GNIPST BULLETIN 2013

1118-1177-4796-9849-7562-5062

TO GROW AS A CENTRE OF EXCELLENCE IN THE FIELD OF PHARMACEUTICAL AND BIOLOGICAL SCIENCE

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28th June, 2013

Volume No.: 26

Issue No.: 03

Vision

Contents
Message from GNIPST Letter to the Editor News Update Health awareness Disease Outbreak News Forth Coming Events Drugs Update GNIPST Photo Gallery
For your comments/contributionOR

Campus News Students Section Editors Note Archive

For Back-Issues,
mailto:gnipstbulletin@gmail.com

1 EDITOR: Soumya Bhattacharya

GURU NANAK INSTITUTE OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY

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MESSAGE FROM GNIPST

GNIPST BULLETIN is the official publication of Guru Nanak Institute of Pharmaceutical Science & Technology. All the members of GNIPST are proud to publish the 26th Volume of GNIPST BULLETIN. Over the last two years this bulletin updating readers with different scientific, cultural or sports activities of this prestigious institute and promoting knowledge of recent development in Pharmaceutical and Biological Sciences. Students section is informing readers about some curious facts of drug discovery, science, sports and other relevant fields. We look forward to seeing your submission and welcome comments and ideas you may have.

LETTER TO THE EDITOR.

NEWS UPDATE

International Day Against Drug Abuse and Illicit Trafficking :26 June,2013
The International Day Against Drug Abuse and Illicit Trafficking on 26th june . this day is observed with United Nation coordiation to strengthen action and cooperation to achieve the goal of an international society free of drug abuse. The theme of this year is
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"Make health your 'new high' in life, not drugs" aims to inform the public and particularly young people, about the harmful effects of new psychoactive substances (NPS) or legal high substances. Today, there is an alarming new drug problem; demand has soared for substances not under international control. veryone has a part to play in protecting the youth of the world from dangerous substances. UNODC leads the annual World Drug Campaign to drive home the message that illicit drugs pose a danger to society, aims to mobilize wide public support and seeks to inspire people to act against drug abuse. Read more

Gene mutation may have effect on benefit of aspirin use for colorectal cancer
(25th June, 2013)

According to recent clinical trials, the association between aspirin use and risk of colorectal cancer was affected by mutation of the gene BRAF, with regular aspirin use associated with a lower risk of BRAFwild-type colorectal cancer but not with risk of BRAF-mutated cancer. The findings suggest that BRAF-mutant colon tumor cells may be less sensitive to the effect of aspirin. Read more

Novel therapy to treat Muscular Dystrophy (25th June,

2013)

Researchers at Boston University College of Health & Rehabilitation Sciences: Sargent College have identified a combinatorial therapeutic
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approach that has proven effective in treating muscular dystrophy in a mouse model. Read more

Antibiotic shows analgesic action following surgery

(25th June, 2013)

Researchers at university Sapienza in Rome analyzed that a single dose of the antibiotic Ceftriaxone given for antimicrobial prophylaxis prior to surgery enhanced patient pain thresholds after the procedure. Read more

Computerized brain fitness program improves the memory of older adults (25th June, 2013)
Researchers have found that older adults who regularly used a brainfitness program called Dakim Brain Fitness on a computer demonstrated significantly improved memory and language skills. Read more

Nano gold for vaccine development

(25th June, 2013)

US scientists have developed a novel vaccination method that uses tiny gold particles to mimic a virus and carry specific proteins to the body's specialist immune cells. The technique differs from the traditional approach of using dead or inactive viruses as a vaccine and was demonstrated in the lab using a specific protein that sits on the surface of the respiratory syncytial virus (RSV). Read more

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New Palm-Sized Microarray Technique Grows 1,200 Individual Cultures of Microbes (25th June, 2013)
Scientists at the University of Texas at San Antonio and the U.S. Army Institute of Surgical Research at Fort Sam Houston have developed a microarray platform for culturing fungal biofilms, and validated one potential application of the technology to identify new drugs effective against Candida albicans biofilms. Read more

