Академический Документы
Профессиональный Документы
Культура Документы
Definition
Kecapean adalah perasaan keletihan, kecapean, atau kurangnya energi Kecapean berbeda dgn drowsiness ( keadaan mengantuk sapanjang hari ). Orang kecapean adalah orang yang kekurangan energi dan motivasi. Namun drowsiness & apathy ( perasaan tidak perduli dengan keadaan sekitar) dapat menjadi penyakit yang disebabkan kecapean. Kecapean itu sendiri dapat terjadi karena respon terhadap penggunaan fisik yang berlebih, stress emosional ( tekanan secara emosi ), kebosanan, kurang tidur. Kecapean ini sendiri dapat menjadi sangat bahaya bila sudah tidak dapat dibantu dengan tidur yang cukup, nutrisi yang baik, lingkungan yang baik, sehingga hal itu harus diperiksakan ke doktor. Apabila pada orang yang sudah cukup tidur namun masih merasa kecapean bila melakukan setiap aktifitas maka orang tersebut dikatakan hipotiroid. Sebaliknya bila ada orang yang dari sejak bangun tidur sudah merasakan kurang energi dan merasa kecapean sepanjang hari, orang tersebut kemungkinan depresi.
Penyebab utama:
allergi Anemia Depression Persistent pain Sleep disorders Hipotiroid or hipertiroid Meminum alkohol, kokain, narcotic secara teratur
Addison's disease Anorexia ( eating disorders ) Arthritis Autoimmune diseases seperti systemic lupus erythematosus
Cancer Congestive heart failure Diabetes Infection, terutama pada infeksi yang lama pengobatannya seperti bacterial endocarditis (infeksi dari otot jantung ) parasitic infections, AIDS, tuberculosis, and mononucleosis Kidney disease Liver disease Malnutrition
fatigue chronic syndrome sering merasa lelah dan tidak bisa melakukan setengah dari akrifitas normalnya.
Severe fatigue that comes on suddenly, especially after you've had the flu Low grade fever (100.4 F) and chills Sore throat and swollen lymph glands in the neck or armpits Muscle and joint aches, without any swelling Headaches Sleep that doesn't feel refreshing Feeling like you are in a fog and are unable to concentrate or remember Mood changes
Penyebabnya itu tidak diketahui, tapi kemungkinan adalah virus atau reaksi dari sistem imun. Faktor resikonya termasuk stress, pernah mengalami flu sebelumnya ( biasanya flu tidak akan sepenuhnya pergi ) kebiasaan makan yang buruk. Depresi mempengaruhi lama dan intensitas dari kelelahan dan ketidakmampuan
Treatment
Berupa antidepressant dan anti anxiety untuk psikologikal support. Untuk rasa sakitnya dapat diobati dengan anti inflammatory dan obat sakit untuk otot dan sakit pada joint.
Definition Fatigue adalah ketidakmampuan kembali fisik atau mental untuk melakukan aktifitas lagi. Bias di karenakan stress, pengobatan, medication, overwork, atau gangguan mental dan gangguan fisik Description Setiap orang yang mengalami fatigue pasti akan ada panggilan dari dalam tubuhnya untuk beristirahat atau tidur Secara fisik fatigue di karakteristikan dengan kekurangannya energi, merasa kelelahan otot, dan mulai menurunnya gerakan atau reflex dari reaksi central nervous system. Physically, fatigue is characterized by a profound lack of energy, feelings of muscle weakness, and slowed movements or central nervous system reactions. Fatigue can also trigger serious mental exhaustion. Persistent fatigue can cause a lack of mental clarity (or feeling of mental "fuzziness"), difficulty concentrating, and in some cases, memory loss. The term fatigue has been used in so many different senses that its applications have become almost chaotic. A reasonable distinction is the common division into muscular fatigue and general fatigue.
Muscular fatigue
External symptoms
Figure 11.1 illustrates the external signs of muscular fatigue as they appear in an experiment with an isolated muscle from a frog. The muscle is stimulated electrically, causing it to contract and perform physical work by lifting a weight. After several seconds it is seen that: the height of lift decreases both contraction and relaxation become slower the latency (interval between stimulation and beginning of the contraction) becomes longer.
Essentially the same result can be obtained using mammalian muscle. The performance of the muscle falls off with increasing strain until the stimulus no longer produces a response.
Page 192
Figure 11.1 Physical manifestations of fatigue in an isolated muscle from a frogs leg. (I) Contraction and relaxation of a fresh muscle. (II) The same, after moderate stress. (III) The same after heavy stress. (IV) The same after most severe stress.
