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Biodiversity for
Sustainability....08
Editorial
The Universe is immeasurable with no definite boundaries. Although human knowledge is limited with respect to the actual universe, we like to say HELLO NEIGHBOUR to galaxies next to us. The scientists are struggling day in, day out to find out new worlds leading to the discovery of a new galaxy near our Milky Way. With Hubble Space Telescope scientists have spotted many new galaxies so far off that they appear to be 400 million years, after big bang event. According to astronomers, it is hard to find these small galaxies near Milky Way as they are distant, faint and could be anywhere in universe. Leo P is a small galaxy in vicinity of Milky Way at a distance of about five or six million light-years discussed for the first time in astronomical journal May 2013. It was first spotted as a cloud of hydrogen gas with hundreds to thousands stars as compared to Milky Way having thousands to billions stars. It contains a number of bright, blue, newly formed stars as well as a region of ionized gas that indicates the presence of a luminous young star. Indeed, the P in the galaxys name stands for Pristine, rest refers to the galaxys location in the constellation Leo as viewed from Eart h, discoverer state. In a nutshell, the discovery makes one think of several small galaxies waiting to be revealed in inexhaustible universe.
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Biomedical Sciences Muhammad Javed Hassan Muhammad Sughis PhD Agriculture PhD Biomedical Sciences Bahauddin Zikria University, Multan, Pakistan Center of Research for Public Health & the Health ch.javedhassan@gmail.com Journal, Pakistan msughis@hotmail.com
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Biology Dr. Muhammad Amjad Ali PhD Biology UFT-BOKU, Austria amjad.ali2001@gmail.com Engineering Malik Waqas Ahmed Civil Engineer NUST, Pakistan engr.vacas@gmail.com
Aneela Yasmeen University of the Punjab, Pakistan editor@nays.com.pk Suha Tirmizi Research Officer AKDN eHealth Resource Center Aga Khan University Karachi suha.tirmizi@aku.edu misstirmizi@gmail.com Dr. Aneela Karim Assistant Professor Federal Urdu University of Arts Science and Technology chemistaneela@yahoo.com Aftab Ahmad School of Biological Sciences, University of the Punjab, Pakistan president@nays.com.pk
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Mirza Abdul Aleem Baig Research Assistant, College of Biomedical Engineering, Ziauddin University, Karachi aleembaig_mughal@hotmail.com Workshop/Conference Corner Audience portion
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Botany Dr. Mehmooda Munazir PhD Scholar, Arid Agriculture University, RWP Kings College London, UK moodi977@gmail.com
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Prof. Dr. Anwar Nasim
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Mr. Aftab Ahmad School of Biological Sciences, University of the Punjab, Lahore president@nays.com.pk
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Dr. S.M. Shahid (KIBGE), University of Karachi vice-president@nays.com.pk
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dom to live on their own. Existing watering systems water the plants according to the time, just like alarm clock. That doesnt work well during different seasons because soil dries more quickly in summer and less in winter which results in over watering, thus most plants die. In this Automatic Watering System, precise analogue readings are taken from the soil of plants with the help of two metal probes that stay deeper in the soil. Then these readings are fed
Any one has time to think about the cause of these accidents in Pakistan? Why these are only happening in Pakistan? OR there is negligence? Page 3
2. 3. 4.
