Mannatech

A Company of Destiny

Since the beginning of recorded time, history has validated the importance of the amazing aloe vera plant.
340 B.C. 1983

History of Glyconutritionals
Mannatech's Discovery of Glyconutrients has Helped Pioneer the Exciting New Field of Nutritional Glycobiology.
1994 1992

Alexander the Great carries aloe vera plants with him for soldiers wounded in war.

Dr. Bill McAnalley discovers first biologically active polysaccharide from aloe vera gel (Manapol and acemannan). More than 150 patents are granted to companies and scientists worldwide on the stabilization and uses of this discovery.
1990 1984
BioTechnology magazine publishes article Capitalizing on Carbohydrates. Carbohydrates are identified as essential for immune function. Multinational chemical and pharmaceutical concerns identify carbohydrates as forming the next wave of drug development.

Acemannan is approved by the USDA for use as a vaccine adjuvant in chickens and licensed to Solvay Animal Health, Inc., the worlds largest manufacturer of veterinary vaccines.

Mannatech negotiates exclusive distribution rights to Manapol and launches company with nutrition industrys first stabilized aloe vera gel dietary supplement.
1996

Like valleys they spread out, like gardens beside a river, like aloes planted by the Lord, like cedars beside the waters. Numbers 24:6
2002

1998

1906

Erythropoietin (a glycoprotein hormone that controls the formation of red blood cells) is discovered.

Hydrogel with polysaccharides from aloe vera gel (Carrisyn Hydrogel Wound Dressing) goes on the market.

Harpers Biochemistry lists the eight sugars found in glycoproteins.

Study by Berger, et al., in Metabolism showed that galactose and mannose were directly incorporated into human glycoproteins without first being converted into glucose. Authors concluded that specific dietary sugars could represent a new class of nutrients.

(July) Scientific American article, Sweet Medicine, reports on pharmas big new strategy for making better drugs from sugars.

2012

2002

(October) New Scientist magazine article, Sugar Rush, emphasizes glycobiology as the basis of understanding immunology, neurology and developmental biology.

National Academy of Sciences publish Transforming Glycoscience, a roadmap for the integration of glycoscience as a significant part of higher-education curriculae within the next decade.

1953

2200 B.C.

Aloe, considered a divine plant in Nippur (Mesopotamia), is used for intestinal health.

Atomic Energy Commission 1988 scientists (Lushbaugh and The term "glycobiology" Hale) demonstrate for the appears in the Oxford English Dictionary to first time the ability of 1990 the merging Journal of Glycobiology topical fresh aloe vera gel recognize of the disciplines of launched by Oxford to protect carbohydrate chemistry University Press. and biochemistry. animal's skin. Glycobiology is the

1993

Injectable acemannan rejected by the FDA as a drug for humans (no LD50). Dr. Bill McAnalley, A Story of Discovery (2010).

1995

Nature magazine article states cell surface sugars are necessary for recognition and immune function.

19982002

1995

1991

study of the structure, biosynthesis and biology of saccharides (sugar chains, or glycans) that are widely distributed in nature.

Injectable polysaccharide from aloe vera gel (Acemannan Immunostimulant) is approved by the USDA for use in cats and dogs.

Dr. McAnalley joins Mannatech with focus on new field of carbohydrate technologies.
Mannatech files patents on the worlds first composition of glyconutrients and introduces Ambrotose complex.

As dietary sugars Ambrotose product approved claims expand to include begin to gain memory, cognition acceptance as a new improved and visual discrimination as well class of nutrients, as positive prebiotic effects.* Mannatech is issued 2001 more than 50 Scripps Institute patents worldwide awarded $34 million from NIH to for Ambrotose study glycobiology. technology.

20022010

2011

1996

The United States of America

Definitive proof! Dr. Azita Alavi and colleagues publish study in the European Journal of Clinical Nutrition showing for the first time that the oral intake of Ambrotose powder can have a significant impact on the glycosylation status of serum glycoproteins with no adverse effects.

Timeline

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Timeline

The Gift of Provision

The Story Behind Mannatech

A Desire to Make a Difference
In 1994, Mannatech founder Sam Caster had one profound desire: to create a business that would make a real difference in the world. This visionary new company began to quietly assemble a team of top scientists. Their goal was to develop advanced, foodbased nutritional technologies that could best address the growing effects of poor nutrition in the world, and its impact on our health, our weight and the worlds most vulnerable children.

Real Food Technology Solutions

Mannatechs current CEO and Chief Science Officer, Robert Sinnott, MNS, PhD, extended Mannatechs proprietary product base through the formulation of PhytoMatrix caplets, the industrys first vitamin and mineral product produced from natural and plant-sourced ingredients at standardized, nutritionally effective levels. This approach quickly led to the development of many new, unique products based on Real Food Technology solutions. In 2012, Dr. Sinnott blended Mannatechs proprietary glyconutrient complex, its proprietary antioxidant composition and its proprietary real-food vitamin/mineral formulation into a whole-food base. This new product was named NutriVerus powder, and it became a complete Real Food Technology solution for global health.

Amazing, Disruptive Discoveries

In 1996, Mannatechs first Chief Science Officer, Bill McAnalley, PhD, made the discovery of a whole new category of plant-based nutrients called glyconutrients. Mannatech formulated the worlds first glyconutrient product, called Ambrotose complex. Though this pioneering discovery was at first questioned, even ridiculed, by the traditional scientific community, technology supporting it has since received more than 50 worldwide patents, and its now revered as sciences next frontier. Ambrotose complex, formulated with the Manapol aloe vera extract, became Mannatechs foundational Real Food Technology solution for proper cell-to-cell communication and immune system support.

