Quick Reference for Treatment of Pesticides Poisoning

Containing treatment outlines for the most commonly used pesticides.

The information and recommendations given in this booklet are based on our best present knowledge. PAPA declines any responsibility or liability arising from the use or misuse of the information contained herein.

Second Edition September 1999

Pakistan Pesticides
909-910, Park Avenue, P.E.C.H.S., Shahrah-e-Faisal, Karachi-75400 Tel: 454 1562 Fax: 454 6131

IMPORTANT NOTES

1.

This booklet is a quick guide for emergency treatment for cases of acute pesticides poisoning meant for use by qualified medical practitioners, doctors and physicians. This is NOT a guide for first aid treatment or a comprehensive medical text. in all cases of reported pesticides poisoning, efforts should be made to obtain the original container to verify the intoxicants. In case of acute poisoning, samples of mesis, gastric lavage or skin washings shouid be taken for chemical analysis.

2.

3.

Acknowledgments:
The Safety, Health and Environment Committee of Pakistan Agricultural Pesticides Association is thankful to its founder member Novartis (Pakistan) Limited who very kindly assisted the Association in developing this reference booklet on treatment of Pesticides Poisoning. This booklet is meant for use by qualified medical practitioners only.

CONTENTS
Page Recommended Method for Gastric Lavage 1. Chlorinated Hydrocarbons ----------------2. Organophosphorous Compounds -------------------------Carbamates ____________; _________-__________--------------------3. Pyrethroids -------4. Aresenicals ________________________________ _______ 5. 6. 7. Phosphine 8. Coumarin lndandiones -- ---- -9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22.
--------- --

_______________________ ---------- ------ -

Emergency

Response

Addiesses

-------------------------

1 2 4 7 9 11 13 14 16 17 18 19 20 21 23 25 26 27 29 32 33 34 42

R E C O M M E N D E D M E T H O D F O R G A S T R I C LAVAGE NOTE: UNCONSCIOUS PATIENTS HAVE TO BE TREATED WITH SPECIAL CARE. FOR EXAMPLE AN ENDOTRACHEAL TUBE SHOULD BE PLACED PRIOR TO GASTRIC INTUBATION

If the patient has a poor cough reflex, protect the lungs and the patency of the airway by inserting a cuffed endotracheal tube before passing a stomach tube. In conscious patients and even unconscious patients with intact cough and gag reflexes, a large bore stomach tube may be passed at once. Place the patient so that his mouth is lower than his trachea. Remove any dentures and keep the mouth open with a gag. Lubricate the tube with glycerine or a suitable jelly, and ease it over the tongue and down the esophagus to a distance of about 50 cm in adults. Suck out the stomach contents using gentle mechanical suction if available. If a source of continuous suction is not available, a large syringe fitted with an adaptor will help. If little or nothing is obtained, it may be that the tube is not correctly located. Proper positioning of the tube can be checked by forcing a little air down it and listening with a stethoscope over the stomach-for bubbling sounds. After making a reasonable effort to remove any stomach contents and being quite certain that the end of the tube is in the stomach attach a large evacuator or funnel to the oral end of the tube. Add water or physiological saline heated to about body temperature. (300 ml for adults, or less for children). If a funnel is used, elevate the oral end of the tube and allow the water to enter the stomach by gravity. For this purpose, it may be necessary to use an adaptor and add a length of tubing between the funnel and the stomach tube so to increase the overall length and make it easier to regulate the height of the column of water. Before all the water has passed into the stomach, lower the tube into a basin or jar and allow the stomach contents to spihon off, do not use more than 300 ml for each washing, because a large volume would have more tendency to cause emptying of the stomach contents into the duodenum. Repeat the lavage the returning fluid is clear. As tube used for evacuating the stomach content must have a rounded, solid end to facilitate passage through the oesophagus. If must have at least one large opening in the side just behind the tip and is better if it has several large holes placed at intervals back from the tip. The outer wall must be very smooth. Stomach evacuator tubes commonly sold for use in children have an outside diameter of 7.33 mm (No 22 Charriere scale). Those for adults commonly measure 10 mm (No 30 Charrfere scale). Source: Guidelines for emergency measures in case of pesticide poisoning GCPF

CHLORINATED

HYDROCARBONS

Examples of Commercial Products and Generic Names

BHC Chlorothalonil DDT Endosulfan (Daconil) (Endon, Sialan, Hektionex,

Thiodan, Thioluxan, Endosulfan + Dimethoate Heptachlor (Aflix)

Pharmacological
Hepatotoxic Neurotoxic Nephrotoxic

Action or Site of Toxicitv

Routes of Absorption
Ingestion Dermal Inhalation (negliglle)

WHO Hazard Classification

Class

svmotoms
Onset: Twenty minutes to four hours after exposure. Nausea, Vomiting, Restlessness, Tremor, Apprehension, Convulsions. Coma, Respiratory Failure, Death. The Biological and Environmental behaviour of Endosulfan is totally different to Chlorinated hydrocarbons but for medical reasons the compound is grouped on Chlorinated hydrocarbons.

Chlorinated Treatment
1. Watch breathing closely. respiration if needed.

Hydrocarbon

Aspirate.

Give

oxygen

and

or/artificial

2.

Diazepam or barbiturates in appropriate dosages repeated as necessary for restlessness or convulsions. (Phenobarbitone (100 mg) or diazepam (10 mg IM or IV), It may be necessary to continue treatment for up to two weeks after poisoning AVOID OILS, OIL LAXATIVES AND EPINEPHRINE (ADRENALIN).

3. 4.

DO NOT GIVE STIMULANTS OR ATROPINE.

Give calcium gluconate (10% four hours. 0 ml ampules) intravenously every

5.

Cholestyramine 4 gm 4 times/day (before meals and bedtime) to accelerate biliary fecal excretion. Prolonged treatment (several weeks) may be needed. Gastric lavage using activated with 30 gm, sodium sulphate. charcoal (40 gm Charcoal) Chatharsis

6. 7

DO NOT INDUCE EMESIS IF THE INGESTED POISON IS PRINCIPALLY A HYDROCARBON SOLVENT (e.g. KEROSENE). If poisoning occurred via dermal route, skin and hair should be decontaminated. In case of AFLIX 2 mg Atropine sulphate IV (to be treated if necessary)

8.

Lab Tests
No simple test. Only complex laboratory procedures. A high urine level of organic chlorine or especial or p-chlorophenyl acetic acid indicates exposure to DDT or to one of the analogous compounds. The level however is no indicative of the severity of exposure.

ORGANOPHOSPHORUSCOMPOUNDS ExampIes
Acephate Azinophos Methyl Cadusafos Chlorfenvinphos Chlorpyriphos Chlorpyriphos methyl Dichlorvos (De De Vap. Dimetaxal, Foiek, Phosvit, Vapona, Nokovos, Vision, Nicavos) (Chemathoate,Dimetaxal. Higonet, Luxagan, Perfekthion, Rogar, Roxion, Systoate, Stinger) (Aflix) (Agrilex, (Basudin) (Ethion) (Anthio) (Sumithion) (Azodrin, Azofas Apadrin, Monophos, Nokout. Suncrotophos. Tiger. Titophos) (Supracide) (Grip, Monitor. Pandaphos, Sundaphos, Shangnong, Tamaron, Chaser, Jiangmen) Methylparathion Malathion Methamidophos + Cyfluthrin Methamidophos + Oxydemetion Methyl (Assomido, Folidol, Pillaron, Paramet. Jiashou) (Emmatos, (Baythriod, (Magnum) (Metasystox R) Fyfanon, T.M.) MLT.) Disystone, Solvirex) (Birlanej (Lorsban, Nurelle-D, Kurifast Cyren)

of Commercial Products and Generic Names

(Asophate, Sephate, Orthene) (Gusa!hion M)

Dimethoate

Dimethoate + Endosulfan Disulfoton Diazinon Ethion Formathion Fenitrothion Mononcrotophos

Methidathion Methamidophos

ORGANOPHOSPHORUSCOMPOUNDS
Profenofos Phorate Pirimiphos Pyrazophos Phenthoate Prothoate + Dimethoate Qunaiphos Trichlorfon Triazophos (Curacron, (Thimet) (Actellic) (Afugan) (Cidial) (Facron-s) (Ekalux) (Dipterex) (Deltaphos, Hostathion) Polytrin C)

Anticholinesterase (Irreversible)

Routes of Absorption
Ingestion Inhalation Dermal

WHO Hazard Classification

class

1.