A sensation of weariness
A major fatigue symptom is a general sensation of weariness. We feel ourselves inhibited and our activities are impaired, if not actually crippled. We have no desire for either physical or mental effort; we feel heavy, drowsy, tired. A feeling of weariness is not unpleasant if we are able to rest but it is distressing if we cannot allow ourselves to relax. It has long been realised, as a matter of simple observation, that weariness, like thirst, hunger and similar sensations, is one of natures protective devices. Weariness discourages us from overstraining ourselves and allows time for recuperative processes to take place.
5 Chronic fatigue: an accumulation of long-term effects. 6 Circadian fatigue: part of the day-night rhythm and initiating a period of sleep.
Functional states
At any moment the human organism is in one particular functional state, somewhere between the extremes of sleep on the one hand and a state of alarm on the other. Within this range there are a number of states, as shown in the following summary: Deep sleep Light sleep, drowsy Weary, hardly awake Relaxed, resting Fresh, alert Very alert, stimulated In state of alarm Seen in this context, fatigue is a functional state which in one direction grades into sleep, and in the opposite direction grades into a relaxed, restful condition.
Figure 11.6 Theoretical diagram of the combined effect of everyday causes of fatigue and the recuperation necessary to offset them. The total stresses must be balanced by the total recuperation within the 24-h cycle. Strain and recuperation must balance over the 24-hour cycle so that neither is carried over to the next day. If rest is unavoidably postponed until the following evening, this can be done only at the expense of well-being and efficiency.
Symptoms of fatigue
Fatigue symptoms are both subjective and objective, the most important being: 1 Subjective feelings of weariness, somnolence, faintness and distaste for work. 2 Sluggish thinking. 3 Reduced alertness. 4 Poor and slow perception. 5 Unwillingness to work. 6 Decline in both physical and mental performance.
External symptoms
Figure 11.1 illustrates the external signs of muscular fatigue as they appear in an experiment with an isolated muscle from a frog. The muscle is stimulated electrically, causing it to contract and perform physical work by lifting a weight. After several seconds it is seen that: the height of lift decreases both contraction and relaxation become slower the latency (interval between stimulation and beginning of the contraction) becomes longer. Essentially the same result can be obtained using mammalian muscle. The performance of the muscle falls off with increasing strain until the stimulus no longer produces a response.
Page 192
Figure 11.1 Physical manifestations of fatigue in an isolated muscle from a frogs leg. (I) Contraction and relaxation of a fresh muscle. (II) The same, after moderate stress. (III) The same after heavy stress. (IV) The same after most severe stress. Human beings show this process, whether the nerve or muscle is stimulated electrically or the research subject makes voluntary and rhythmical contractions of a muscle over a period. This phenomenon of reduced performance of a muscle after stress is called muscular fatigue in physiology and is characterised not only by reduced power but also by slower movement. Herein lies the explanation of the impaired coordination and increased liability to errors and accidents that accompany muscular fatigue.
Biochemical changes
We know that during muscular contraction chemical processes occur which, among other things, provide the energy necessary for mechanical effort. After contraction, while the muscle is relaxed and resting, the energy reserves are replenished. Both energy-releasing breakdown and energy-restoring synthesis are going on in a working muscle. If the demand for energy exceeds the powers of regeneration, the metabolic balance is upset, resulting in a loss of muscular performance capability. After a muscle has been heavily stressed, its energy reserves (sugar and phosphorus compounds) are depleted while waste products multiply; the most important of these are lactic acid and carbon dioxide. The muscular tissue becomes more acidic.
Electrophysiological phenomena
There are statements in the literature to the fact that even after a muscle has been exhausted by repeated voluntary contractions it still responds to an electrical stimulus applied to the skin, suggesting that this form of fatigue is a phenomenon of the central nervous system (the brain). This interpretation cannot, however, be confirmed in every case. Many physiologists have made the opposing observation: when the muscle itself is in an exhausted state it does not contract
page_192
page_193
any more, even though further motor nerve impulses sent by the brain are visible on the electromyogram. It seems that fatigue has now become a peripheral phenomenon, affecting the muscle fibres, as Scherrer (1967) suggested. We must presume that one group of researchers were looking for the first sign of fatigue, whereas the others were studying muscles that were already in a state of exhaustion.