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able to migrate to locations where the climate is suitable for their survival and reproduction at a faster rate than tree species. Climate change will affect the life cycles and biological synchronicity of many forest trees and pathogens. In this artifact the diseases and their causal pathogens or agents are divided into three groups: diseases caused by pathogens directly affected by climate; diseases caused by pathogens indirectly affected by climate; and decline diseases. Pathogens directly affected by climate: This group of pathogens e.g. Phytophthora root rot can cause disease in a healthy, vigorous host, if the pathogens environmental requirements are met. Their life cycles are directly affected by temperature and moisture. For example, many pathogens causing needle diseases are sensitive to precipitation and humidity and their rates of reproduction, spread, and infection are greater when conditions are moist. In these cases, changes in temperature and moisture more directly affect the pathogen regardless of
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Evaluate the Strengths and Weaknesses of the Major Traditions and Approaches to Value the Environment
Abdullah Mohiuddin Sustainable environment and energy systems, Middle East Technical University
Evaluate the strengths and weaknesses of the major traditions and approaches to value the environment. Referring to the classical, neo-classical (marginalist), environmental and/or ecological traditions, and their variants as you see appropriate, outline your preferred approach to value the environment. Illustrate your responses using real historical environmental problems. Why there is need to estimate or assign the value to the environment? If something is there for free, it is ignored in every step of decision making. Thus in order to save the environment the first step required by the economists is to come up with the concept of assigning the monetary value to the environment and thus somehow limit the environmental degradation using economical principles. There are various approaches for the
estimation of the value of the environment. In Neo Classical economics, one major approach is the creation of market. A brief introduction and strengths and weaknesses of this approach are discussed in this essay. Two examples from the recent history in this essay will extend the understanding about how development of a market can help in the reduction of the degradation of the environment. Second most important concept is of market failures. After which another approach named as willingness to pay is discussed which is for the estimation of value of non-market based environmental goods and services. A brief discussion of the ecological economic approach will be followed by the conclusion. In neo classical tradition, the centre of economic activities is the market. Market is a place where customers and suppliers gather for the exchange of goods and
services. The basic difference between classical and neo-classical approaches of market are that in neo-classical economics the valuation of price comes from the equilibrium of supply and demand where as in classical economics the price is determined by the cost of production. So in Neo-classical Market, the instruments of supply and demand operate and determine the price of the goods and services. Markets are meant for the efficient allocation of resources. Creation of markets for environmental goods and services will provide the monetary value to them and thus it will directly influence the decisions and preferences of the people and the corporations. A new commodity will be created and new opportunities of trade will emerge. Markets are created by humans, they are not natural.
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For example, the consumption of resources such as fossil fuels, how much would the people of future generation like to pay for these resources? Conventional economists however define a concept of intertemporal discounting where methods of discounting can be applied to find the future value of the environmental resources and this evaluation can be used in the decision making process. Then a problem emerges that future assets may be valued much lower. As it is evident, in modern world money is considered as a criterion for depiction of value of any asset, and according to the economic principles the value of money decreases with time. This may be proved as a setback, as environmental goods and services will be valued lesser in future than in the present. Future environmental resources when evaluated with the discounting factor, if results in lower estimation of their value, will make it difficult to decrease the excessive consumption in the present. Above mentioned example is a reason of market failure, where market fails to serve the purpose of efficient allocation of the resources. There can be various other reasons of market failure as well and they could be because of any inherent feature of the resource. In case of a market absence of an environmental good, economists suggest an empirical method of estimation of their value. This approach to find the value of environment is the concept of willingness to pay, how much people are willing to pay to stop the degradation of the environment. This non-market based method can help the policy makers and governments to decide the amount of funding they must allocate towards the solutions of environmental problems. One of the major problems with the neoclassical approaches is the possibility of errors and misjudgment in valuation of environment. The pricing technique or the calculation of monetary value of environmental goods and services may not reflect the actual value. Also not everything can be put in terms of money. A different perspective in valuation of environment is found in ecological economics. As Kenneth Boulding, who is regarded as one of the founding fathers of ecological economics describes spaceman economy,
not to be much fruitful because, some major players in the CO2 emissions are not taking part in it. United States for instance, being the major CO2 emitter is not the part of the deal. China is not required to reduce its emissions since its emissions of CO2 per capita is very low (Liliana LaValle and Amy Braun) .The estimation of price of a market good is affected by the supply and demand of the goods and services. The number of participants of a market is thus very important. The achievements of this protocol might have been very different if United States would have agreed to sign this protocol. Apart from these examples there are other things to be considered as well which are related to the market based approach of valuing the environment. There is a possibility of miscalculation of the value of environmental goods and services through market based mechanisms because the number of participants in the market is restricted to the present generation. There is a possibility that if future generation could somehow participate in the market, then the value that we will get via supply and demand principles could turn out to be far greater. But since future generation does not exist right now, and with future there is a factor of uncertainty, we cannot know how valuable the environment will be for them in terms of monetary criteria.