A World-Changing Approach
As of early 2013, Mannatech operates in 23 countries around the world. The company adopted the dynamic business model of social entrepreneurship to link its international product sales directly to the needs of the worlds most at-risk children. Through its Give for RealSM program, Mannatech empowers caring individuals all around the world to join the fight against childhood malnutrition by simply choosing to nourish themselves with advanced nutrition sourced from real foods. At the same time, Mannatech offers an unprecedented, purpose-driven business opportunity for those who choose to champion this cause.
Enjoy the full story behind the beginning of Mannatech in this video,

Destiny Unfolding.
http://bit.ly/11aYMAR

The Story

The Story

Our Mission and Vision

Our mission is to fight global malnutrition by nourishing the world with Real Food Technology supplementation while empowering and rewarding the lives of those who champion our cause. Our vision is to impact the global epidemic of childhood malnutrition by linking five million consumers of Real Food Technology supplementation with five million children in need.

Three to five million children under the age of five die every year from the devastating effects of malnutrition.1 That means every six seconds a child dies from malnutrition. Thats 14,000 a day. The facts are heartbreaking. Staggering. But not unbeatable, thanks to people like you.
1

"Progress for Children: A Report Card on Nutrition" UNICEF, May 2006

Find out how you can join in the fight against global malnutrition. Visit GiveForReal.com today.

Mission and Vision

Science Department

Pioneers of Real Food Technology Solutions

Everything man needs to sustain good health is provided by God in nature. The job of science is to find it.
Paracelsus 14931541

Mannatech accepted the challenge!

Robert A. Sinnott, MNS, PhD
CEO and Chief Science Officer

Oversees the overall development and R&D management of Mannatechs Real Food Technology products Earned Bachelors Degree in Biological Sciences, a Master of Natural Sciences Degree and a PhD from 19871995, all from Arizona State University Focused on plant medicinal chemistry and plant biotechnology in graduate training Instrumental in establishing the science branch of a nonprofit educational institution for training economically disadvantaged students in science-based careers Joined Mannatech in 2005 Instrumental in the creation of Mannatechs Real Food Technology approach

Thanks to its dedication to food-based research and development, Mannatech has become a leader in the Real Food Revolution.

Mannatech has invested tens of millions of dollars in the research, Working from Mannatechs in-house laboratories, the companys The companys Research Group collaborates
with major universities and research firms around the world to conduct clinical trials and studies on our products and ingredients. development and validation of Real Food Technology solutions.

scientists and product development specialists actively explore new technologies for sourcing and formulating real-food solutions for consumer health and nutrition.

Visit MannatechScience.org for full details.

Science

Science

Glycoscience Validation
Patents
We hold more than 50 patents in 30 countries for the technology relating to our Ambrotose complex glyconutrient formulation. And our patent positions have been repeatedly reaffirmed in court, most recently in July 2010, when Mannatech won judgments against seven companies found to be manufacturing and marketing products that infringed on our patented glyconutrient technology.

The World's View Self-Evidence

Dr. John Rollins, a former award-winning U.S. Trademark and Patent Office official, upon his introduction to glyconutrients, said, "In the past 23 years ... our group at the U.S. Patent Office had the opportunity to review the best technology presented by the world's best scientists. There have been many significant discoveries, but one stands head and shoulders above the rest: the discovery of a new category of vital nutrients called glyconutrients."

Recent Glyconutrient Studies

October 2012 University of Ghent scientists publish Ambrotose product prebiotic study in the
Antoine van Leeuwenhoek Journal of Microbiology. cognitive benefits of glyconutrients and other polysaccharides are explored.

The United States of America

February 2012 Review of effects of polysaccharides on brain function is published, Mechanisms that might explain the September 2011 Study shows Mannatech's Ambrotose complex improves well-being in healthy adults (titled Perceived changes in well-being following polysaccharide intake in middle-aged adults).

Quality and Standards

Mannatech is committed to meeting customer, regulatory and industry standards by manufacturing products of the highest quality and value. Our suppliers conduct statistical sampling then follow it with inspection and testing. No product is ever shipped from Mannatech without the highest level of assurance that it meets our quality standards.

Recent Discoveries
A suite of tools analagous to those available for studying nucleic acids and proteins is needed to detect, describe and purify glycans (glyconutrients) from natural sources, and characterize their chemical composition and structure.
In 2011, an open-label dosing study published in the European Journal of Clinical Nutrition concluded for the first time in the scientific community that the ingestion of a standardized blend of plant polysaccharides (Ambrotose complex) can induce significant changes in cell-surface glycoprotein structures. And, there were no reported adverse events.1 In 2012, a report titled Transforming Glycoscience: a Roadmap for the Future conducted by the National Academies of Science offered bold support for the function and importance of glycans (or glyconutrients).

Current Good Manufacturing Practices

As a global innovator, we adhere to industry-wide current Good Manufacturing Practices (cGMPs) established by various U.S. and international regulatory agencies. You can rest assured that our products are safe, effective and precisely labeled.

NSF CertificationThird-Party Mark of Excellence

A growing number of our health products have been Certified by NSF International, an independent, third-party organization that helps ensure that supplements and ingredients are labeled accurately and contain no adulterants or contaminants.
PRODUCE
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NERGY

CERTIFIED

100% Satisfaction Guarantee

You can trust the science and quality behind our products. Were so confident youll love our products that we offer a six-month Satisfaction Guarantee.

Mannatech guarantees your full satisfaction. If not completely satisfied, contact Customer Care and return the product within 180 days for a full refund. See Mannatech.com for details.

10

Glycoscience Validation

To see the full collection of studies and published research, visit MannatechScience.org.