MILD--anorexia, headache, dizzines, weakness anxiety, tongue and eyelids, miosis, impairment of visual

tremors

of

2.

MODERATE--nausea, salivation, lacrimation, abdominal cramps. vomiting, sweating, slow pulse, muscular tremores. SEVERE-diarrhoea. pinpoint and non-reactive puplis, respiratory difficulty, pulmonary edema, cyanosis, loss of sphincter control convulsions. coma and heart block.

3.

Organo Phosphorus

compounds

Treatment SPEED IS IMPERATIVE. Persons giving First aid should avoid contact with contaminated clothing and vomitus. 1. Maintain adequate and cardiac functions. Keep airway open.
Aspirate, use oxygen, insert endotracheal tube. Artificial respiration and tracheostomy in severe cases. 2. INJECT MASSIVE DOSES OF ATROPINE (l-3 mg) EVERY MINUTES UNTIL SIGNS OF ATROPINIZATION OCCUR. Signs of atropininzation include dry, flushed skin, pupillary size of at least 4mm, & heart rate of 120/min. Do not give atropine to a cyanotic patient. Give artificial respiration first than administer atropine I.M. or S.C. Atropine prophylaxis is not recommended. Maintain atropinization for at least 24it 48 hours and carefully observe the patient as the drug is withdrawn may be necessary to recommence treatment if signs of poisoning returns. Draw blood for cholinesterase test, preferably before Antidote (2 PAM or Toxogonin) are given. If available, protopam chloride, (2-PAM or Toxogonin), 1 gm I.V. slowly over a period of 5 minutes, Given second dose of 500 mg, in 30 minutes if muscle weakness persists. This drug must NOT be used as an alternative or in preference to atropine the use of which is ESSENTIAL. AVOID MORPHINE, TEHOPHYLLIN A M I N O P H Y L L I N E , BARBITURATES OR PHENOTHIAZINES. For skin contact, wash with soap and water, Wear rubber gloves while washing contact areas. For ingestion, lavage with activated charcoal slurry (100 gm charcoal in 150 ml water). Because of reabsorption of these compounds from fatty tissue, treatment of exposed people should continue for several days. Patient must remain atropinised for sufficient length of time (24-48 hrs.) Drug treatment may be required for upto 10 days in sever cases. Keep patient strictly at rest.

3. 4.

5. 6. 7. 8.

9.

Lab Tests
Red cell cholinesterase test. Levels 3050% of normal indicate exposure, although symptoms may not appear until the level falls to 20% or less, urine p-nitrophenol may indicate exposure to parathinon, chlorthion, ethion and EPN. Serum cholinesterase test to be done.

CARBAMATES
Aldicarb Carbosulfan Carbofuron Cartap Carbaryl Dithiocarbamate Furathiocarb Methomyl Pirimicarb Thiofanox Triazamate (Temik) (Advantage) (Brifur, Curaterr, Sunfuran) (Padan) (Sevin) (Antroacol) (Deltanet) (Lannate, Nudrin) (Pirimor) (Decamox) (Aztec) Furadan,

Action or Site of Toxicity

Anticholinesterase (Reversible)

Routes of
Ingestion Inhalation Dermal

WHO Hazard Classification

Class

Blurred Vision, disturbances of Retrobulbar pain, constriction of pupils, Salivation, Profuse sweating, Lasstude, Muscle Incoordination, Nausea, Vomiting, Diarrhoea, Epigastric pain, Tightness in chest.

Carbamates Treatment SPEED IS IMPERATIVE

Persons giving first aid should avoid contact with contaminated clothing and vomitus. 1. Maintai adequate respiratory and cardiac aspirate, use oxygen, insert endotraceal tracheostomy in severe cases. functions. Keep airway open, tube. artificial respiration and

2.

FOR EXTREME SYMPTOMS OF O.P. POISIONING INJECT (1-3 mg) EVERY 5-10 MINUTES UNTIL ATROPINE SIGNS OF ATROPINIZATION OCCURS. Signs of atropinization includes dry flushed skin, pupillary size of at least 4 mm, & heart rate of 120/min. Do not give atropine to a cyanotic patient. Give artifical respiration first then administer atropine I.M. or S.C. Atropine prophylaxis is not recommended. In case of Padan I.V. Injection of 100-200 mg L-cystine or I.M. injection of 20-60 mg of BAL are recommended by the manufacturer. For skin contact, wash with soap and water. Water rubber gloves while washing contact areas. For ingestion, lavage with activated charcoal slurry (100 gm charcoal in 150 ml water). AVOID MORPHINE, BARBITURATES THEOPHYLLINE, AMINOPHYLLINE, OR

6.

2-PAM OR TOXOGONIN

IS CONTRA-INDICATED therefore do not use

Lab Tests
Red cell cholinesterase test. Levels 30-50% of normal indicate exposure, although symptoms may not apthe level falls to 20% or less. Values may return to normol within 12 pear to 72 hrs. depending on severity of poisoning. 1 -naphthol, normally found in traces, is excreted in urine in much higher concentration following Carbaryl (Sevin) ingestion. Serum cholinesterase test to be done.

PYRETHROIDS of Commercial Products and Generic Names

Alpha-Cypermethrin Bifenthrin Beta Cyfluthrin (Bestox, Talstar Bulldock Magnum (Arrivo, Cheeta, Cymbush, Cyperkill, Lucky Cypermethrin, Nurelle, Ripcord, Sherpa, S u n n m e r i n , Ustad) (Baythriod) (Baythriod TM) (Aimos-D, Laser) (Nurelle-D) (Decis) (Decis-D) (Pay-off) (Danitol, (Karate, Labdathrin) (Ambsh, Coopex, Permasect, Pounce, Talcord) (Fenkill, Sumicidin) (Sumincidin Super) (Fury) Fenthrion) Fastac, Alphafos, Skolix)

Beta Cyfulthrin + Methomidophos Cypermeihrin

Cyfluthrin Cyfluthrin + Methamidophos Cypermethrin + Dimethoate Cypermethrin + Chlorpyriphos Deltamethrin Deltamethrin + Dimethoate Flucythrinate Fenpropathrin Lambda-Cyhalothrin Permethrin Fenvalerate ES-Fenvalerate Zeta-Cypermethrin

Action or Site of Toxicity

Allergnic neurotoxic

Routes of Absorotion
Ingestion Dermal Inhalation

Pyrethroid WHO Hazard Classification

Class III

Symptoms
Allergic reaction following pyrethroids exposure manifest themselves like asthmatic symptoms (bronchospasm swelling of mucous membranes etc.) upto anaphylaxis. Excessive salivation, choreoathetosis., convulsions, tremors.

Treatment
1. 2. 3. Severe allergic reactions have to be treaied wiih adrenalin Less severe allergic reaction can be treated with antihistamines. For ingestion lavage using activated charcoal slurry (100 gm in 150 ml water). For skin contact wash exposed area. Symptomatic treatment. Atropine sulphate to suppress salivation & reduce severity of some of the signs of poisoning. Diazepam for convulsions.

Lab Tests
No simple test. Only complex laboratory procedure.