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Middle East Technical University Field: Political Economy and Law in Sustainability
sources of victuals and the chances of discovery of new pharmaceuticals, the other benefits that are not known to men yet, will trim down if biodiversity loss is not curtailed (Hans-Peter Weikard, 2002). In other words, biodiversity itself is very important for a sustainable world for mankind. Some scholars believe that we cannot attach a value to essentials, like the services provided by the ecology. According to Gowdy (1997) we cannot affix a value to an indispensable resource. Some claim that biodiversity is not substitutable. As, Mainwaring (2001, Page 81) states that, the replacement of ecosystem services is far from human capacity. Even if Gowdy and Mainwaring`s arguments are accepted, we will still require a valuation of biodiversity since our decisions towards anything extensively depend upon what value we give to it. The survival of ecosystems and the conservation of biodiversity all these things need an evaluation to be a part of decision making. (Hans-Peter Weikard, 2002). Even though it may be tough to find the absolute valuation of the biodiversity, (for various reasons like lack of knowledge or lack of operational definition of biodiversity), the mitigation and compensation values of the impacts of human activities on biodiversity may help in the reduction of the loss of biodiversity. Moreover, considering the significance of biodiversity for sustainability of mankind, these mitigation and compensation values will help us understand the extent of efforts that are required to preserve biodiversity. This approach seems effective in the valuation of biodiversity, because it involves the conservation of biodiversity and conservation of biodiversity is inevitable for sustainability. Later on in this essay the valuation approach of mitigation and compensation is defined. The work of Alexander James et al. (2001) is discussed as an example of mitigation and compensation value. The work of Hanspeter Weikard (2002) is presented as a support of area-based approach of Alexander James et.al. In the second part of the essay the notion of possibility of sustainable development that respects biodiversity is presented. In this part of the essay examples from agriculture, aquaculture and livestock farming are given to support the notion that developments in these areas can be done while conserving the biodiversity. Next
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cancer each year and we have facility of just 500 beds with only 35 specialist doctors in this area.
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engineering domain but it also provides an opportunity for it to be integrated with many simulation softwares. Besides its applicability in academia, SI-ARCS can be used by musicians to have their notes interpreted or even by children to doodle on walls with the inkless pen. Our inspiration to choose the domain of HCI and then develop SI-ARCS, was the current research that is being conducted in the state-ofthe-art research facilities all around the world including MIT, Stanford and Microsoft. We aimed at bringing a user-friendly teaching aid that would have both educational and commercial utilities, within the reach of the institutes of Pakistan. But the vision doesnt end here. For us, SI-ARCS is not just an idea, its a realization.
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Full length research paper Field: Strategic and Security Studies Ahmed_ishaq669@yahoo.com
ing the security of Pakistans nuclear weapons. Prior to that, two attacks have already being carried out on Kamra. As the result of 2012 Kamra Air Base attacks, new questions are stirrer in the international media about terrorist networks attacking and taking over Pakistans nuclear arsenal 2. Pakistan has introduced an effective command and control structure in 2001. However, with the passage of time, the global concerns about Pakistans nuclear safety and security were cultivated and scenarios were formulated about the possibilities of terrorists getting nuclear materials from nuclear facilities, to make nuclear explosion devices and RDD. Pakistans nuclear program, for the last one and half decade, has got much attention and negatives publicity from across the globe. During all this propaganda campaign, there was not a single credible day left when Pakistan did not defend its nuclear program. The global propaganda campaign coupled with deliberate piercing by some Pakistani nuclear pessimists, has got pace. In a recent interview with DAWN, Pervaiz Hoodboy hoists concerns about Jihadi Networks, taking over key nuclear installations to fulfill their political objectives. He deliberately neglected Pakistans efforts to ensure the nuclear safety and security of its nuclear arsenal. However, the question arises, are terrorists networks attacking and taking over Pakistan Nuclear weapons is a reality or its just a mere myth? 3. P-5 nuclear weapons states have significant number of nuclear weapons. On the other hands, the de facto states India, Pakistan, Israel, and North Koreaare having sizeable nuclear infrastructure. Pakistan falls under the category of those states, which have not signed Non-proliferation Treaty (NPT) yet; however Pakistan, has signed number of agreements with the IAEA, based on guidelines contained in Safeguards Document INFCIRC. Pakistans plan to expand its nuclear program has come under severe criticism, raising countless questions about its safety and security mechanism to