Zebra fish Study Paves the Treatments for Genetic Disorder

Way

for

New

(26th June, 2013)

A research project conducted at the Sheffield Institute for Translational Neuroscience (SITraN) and the MRC Centre for Developmental and Biomedical Genetics (CDBG) by Dr Andrew Grierson and his team has revealed that zebrafish could hold the key to finding new therapeutic approaches to treat Charcot Marie Tooth disease (CMT), a genetic disorder Read more

Simple Two-Drug Combination Proves Effective in Reducing Risk of Stroke

(26th June, 2013)

Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs - clopidogrel and aspirin lowered the risk of stroke by almost one-third, compared to the standard therapy of

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aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks. Read more

HEALTH AWARENESS Drug Abuse-A Psychosocial Disorder

Substance abuse or Drug abuse is a complex and multifactorial disorder involving individual, cultural, biological, social and environmental factors. Substance abuse refers to the harmful or hazardous use of psychoactive substances, including alcohol and illicit drugs. Psychoactive substance use can lead to dependence syndrome which includes behavioural, cognitive, and physiological phenomena that develop after repeated substance use and that typically include a strong desire to take the drug, difficulties in controlling its use, persisting in its use despite harmful consequences, a higher priority given to drug use than to other activities and obligations, increased tolerance, and sometimes a physical withdrawal state. The World Drug report (UNODC 2009) estimates the total number of people using illicit drugs at upwards of 250 million peopleequivalent to about 4 per cent of the global population aged 15 to 64. Of that number, as many as 38 million people are drug dependent, but only about 4.9 million of them receive evidence-based drug dependence treatment and care.

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Common Drugs for substance abuse: Stimulants: These drugs speed up the bodys nervous system and create a feeling of energy. They are also called uppers because of their ability to make you feel very awake. Constant use of such drugs can have very negative effects on the user. In order to prevent extreme negative side effects of these drugs and the impact they have on life, drug treatment centers are often recommended. The drugs of this category are:

Cocaine Methamphetamines Amphetamines Ritalin Cylert Inhalants: Inhalants are sniffed or huffed and give the user immediate results. Unfortunately, these immediate results can also result in sudden mental damage. When inhalants are taken, the body becomes deprived of oxygen, causing a rapid heartbeat. Other effects include liver, lung and kidney problems, affected sense of smell, difficulty walking and confusion. Types of drugs include:
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Glues Paint thinner Gasoline Laughing gas Aerosol sprays Cannabinoids: These drugs result in feelings of euphoria, cause confusion and memory problems, anxiety, a higher heart rate, as well as staggering and poor reaction time. Types of drugs include:

Hashish Marijuana Depressants: Depressants slow down activity in the central nervous system of your body. These drugs are also called downers because they slow the body down and seem to give feelings of relaxation. Depressants are available as prescription drugs to relieve stress and anger, although drowsiness is often a side effect. The relaxation felt from these drugs is not a healthy feeling for the body to experience, to stop abuse of this drug, drug treatment is suggested. Types of drugs:
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Barbiturates Benzodiazepines Flunitrazepam GHB (Gamma-hydroxybutyrate) Methaqualone Alcohol Tranquillisers Hallucinogens When taking hallucinogens, switching emotions is frequent. These drugs change the mind and cause the appearance of things that are not really there. Hallucinogens affect the bodys self-control, such as speech and movement, and often bring about hostility. Other negative side effects of these drugs include heart failure, increased heart rate, higher blood pressure and changes in the bodys hormones. Types of drugs include:

LSD (lysergic acid diethylamide) Mescaline Psilocybin Cannabis Magic Mushrooms Prescription Drugs Prescription drugs can be very helpful drugs when used properly and when under the guidance of a qualified physician. These drugs can be used as aids in surgery, to treat medical conditions and while
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controlling various symptoms. Misuse and abuse of prescription drugs however can be very dangerous. Types of drugs include:

Opiods: Codeine, Oxycodone, Morphine Central nervous system depressants: barbiturates, benzodiazepines Stimulants: dextroamphetamine, methylphenidate Common signs and symptoms of substance abuse: Physical Symptoms: Glazed eye, Drowsiness, Runny nose, Coughing, Needle marks, Weight loss, Malnutrition, Tremor, Hallucination etc. Emotional and social signs : Moodiness, excitement, anger, hostility, depression Constant lying and stealing Refusing to admit to the harmful effects of drugs

Avoiding old friends or people who could confront them about behavior changes Being secretive about phone calls Having friends they do not want you to meet or talk about Being evasive about their whereabouts Loss of motivation No interest in everyday life
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Playing truant from school

Treatment strategies for substance abuse: Drug dependence is as much a disorder of the brain as any other neurological or psychiatric illness. One of the main barriers to treatment and care is the stigma and discrimination associated with this treatable health disorder. The major two approaches for the treatment of substance abuse are

Psychosocial therapy: behavioral therapy, motivational therapy,

cognitive therapy, family therapy, social engagement

Pharmacotherapy: use of opioid agonist or use of some antagonist

(disulfiram for alcohol) Impact of substance abuse on society and health: The negative consequences of drug abuse affect not only individuals who abuse drugs but also their families and friends, societies, and government resources. The most obvious effects of drug abuse which are manifested in the individuals who abuse drugs include ill health, sickness and, ultimately, death. Injecting drug abuser is more prone to needle borne infection like hepatitis and HIV AIDS.

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Children of individuals who abuse drugs often are abused or neglected as a result of the individuals' preoccupation with drugs. Children whose parents and other family members abuse drugs often are physically or emotionally abused and often lack proper immunizations, medical care, dental care, and necessities such as food, water, and shelter. The risk to children is even greater when their parents or guardians manufacture illicit drugs such as methamphetamine. Methamphetamine abusers often produce the drug in their own homes and apartments, using hazardous chemicals such as hydriodic acid, iodine, and anhydrous ammonia. Children who inhabit such homes often inhale dangerous chemical fumes and gases or ingest toxic chemicals or illicit drugs. Alcohol use contributes to a wide range of diseases, health conditions and high-risk behaviours, from mental disorders and road traffic injuries, to liver diseases and unsafe sexual behaviour. The economic impact of drug abuse on businesses whose employees abuse drugs can be significant. While many drug abusers are unable to attain or hold full-time employment, those who do work put others at risk, particularly when employed in positions where even a minor degree of impairment could be catastrophic; airline pilots, air traffic controllers, train operators, and bus drivers are just a few examples.
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Drug or substance abuse is a social cancer. It is essential to stop the further proliferation of this evil disorder. Only a pro-life attitude of young generations can break this age old psychosocial dogma.
Source: World Health Organization UNODC Narcotic Control Bureau, India

DISEASE OUTBREAK NEWS

Middle East respiratory syndrome corona virus (MERS-CoV)

(26th

June, 2013)

The Ministry of Health (MoH) in Saudi Arabia has announced seven additional laboratory-confirmed cases and a death in a previously confirmed case of Middle East respiratory syndrome coronavirus (MERS-CoV). Read more

FORTHCOMING EVENTS

A Teachers Development Programme

for School

Techers will be organized by GNIPST on 29th June, 2013 at college auditorium. The theme of the programme is Recent Trends of Life Sciences in Higher Education
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Two short-term (2 weeks each) AICTE-sponsored refresher

courses on: Innovation and excellence in Pharmaceutical Sciences for teaching staffs of the Indian Universities and colleges in QIP Nodal Cell (Pharmacy), Department of Pharmaceutical Technology, Jadavpur University, Kolkata-700 032 from 2nd July to 29th July,2013. Read more