Alavi, A., Fraser O, Tarelli E, et al. An open-label dosing study to evaluate the safety and effects of a dietary plant-derived polysaccharide supplement on the N-glycosylation profile of serum in healthy subjects. Eur J Clin Nutr 2008; 65: 64856

Self-Evidence

11

Awards and Recognition

June 2005In its June 6, 2005, edition, BusinessWeek magazine ranked Mannatech #6 on its annual list of Hot Growth Companies. June 15, 2005Mannatech was awarded the coveted Success Award by the Direct Selling Association for the unique changes of the companys compensation plan at this years annual DSA convention held in Orlando, Florida. March 14, 2006Mannatech was the 29th fastest-growing public company in the Dallas/Fort Worth Metroplex, according to the Dallas Business Journal. March 22, 2006Nutrition Business Journal awarded global health and wellness provider Mannatech, Incorporated, a bronze medal in the publications annual Business Achievement Awards. April 16, 2006The U.S. Department of Commerce recognized global health and wellness leader Mannatech for its successful entry into the international marketplace. May 14, 2006The Dallas Morning News named Mannatech as one of DFWs Top 200 Publicly Traded Companies. October 18, 2006Forbes magazine recognized Mannatech as one of the top 10 best small companies in America. January 31, 2007Mannatech received first- and second-place awards for basic science research indicating bacteria from the human digestive tract can metabolize the complex carbohydrates in the companys glyconutritional supplements. May 30, 2007Mannatech was recognized by BusinessWeek as the 12th-best Hot Growth small company in America and as the 4th best in average return on capital over three years. March 14, 2009Chief Science Officer and Senior Vice President Robert Sinnott, MNS, PhD, was selected as the vice chairman of the Senior Scientific Advisory Council (SSAC) for the Council for Responsible Nutrition (CRN). March 2009Mannatech was honored by members of the U.S. House of Representatives, the Texas House of Representatives and the Dallas City Council. November 24, 2009Mannatechs educational website, MannatechScience.org, received a Web Health Merit Award for its accuracy, success in reaching its targeted audience and overall quality. June 2011CEO and Chief Science Officer Dr. Rob Sinnott featured in Natural Products Insider magazine article, Aloe veritas. October 2011Mannatech and Texas Womens University announce the development of a Nutrition and Personal Health Coaching Certification Program. Mannatech helps develop course materials. April 2012Mannatech presents new study at the 10th Jenner Glycobiology and Medicine Symposium in the Netherlands. July 2012Mannatech presents product research at the 9th Annual International Society of Sports Nutrition Conference. April 2013Dr. Sinnott featured in Nutraceuticals World magazine article, Open Innovation in Nutraceuticals & Functional Foods.

A Company of Provision

We do all that we can to earn the trust consumers place in us every time they use a Mannatech product.
12

Awards & Recognition

A Company of Provision

13

The Problem We All Face

Many of us are not consuming enough essential nutrients!

And Industrys Solution

Industry saw an opportunity in our problems.
Industry set out to improve food
In the mid-1900s, commercial farming found new ways to grow food faster and bigger.

The nutritional value of many fruits and vegetables The USDA now recommends that adults consume
3.55 cups of fruits and vegetables per day.3 has declined over the last 50 years.1,2 Nearly the entire U.S. population fails to eat a diet in line with the dietary guidelines for Americans.4 used to buy processed food.5

S tarved

+ + =
Genetically Modified Seeds Bigger Livestock Pesticides Big Profits

90% of all the money Americans spend on food is

1

Davis DR, Epp MD, Riordan HD (2004) Changes in USDA Food Composition Data for 43 Garden Crops, 1950 to 1999. Journal of the American College of Nutrition 23: 669-682. 2 Mayer A-M (1997) Historical changes in the mineral content of fruits and vegetables. Brit Food J 96: 207-211. 3 www.choosemyplate.gov/food-groups/vegetables-amount.html 4 Krebs-Smith, S.M., Guenther, P.M., Subar, A.F., et al. Americans do not meet federal dietary recommendations. J Nutr 2010; 140(10): 1832-8. 5 Schlosser E. Fast Food Nation: The Dark Side of the All-American Meal. Perennial/Harper Collins: 2001.

Industry has radically changed our food over the last 50 years.
Then, industry focused on reinventing food by combining highly processed food
ingredients with chemically made sweeteners, colorings, flavorings and preservatives. They are so poor in nutritional value that one expert refers to them as edible food-like substances.6

We are stressed!

S tressed

Oxidative stress causes free radicals.

Emotional stress Excessive exercise Smoking (including second-hand) Excessive alcohol consumption Use of pharmaceuticals Food preservatives
We live in a toxic environment!

Pollan M. In Defense of Food. New York, New York: The Penguin Press, 2008.

Over 75,000 synthetic chemicals Numerous pollutants common Artificial sweeteners, colorings Household cleaners, pesticides
and other chemicals and preservatives in our air and water introduced since 1930

high-dose synthetic vitamin and mineral products. It was cheaper and more profitable to develop vitamins and minerals from things like petroleum, coal tar derivatives and crushed up rocks than to extract them in their natural form, from whole foods.

Once the public turned to supplements to fill the gap, industry saw a new opportunity and began marketing

Tox i c

Every so-called "solution" has typically presented more problems. For many of us, while the "solutions" continue to increase, our health continues to decline overall.

14

The Problem

The Problem

15

Synthetically Made Nutritional Alternatives

Synthetic vitamins are chemically produced
and often include nutrients sourced from petroleum and coal tar derivatives, not food. They are inexpensive to produce and easy to standardize at RDI levels. sold are synthetically made.