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guard its nuclear materials. However, President Obama and to U.S officials have showed their confidence in Pakistans nuclear security apparatus. Security System of Nuclear Weapons, Nuclear Materials, and Facilities: 1. In February 2000, Pakistan National Security Council (NSC) established the National Command Authority (NCA), the apex civilian led authority to supervise the employment, deployment, research and development, and command and control structure of Pakistan nuclear program. After its establishment, the NCA has took measures for the safety and security of the nuclear arsenals, materials, and facilities, which include the formalization of the nuclear safety procedures, security of nuclear arsenals, physical protection, control, accounting and creation of vital infrastructure and legislation. As Zafar Nawaz Jaspal articulated, since the establishment of Pakistan Nuclear Program, it has institutionalized highly-secured system, which has been improved gradually to thwart internal and external security challenges, posed to its nuclear program. 2. Security Division: The Security Division in one the most important organs of the Strategic Planning Division (SPD), responsible for the security and protection of Pakistan nuclear arsenal, facilities and the entire strategic organizations. Today, the Security Division comprises more than 20,000 highly trained, skillful security personnel to guard the arsenal. Having said so, these personnel are capable of protecting both nuclear weapons and high sensitive strategic facilities from any terrorist attacks. They are trained to counter the terrorist attempt of sabotage as well as any foreign power raid on the nuclear facilities. This security division is headed by a two Star General, who has his eyes and ears inside the strategic organizations. 3. Personal Reliability Program (PRP): The security clearance and screening processes of all individuals for employment in the strategic organizations has been further consolidated through the enhancement of PRP. The SPD has overall approval of key personnel and also retains information on all retired personnel. Besides PRP for military personnel, SPD has also introduced Human Reliability Program (HRP) for civilian. All these efforts are made to prevent the insiders link with any terrorist organizations or groups. Any individual dispensed a
strategic task goes through multiple intelligence agencies security clearances, which is very much similar to the Unites States Safety and Security System. In Pakistan, The Warheads and the delivery systems are separated from each other, so that the chances of accidental or unauthorized launch of the weapons can be prevented. Furthermore, the individuals who have information about the locations of the nuclear weapons are strictly monitored and ought to be under constant surveillance. 4. Physical Protection of Nuclear Facilities: The Security Division is the solely responsible for the physical protection of all the civilian and military nuclear installations. Today, it is fully established and operating a multilayered security perimeter to protect the nuclear installations. The first layer encompasses of the security personnel from the respective organization; however, it works in coordination with the SPD. Prior to that the providing security to the installations was the sole responsibility of the respective organization. In the Inner Perimeter, the specially trained forces operate on a permanent basis. In the Outer Perimeter, additional fencing is being reinforced by installing closed circuit cameras and electronic sensors. Besides inner and outer security arrangements, an Air Defense System around the particular nuclear facility is also installed. The sensitivity of the nuclear installations is protected by Air Defenses elements, and is designated as no-fly zones. The last tier of the Physical Protection System consists of counter-intelligence teams, who are tasked to indentify the external threats to facilities and provide covert security. 5. Transportation Security: While transporting the nuclear materialsthe nuclear waste, and radioactive materialscan become a potential target for the terrorists. The security and protection of materials, such as Spent Nuclear Fuel (SNF) and highly radioactive sources is more difficult especially transit when in fixed locations. Pakistan has approved the Convention on Physical Protection of Nuclear Material (CPPNM) during 2000, and worked to ensure that it meets all the guidelines included in the convection. In 2005, an amendment was introduced in the convection; however, officials are also considering accession to the July 2005 amendments that are intended to strengthen the CPPNM. Above all, specialist vehicles and
tamper-proof containers are provided for the transportations of nuclear materials that are escorted by military personnel. 6. Fissile Material Protection, Control and Accounting: The A.Q Khan Proliferation saga has forced Pakistan to introduce strict measures for protection of fissile material. Prior A.Q Khan Chapter, there were no formal reporting channel of the apparatus that could check the account for shipments and personal travels. In fact, no formal procedures existed for the physical protection and accounting (MPC&A). Today, the SPD has adopted strict measures to conduct external audits on the nuclear inventories, and implementing regular and surprise inspections at all facilities. 7. Export Control Regimes: In 2001, Pakistan established a Strategic Export Control Division (SEDIV) in the Ministry of Foreign Affairs. The SEDIV comprises of personnel form Customs, Ministries of Foreign Affairs, Commerce, Defence, Federal board of Revenue. In addition, the personnel from PEAC, PNRA, and SPD also work in coordination with the rest of the personnel. SEDIV operates independently so that personnel will not face any conflict of interest. To oversee SEDIV, a board is also formulated, headed by the Foreign Secretary and other high-level officials to implement of the act. 8. International Agreements to Prevent Nuclear Terrorism: Pakistan has joined the US led Container Security Initiative (CSI) in 2006 and Global Initiative to Combat Nuclear Terrorism (GICNT) in 2007. Pakistan has also cooperated with Secure Freight Initiative (SFI). Pakistan for the last one decade is actively participating in all these agreement to prevent the nuclear or radiological terrorism23. 9. Pakistan Nuclear Regulatory Authority (PNRA): In 1994, Pakistan signed Convection of Nuclear Safety (CNS). In order to fulfill the obligation under CNS, each member state has to establish an independent regulatory body. In this regards, Pakistan Nuclear Regulatory Body came into being under Pakistan Atomic Energy Commission (PAEC). To further this process of having independent regulatory infrastructure, Pakistan Nuclear Regulatory Authority (PNRA) was established after the promulgation of PNRA Ordinance 2001. PRNA is an independent organization responsible for regulating all the aspects of radiation and nuclear energy.