10

ARSENICALS

(INORGANIC)

of Commercial Products and Generic Names

Lead Arsenate Paris Green Sodium Arsenite

Action or Site of Toxicity

Blocking of the functional thiol groups, especially on capillaries, epidermis and nervous system.

of
Ingestion Inhalation

WHO Hazard Classification Class I Symptoms

In acute arsenic poisoning a garlic odor to breath and feces helps to identify the responsible toxicant. Arsenic inhalation causes Haemoglobin leading to acute tuber necrosis followed by anuria, Other symptoms are Chills, weakness cramps, vomiting and prostration. After thirty minutes to many hours profuse vomiting & painful diarrhoea which may become bloody later. Colicky pains in esophagus, stomach and bowel. Dehydration, thirst, muscular cramps, cyanosis, feeble pulse and cold extremities. Headache, Dizzines, Vertigo, Delirium or Stupor, Skin eruption, Convulsions. Three terminal signs. Coma General paralysis Death

INGESTION: Chief Initial symptoms are those of a violent

gastroenteritis, burning esophageal pain, vomiting, watery or

bloody diarrhoea containing much mucous, later collapse, shock, market weakness, Death generaly due to circulatory failure. INHALATION: may cause pulmonary edema, restlessness, dyspensia
cyanosis and foamy sputum.

11

Arseniclas (Inorganic) Treatment

1. 2. 3. 4. For ingestion, gastric lavage followed by Instillation of activated charcoal slurry (40 gm charcoal). For skin contact wash with soap and water. Acute symptoms will not develop except for sodium arsenite Saline catharitc (15 to 30 gm sodium sulfate). BAL in a 10% solution in oil -- intra muscularly -- (see schedule) or D-Pencillamine 0.5 g q6 h given 30 to 60 minutes before meals and at bedtimes. Check blood pressure and treat shock. Isotonic saline for Intravenous use to contract dehydration. Electrolyte infusion might be necessary to substitute losses due to diarrhoea. Morphine may be needed for abdominal pain.

5. 6. 7.

BAL SCHEDULE SEVERE

POISONING
Day 1 2 3 (6 3 (4

MILD

POISONI NG

Injectins)

2.5 (4 Injections) 2.5 mglkg (2 Injections) 2.5

Day2

Injectins)

Day 4-10

3 mglkg (2 Injectins)

BAL: Brithsh Anti Lewisite Compound. (2.3 Dimercapto-1 dimercaprol)

or

Lab Tests
No simple test. Only complex laboratory procedures. Save initial stomach contents and urine for arsenic analysis. Urine may show red blood cells, albumin and casts. After arsenic inhalation urine shows Haemoglobin relnsch Test.

HALOGEN FUMIGANTS Examoles of Commercial Products and Generic Names

Methyl Bromide (Dofume, Bromomethan, Terabol, Saibrom, Brom-o-Gas)

Action or Site of Toxicity

CNS depressant Nephrotoxic Liver damage

Routes of Absorotion
Ingestion Inhalation Dermal

WHO Hazard Classification

Class I

Svmptoms
Appears after four to twelve hours following inhalation. Symptoms include dizzines. headache, anorexia, nausea, vomiting, and abdominal pain, lassitude, weakness, slurring speech and staggering gait. Mental confusion, mania, tremors and epileptiform convulsions, Bromides cause: Rapid respiration, pulmonary edema, cyanosis, collapse, coma, areflexia and death due to respiratory or circulatory failure. Late manifestation may include bronchopneumonia, pulmonary edema, and respiratory failure. Methyl bromide may produce cutaneous blisters and kill via dermal exposure.

Treatment
IN METHYL BROMIDE POISONING, EARLY TREATMENT WITH BAL MAY BE CONSIDERED. GIVE BAL SOON AFTER LIFE THREATENING EXPOSURE. 1. First remove patient from contaminated area. Give BAL 3-5 for 4-6 doses. 2. 3. 4. 5. Remove all contaminated clothing and wash contaminated skin penetrate ordinary rubber gloves. Restrain confused convulsions. and maniacal patients. Diazepam or barbiturates can for

May require specific therapy for acidosis, pulmonary edema, bronchospasm, (use epinephrine subcutaneously). Respiratory paralysis and/or kidney failure.

Lab Test
No simple test. Only complex laboratory procedures. Blood electrolytes to detect acidosis. Note: BAL British Anti Lewisite Compound. Dimercapto-1-proponal or dimercaprol).

CYANIDE FUMIGANTS Examples of Commercial Products and Generic Names

Acrylonitrite Calcium Cyanide Hydrogen Cyanide (Organic Bound Cyanides) (Cyanogas) (Hydrocyanic Acid)

Action or Site of Toxicity

Cell Metabolism Cyanide fumigants affect cytochomoxidases primarily in heart and brain.

Routes of Absorption
Ingestion Inhalation Dermal

WHO Hazard Classification

Class I

Symptoms
One of fastest acting known poisons. MASSIVE DOSE unconsciousness and death without warning. SMALLER DOSES illness may last one or more hours. FOLLOWING INGESTION: bitter, acrid, burning taste followed by constriction of membrane in throat. Salivation and nausea without vomiting, anxiety, confusion, and dizziness. Variable respirations inspiration short and expiration prolonged. Order of bitter almonds in breath and vomitus. Initial increase in blood pressure and slowing of heart followed by rapid and irregular pulse. palpitation and constriction of chest. Unconsciousness, and death from respiratory failure.

Treatment
SPEED IS IMPERATIVE If apneic, start artificial respiration. Keep airway open. INHALATION OF AMYL NITRITE (AMYL NITRITE PEARLS) every 15 30 seconds of glycerol trinitrate (Nitrol) 1 inch applied on the non-halry past of the chest near the heart. Intravenous injection (even of non-sterile solution) of 10 ml of 3% sodium nitrite over 2-4 minute period. DO NOT REMOVE NEEDLE. Through same needle give 50 ml of 25% solution of sodium thiosulfate over 10 minutes.

14

Cvanide ALTERNATIVE 5. 6. 7. 8. to sodium 5

Fumiaants

nitrate and sodium thiosulfate: IV bolus, single dose.

If symptoms recur repeat the nitrite and thiosulfate. In case of ingestion stomach lavage with 5% sodium bicarbonate should follow the above procedure. After lavage, Charcoal (40 gm) should be placed into the stomach. Oxygen therapy end blood transfusions may be necessary if nitrite methemoglobinemia becomes severe.

Lab Tests No simple tests. Only complex laboratory procedures. Send blood for cyanide levels. usually associated with symptoms. Levels of 0.1

15

PHOSPHINE

FUMIGANTS

of Commercial Products and Generic Names

Aluminium Phosphide (Celphos, Quickphos, Phostoxin, Gastowin, Delitia, Detia gas, Agtoxin)

Action of Site or Toxicity

Toxic to lungs CNS depressant Toxic to myocard

Routes of Absorption
inhalation

WHO Hazard Classification

Class I

Symptoms
Nausea, vomiting, diarrhea, great thirst, headache, vertigo, tinnitus, pressure in chest, back pains, dyspnea, a feeling of coldness. and stupor or attacks of fainting. May develop hemolytic icterus and cough with sputum of a green fluorescent color. Tremors, convulsions, and coma leading to death. Hematuria and anurla due to kidney damage. Acute pulmonary edema, hypertension, cardiac arrhythmlas and convulsions in severe cases.

Treatment
No specific antidote. Symptomatic treatment 1. 2. 3. Control of convulsions with injection of diazepam (5-10 Keep patient quiet and warm. May need to treat incipient pulmonary edema with venesection. oxygen, and hypertonic glucose (50%) infusions. Intravenous isotonic solutions are contraindicated. In case of ingestion, Copper Sulfate 0.25 gm in a glass of water, (Forms insoluble Copper Phosphides) Monitor Calcium levels, Give 10% Calcium Gluconate 10 ml IV to maintain Calcium level. Monitor heart rate while giving calcium. gm in adults).

4. 5.

Lab Test
None

COUMARIN

INDANDIONES

Examoles of Commercial Products and Generic Names

Coumarin Diphacinone Calciferon Brodifacoum Coumate tralyl (Ratilan, Tomorin) (Diphasin, Ramik) (Warfarin) (Klerat) (Racumin)

Action or Site of
Anticoagulant

Routes of Absorption
Ingestion Dermal

WHO Hazard Classification

Class I-III

After repeated ingestion for several days, bleeding from nose, gums and into conjunctive urine and stool. Possible pallor and petechial rash. massive ecchymoses or hematoma of skin, joints, brain hemorrhage, Late -(back pain, renal colic and weakness due to hemorrhage) Shock and death.

