 Fatal if swallowed or in contact with skin Fatal if swallowed or if inhaled Fatal in contact with skin or if inhaled Fatal if swallowed, in contact with skin or if inhaled Toxic if swallowed or in contact with skin Toxic in contact with skin or if inhaled Toxic if swallowed, in contact with skin or if inhaled Harmful if swallowed or in contact with skin Harmful if swallowed or if inhaled Harmful in contact with skin or if inhaled Harmful if swallowed, in contact with skin or if inhaled Causes skin and eye irritation

Health Hazards
H300 H301 H302 H304 H310 H311 H312 H314 H315 H317 H318 H319 H330 H331 H332 H334 H335 H336 H340 H341 H350 H351 H360 Fatal if swallowed Toxic if swalloed Harmful if swallowed May be fatal if swallowed and enters airways Fatal in contact with skin Toxic in contact with skin Harmful in contact with skin Causes severe skin burns and eye damage Causes skin irritation May cause an allergic skin reaction Causes serious eye damage Causes serious eye irritation Fatal if inhaled Toxic if inhaled Harmful if inhaled May cause allergy or asthma symptoms or breathing difficulties if inhaled May cause respiratory irritation May cause drowsiness or dizziness May cause genetic defects Suspected of causing genetic defects May cause cancer Suspected of causing cancer May damage fertility or the unborn child

P260 P261 P262 P263 P264 P270 P271 P272 P273 P280 P281 P282 P283 P284 P285 P231 + P232 P235 + P410

Additional Hazard statements

EUH001 EUH006 EUH014 EUH018 EUH019 EUH029 EUH031 EUH032 EUH044 EUH059 EUH066 EUH070 EUH071 Explosive when dry Explosive with or without contact with air Reacts violently with water In use may form flammable/explosive vapour-air mixture May form explosive peroxides Contact with water liberates toxic gas Contact with acids liberates toxic gas Contact with acids liberates very toxic gas Risk of explosion if heated under confinement Hazardous to the ozone layer Repeated exposure may cause skin dryness or cracking Toxic by eye contact Corrosive to the respiratory tract

PICTOGRAMS

Response
P310 P311 P312 P313 P314 P315 P320 P321 P322
GHS01 GHS02 GHS03

Storage
P401 P402 P403 P404 P405 P406 P407 P410 P412 P413 P420 P422 P402 + P404 P403 + P233 P403 + P235 P410 + P403 P410 + P412 P411 + P235 Store... Store in a dry place. Store in a well-ventilated place. Store in a closed container. Store locked up. Store in corrosive resistant/ container with a resistant inner liner. Maintain air gap between stacks/pallets. Protect from sunlight. Do not expose to temperatures exceeding 50o C/ 122o F. Store bulk masses greater than kg/lbs at temperatures not exceeding oC/oF. Store away from other materials. Store contents under Store in a dry place. Store in a closed container. Store in a well-ventilated place. Keep container tightly closed. Store in a well-ventilated place. Keep cool. Protect from sunlight. Store in a well-ventilated place. Protect from sunlight. Do not expose to temperatures exceeding 50o C/122o F. Store at temperatures not exceeding oC/oF. Keep cool.

Immediately call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician. Call a POISON CENTER or doctor/physician if you feel unwell. Get medical advice/attention. Get medical advice/attention if you feel unwell. Get immediate medical advice/attention. Specific treatment is urgent (see on this label). Specific treatment (see on this label). Specific measures (see on this label). Rinse mouth. Do NOT induce vomiting. Immerse in cool water/wrap in wet bandages. Brush off loose particles from skin. Thaw frosted parts with lukewarm water. Do not rub affected area. Remove contact lenses, if present and easy to do. Continue rinsing. Remove victim to fresh air and keep at rest in a position comfortable for breathing. If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. If experiencing respiratory symptoms: Gently wash with plenty of soap and water. Rinse cautiously with water for several minutes. Wash with plenty of soap and water. Rinse skin with water/shower. Rinse immediately contaminated clothing and skin with plenty of water before removing clothes. Remove/Take off immediately all contaminated clothing. Take off contaminated clothing and wash before reuse. Wash contaminated clothing before reuse. In case of major fire and large quantities: Explosion risk in case of fire. DO NOT fight fire when fire reaches explosives. Fight fire with normal precautions from a reasonable distance. Stop leak if safe to do so.

Exploding Bomb

Flame

Flame over Circle

P330 P331 P334 P335 P336 P338 P340 P341 P342

GHS04

GHS05

GHS06

P350 P351 P352 P353 P360 P361 P362 P363 P371 P372 P373

Gas Cylinder

Corrosion

Skull and Crossbones

Disposal
P501 P502 Dispose of contents/container to.. Refer to manufacturer/supplier for information on recovery/recycling

GHS07

GHS08

GHS09

Exclamation Mark

Health Hazard

Environment

P374 P376

For more information, please visit the online Safety Center: sigma-aldrich.com/safety-center.html
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