Figure 11.2 Three sections from the electromyogram of the extensor muscle of the upper arm after it has been fatigued by a long series of contractions of equal strength. From top down, the EMG after 2, 4 and 16 min work. After Scherrer (1967).
page_193
Page 4 -
page_194
If we now turn to a state of exhaustion, which is certainly located in the muscles themselves, we find that this is accompanied by a reduction in muscular strength. Initially this can be partly compensated for by increasing discharges of the motor neurones.
A sensation of weariness
A major fatigue symptom is a general sensation of weariness. We feel ourselves inhibited and our activities are impaired, if not actually crippled. We have no desire for either physical or mental effort; we feel heavy, drowsy, tired. A feeling of weariness is not unpleasant if we are able to rest but it is distressing if we cannot allow ourselves to relax. It has long been realised, as a matter of simple observation, that weariness, like thirst, hunger and similar sensations, is one of natures protective devices. Weariness discourages us from overstraining ourselves and allows time for recuperative processes to take place.
5 Chronic fatigue: an accumulation of long-term effects. 6 Circadian fatigue: part of the day-night rhythm and initiating a period of sleep. This classification of types of fatigue is based partly on the cause and partly on the way in which the fatigue manifests itself, with the obvious corollary that the two should be linked as cause and effect. This should be particularly true for the different sensations of
fatigue, which vary according to source. Grandjean believed, however, that certain regulatory processes in the brain are common to fatigue of all kinds and considered these in more detail, as follows.
Functional states
At any moment the human organism is in one particular functional state, somewhere between the extremes of sleep on the one hand
Page 195 and a state of alarm on the other. Within this range there are a number of states, as shown in the following summary: Deep sleep Light sleep, drowsy Weary, hardly awake Relaxed, resting Fresh, alert Very alert, stimulated In state of alarm Seen in this context, fatigue is a functional state which in one direction grades into sleep, and in the opposite direction grades into a relaxed, restful condition.
The electroencephalogram
Before we discuss the neurophysiological basis of this functional state it would be sensible to take a look at the most important method by which fatigue can be studied: the electroencephalogram (EEG), which records the electrical activity of the brain. When studying human subjects the electrodes are usually applied to the skin of the head, where they detect and register the waves of electrical potential in the cerebral cortex. The resulting EEG makes it possible to study the varying amplitudes and frequencies of these waves. In greatly simplified form, the most important features recorded in an electroencephalogram are as follows:
The alpha rhythms comprise waves in the frequency band 812 Hz. Alpha waves are present during waking hours and are blocked by sensory impulses, so that a high 1 alpha wave component indicates a relaxed condition and a reduced readiness to react to stimuli. A lower alpha component, coupled with a higher beta component, indicates a more alert state. The theta rhythms (47 Hz) are slow, long-period waves, which replace the alpha waves when we go to sleep. Sleep is characterised by a whole series of other 2 phenomena, which have been discussed by Horne (1988) and with respect to shiftwork by Kroemer et al. (1994). 3 The delta rhythms are also slow waves, of less than 4 Hz, which are present only during sleep.
Desynchronisation, producing beta rhythms of 1430 Hz, is an irregular electrical activity of very low amplitude. It occurs after the receipt of a sensory stimulus and is the expression of an interruption of the synchronised activities of neurones which 4 make up the alpha rhythm. Desynchronisation is the sign of a state of increased alertness and it is also known as an arousal reaction. It may be mentioned here that adrenalin (a stimulant derived from the adrenal medulla), which is released into the
page_195
page_196
Figure 11.3 Five sections from electroencephalograms, characteristic of various functional states. The vertical lines indicate the scale for 1 V. After Jasper (1974). blood as a reaction to stress, acts by inducing desynchronisation. Evoked potentials are single fluctuations of potential which are induced by isolated sensory stimuli. They are located in that area of the cerebral cortex where the 5 ascending nerve tract from that particular sense organ terminates (this has made it possible to plot a map of the cortex showing which area serves which sense organ). Figure 11.3 shows five extracts from electroencephalograms, each characteristic of a different functional state of the body. What has been said up to now gives the impression that for every functional state that we can describe by terms such as weary or lively there should be a distinctive pattern on the EMG. Unfortunately, this is not the case. The patterns shown in Figure 11.3 indicate no more than a very rough correspondence between the encephalogram trace and the underlying physiological state.
page_196
page_197
awareness is localised, including the powers of perception, subjective feeling, reflection and willpower. Increasing the sensitivity of the cortex will therefore bring all the conscious functions to a higher level of alertness. Thus it appears that the reticular formation controls the degree of alertness, including attention, and readiness for action. Its level of activity is very low during deep sleep, increases when sleep becomes shallow and rises steeply on awakening. The higher the level of reticular activity, the higher the level of alertness, culminating in a state of alarm. These reticular structures, which control the sensitivity of the conscious functions, are called the ascending reticular activating system, whereas those structures that increase the readiness of the skeletal musculature are the descending activating system. In what follows we shall be concerned solely with the arousal activating system. The activating structures of the reticular formation do not, however, act on their own initiative. They must be activated by afferent nerve stimuli, which come mainly from two sources, the conscious sphere of the cerebral cortex and the sense organs. What significance do these two have?