Treatment
Lavage stomach with tap water. Catharsis 30 gm, sodium sulfate in 250 ml tap water. Charcoal suspension should be instilled after gastric lavage. To restore blood clotting give 10 to 20 mg Vitamin K (Aquamephyton I.V. or Menaphthone Sodium Bisulfite KAPLIN) by oral. Intramuscular or intravenous route depending on severity of case. Vitamin C may be a useful adjunct. Transfuse with fresh blood if bleeding is severe or until anemia is corrected. 5. 6. Iron (ferrous sulfate) by mouth for correction of secondary anemia 0.3 gm t.i.d. Treatment of intoxication with anticoagulants should be followed up for several weeks. in urine and faeces.

Lab Tests
Prothrombin activity of blood plasma, blood

17

CHLOROPHENOXY Exarnoles

COMPOUNDS

of Commerdal Produas and Generic Names

4-D) DMA-6

Dichlorophenoxyacetic acid (2. DSMA. MSMA (Sodium t&noananares)

Phannacoloqical Adion or Site of Totic@ Hepatototic Nephrotoxic Newo Toxic Routes of Absorotion
Ingestion DerrlM Inhalation

WHO Hazard Classification Cl&s III

Irritation of inhalation route (skin. nascpharynx. mouth throat, gastrointestinal tract). em&s. abdominal pain, muscle twitching and metabolic acidosis. diarrhea. Weakness. and p3haps lettmrgy. anorexia. Muscle weakness . may involve the muscles of mastication and swallowing Ventricular fibrillaton and/or cardiac arrest and death

Treatment t. 2. 3. 4. 5.
For ingestion, lavage with activated charcoal slurry. For skin contact wash exposed area. Metabolic addosis should be treated with infus&s of sodium biirbonate (Alkalinix the urine by IV scdwm bicarbonate lo-15 gm daily) Supportive treatment.

Ouinidine

sulfale

w calcium Mockers to svppress abmxmal

ventricular

cardiac rhythm. For muscle and cardiac irritability give Lidocafne by l-4 mglmin by infusion as needed.

50-l 00 gm IV. followed

labTests No simple test. Only complex laboratory prccedures.

18

UREAS Examples of Commercial Products of Generic Names

Cinmethylin Chlorotoluran Cyanazine Dicamba Fluometuron Flufenoxuron FIufenoxuron+alphacypermethrin Isoproturan Methabenzthiozuron Triasulfuran Teflubenzuron (Argold) (Dicuran) (Bladex) (Banvil) (Cotogard) (Cascade) (Casfas) (Arelon, Graminon, Matrix, Tolkan. Proton, Swat) (Tribunil) (Log ran) (Nomolt)

Mocous

membrane irritant

Routes of Absorotion
Ingestion

WHO Hazard Classification

Class

Svmptoms
During handling may cause irritation of eyes, nose, throat and skin ingestion may cause gastroenteritis.

Treatment
1. 2. 3. For ingestion, lavage with activated charcoal slurry, for skin contact, wash exposed areas. Supportive treatment. Avoid contact with skin, eyes and clothing.

Lab Tests
No simple test. Only complex laboratory procedures.

19

HYDOXYBENZONITRILE of Commercial Products and Generic Names

Bromoxynil (Buctril, Quattro)

Action or Site of Toxicity

Increase cellular metabolism

Routes of Absorption
Ingestion Dermal

WHO

Classification

Class II Moderately Hazardous

Svmptoms
May cause irritation of eyes, Ingestion may cause raised body temperature. increased heart and respiration. rate, sweating, disorientation, Stomach pain, Vomiting and Nausea.

Treatment
For skin contact flood exposed skin with water. Remove contaminated clothing and wash skin with soap and water. If swallowed the stomach should be emptied, ingestion should be treated symptomatically.

Lab Tests
No simple test. Only complex laboratory procedures.

20

BIPYRIDYLS Examoles of Commercial Products and Generic Names

Paraquat (Gramoxone. Pillaroxone)

Action or Site of Toxicity

All Pharmacological actions are based on a generation of free radicals caused by bipyridyls. This happens in almost every tissue. Neurotoxic Nephrotoxic Oculo toxic Toxic to lungs Hepatotoxic

Routes of Absorotion
Ingestion Inhalation Dermal

WHO Hazard Classification

Class II

Symptoms
Early symptoms stem from an injury of all epithelial tissues that have been in contact with the pesticide e.g. burning of mouth, oral ulcerations, substernal. abdominal pain, vomiting, diarrhea and myalgia. INGESTION: burning in the mouth & throat, vomiting.

AFTER 2-5 DAYS: Hemolysis, oliguria, ulceration of the tongue, pharynx and esophagus. AFTER 5-8 DAYS: Jaundice, fever, tachycardia, respiratory distress and cyanosis. PROLONGED Inhalation of spray droplets: Nosebleed EYE CONTAMINATION: Sever conjunctivitis & sometimes protracted & even permanent opacification.

21

Bipyridyls Treatment SPEED

1.

IS

IMPERATIVE

For ingestion, lavage with activated charcoal (50-l 00 gm in 100 ml water) followed by 200 ml of 30% suspension of Fullers earth (Bentonite), repeated twice daily for the first 48 hours. if fullers earth is not available use activated charcoal. Also administer 200 ml of 20% mannitol in the gastric tube. Bentonite is the ideal absorbent (alternate Charcoal) which should be instilled after forced emesis or gastric lavage. Decontaminate, Flush amounts of water. Do not administer contaminated supplemental skin, oxygen. hair and eyes with large

2. 3. 4. 5.

Forced diuresis, hemodialysis or peritoneal dialysis. Maintain urine out put at 200 ml/hr. Furosemide 20 mg I.V. every 4-8 hrs may be necessary. Charcoal hemoperfusion is most effective if begun within the first 12 hours.

Lab Tests
Simple calorimetric (dithionite) test in the urine. Blue Colour indicates the pres-ence of paraquat in excess of 0.5 mg/l.

22

ALL Examples of Commercial Products and Generic Names

Atrazine Ametryn + Atrazine Amitraz Bupirimate Clodinafop Propargyl Chlorfenapyr Carbendazim Carfentrazone Ethyl Carfentrazone + lsoproturon Clomazone Cinmethylic Cyanazine Dimethormorpt Diafenthiauron Dazomet Ethalfluralin Flurochloridone Fenarmol lmazamethabenz Metaolachlor Metalaxyl Pendimethalin Percloraz Pertilachlor Penconazole Terbuthylazine + Terbutryn Thiamethoxam Trifuralin Mucous memberane and skin irritant (Primextra, Aatrax) (Gesapax) (Obasyn. Mitac) (Nimrod) (Topik) (Pirate) (Derosal) (Aim) (Affinity) (Commond) (Argold) (Bladex) (Acrobat) (Polo) (Basamid) (Sonalan) (Racer) (Rubigan) (Assert) (Dual Gold) (Octave) (Rifit) (Topogard) (Actara,Cruiser) (Treflan, Drifan, Orifan. lpiflour

Action or Site of Toxicity Routes of Absorption

Ingestion Dermal Inhalation

WHO Hazard Classification

Class During handling many cause irritation of eyes, nose, throat and skin ingestio may cause gastroenteritis.

23

Treatment
1. Eyes: 2. Skin: 3. Ingestion: Flush eyes with plenty of water. a physician if irritation develops. Wash ail exposed areas with plenty of soap and water. Contact a physician if irritation develops. If swallowed, do not induce vomiting. Call a physician, administer activated charcoal (6-8 heaping teaspoonfuls) with plenty of water. Do not give anything by mouth to an unconscious patient. Transport to medical care facility and see a physician. Remove individual to fresh air. If breathing difficulty occurs, call a physician.