AICTE

Sponsored

Quality

Improvement

Programme

on

Production to Prescription - Opportunities for Innovation on MCOPS, Manipal University from 1-13th July, 2013. Read more

DRUGS UPDATES

FDA approves Vibativ for hospitalized patients with bacterial pneumonia (21st
June)

The U.S. Food and Drug Administration today expanded the approved use of the antibiotic Vibativ (telavancin) to treat patients with hospital-acquired and ventilator-associated bacterial pneumonia (HABP/VABP) caused by Staphylococcus aureus. Vibativ should be used for the treatment of HABP/VABP only when alternative treatments are not suitable. Read more

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FDA approves Xgeva to treat giant cell tumor of the bone

(13th June, 2013)

The U.S. Food and Drug Administration today expanded the approved use of Xgeva (denosumab) to treat adults and some adolescents with giant cell tumor of the bone (GCTB), a rare and usually non-cancerous tumor. Read more

CAMPUS NEWS The following B.Pharm. final year students have qualified, GPAT2013. We congratulate them all.

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STUDENTS SECTION
WHO CAN ANS WER FIRS T???

Which drug was first synthesized by C.R.A. Wright in 1984 ?

Which drug was first isolated by R. Mechoulam and Y .Gaoni?

Answer of Previous Issue Question:

A) Albendazole B) Ancylostoma

Send your thoughts/ Quiz/Puzzles/games/writeups or any other contributions for Students Section & answers of this Section atgnipstbulletin@gmail.com EDITORS NOTE I am proud to publish the 3rd issue of 26th Volume of GNIPST

BULLETIN. GNIPST BULLETIN now connected globally through facebook account GNIPST bulletin I want to convey my thanks to all the GNIPST members and the readers for their valuable comments, encouragement& supports. I am thankful to Dr. Abhijit Sengupta, Director of GNIPST and Prof. Dipankar Chakraborty, Registrar of GNIPST for their valuable advice and encouragement. Special thanks to Dr. Prerona
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Saha and Mr. Debabrata Ghosh Dastidar for their kind co-operation and technical supports. An important part of the improvement of the bulletin is the contribution of the readers. You are invited to send in your write ups, notes, critiques or any kind of contribution for the forthcoming special and regular issue.

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ARCHIVE The general body meeting of APTI, Bengal Branch has been conducted at GNIPST on 15th June, 2012. The program started with a nice presentation by Dr. Pulok Kr. Mukherjee, School of Natural Products, JU on the skill to write a good manuscript for publication in impact journals. It was followed by nearly two hour long discussion among more than thirty participants on different aspects of pharmacy education. Five nonmember participants applied for membership on that very day. GNIPST is now approved by AICTE and affiliated to WBUT for conducting the two years post graduate course (M.Pharm) in

PHARMACOLOGY. The approved number of seat is 18.

The number of seats in B.Pharm. has been increased from 60 to 120. 2nd World Congress on Ga-68 (Generators and Novel Radiopharmaceuticals), Molecular Imaging (PET/CT), Targeted Radionuclide Therapy, and Dosimetry (SWC-2013) : On the Way to Personalized Medicine Dates 28 Feb 2013 02 Mar 2013 Location: Chandigarh, India.Details. AICTE has sanctioned a release of grant under Research Promotion Scheme (RPS) during the financial year 2012-13to GNIPST as per the details below:
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a. Beneficiary Institution: Guru Nanak Institution of Pharmaceutical Science & Technology. b. Principal Investigator: Dr. Lopamudra Dutta. c. Grant-in-aid sanctioned :Rs. 16,25000/- only d. Approved duration: 3 years e. Title of the project: Screening and identification of potential medicinal plant of Purulia& Bankura districts of West Bengal with respect to diseases such as diabetes, rheumatism, Jaundice, hypertension and developing biotechnological tools for enhancing bioactive molecules in these plants.

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