Feedback control
Nervous tracts coming from the cerebral cortex carry impulses from the conscious sphere into the reticular activating system. Such impulses arise, for example, when an idea, or something noticed outside, seems ominous and calls for increased alertness. A closed circuit is then set up; the reticular activating system arouses the cerebral cortex and alerts conscious perception. If this results in any significant signals being received, these stimuli send impulses back along the nerve tracts from the cortex to the reticular activating system. The result is a feedback system, analogous to that in many electronic devices.
external world.
page_197
page_198
Figure 11.4 The activating and inhibitory systems in the brain. Dotted area=reticular formation; 1=ascending reticular activating system; 2=descending activating system; 3=pathways from the cerebral cortex; 4=incoming sensory pathways; 5=inhibitory (damping) system; 6 and 7=links with vegetative (autonomic) centres; 8=vegetative tracks leading to the autonomic nervous system of the internal organs. For example, suppose that a loud noise is heard. Any sudden noise stimulates the reticular activating system by way of the afferent sensory stream and thereby increases the alertness of the cerebral cortex. There the noise is perceived and interpreted, perhaps resulting in precautionary action against possible danger. In this case the reticular activating system is operating as a distributor and amplifier of signals from the outside world and makes sure that the organism is alerted as much as is necessary for the preservation of its life. Figure 11.4 shows diagrammatically the flow of stimuli from the cortex and the sense organs to the reticular activating system, as well as the presumed pathways in the cortex itself.
page_198
page_199
centres for circadian rhythm (day-night periodicity), fear, rage and calmness, as well as on motivation. Since the limbic system is involved in the generation of emotional states and the buildup of motivation, it seems obvious that the activity level of the cerebral cortex, and through it of the entire organism, will be influenced by what goes on in the limbic system. Links between the flow of afferent sensory impulses and the reticular activating system lead to the further assumption that the two systems have a reciprocal effect on each other.
Inhibiting systems
These two activating systems are not alone. There are other structures which clearly work in opposition to them. In fact many physiologists have conducted experiments showing the existence of nervous elements both in the inter-brain and in the medulla which have an inhibitory or damping effect on the cerebral cortex. These inhibiting pathways are shown in Figure 11.4. It is generally accepted that such inhibiting structures can finally induce sleep but there is certainly no proof yet that they are related to states of fatigue.
increase in heart rate rise in blood pressure more sugar released by the liver increased metabolism.
Ergotropic setting
This increased sensitivity spreads from the activating system to all parts of the body brain, limbs and internal organsuntil the entire organism is braced up for a period of high-energy consumption, whether this is for work, for fighting, for flight or whatever. Hess (1948) coined the term ergotropic setting for this process.
Trophotropic setting
By an analogous process, increased activity of the inhibitory system lowers the heart rate and blood pressure, cuts back respiration and metabolism, and relaxes the muscles, while the digestive system works more vigorously to assimilate more energy. Hess term trophotropic setting means that this process accelerates the recuperative functions by assimilating more food and replacing lost energy.
page_199
page_200
Thus we see that the nervous structures in the inter-brain and brain stem (medulla) play a key role in the regulation and coordination of functional states of the body. The brain as well as the internal organs are directed in a logical manner by these nerve centres, as an example will show A fire alarm sounds in a factory. The acoustic signal raises the level of activity of the reticular formation in all the persons within the danger zone. It also activates the cerebral cortex to a greater awareness of its surroundings, while alerting the internal organs to be ready for a greater consumption of energy and physical performance.
Humoral control
Humoral control means regulation by means of chemical substances which circulate in
the body fluids. We have seen that the reticular activating system is not autonomous but is dependent upon stimulation from the cerebral cortex as well as from afferent sensory signals. In addition to these purely nervous mechanisms there are also the humoral effects which have a part to play in tuning-up the activating system as well as regulating the sensitivity of the limbic system.