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It issues licensed for export control of radiological materials. Furthermore, it regulates, and supervises all the matters relating to nuclear safety and radiation protection. PNRA being a multilateral coordinating agency is responsible for interacting with domestic and foreign entities. PNRA in coordination with IAEA evaluates and submits reports in compliance with UN Security Council Resolution 1540, which calls for national measures to prevent non-state actors from obtaining highly dangerous weapons. 10. Radiological Source Security: The PNRA is tasked to protect workers in the facilities, public, and the environment against accidental or malicious acts involving nuclear materials and facilities. It continuously reviews and updates safety and security measures according to recommendations and guidance received from the IAEA. Pakistan has signed the CSI, which provided radiation detectors at Karachi port. Pakistan also participates in the IAEA Illicit Trafficking Database, to share information on incidents involving theft, loss, or pilferage of radiological materials. Pakistan is working to cooperate with the U.S. Department of Energy on export and border control programs. 11. Nuclear Security Summit (NSS): Pakistan has participated in two NSS in 2010 and 2012. During his address in Seoul NSS Prime Minister Yousaf Raza Gillani said, Pakistan has taken effective measures which are the most important part of its efforts to enhance nuclear security. He also said, As we meet here, we break new ground on the evolving global nuclear security architecture, the role of the IAEA, a n d protection of nuclear materials and radioact i v e
sources. Pakistan offered her support to the international community in establishing Nuclear Security Training and Support Centers. Besides, Pakistan also agreed to deploy Portal Monitors to detect smuggling of nuclear materials in order to prevent the illicit trafficking. 12. Nuclear Plant Stress Test: After the Fukushima power plant disaster, the debate about safety of the nuclear power plants gained new pace. Moreover, the debate was further fueled right before the beginning of the NSS in Seoul. Scores of concerns were raised in the world about the safety of the nuclear energy. After Fukushima, Pakistan immediately carried out IAEA recommended stress tests on its civilian nuclear power plants, which were very successful. 13. International Cooperation: Pakistan has signed number of agreements with the IAEA demonstrating its firm commitments, and strong level of cooperation with the IAEA. The most important agreement in this regard is the Technical Cooperation (TC). In addition, Pakistan is currently one of the top three recipient countries in terms of TC assistance and receives around $ 2-3 million worth of Assistance annually. Pakistan was among the first countries that submitted a report to the UN to fulfill its obligations under the UNSCR 1540. More to the point, Pakistan has also applied Facility Specific Safeguards (INFCIRC/66). Pakistan has also made political commitment to apply the non-binding IAEA Code of Conduct on the Safety and Security of Radioactive Sources and also participates in the IAEA Illicit Trafficking
Database (ITDB). In October 2001, Pakistan also initiated a bilateral dialogue with U.S to improve its nuclear security. U.S officials have repeatedly expressed their satisfaction over nuclear safety and security apparatus of Pakistan. On September 22, 2008, Chair of the Joint Chiefs of Staff, Admiral Michael Mullen described U.S. concerns that, to the best of my ability to understand itand that is with some abilitythe weapons there are secure. And, that even in the change of government, the controls of those weapons havent changed. Certainly at a worst-case scenario with respect to Pakistan, I worry a great deal about those weapons falling into the hands of terrorists and either being proliferated or potentially used. And so, control of those, stability, stable control of those weapons is a key concern. And I think certainly the Pakistani leadership that I've spoken with on both the military and civilian side understands that. After the terrorist attack on the Minhas Air Base in 2012, the State Department Spokeswoman Victoria Nuland said that We do talk about these issues and support Pakistani efforts to keep them secure we have for quite a long, long time. And we dont have any reason to be concerned at this moment. During the Foreign Ministry weekly press briefing, spokesperson Moazzam Ali Khan said, Pakistans strategic assets are safe and sound and we have a robust command and control in place, so nobody should worry about the safety and security of our nuclear assets. Conclusion: The terrorist attack on twin towers and Fukushima power plant disaster has changed the whole global discourse of the nuclear safety and security. Prior to Fukushima, not much attention has been paid to the safety of the nuclear power plants. On the other hand, a lot debate has been carried out on the issue of security of the nuclear arsenal. In this regards, Pakistan has been made a punching pad. Despite the political turmoil and the country facing both kinetic and non-kinetic threats, its nuclear weapons are the jewel of her crown. In fact, Pakistan has unearthed all the stones to make its nuclear safety and security apparatus stringent. Scenarios developed against the possible theft of nuclear materials, and revolutionist group in connection with military and persons working inside the nuclear facilities .