4.

inhalation:

Lab Test
No simple test. Only complex laboratory procedures.

24

THIOCARBAMATES of Commercial Products and Generic Names

Captan (Thalamide group) Dithianon Maneb Mancozeb Thiobencarb (Captan) (Delan) (Dithene, Polytram) (Manzate, Nemispor, Pencozeb, Sancozeb) (Saturn)

Neurotoxic Skin irritant Inhibition of aldehyde dehydogenase

Routes of Absorption
Ingestion Dermal Inhalation

WHO Hazard Classification

Class

WITHOUT ALCOHOL INGESTION. Itching, redness, dermatitis, hoarseness, coughing, nausea, vomiting, ataxia, muscle weakness, paralysis. WITH ALCOHOL INGESTION. (Due to aldehyde dehydrogenase inhibition). Flushing sweating shortness of breath, chest pain, hypotension.

Treatment
1. 2. 3. 4 . Decontaminate, Wash vated charcoal. Supportive therapy If complicated with alcohol, oxygen as needed and Vitamin No alcohol for three weeks in any case. C. skin and hair for ingestion, lavage using acti-

Lab Tests
No simple test. Only complex laboratory procedures.

25

ACETAMIDE Name of Commercial Products and Generic Names

Butachlor (Machete, Bandox)

Action or Site of
information not available at present.

Routes of Absorption
Information not available at present.

WHO Hazard Classification

Class Ill

Svmotoms
There are no diagnostic symptoms of poisoning associated with the product other than to know that if actually got into eyes or was ingested.

Treatment
1. Eyes: 2. Skin: 3. Ingestion: Flush eyes with plenty of water. Call a physician if irritation develops. Wash all exposed areas with plenty of soap and water. Contact a physician if irritation develops. If swallowed, induce vomiting and treat symptomatically. Call a physician. Do not give anything by mouth to an unconscious patient. Remove individual to fresh air. If breathing difficulty occurs, call a doctor.

4. Inhalation:

Lab Test
Not applicable.

DERIVATIVES of Commercial Product and Generic Names

Metribuzin

Action or Site of
Neurotoxic

Routes of Absorotion
Ingestion

WHO Hazard Classification

Class III

Svmotoms
Not Known as yet.

Treatment
1. 2. 3. 4. Antidote not known, symptomatic treatment is recommended. and action. Check blood pressure and pulse rate frequently since brady cardia hypstonia are possible. Supportive measures for re-enforcement of breathing and Give artificial respiratory if signs of Paralysis appear. Additional therapeutic measures involve elimation of the from the body acceleration of its excretion (gastrolavage. Saline laxatives). heart

substances

5.

On oral ingestion give plenty of water (no milk no alcohol) to drink, and a suspension of 1 Og or more of medical charcoal in 150-200 ml water. Take care before inducing vomiting (should be done if chemical swal lowed is highly toxic and if medical assistance is not readily available), as there is a danger of aspiration of the solvent, with possible induction of pneumonid or pneumonitis. Only in fully conscious persons may vom iting be induced by stimulation of the back of the throat, e.g. with a fin gertip. Give plenty of liquid to drink (several litres in the course of hours) to cause forced diuresis. If sodium bicarbonate is added to infusions follow the dosage instructions exactly because of the danger of respira tory depression.

6.

Eyes: Open the eyelids with fingers and wash the conjunctiva with running water for several minutes or wash the conjunctiva with an appropriate eyewash device (e.g. plastic wash bottle filled with water).

27

T~zenona Derivatives 7. Gastric lavage should only be carriad out by a doctor and requires the presence of 2 other qualified people. It rS a mea.wre indiited for all orally ingested life-threatening quantities of poison. even after earlier vomMg and in unconsaouapersons. In convu:sions first injact 10 mg Diazepam (other banzodiarepine de rivatives may al.50 be used) intravenously as a spasmo&tiic. and to pra vent vagal reflex aIs0 first 14 administer 1 mg atropine. again by an ix. I#XtiOtl. The lavage itsetf should be carried out with wata$ vated charcoal if possible. Adults and children over 12 years: 50-100 300 to 800 ml of water (lukewan). suspension of acti

g activated charcoal in every

Children under 12 years: 50-30 g activated charcoal in every 100-300 ml of water (lukewan). If actlvatad charcoal is not available. the lavage may be carried out Wim lukewarm water alana.

a.

Ii poisoning occur& via dermal route. skin and hair should be dawn taminated.

LabTWSS
Not applicable.

NITROGUANIDINE tiamoles
lmldacloprld

of Commercial Products and Generic Names

(Confider)

Pharmacolooical Action or Site of Toxicity

NeUrOtOXiC

Routes of Absorption IngestIon

Dermal Inhalation (negligible)

WHO Hazard Classification Class II Svmotoms

(Similar to those caused by nicotine poisoning) Apathetic state. depressed muscular tone. respiratory disturbance & trembling, muscular cramps in severe cases of poisoning.

Treatment 1.
2. 3. 4. Antldote not known, symptomatic treatment is recommended. and action. Check blood pressure and pulse rate frequently since brady cardia hypstonia are possible. Supportive measures for re-enforcement of breathing and heal Give artificial respiratory if signs of Paralysis appear.

AddItional therapeutic measures involve elimation of the substances from the body acceleration of its excretion (gastrolavage, Salmelaxatives). On oral ingestron gwe plenty of water (no milk, no alcohol) to drink, and a suspension of log or more of medrcal charcoal in 150-200 ml water. Take care before inducing vomiting (should be done if chemical swal lowed is highly toxic and if medical assistance is not readily available), as there is a danger of aspiration of the solvent. with possible induction of pneumonid or pneumonitis. Only in fully conscious persons may vom sting be induced by stimulation of the back of the throat, e.g. with a fin g&p. Give plenty of liquid to drink (several litres in the course of hours) to cause forced diuresis. If sodium bicarbonate is added to infusions follow the dosage instructions exactly because of the danger of respira tory depresson.

5.

29

Nitroauaniding
6. Eyes Open the eyelii with fingers and wash ~Jw conjunUiva with running water for several minutes or wash the conjunct~va with an appropriate eyewash device (e.g. plastic wash bottfe filled with water) Gasaiclavageshould~becamedoutbyaboQocandrequiresme presence of 2 other qualified people. If is a measure indicated for all orally ingested life-threatening quanMies of poison. even after earlier vomiting and in uwxnsciws persors. In wnvulsions first inject 10 mg Diazepam (other banzodiiepme de rivatives may also be used) intravenously as a apasmofytic. and to pte vent vegal reflex afso first 14 administer 1 mg atropine. again by an i.v. l+CtiOfl. The &age itseff should be carried out wilt? watery suspension of actf vated charcoal if possible. Adults and children over 12 years: 60-100 g abated charcoal in avew 300 to 800 ml of water (lukewarm). Children wdef 12 years: 50-30 g activated charcoal in every 1 W-300 ml of water flukewarm). ff activated chmwal is not available. tha lavaga may be carried out wim lukewarm water alone. 8. If poisoning ccu~ned via darmaf route. skin and hair should be decon taminated. J

7.

I=lbTTesf. Not applicable.

30

TRIASOLE

DERIVATIVES

of Commercial Products and Generic Names

Triadimenol Triadimetion (Bayletan)

Action or Site of
Neurotoxic

Routes of Absorotion
ingestion Dermal inhalation

WHO Hazard Classification

Class III Effects CNS and at highdose, stomach & liver symptoms.

Treatment
1. 2. 3. 4. Antidote not known, symptomatic treatment is recommended. and action. Check blood pressure and pulse rate frequently since brady cardia hypstonia are possible. Supportive measures for re-enforcement of breathing and Give artificial respiration if signs of Paralysis appear. heart

Additional therapeutic measures involve elimation of the substances from the body acceleration of its excretion (gastrolavage, Salinelaxatives). On oral ingestion give plenty of water (no milk no alcohol) to drink, and a suspension of 1 Og or more of medical charcoal in 150-200 ml water. Take care before inducing vomiting (should be done if chemical swal lowed is highly toxic and if medical assistance is not readily available), as there is a danger of aspiration of the solvent, with possible induction of pneumonid or pneumonitis. Only in fully conscious persons may vom iting be induced by stimulation of the back of the throat, e.g. with a fin gertip. Give plenty of liquid to drink (several litres in the course of hours) to cause forced diuresis. If sodium bicarbonate is added to infusions follow the dosage instructions exactly because of the danger of respira tory depression.