Adrenalin
We have already mentioned desynchronisation, the effect produced by the performance hormones adrenalin and noradrenalin which raise and lower the degree of alertness and activation level of the body. Bonvallet and co-workers (1954) postulated that every time the activation level is raised by stimuli from outside the body there is a release of adrenalin, which in turn stimulates activity of the reticular formation. The increased activity triggered by outside stimuli would soon fade away if this hormone did not intervene to maintain it. In this theory, the reticular activating system is responsible for short-term reactions, while effects of longer duration depend upon the action of adrenalin. We can say, therefore, that the level of activity of the reticular activating system depends upon: 1 2 3 The inflow of sensory stimuli. Stimulation of the cerebral cortex. Level of adrenalin.
Adrenalin and noradrenalin are also considered stress hormones since their secretion into the blood is greatly increased in stress situations. This will be discussed in Chapter 12. Our concept can be summarised in different terms, as follows. The level of readiness to act lies somewhere between the two extremes of sleep and the highest state of alarm. Control mechanisms in the medulla and the inter-brain regulate the
page_200
page_201
Figure 11.5 A theoretical model to illustrate the neurophysiological mechanism which regulates the functional state of the organism. The level of activation of the cerebral cortex, the degree of readiness for action and the level of alertness all increase from left to right. readiness level and adjust it to meet the momentary demands of the organism. If external influences are dominant, then the activating systems prevail; the person feels keyed up, even in a state of alarm, and is ready for action both physically and mentally. If, however, inhibiting influences from inside the body predominate, then the damping system prevails; the person feels sluggish, drowsy and lethargic. Figure 11.5 compares the neurophysiological model with a balance scale in which the activating system is regulating the general functional state of the central nervous system.
page_201
page_202
Page 202
Figure 11.6 Theoretical diagram of the combined effect of everyday causes of fatigue and the recuperation necessary to offset them. The total stresses must be balanced by the total recuperation within the 24-h cycle. Strain and recuperation must balance over the 24-hour cycle so that neither is carried over to the next day. If rest is unavoidably postponed until the following evening, this can be done only at the expense of well-being and efficiency.
Symptoms of fatigue
Fatigue symptoms are both subjective and objective, the most important being: 1 Subjective feelings of weariness, somnolence, faintness and distaste for work. 2 Sluggish thinking. 3 Reduced alertness. 4 Poor and slow perception. 5 Unwillingness to work. 6 Decline in both physical and mental performance.
Some of the fatigue states arising from industrial practice are of a chronic nature. These are conditions that are brought about not by a single instance of overstrain but by stresses which recur over
page_202
page_203
days or even longer periods. Since conditions such as these are usually also accompanied by signs of ill health, this may correctly be called clinical or chronic fatigue. Under these conditions the symptoms occur not only during the period of stress or immediately afterwards but are latent almost all the time. The feeling of tiredness is often present on waking up in the morning, before work has begun. This form of fatigue is often accompanied by feelings of distaste for work, which have an emotional origin. People so fatigued often show the following symptoms: 1 Increased psychic instability (quarrelsomeness and associated behaviour). 2 Fits of depression (baseless worries). 3 General weakening of drive and unwillingness to work. 4 Increased likelihood of illness. These ailments are mostly vague and come under the heading of psychosomatic disorders. This term is applied to functional disturbances of the internal organs or the circulation which are judged to be external manifestations of psychological conflicts and difficulties. Some of the more common symptoms are: headaches giddiness loss of sleep irregular heart beat
sudden sweating fits loss of appetite digestive troubles (stomach pains, diarrhoea, constipation). More ailments mean more absences from work, especially short absences, indicating that the cause of the absenteeism is the need for more rest. People who have psychological problems and difficulties easily fall into a state of chronic fatigue and it is often difficult to disentangle their mental from their physical problems. In practice, cause and effect are hard to distinguish in cases of clinical fatigue. The cause may be dislike of the occupation, the immediate task or the workplace, or conversely these may be the cause of maladjustment to work or surroundings.
Page 204 The question asked by industry is often simply whether the working conditions make excessive demands on the operatives or whether the stresses involved are physiologically acceptable.
Methods of measurement
Currently used methods fall into six groups: 1 2 3 4 5 6 Quality and quantity of work performed. Recording of subjective perceptions of fatigue. Electroencephalography (EEG). Measuring frequency of flicker-fusion of eyes. Psychomotor tests. Mental tests.
Measurements such as these are frequently taken before, during and after the task is performed, and the extent of fatigue is deduced from these. As a rule the result has only relative significance since it gives a value to be compared with that of a fresh subject or at least with that of a control person who is not under stress. Even today we have no way of measuring fatigue in absolute terms.