OVERVIEW OF NOVEL DRUG DELIVERY SYSTEM

Dissertation submitted to Rajasthan University of Health Sciences, Jaipur,

in the partial fulfillment of the requirements For the degree of

BACHELOR OF PHARMACY

Submitted by
Mr. Ashiwini Dubey Roll. No: B.PHARMACY PART- IV (Enrollment No. 08 / )

Under the Guidance of

Dr. Rajesh Yadav
M.Pharm, Ph.D* Vice Principal

2012-2013
ALWAR PHARMACY COLLEGE NORTH EXTENSION, M.I.A. ALWAR-301 030 (RAJASTHAN)

Certificate
This is to certify that the assignment illustrated in this Report entitled OVERVIEW OF NOVEL DRUG DELIVERY SYSTEM was carried out by Mr. Ashiwini Dubey B.Pharmacy Part-IV (Roll No. .........; Enrollment No. 09/...............) under the Supervision of Dr. Rajesh Yadav, M.Pharma, Ph.D* Vice Principal in Alwar Pharmacy College. Alwar, Rajasthan during the academic session 2012-2013.

Dr. Rajesh Yadav Vice Principal Alwar Pharmacy College

Dr. G. Jeyabalan Principal Alwar Pharmacy College

ACKNOWLEDGEMENT

In many ways it, more difficult to acknowledge ones debt. But I express my deep sense of gratitude to each and every one whose support and cooperation helps us to complete this project report successfully, and without which the complete of the project would never have been easier. The largest debt most go to our honorable and beloved Dr. Rajesh Yadav Who help me in each and every aspect of this project , and gave me moral support and encouragement during this project . Without his commitment, guidances and encouragement the project would never had been completed. Next I have thank, Dr. Rajesh Yadav, help me a lot in the development the entire project . They provide me the best working environment and the entire relevant environment and all the relevant information about the OVERVIEW OF NOVEL DRUG DELIVERY SYSTEM. At last I solemnly acknowledge one again one and all who helped me.

Dated: Alwar:

ASHIWINI DUBEY

This treatise is Dedicated to My family member & my project guide Who Encouraged and flared Passion in me to learn more always And My profession Pharmacist is the founder stone of the medicine

ASHIWINI DUBEY

ABSTRACT
Novel drug delivery system is a novel approach to drug delivery that addresses the limitations of the traditional drug delivery systems. Our country has a vast knowledge base of Ayurveda whose potential is only being realized in the recent years. However, the drug delivery system used for administering the herbal medicine to the patient is traditional and out-of-date, resulting in reduced efficacy of the drug. If the novel drug delivery technology is applied in herbal medicine, it may help in increasing the efficacy and reducing the side effects of various herbal compounds and herbs. This is the basic idea behind incorporating novel method of drug delivery in herbal medicines. Thus it is important to integrate novel drug delivery system and Indian Ayurvedic medicines to combat more serious diseases. For a long time herbal medicines were not considered for development as novel formulations owing to lack of scientific justification and processing difficulties, such as standardization, extraction and

identification of individual drug components in complex polyherbal systems. However, modern phytopharmaceutical research can solve the scientific needs (such as determination of pharmacokinetics, mechanism of action, site of action, accurate dose required etc.) of herbal medicines to be incorporated in novel drug delivery system, such as nanoparticles, microemulsions, matrix systems, solid

dispersions, liposomes, solid lipid nanoparticles and so on. This article summarizes various drug delivery technologies, which can be used for herbal actives together with some examples. Keywords: Herbal medicines, herbs, novel drug delivery system, phytopharmaceuticals

CONTENTS
S.NO. CHAPTER PAGE NO.
1-9 10-19 20-25 26-29 30-32 33-35 36-38 39-40 41-42
43-44

1. 2. 3. 4. 5. 6. 7. 8. 9.
10.

Introduction Nanoparticles
Development And Production Of Nanoparticles Evaluation Of Nanoparticles Marketed Products Of Nanotechnology: Applications Of Nanotechnologies Nanoparticles And Their Health Effects Future Opportunities and Challenges

Conclusion References