5.

6.

Eyes: Open the eyelids with fingers and wash the conjunctiva with running water for several minutes or wash the conjunctiva with an appropriate eyewash device (e.g. plastic wash bottle filled with water).

31

Triasole 7.

Defivaties

Gash lavage should only be carried wt by a doctor anf rWJireS tf~ presmca of 2 other quafiii people. lf is a measure indhzated for all orally ingested life-threatening quantities of poison. even after earlier vomiting and in unconscious persNS In convulsions first inject 10 rng Diazepam (0tfEr banZ0diiazePirW de rivaties may also be used) intrwenOusly as a spasmdytic. and to pre vent vegaI reflex also first 14 administer 1 mg atropine. again by an i-v. lnjeclion. The lavage itseii should be carried out with watery suspension Of ti vated charcoal if possible. Aduits and children over 12 years: 50-100 g activated charcoal in every 300 to 800 ml of water (lukewarm). Chlkiren under 12 years: 50-30 g activated charcoal in every 100-300 ml of water (lukewarm). If bated charcoal is not available. the Wage may be carried out wim lukewarm water $qw. If poisoning occurred via dennal route. skin and hair should be deccm taminatad.

I?bTasr.
Not applicable.

WHO BASED

OF PESTICIDE ON TOXICITY AND HAZARD

ACUTE LD50 (RAT) body weight TOXIC RING COLOUR

CLASS

ORAL

DERMAL

SOLID

LIQUID

SOLID

LIQUID

la Extremely

RED Hazardous

5 OR LESS

20 OR LESS

10 OR LESS

40 OR LESS

lb Highly

BLUE Hazardous

lo-loo

40-400

II Moderately

YELLOW Hazardous

BROWN Slightly Hazardous

OVER

OVER 2ooo

OVER 1000

OVER

INDEX
PRODUCT GROUP PRODUCT USE PAGE NO.

2,4-D A Aatrax Acephate Acrobat Acrylonitrite Actellic Advantage Afugan Agrllex Agtoxin Aldicarb Airnos-D Alphacypermethrin Aluminum Phosphide Ambush Amettyn Anthio Antracol Apadim Arelon Argold Arrivo Asornido Atrazine Azinophos Azodrin Azofos Actara Amitraz Aztec B Banvil Basudin Bayiefon Baylan Baythorid TM Baythroia Bestox Beta Cyfluthrin BHC

Chiorophenoxy Compounds H

18

Triazine phosphorus All Others Cyanide Fumigants phosphorus Carbamtes Chlorinated hydrocar phosphorus phosphorus Phospine Fumigants Carbamates Phrethroids Phrethroids Phosphine Fumigants Phyrethroids All Others phshorus Carbamates Orgno phosphorus Urteas All Others Pyrethrolds phosphor& All Others phosphorus phosphorus phosphorus Neonicotinoid All Others Carbamate

H H 4 23 14

F 7 16 23 F H H 7 23 23 4 23 23 7

Ureas phosphorus Triazole Derivative Triazole Derivative phosphorus Pyrethroids Pyrethroids Pyrethroids Chlorinated Hydrocarbons

H F F

19 5

34

PRODUCT

GROUP

PRODUCT

USE

PAGE

NO.

Bifenthrin Birlane Bladex Bootachlor Brifur Brodifacoum Bromoxynil Bromomethan Buctrill Bulldock Bupirimate

Pyrethroids phosphorus Ureas Acetamide Carbamates Coumarin lndandiones Hydrooxybenzonitrille Halogen Fumigants hydrooxybenzonitrille Pytethrords All Others

I H H R H H I F

17

23

C
Calclferon Calcium Cyanide Captan Carbaryl Carbendazine Carfentrazone Ethyl Carfentrazone Carbofuron Carbosulfan Cartap Celphos Cheeta Chemathoate Chlorfenivnphos Chlorothalonii Chlorotbluran Chlorpyriphos Chlorfenapyr Chlorpyriphos Methyl Cadial Cinmethylin Clodinafop Clomazone Codusafos Confidor Coopex Coumarin Coumate tralyl Curacron Curaterr Cyanogas Cyfluthrin Cymbugh Cyanides 35 Coumarin lndandiones Cyanide Fumigants Thiocarbamates Carbamates All Others All Others All Others Carbamates Carbamates Carbamates Phsphine Fumigants Pyrethroids Phosphorus Phosphorus Chlorinated Ureas Phosphorus All Others phosphorus Phosphorus All Others All Others All Others phosphorus Nitroguanidine Pyrethroids Coumarin lndandiones Coumarin lndandiones phosphorus Carbamates Cyanide Fumigants Pyrethroids Pyrethroids Cyanide Fumigants R F 17 14 25 7 23 23 23 7 7 7

A A I I I F H A H

4 2 19 23 4 23 23 23 4

17 17 I I I

PRODUCT

GROUP

PRODUCT

USE

PAGE

NO.

Cyanazine Cyperkill Cypermethrin Cruiser Chlorfenapyr

All Others Pyrethroids Pyrethroids Neonicotinoid All Others

23 9 23

D
Daconil Dannitol Dazomet DDVP Decamox Decis Decis-D Delltia Deltamethrin Deltanet Deltaphos Detia gas Diazinon Dual Gold Diafenthiuron Dithiocarbamate Dicamba Dimetaxal Dimethormorpt Dimethlocarbamate Dimethoate Dimethomorph Diphacinone Diphasin Dipterex Disulfoton Disyston Dithane DMA-6 Dofume E Ekalux Emmatos Endon Endosulfan ES-Fenvalerate Chiorinated Hydrocarbons Pyrethroids All Others Chlorinated Hydrocarbons phosphorus Carbamates Pyrethroids Pyrethroids Phoshine Fumigants Pyrethroids Carbomutes phosphorus Phosphine Fumigants phosphorus Acetanilide All Others Carbamate Ureas phosphorus phosphorus All Others Carbamates phosphorus All Others Coumarin lndandiones Coumarinlndandiones phosphorus phosphorus phosphorus Thiocarbamates Chiorophenoxy Halogen Fumigants F 23 2

4
H 23 23 7 18 19

H H

23

R R

17 17 4 4

F H

phosphorus phosphorus Chiorinated Hydrocarbons Chiorinated Hydrocarbons Pyrethroids

9 36

PRODUCT

GROUP

PRODUCT USE

PAGE NO.

Ethalfluralin Ethion F Facron-S Fastac Fatek Fenitrothion Fenkill Fenpropathrin Fentlfothion Fenvaletate Flucythrinate Fluometuron Flufenoxuron Flurochloridene Folidol Formathion Furadan Furathiocarb Fyfanon

All Others phosphorus

23 4

phosphorus Pyrethroids phosphorus phosphorus Pyrethroids Pyrethroids phosphorus Pyrethroids Pyrethroids Ureas Ureas All Others phosphorus phosphorus Carbamates Carbamates phosphorus

9 9 9
H H H 19 19

4 7

G
Gastoxin Gesapex Granmoxone Grip Gusathion M Phosphine Fumigants All Others Bipyridyis phosphorus-. phosphorus I H I I

H
Heptachior Higonet Hostathion Hydrocyanic Acid Hygrogen Cyanide Chiorinated Hydrocarbons phosphorus phosphorus Cyanide Fumigants Cyanide Fumigants

I
Imidacioprid lmazamethabenz lsoproturan lpifluor K Karate Klerat Kumulus Nitroguanidine All Others Ureas

29
H 23 19.23

Pyrethroids Coumarin lndandiones

17

37

PRODUCT

GROUP

PRODUCT

USE

PAGE

NO.