Industry's Solution

Easily Identify Synthetic Vitamins

Take a look at your current brand of nutritional supplement and find out if it contains synthetic sources.
Synthetic Vitamins May Include: Vitamin B2 Vitamin C Vitamin D Vitamin E Vitamin K Pantothenic acid Folic acid Listed on the label as: Riboflavin Ascorbic acid Calciferol dl-alpha tocopheral Menadione or phytonadione Calcium D-pantothenate Pteroylglutamic acid

It's estimated that over 95%1of all vitamins

1

wwworganicconsumers.org/articles/article_3697.cfm

Minerals are generally recovered by mining ores or from chemical processes. Tests have shown that minerals contained in [many of ] the most popular brands of multivitamins do not dissolve (they are not soluble) in the stomach or small intestine. They probably pass through the body without being absorbed.2
2

Any vitamin ending in the following is synthetic: acetate, hydrochloride, mononitrate, palmitate or succinate. Inorganic mineral names will usually end in one of the following:
ascorbate citrate iodide orotate
ide for ick Gu and A Qu Vitamin ents lem ating Evalu ral Supp Mine

aspartate disulfide lactate oxide

carbonate gluconate malate picolinate

chloride glycerophosphate methionine sulfate

an min? of vitamin es: o sourc r Vita d levelson ly tw Is You ndardize are there d Real To achieve sta ients, Source How ingred Plantneral d mi
mically or Made ed che roleum tically produc from pet Synthe s are e . vitamin be mad form tic Synthe ry and may in a food not laborato theyre coal tar; in a

or foods d from extracte s are vitamin in yeast. ulate rced accum and then ly sou cultured es to m Natural ts or are process igest the s from plan ltiple eral soil, pred rix. Min use mu Plants s from the food mat soluble. re a mineral m into refore, mo the bond ts are, the plan

most ensive, n are less exp entatio tured y are e the supplem manufac Becaus s used for und or gro mineral from the cesses. do not the erals mined mical pro se min in either che from that the soluble) not shown have l (they are e. Tests stin wel ll inte dissolve or sma ach stom

sourced n urally retain tha that nat and gests to absorb h sug s. ier Researc s are eas de vitamin vitamintically ma synthe

How Real Is Your Vitamin?

Find out with this tear sheet at http://bit.ly/ZC8v0v

Ensley BD, Elless MP, Blaylock MJ, Huang JW. Hydroponic cultivation of metal-accumulating plants as a source of mineral nutrient supplements. Metal Ions in Biology and Medicine 2000;5313.

ow u Kn Do Yo Your Where itamin Multiv s From? Come

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There is a Better solution

16

Industry's Solution

Industry's Solution

17

Ancient Wisdom
What Did They Tell Us?

The Design of Life: I have given you every seed-bearing plant throughout the earth and all of the fruit trees for your food. Genesis 1:29

Paracelsus and Hippocrates, considered to be the fathers of pharmacology and medicine, respectively, believed that having good health was dependent upon proper nutrition. Over the centuries, technologies have evolved in both food and medicine, but this principle remains as true today as it was then. New research is showing us how the human body functions at the cellular level and how nutrients in their realfood form support these critical functions. Science is now bringing us full circle to the very foundations of health and ancient wisdom.

Everything man needs to sustain good health is provided by God in nature. The job of science is to find it. Paracelsus

18

Ancient Wisdom

Pietro Longhi. The ApothecaryAloe vera was a common tool in doctors' offices in the mid 18th century.

Ancient Wisdom

19

Real Food Technology:

The Solution

Most nutritional solutions today are falling way short of what your body actually considers to be good nutrition. Sure, the label touts all the popular vitamins, minerals and other trendy nutrients at levels that seem impressive on the surface. But your body isnt fooled. Your body is complex, and its looking for more than just a combination of high-dose synthetic nutrients to feel its best.

Which Plant Would You Want YOUR Supplements to Come From?

A chemical plant?

Your body wants nutrition from real-food sources.

Mannatech recognizes the importance of nutrients from nature. We introduced Real Food Technology solutions to take a different approach to nutritional supplementation. Simply put, we use science not to create nutrition, but rather to capture nutrition from nature, of course.

OR

And as far as your body is concerned, this approach makes all the difference. Real Food Technology solutions provide standardized and nutritionally effective levels of vital nutrients from whole-food sources.

The Keys to a Real Food Technology Approach

Standardized Nutritionally effective levels Whole-food sources

A real plant?
20

Real Food Technology

Real Food Technology

21

Real Food Technology Solutions

A Common-Sense Approach to Optimal Health
DRIVER OIL WATER AIR GAS

Role of Nutrients
Body Systems Organs Tissue Cells
For optimal wellness, your body needs ongoing maintenance in such areas as:
IMMUNE CELL Nourish Me Repair Me Destroy Me Protect Me Regulate Me

Completing the Circle of Care

Consider for a minute your body as an automobile. Daily support and maintenance is required or breakdowns occur.

The modern car is designed to run on certain It requires routine maintenance. It will usually last about 100,000 miles or so.
raw materials.

It All Starts with the Cells

A variety of food-based nutrients is required to support healthy cells. Healthy cells are necessary to support healthy glands, organs, tissues, bones, fluids, blood and skin.

The car must have fuel in the tank, oil in the engine, water in the radiator; air in the tires and, of course, a driver behind the wheel. The car also must be maintained by changing the oil and filling the gas tank. There are numerous things that may improve its performance or looks, but these components are mandatory for it to start and run. If any of the basic components are missing, or the car isnt maintained properly, its not going to travel very far without breaking down. And a shiny new paint job or fresh tires wont help if the basics are not met.

Cellular Support
Communication Protection Nourishment

Healthy cells = Healthy tissue Healthy tissue = Healthy organs Healthy organs = Healthy systems Healthy systems = Healthy bodies

The same concept can be applied to understanding the human body.

System Support
Endocrine Cardiovascular Digestive

Our bodies were designed to run on very

Countless things may enhance how we look or feel, but nutrients are essential. Unless we provide our bodies with these basic essentials and perform the necessary maintenance, it is very difficult to sustain good health.

They require routine maintenance. And they are designed to last about 85 years or so.

specific raw materials.

Body Fitness
Fat Loss Performance Recovery

22

System Support

Role of Nutrients

23

Sweet Language of Life

The Missing Link
Of the 200 that naturally occur in nature, our cells use eight of these sugars like letters of an alphabet to create cellular words. The potential information content of these sugar structures vastly exceeds that of any class of macromolecules.1 Every living cell on the planet is covered with a dense and complex array of sugar molecules called glycans. Every molecule, cell or 1 organism that interacts with a cell must do so through these cell-surface glycans. Immune cells read these sugar structures to determine if our cells are healthy, in need of repair or need to be destroyed.
1

Ambrotose Complex and Advanced Ambrotose

Glyconutrients
The first standardized blend of plant-sourced polysaccharides. More than 50 patents issued worldwide for this breakthrough technology.

