Академический Документы
Профессиональный Документы
Культура Документы
Introduction
Cerebral Palsy is a non-progressive disorder caused by damage to the motor control centers of the develo-
1 1, 2
ping brain . The incidence of Cerebral Palsy varies between 2.12 to 2.45 per 1000 live births . In more than
3
75%, the brain damage happened during pregnancy. At the moment there is no cure for Cerebral Palsy .
Treatment with Autologous Stem Cells seems to be a promising therapy to improve the condition of the Ce-
4
rebral Palsy patient .
Methods
30 patients with Cerebral Palsy were treated with Autologous stem cells by the XCell-Center. Injection of the
Stem Cells was performed by Lumbar Puncture. 200 ml of Bone Marrow was extracted out of the Iliaca crest
and was concentrated for transplantation using gradient centrifugation (mean number of given cells was
6.000.000). After treatment the patients were evaluated using a post treatment survey. The results of 30 trea-
ted patients are presented in this poster.
+
distribution was nearly equal. Nearly 70% 9
70%
50%
30%
0%
s
g
d
er
er
er
llin
an
ng
ng
ng
pi
/h
/fi
/fi
/fi
ts
m
nd
nd
ou
ar
ha
ha
ha
ith
ity
w
tic
ills
tio
us
sk
as
cu
na
r
or
Sp
tte
ld
ot
di
Be
ss
Ho
or
M
Le
co
e
Fin
r
tte
90%
60%
40%
No
the number of transplanted stem cells.
20%
10% Yes
42,9 % 42,9 % 62,4 % 33,1 % 19,0 %
0%
et
et
g
et
Conclusions
in
kin
/fe
/fe
/fe
nd
al
gs
gs
gs
sta
w
le
le
le
r
tte
r
e
n
ity
tte
tio
us
Be
tic
Be
na
r
tte
as
di
Sp
Be
or
ss
co
Le
References
Total 21 100%
1. Pharoah PO. Epidemiology of cerebral palsy: a review. Journal of the Royal Society of Medicine. Jul 1981;74(7):516-520.
2. Westbom L, Hagglund G, Nordmark E. Cerebral palsy in a total population of 4-11 year olds in southern Sweden. Prevalence and distribution according
to different CP classification systems. BMC pediatrics. 2007;7:41.
3. O'Shea TM. Diagnosis, treatment, and prevention of cerebral palsy. Clinical obstetrics and gynecology. Dec 2008;51(4):816-828.
4. Goldman SA, Schanz S, Windrem MS. Stem cell-based strategies for treating pediatric disorders of myelin. Human molecular genetics. Apr 15
2008;17(R1):R76-83.