L Lambda-Cyhalothrin Lannate Laser Lead Arsenate Logran Lorsban Lucky cypermethrin Luxagan

Pyrethroids Carbamates Pyrethroids Arsenicals Inorganic Ureas phosphorus Pyrethroids phosphorus

9 9
11 H

M
Machete Magnum Malathion Mancozeb Maneb Maneb + Zineb Manzarte Matrix Methamidophos Methabenzthiozurom Metolachlor Metalxyl Metasystox R Methidathion Methomyl Methyl Bromide: Methylparathion Metribuzin MLT Monitor Monocrotophos Monophos MSMA Mitac Acetamide Pyrethroids phosphorus Thiocarbamates Thiocarbamates Thiocarbamates Thiocarbamates Ureas phosphorus Ureas All Others All Others phosphorus phosphorus Carbamates Hologen Fumigants phosphorus Trizenone Derivatae phosphorus phosphorus phosphorus phosphorus Chlorophenoxy Compounds H 4 25 25 25 25 4 19 23 23 4 7 4 27

H F

4 H

N
Nemispor Nimrod Nokout Nokovos Nudrin Nurelle Nurelle-D Thiocarbamats All Others phosphorus phosphorus Carbamates Pyrethroids Pyrethroids F F A

PRODUCT

GROUP

PRODUCT USE

PAGE NO.

0 Organic Bound Oxydemeton Methyl Octave P Padan Pandaphos Paramet Paraquat Paris Green Pay-off Pencozeb Pendimethalin Percloraz Penconazole Phenoxyacetic acid Phenthoate Permasect Permthrin Phorate Phostoxin Phosvit Pillaron Pillaroxone Pirimicarb . Pirimor Polo Polytram Polytrin C Puma Super Pounce Primextra Primiphos Profenofos Prothoate Propargyl Pretilachlor

phosphorus

Carbamates phosphorus phosphorus H Bipyridyis Arsenicals Inorganic A Pyrethroids Thilcoarbamates F All Others All Others All Others F Chiorophenoxy Compounds H phosphorus Pyrethroids Pyrethroids phosphorus Phasphine Fumigants phosphorus phosphorus H Bipyridyls Carbamtes Carbamates All Others Thiocarbomates F phosphorus Pyrethroids All Others phosphorus phosphorus phosphorus All Others All Others phosphorus

21 11 23 23 23

H H

23 5 5 5 23 23 5

Q Quickphos Qunaiphos

Phosphine Fumigants phosphorus

PRODUCT R

GROUP

PRODUCT USE

PAGE NO.

Racer Racumin Ramilk Ratilan Reldan Ridomil Rifit Ripcord Rogor Roxion S Salbrom Saturn Sencor Sevin Shangnong Sherpa Sialan Sodium Arsenite Sodium Monoarsonates Solvirex Stinger Sumicidin Sumicidon Super Sumithion Suncrotophos Sundaphos Sunfuran Sunmerin Supracide Systoate scout T Taicord Taistar Tamaron Temik Terabol Teflubenzuron Terbuthylazine Terbutryn Thiamethoxam Thimet Thiobencarb

All Others Coumarin lndandiones Coumarin lndandiones Coumarin lndandiones phosphorus All Others Others Pyrethroids phosphorus phosphorus

H R R R F H

17 17 17 23 23

Halogen Fumigants Thiocarbamates Trizehone Derivate Carbamates phosphorus Pyrethroids Hydrocarbons Arenicals Inorganic Chlorophenoxy Compounds phosphorus phosphorus Pyrethroids Pyrethroids phosphorus phosphorus -phosphorus Carbamates Pyrethroids phosphorus phosphorus

11

Pyrethroids Pyrethroids phosphorus Carbamates Halogen Fumigants Ureas All Others All Others All Others phosphorus Thiocrbamates

H H

19 23 23 23 25

PRODUCT

GROUP

PRODUCT USE

PAGE NO.

Thiodan Thiofanox Thioluxan Tiger Tolkon Tomorin Topas Topik Topogard Triadimenol Triadimeton Triasuiforan Xazophos Triazamate Tribunil Trichlorfon Trifuralin U Ustad V Vapona Vitigran Warfarin Exolanation H = I = F =

Chlorinated Carbamates Chlorinated Hydrocarbons phosphorus Ureas Coumarin lndandiones All Others All Others All Others Triazole Derivative Triazole Derivative Ureas phosphorus Carbamate Ureas phosphorus All Others Pyrethroids phosphorus

7 I H R F H H F F H A H

17 23 23 23 31 31 19 5 7 19 5 23

Coumarin oft e r m s Herbicides Insecticides Rodenticides Fungicides Acaricides

lndandiones

17

41

EMERGENCY RESPONSE ADDRESS AND TELEPHONE NUMBERS

Bhawalpur
Novartis (Pakistan) Ltd. Edgro (Private) Limited Jaffer Brothers (Private) Ltd. Granulars (Pvt) Ltd.. United Distributors Pakistan Ltd. Pakistan Agro Ltd. Chemicals Cyanamid (Pakistan) Ltd FMC United (Pvt) Ltd. NICL Opposite Zakhira, Ahmedpur Sharqia Road, 877762 882664

6-B, Model Town A 6621 6176 House No. B-4,329, Karbala Road, Model Town-B, Rainbow Shopping Centre, F-3, Chowk 13-A, Block-V, Model Town C Model Town B, Chowk Saith Abaii-ur-Rehman House No. 22-A, Satellite Town House No. Model Town Bypass Karachi Road, Model Town 6458 84123 875611 81894 80635 874974 874129

D-G. Khan
FMC United Ltd. 272-C Khyaban-e-Sarwar 241 -A, Khyaban-e-Sarwar Laskani Manzil, Chowk Road. Chorhatta, Khyaban-e-Sarwar Engro near Chowk Churhatta 62438

United Distributors Pakistan Ltd. Granulars (Pvt) Ltd. Pakistan Agro Chemicals (Pvt) Ltd.

61236

Faisalabad
(Private) Ltd. Granulars (Pvt) Ltd Shop 13, Market, Gulistan Colony-3 88, Commercial Centre No. 2, Gulistan Colony, 783939

56501

Mehran Ltd. Agro Chemicals (Pvt) Ltd. Cyanamid (Pakistan) Ltd. Gujranwala Granulars (Pvt) Ltd. Jaff er Brothers (Pvt) Ltd Pakistan Agrochmicals (Pvt) Ltd. Hyderabad (Private) Limited

112, Madina Town 70-Shahzad Market Road 243-C Colony No. 2

27554 716483 730818

18, Mohallah Faisalabad, 84831 Ghalla Mahdi, Near Deen Plaza. Mir Nazir Street, Road, Satellite Town. Road Eimnabad 43069 263717

A/22/A-2, S.I.T.E.,

41787 880530 880441 880820 780771 880011 880012

(Pakistan) Limited Plot A/66-A, S.I.T.E.,, Pakistan Ltd. ICI Pakistan Ltd. Jaffer Brothers (Private) Ltd. United Distributors Pakistan Ltd. Pakistan Agro Chemicals Ltd. A-25, S.I.T.E., Lines, Opposite 24 T&T Tower Plot No. S.I.T.E.,

430 Haji Shah Chowk, Saddar. 782746 577, Unit No. 2 Latifabad. A-51QS.I.T.E. House No. B-50, Block-B, Latifabad No.2 Manzil Garikhata 862809 880011 810351 782921

FMC United (Pvt) Ltd. Cyanamid (Pakistan) Ltd Karachi AG Services and Supplies

18-20, Naval Fleet Club, lnverarity Road

7781626 7783741 7781626 570941 570942

Agticides (Private) Limited. Marine Trade Centre, BC 3, Kehkashan Block-9, Clifton

Chemdyes (Pvt) Ltd.

Pakistan

Block-6.P.E.C.H.S.