Committee on Assessing the Importance and Impact of Glycomics and Glycosciences. Transforming Glycoscience: A Roadmap for the Future. The National Academies Press: 2012.

When Your Cells Talk, Your Body Listens

When bad cells go undetected, as in degenerative type functions, research has shown that sugars are missing from their glycoprotein structures. Capitalizing on Carbohydrates, 1991 Removing one sugar [from their cell-surface structures] turns protective antibodies (repair cells) into attackers. The research shows that the mere destructive autoimmune functions appear to be lacking antibodies associated with this (sugar). Rockefeller University, July 4, 2007 Bill McAnalley's A Story of Discovery Ambrotose: http://bit.ly/11DgiyU

Ambrotose Products

Support cellular communication* Improve cognitive function* Improve memory, concentration and attentiveness* Improve mood and decrease irritability* Support immune system function* Support digestive system health*

Benefits vary by product.

24

Cellular Suppor t

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Ambrotose

25

Real Food Technology Solutions for Cellular Protection

In part, premature aging is the breakdown of the bodys natural ability to regenerate its It has been postulated that naturally occurring invaders, called free radicals, can
radicals that can damage cells and accelerate the aging process. trillions of cells and produce new ones. This repair and renewal process goes on every second of every day of your life. damage cells, interfere with their repair and regeneration, and thereby speed up the aging process.

Ambrotose AO
Antioxidants Ambrotose AO is a scientifically proven antioxidant supplement designed to support optimal health by effectively enhancing antioxidant protection in the body.*

Sunlight, physical and emotional stress, and environmental toxins are sources of free Cells can protect themselves from these environmental factors, but research suggests Certain fat- and water-soluble vitamins, minerals and plant phytochemicals are It has been postulated that premature aging can start to occur when cells dont get Antioxidant nutrients are abundant in vine-ripened fruits and vegetables.
enough antioxidant support, and the body cannot keep up with the demands of damaged cells. antioxidants that can neutralize free radicals and prevent the damage they cause. that they require the right nutrients, called antioxidants, to provide proper protection.

Research has shown that two Ambrotose AO capsules

can increase overall antioxidant protection in humans by 37.9%. Thats more than two and a half times the ORAC impact of five servings of fruits and vegetables (serum ORAC results).

Ambrotose AO capsules: Help protect against cell damage caused by Provide plant-sourced ingredients for
antioxidant and immune support. *

physical and oxidative stress (free radicals), toxins, environmental stress, and poor diet, all of which can damage cells, tissues, and DNA.*

Included in OSP Packets

Free radicals can attack our cells as many as 10,000 times a day.
The right blend of fat- and water-soluble antioxidants may protect our cells from this attack.

Comparison of serum ORAC values obtained in two separate clinical studies funded by Mannatech.

According to a study funded by the USDA,

five daily servings of fruits and vegetables can increase overall antioxidant protection by 13.9% (serum ORAC results).1 Ambrotose AO capsules can increase overall antioxidant protection in humans by more than two and a half times that amount. Read the full study at: http://bit.ly/11otcQf
1

Cao G, Booth SL, Sadowski JA, Prior RL. Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr 1998;68:10817.

26

Protection

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Ambrotose AO

27

Real Food Technology Solutions for Cellular Nourishment

Your Cells Need Nourishment

PhytoMatrix Caplets
Vitamins and Minerals Mannatechs PhytoMatrix multivitamin/mineral supplement provides the industrys first standardized blend of foodsourced vitamins, minerals and phytonutrients.
PhytoMatrix caplets support:

Every cell in your body requires a variety of nutrients to help build and support its proper Your body is building millions of new cells every second. There are more than 26 essential vitamins and minerals, and multiple trace elements,
that MUST be obtained through your diet. structure and function.

Foods are comprised of synergistic blends of [essential] nutrients bound together into the food matrix.
It is the food matrix [blend] that best supports human biological processes. Jacobs DR, Jr., Tapsell LC. Food, not nutrients, is the fundamental unit in nutrition. Nutr Rev 2007;65:439-50.

Cell protection with powerful antioxidants* Energy production with a full complement of Heart health with vitamins B , B
(folic acid)*
6

B vitamins*

12

, B3 (niacin), C, and B9

Healthy eyesight with vitamins A, C, E, and niacin, plus Immune system function with vitamins A, C, E, B , and folic acid, plus
minerals zinc, copper and iron*
6

Included in OSP Packets

the mineral zinc*

Proprietary Hydroponic Growing Technology

At the heart of our PhytoMatrix product is a patented, hydroponic cultivation technology that uses the Indian mustard plant nicknamed natures magnet for its ability to absorb minerals from the soil. These plants are hydroponically grown in solution, allowing them to absorb a controlled amount of concentrated minerals, which are then stored in the plant tissue. Why is this significant? Because food sourceslike Indian mustardprovide minerals in their most natural form, so they can be readily absorbed and utilized by the body. The hydroponic process ensures standardized concentrations of essential minerals that meet minimum requirements with a daily serving of four tablets. Even fresh fruits and vegetables which usually have high concentrations of vitaminsmay be low in essential minerals.

