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Both bind GTP and GDP and are involved in signal transduction.
• Heterotrimeric G proteins
• Activation
The Gα subunit will eventually hydrolyze the attached GTP to GDP by its
inherent enzymatic pathway activity, allowing it to re-associate with Gβγ
and starting a new cycle.
• Specific mechanisms
GαI –
G αQ/11-
Gα12/13 –
Gβδ-