430184 430185 430186 256494043 2564947 0300 241396 0300 241397 2567411-34 111-777-333 567226265 570943 570944 7728046 7728047 7728048 575041 575042 5060721-23

Novartis (Pakistan) Ltd.

S-50, S.I.T.E., Hawks Bay Road

Cyanamid (Pakistan) Ltd. D. E. United (Pvt) Ltd. Edgro (Private) Limited (Pvt) Ltd.

S-33, S.I.T.E., Hawks Bay Road 11, Civil Lines, Street

Marine Trade Centre, BC-3, Kehkashan Block-9, Clifton 1 st Floor, Kassam Manzil, Road. 303, Kassam Court, BC-9 Block-5, Clifton Hoechst House, Plot No. 23 Sector No. 22, Korangi Industrial Area floor, At-Syed Arcade, 2nd Minhas Road,

GHR (Pvt) Limited Pakistan Ltd.

Mehran Ltd. National Agro Trading (Pvt) National Insecticides Ltd. (NICL) United Distributors Pakistan Ltd. Pakistan Agro Chemicals (Pvt) Ltd. Lahore Novartis (Pakistan) Ltd. Granulars (Pvt) Ltd..

469843 4971812 218200 2620529 2623072 2576441 519051-54

208 Swami Building, 1 st Floor, F-52, S.I.T.E. 9th Floor NIC Building, Abassi Shaheed Road. P.E.C.H.S.

Plot No. 90, Industrial Area, Kot Lakhpat 1 Lahore-3

5118582 5116760 7586982 7586955

AgrEvo Pakistan Ltd.

13 Kilometer Multan Road, Hanjarwal 63 Mozang Road Floor, Flat No. Eden Center, jail Road. 18 Sikander Block, lqbal Town 18 km Multan Road 2-A, Main Plaza lqbal Road

5413891 5413892 5417993 631127181 7588329 5414249 751009596 7842491

ICI Pakistan Ltd. Jaffer Brothers (Private) Ltd. United Distributors Pakistan Ltd. FMC United (Pvt) Ltd. Pakistan Agro Chemicals (Pvt) Ltd.

Edgro (Private) Limited

House No. Near Nawab Aziz Adam Town Road. C-7, Block 14, Unit No. Satellite Town Satellite Town.

Pakistan Agro Ltd. Chemicals Granulars Ltd. Multan Agricides (Pakistan) Ltd

Park, Kahnewal Road Mouza Abdul Fateh, Near Industrial Estate, Off Bypass Road. En. En. Building, 1st Floor Khanewal Road. 757 A3 Nawan Abdali Road Gulgusht Colony, Bosan Road. 7-C/1, Industrial Estate Ginning Factory, 1 -A, Industrial Estate.

551276 551277 537071 539658 539659 556494 43009 573928 511218 520640 538251-56 539063 Emergency 539636 539212 No.

(Pakistan) Ltd.

D.E. United (Pvt) Ltd. Edgro (Private) Limited.

Ltd. Pakistan Ltd. ICI Pakistan Ltd..

Jaffer Brothers (Private) Ltd. Mehran Agro-Chem (Pvt) Ltd. United Distributors Pakistan Ltd. Pakistan (Pvt) Ltd. Cyanamid (Pakistan) Ltd. FMC United (Pvt) Ltd.

Madina Palace, Ex-9 Colony, Khanewal Road. Mehran House, 25-Y, New Muitan Colony 33-A, Gulgasht Colony Colony Humayun Road. near Pasco Industrial Estate 21 -A, Gulgast Colony 37-C, 15 Industrial Estate

33584 34925 553458 573546 524566 555125 584023 573411 539822 539321 521321 221319 538202 563569

Peshawar Ag ricides (Pvt) Limited Edgro (Pvt) Limited Pakistan Ltd. ICI Pakistan Ltd. Zinat Plaza, haji Camp, Road. 253043

Jan Market, Industrial Estate, Kohat Road. Sardar Garhi, Malik 261685 263630 Road Goods, Plaza, University Road. 8 4 1 7 8 4 641785 Room No. Floor, Hotel, l/S, Plaza, Charsadda 6-C Road Shakeel Mansion, Jamrud Road, Wahidabad, Opposite lslamia College Mag Agro Chemicals,11 -A, Officers Colony

Mehran Agro-Chem (Pvt) Ltd. United Distributors Pakistan Ltd. Pakistan Agro Chemicals (Pvt) Ltd.

Road. 240043 40664

273370 817690

Cyanamid (Pakistan) Ltd.

House No. Phase-l, Hayatabad

Agricides (Pvt) Limited Novartis (Pakistan) Ltd Edgro (Private) Limited Granulars Ltd.

Khanpur Road By Pass Road House No. 1 -A, Street No. 9, Jugnoo Chowk, Jinnah Park Khanpur Road 7 km, Shehbazpur Road Shehbazpur Road Satellite 72863 72763 78928 71913 7796 78138 70768 76272

AgrEvo Pakistan Ltd. ICI Pakistan Limited Jaffer Brothers (Private) Ltd. Pakistan Agro Chemicals (Pvt) Ltd. Mehran (Pvt) Ltd. United Distributors Pakistan Ltd. FMC United (Pvt) Ltd Cyanamid (Pakistan) Ltd.

House No. 301

4 New Colony, Shahrah-e-Sheikh Zaid Bin Sultan Road. Complex, Opp 10 Jinnah Hall Behind Punjad Tractors, Shah Road. 558-A, College Road Satellite Town 8-D, Commercial Area 21-22, Factory Area Pur Road 73755 74200 72409 4636 74082 74831

Shaiwal Agricides Limited Novartis Ltd. (Private) (Pakistan) 11 -J. Town 52287 75765 75706 2956 52972 6304546 63148

United Farms, Pak Road. 51 O/B-VII, Road. Road, Civil

Edgro (Private) Limited Granulars (Pvt) Ltd AgrEvo Pakistan Ltd.

166-A, Govt. Servants Housing United Farm, Pak Sharif Road.

ICI Pakistan Ltd Jaffer Brothers (Private) Ltd. Mehran Ltd. United Distributors Pakistan Ltd. Pakistan Agro Chemicals Ltd.

United Farm, Pak Road. 1 Bin Colony

78969 78264 77832

147, Railway Road 6-B, Ciil tines, Stadium Road Road House No. 8, Katchehri Road New Civil tines Saeed Moukal Colony Gulberg Road Rohail Oil Mill No. 65954 574476 53889 53681 82987 863851 77689

74764

FMC United (Pvt) Ltd. Cyanamid (Pakistan) Ltd

Sukkur Granulars

Ltd.

Barrage Colony, F-l Workshop Road A/l Workshop Road, Barrage Colony F-331415, Workshop Road Agro House, VIP/Military House House No. W-l 66, Auqaf Plots, Waritar Road

ICI Pakistan Ltd. United Distributors Pakistan Ltd. . . Pakistan Agro Chemicals (Pvt) Ltd. Cyanamid (Pakistan) Ltd.

39855 612687

Vehari Agricides Limited Novartis Limited. (Private) (Pakistan) 407 Sharqi Khanewal Road 62573 63573 62561 61974 2181 62433 62434 62596

Edgro (Private) Ltd. (Pvt) Ltd. Pakistan Ltd ICI Pakistan Ltd

17 H Block, 32-B, Grain Market 4th Kilometer, Burewala Road Burewala Road

Brothers (Private) Ltd. United Distributors Pakistan Ltd. Pakistan Agro Chemicals (Pvt) Ltd. Cyanamid (Pakistan) Ltd. FMC United (Pvt) Ltd

House No. 174-F, Street No. 10, Block-F. Road 2 km, Khanewal Road Oil Mills, Chak Burewala Road Vehati House No.

61301 3159 62874 61675 65675 63748

Quetta 22, Rahim Colony 832693

FMC United (Pvt) Ltd.

2, Pohan Colony Malakand Road

66271

Chishtian FMC United Ltd. 4-X. Satellite Town 52274 51993

FMC

Ltd.

5, Civil Lines Chak

Road