PhytoBurst Chews
Essential Nutrition PhytoBurst Chews: A Delicious Delivery Method for Food-Sourced Nutrition

Delicious fruit-flavored chews (lemon and mixed berry) Incorporates hyrdroponic technology found in our Great on-the-go bursts of nutrition
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

PhytoMatrix caplets

28

Nourishment

Nourishment

29

Cellular Health Value Proposition

The Ultimate Solution for Cellular Health
Mannatechs Core Innovations in One Product
NutriVerus powder delivers the nutrition your body needs, the way your body wants it. This completely unique supplement combines natural, food-sourced vitamins, minerals, glyconutrients and fat- and watersoluble antioxidants in a nutrient-dense, real-food base of stabilized rice bran and organic fruits and vegetables. The result? Energy-boosting, immune systemsupporting nutrition in an environment just right for nutritional synergies to occur, increasing the potential interaction of the individual nutrients.*
Fat- & Water-Soluble

NutriVerus Powder
Nutrition the Way Your Body Wants It.
NutriVerus features a nutrient-dense, real-food base of stabilized rice bran, organic fruits and vegetables, antioxidants and glyco- and phytonutrients.

Antioxidants

Essential

Glyconutrients

Vitamins & Minerals

from Real Food

Organic Fruit Blend Strawberry Raspberry Blueberry Tart Cherry Pomegranate Cranberry

Organic Vegetable Blend Broccoli Broccoli Sprouts Tomato Carrot Spinach Kale

Real Food Base

from rice bran and organic fruits and vegetables

Stabilized Rice Bran (SRB) is one of the most nutrient-dense food ingredients in the world.

Unlike other grains, it is gluten-free More than 100 antioxidants, metabolic co-

Highly Valued Benefits at a Value-Conscious Price

Glyconutrients and food-sourced nutrients for just $2 a day!
Supports cell-to-cell communication through a blend of specific plant saccharides including glyconutrients* Offers antioxidant and immune system support* Supports brain health* Helps protect your cardiovascular system* Supports healthy digestion* Helps your body maintain energy levels* Provides a natural, food-sourced vitamin/mineral complex for maximum absorption* Suitable for all ages, including kids age four and up

Vitamin E complex with tocopherols and tocotrienols Naturally rich in B vitamins High in inositol Rich in phytosterols Rich in fatty acids Good protein source Good source of potassium, magnesium and phosphorus
Learn more about NutriVerus powder and the Real Food Revolution. Watch this video.
http://bit.ly/YzLo7G

factors, and trace elements in its food matrix

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Cellular Health

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Cellular Health

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Real Food Technology Solutions for System Support

The Endocrine System Is Your Bodys Command Central.
When functioning well, its glands direct operations by producing vital hormones that send signals to keep you ready for anything and help your body stay balanced. Because this important control center ultimately influences almost every cell organ and function of your body, making sure it gets the nutrients it needs is a must. Mannatechs PLUS caplets, can help by keeping this vital system functioning smoothly in a state of equilibrium.* Mannatechs PLUS caplets dont contain hormones. Instead, they provide specific nutrients, including plant sterols to support your glands natural function.* And because we dont always eat right, we can miss out on important nutrients like plant sterols and amino acids that help keep our systems functioning well. Thats why Mannatech developed PLUS capletsto supply the body with a proprietary blend of specific, standardized nutrients, including important plant sterols and amino acids that we may not always get on a consistent basis from diet alone.

Mannatech PLUS
Endocrine System Support Mannatech PLUS caplets include a proprietary blend of standardized plant sterols formulated to support a well-functioning endocrine system.*
PLUS caplets:

Furnish raw materials for endocrine support* Supply essential amino acids to support
natural hormone production*

Support breast, bone and colon health as well as the

immune, nervous and cardiovascular systems*

Support prostate health*

Included in OSP Packets

Amino acidsthe building blocks of proteins

Did you know that of the 20 amino acids that we all need to survive, the human body produces only 10? We must rely on our diets for the other half, but not all proteins are created equal. Some contain specific amino acids for hormone production while others do not. And because humans dont store amino acids in their bodies, we need a steady supply every day.

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Endocrine

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Endocrine

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Real Food Technology Solutions for Cardiovascular

Support

Omega-3 with Vitamin D3

Healthy Heart
Mannatech's Omega-3 with Vitamin D3 is your best choice with:
ultra-purity

Research shows that most people are deficient in Omega-3 fatty acids
Your body doesn't produce Omega-3
For centuries, people got enough omega-3s through their diets. Not so anymore. Today's diet trends result in too much omega-6 in our bodies. Even farm-raised fish are often grain fed and contribute more omega-6 than omega-3. Although omega-6 is important, it competes with omega-3 for space in our cells. Our current diets have created a ratio that ranges as high as 30:1 omega-6 to omega-3. This imbalance has given rise to an unhealthy inflammatory response, which is a key contributor to many of the health concerns in our diet.

Omega-3 fatty acids are considered essential because they are vital to your health and your body cannot produce them.

Over 1,000 mg of highly concentrated EPA and DHA per serving Made from molecularly distilled, high-quality fish oils, for Pleasant lemon flavor in an easy-to-swallow gel capsule 830 IU of vitamin D , a natural and preferred source of vitamin D
3

A Fat Your Body Needs

There are good fats and bad, but omega-3 fatty acids are a fat that you absolutely must have. Help support cardiovascular and heart health* Help support brain health and function* Help maintain a healthy immune system and support a healthy inflammatory responsea key contributor to good health* Provide support for healthy triglyceride levels already within normal levels* Vitamin D is essential for calcium absorption*

CardioBALANCE
For Additional Cardiovascular Support CardioBALANCE Capsules:

Provide nourishment for cardiovascular health through

a unique herbal vitamin and amino acid blend.* already within normal range.*

Learn more about how our Omega-3 with Vitamin D3 is unique. Watch this video.
http://bit.ly/110zN2U

Help maintain homocysteine levels that are Include folate as well as L-arginine, which is thought to
increase nitric oxide productionessential in maintaining blood vessel healthas well as CoQ10, which is often depleted by cholesterol-lowering drugs.*

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Cardiovascular

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Cardiovascular

35

Real Food Technology Solutions for Digestive System

Support
Healthy Digestion

Did you know that approximately 70% of your immune system is located in your digestive tract?
One of the digestive system's most important Because the digestive system's organs rely on To digest food, the intestines maintain an
environment that includes healthy bacteria and enzymes. digestion. Enzymes regulate the speed of metabolism, among other bodily processes. were found in many common, raw foods. However, preservatives, pasteurization and other processing have generally eliminated probiotics from todays foods. This forces the body to dip into and, perhaps, deplete its own supply. functions is to process food and absorb all the nutrients our cells can use. It also serves as the first line of defense against harmful bacteria. nutrients from food, the health of the digestive system depends on the quality of our diet.

GI-ProBalance
Mannatech's GI-ProBalance slimsticks provide the right bacteria to help maintain the microbial balance in a healthy intestine.*
This balance can promote a healthy effect among the various microflora that live in the human intestine, thereby supporting optimal digestive function.*

So when your gut is healthy, it helps your whole body stay healthy.

Probiotics are dietary bacteria that assist in

Probiotic bacteria must be regularly replenished. In the past, they

GI-Zyme
Healthy Digestion Mannatech's GI-Zyme capsules are formulated to:

Performance
tuned to unleash

Ambrotose
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the power of

Developed after extensive research on the digestion and beneficial effects of Ambrotose powder, GI-ProBalance slimsticks were formulated to enhance the benefits of Ambrotose products. The specially formulated probiotic blend breaks down the polysaccharides in the Ambrotose products, thereby enhancing the ability of both exceptional products to support the digestive and immune systems.*

Help improve the level of digestion* Assist in breaking down proteins, fats and carbohydrates*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Digestive

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Digestive

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A New Perspective on Fat Loss

We're Dieting More Often
The desire to lose weight is not a new one. But its one thats received unmatched attention in the past thirty years. Conventional wisdom tells us that too many calories and too little exercise are the major contributors to weight gain. So weve tried to address those issues in many creative ways. From exercise programs and eating plans, to metabolism-enhancing pills, meal replacements and even surgery, weve virtually thrown the kitchen sink at losing weight.

Real Food Technology Solutions for Sustainable

Fat Loss

Dont be fooled by trendy, synthetic, weight-loss shakes and plans. Feed your body with the only protein shake that incorporates a unique glyconutrient blend and a protein mix based on Real Food Technology solutions.

Available Summer 2013

16 grams of vegetable-sourced proteins (rice and yellow pea) Glyconutrient blend helps amplify support at the Delicious natural vanilla flavor Gluten-free No soy No dairy Vegetarian-friendly
cellular level*

The typical American dieter now makes four weight-loss

75 to 100 million Americans diet each year.1 attempts per yearthe highest number in 15 years.1

The weight-loss industry by the numbers, ABC News, May 8, 2012

We're Spending More Money

The U.S. weight-loss market now exceeds $60 billion.

U.S. Weight Loss Market Worth $60.9 billion, PRWeb, May 9, 2011

With ongoing proper diet and exercise.

If you consider that only 75 million Americans are trying to lose

weight, thats $800 per person per year!

Dont Make This Common Weight-Management Mistake!

When shedding pounds, dont overlook your bodys basic nutritional needs. Add NutriVerus powder to your weight-management regimen and give your body the foundational, whole-food nutrients it craves.

We're Gaining More Weight

Even worse, even when we do lose weight, we seem to have even bigger challenges keeping it off. Many of us lose a few inches today, only to gain it all backand even more tomorrow. and the number is growing.

Globally, there are more than 1 billion overweight adults,

Worldometers.com, Marketdata research 2013

OsoLean Powder
Target Fat Loss
Retaining lean muscle when burning fat is important in maintaining body strength and a healthy metabolism. In a clinical study, the key ingredient in OsoLean powder promoted fat loss and minimized muscle loss when combined with a proper diet and exercise.* More than a just typical whey protein product, OsoLean powder incorporates a proprietary advanced peptide technology that separates and concentrates specific parts of whey protein, called peptides, to ensure your body receives the optimal level of fat-loss peptides.*
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

According to the American Heart Association, 66% of

Americans are overweight and 34% are obese.
Trend spotting 2013, Foodnavigator.com, December 3, 2012

SUSTAINABLE weight management from REAL-FOOD SOURCES.

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The Answer?

Fa t L o s s

Fa t L o s s

39

Performance
Perform Better
Mannatechs advanced Weight and Fitness products are natural and formulated with food-sourced nutrients to help you go the extra mile, and look amazing while doing it.

Recovery
Recover Faster
Our BounceBack capsules allow you to stay active and mobile.*
When taken daily, over time, BounceBack capsules can:

SPORT capsules:

Help reduce muscle pain and stiffness due to

overexertion or physical activity* Aid the bodys natural recovery process* Support optimal joint and cartilage health* Provide immune system support*

Help maintain existing normal blood sugar levels

and support carbohydrate utilization* A proprietary blend of herbs and herbal extracts A plant sterol supplement formulated with a combination of Ambrotose complex and wild yam

Mannatechs ImmunoSTART tablets prime your immune system.*

If its operating well, your immune system will remove toxins and keep you healthy. But, everyday stresses, not eating properly and irregular sleep habits can take a heavy toll on your immune system. These factors may accelerate your use of and need for nutrients. Eventually, your immune system may encounter difficulty keeping up with the demands placed upon it, so its critical that you give it the right nourishment.

AmbroStart drink mix is a delicious, orange-flavored, energy-releasing supplement that:

Delivers nutrients that provide the body with energy* Includes medium-chain triglycerides that are
readily broken down into short-chain, free-fatty acids that can be used as fuel for muscles* Is a good source of fiber Helps support a healthy immune system*

Helps build, support and nurture immune system health* Engineered with a targeted array of nutrients, including

bovine colostrum and lactoferrin that work to stimulate and support the bodys natural immune response* Increases plasma levels of neutrophil precursorsneutrophils are the most abundant immune cells and form an integral part of the immune system*

EMPACT citrus-flavored drink mix:

May enhance the bodys ability to use oxygen

Manna-C capsules contain natural forms of vitamin C from wild bush plum and acerolawild fruits that are considered two of natures richest sources of this vitamin.

during athletic exertion* May improve athletic endurance* Includes medium-chain triglycerides (MCTs) that are readily broken down into short-chain, free-fatty acids that are used as fuel for muscles* Has been clinically shown to enhance cardiorespiratory fitness and improve endurance* Mannatech-funded clinical studies.

Includes classic Ambrotose complex, along with wild bush plum

and acerola fruit extract, both natural sources of vitamin C Herbal blend with a natural plant source of vitamin C for the maintenance of good health* Our Manna-C capsules combine Ambrotose complex plant polysaccharides with an herbal blend that yields natural sources of vitamin C. This specially formulated herbal blend includes lemon verbena, sage, peppermint and other herbs.

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Per formance

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Recovery

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Protecting Our Future

Kids
Start a Tradition of Good Nutrition
The pursuit of wellness is one that lasts a lifetime. Give your child the healthy advantages that come from good nutrition early in life. Many Mannatech products are appropriate for children. Just check the labels for any possible age and/or directional restrictions. For starters, here are some products deemed as favorites by kids and parents alike.

MannaBears Gummies
A tasty alternative to sweets full of refined sugars and other junk foods, MannaBears gummies include a specially formulated glyconutrient blend as well as 11 dehydrated fruits and vegetableslike broccoli, carrot, cauliflower, tomato, papaya and pineappleto help protect cells from free radical damage.*

GI-ProBalance Probiotic Slimsticks

Since 70% of your childs immune system is located in the digestive tract, her body relies on a wide variety of bacteria and other microorganisms to help keep it running properly, including probiotics and prebiotics. Kids love the taste of these delicious slimsticks as much as parents love how they're working.
Recommended for children four years of age and older.

NutriVerus Powder
NutriVerus brings real-food glyconutrient and vitamin/mineral technologies in a nutrient-dense food base of stabilized rice bran and organic fruits and vegetables. Sprinkle it on your childs food every day to help ensure his meals are more nutritious.
Recommended for children four years of age and older.

"This could be the first generation of children in the United States that lives less than its parents." Richard Carmona, former Surgeon General of the United States, 2009

ImmunoSTART
With everything going on in their world, your childs immune system can become overloaded quickly. Give them ImmunoSTART tablets every day to help build, support and nuture immune system health.*
Do not give to children under age 4 without adult supervision.

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Kids

Kids

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Skin Care
Healthy Body, Healthy Skin Weve Got You Covered
Mannatech products not only help you feel your best, our natural, glyconutrient-infused skin care products help you look great, too.

Creating a Life of Significance

The Age-Defying Mannatech LIFT Skin Care System

Glowing, younger-looking skin is achievable at any age. Inspired by French technology and formulated with over 30 botanical ingredients, the Mannatech LIFT skin care system is paraben-free and can help turn back the clock to give skin a more natural, youthful appearance. With just three easy stepscleanse, treat and moisturizeplus our Jeunesse 7 proprietary blend that is known to moisturize, hydrate and reduce the appearance of fine lines and wrinkles, you can say bonjour to youngerlooking skin in no time. Aging is natural. Looking your age doesnt have to be. Look as healthy as you feel with the Mannatech LIFT Skin Care System.

FIRM with Ambrotose Body Creme

Suitable for all skin types, this rich, botanically based body creme is a proprietary blend utilizing both science and nature. Formulated without synthetic colors, its also parabenfree and contains no mineral oil to clog pores. It will leave your whole body feeling refreshed, hydrated and soft.

Emprizone Gel
Refresh and moisturize dry, itchy skin with hydrating, aloe-based Emprizone gel. With vitamins A and E, its pH-balanced to leave your skin feeling soft and revitalized after shaving or waxing. Its also perfect after drying exposure to the sun and contains no oils or pore-clogging ingredients.

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Skin Care

Life of Significance

45

How You Can Help

One for One
Become a CUSTOMER and help nourish a child in need.

Consume

As a Member, refer a few people, earn discounts on your orders (up to FREE!) and help nourish more children.

Our Goal
Share Linking five million consumers with five million children in need.

Become a Champion
Help us change the world while creating a life of significance for yourself.

Champion

Will You Help?

Find out how people just like you are playing a crucial role in the fight against global malnutrition.

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How You Can Help

Give for Real donations are generated through monthly automatic product orders. 4Free Member Discount Program credits are based on monthly automatic product orders.

Will You Help?

47

Be the Change You Want to See.

Helping to nourish many of the worlds most vulnerable children is as easy as simply nourishing yourself. Just purchase the daily supplements you need, and Mannatech, through MannaRelief, helps a child in need. When you do this, MannaRelief will provide a monthly donation of PhytoBlend powder, formulated based on Real Food Technology solutionsplant- and foodbased nutritionto help battle malnutrition in developing countries. Partner with Mannatech through our Give for Real program, and be a part of the change you want to make in the world. For more information about this important program, visit GiveForReal.com today.

A Hope for the Future.

Mannatech, Incorporated 600 S. Royal Lane, Suite 200 Coppell, TX 75019 Mannatech.com
16517.0413

Item Number: 1275101

Advanced Ambrotose, AmbroStart, Ambrotose, Ambrotose AO, Ambrotose Phyto Formula, BounceBack, CardioBALANCE, Catalyst, EMPACT, Emprizone, FIRM with Ambrotose, GI-ProBalance, Give for Real and Design, GI-Zyme, ImmunoSTART, Jeunesse 7, Live for Real, Manapol, MannaBears, Manna-C, Mannatech LIFT, NutriVerus, OsoLean, PhytAloe, PhytoBlend, PhytoBurst, PhytoMatrix, PLUS, Real Food Technology, SPORT, Stylized M Design and Mannatech are trademarks of Mannatech, Incorporated.