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References
1. Overview, thenuclearsecuritysummit.org, accessed on March 10, 2013, http:// www.thenuclearsecuritysummit.org/eng_info/ overview.jsp. 2. Maurizio Martellini, Nuclear Safety, nuclear stability and nuclear strategy in Pakistan: A concise report of a visit by Landau Network-Centro Volta, Pugwash Online, February 9-13, 2008, accessed on February 25, 2013, http://www.pugwash.org/ september11/pakistan-nuclear.htm. 3. Ibid. 4. Nuclear Security Recommendation on Physical Protection of Nuclear Material and Nuclear Facilities, International Atomic Energy Agency, IAEA Nuclear Security Series no.13, accessed on February 25, 2013, http://www-pub.iaea.org/MTCD/ publications/PDF/Pub1481_web.pdf, 3. 5. Naeem Salik and Kenneth N. Luongo, Challenges for Pakistans Nuclear Security, Arms Control Association, March 2013, accessed on March 20, 2013, http:// www.armscontrol.org/ act/2013_03/ Challenges-forPakistans-NuclearSecurity. 6. Ibid. 7. Many Western experts believe that at Kamra 100 nuclear warheads were stored, and terrorists aimed to attack the nuclear arsenals. However, according to Pakistani official report is not credible and lacks does not depicts the true picture of Pakistan nuclear security apparatus. See Declan Walsh, Militants attack Pakistani Air Base, The New York Times, August 16, 2012, accessed on March 10, 2013, http:// www.nytimes.com/2012/08/17/world/asia/pakistaniair-force-base-with-nuclear-ties-is-attacked.html? _r=0.; Salik and Luongo, Challenges to Pakistan Nuclear Security. 8. Zafar Nawaz Jaspal, Pakistans nuclear weapons safety and security, The Nation, February 23, 2013, accessed on February 28, 2013, http:// www.nation.com.pk/pakistan-news-newspaper-dailyenglish-online/columns/23-Feb-2013/pakistan-snuclear-weapons-safety-and-security. 9. Pervaiz Hoodboy, interview to DAWN, DAWN, February 20, 2013, accessed on February 28, 2013, http://dawn.com/2013/02/20/pervez-hoodbhoy-thebomb-is-immoral/. 10. Henry D. Sokolski, Pakistans Nuclear Woes, in Pakistans Nuclear Future: Worries beyond War, (ed.) Henry D. Sokolski (United States: Strategic Studies Institute, 2008), 5. 11. Pakistan establishes Nuclear Control Body, Arms Control Today, March 2000, accessed on February 26, 2013, http://www.armscontrol.org/node/2899. 12. Zafar Nawaz Jaspal, Pakistans nuclear weapons
safety and security, The Nation, February 23, 2013, accessed on February 26, 2013, http:// www.nation.com.pk/pakistan-news-newspaper-dailyenglish-online/columns/23-Feb-2013/pakistan-snuclear-weapons-safety-and-security; and also see Pakistans Nuclear Safety and Security: A Critical Analysis, Weekly Pulse, March 06, 2013, accessed on March 10, 2013, http://weeklypulse.org/ details.aspx?contentID=3368&storylist=1. 13. Passing out of soldiers of Strategic Plans Division held, Pakistan Today, April 19, 2012, accessed on February 27, 2013, http://paksoldiers.com/isprpress-releases/passing-out-of-soldiers-of-strategicplans-division-held/. 14. Kenneth N. Luongo and Naeem Salik, Building Confidence in Pakistans Nuclear Security, Arms Control Today, December 1, 2007. 15. Jaspal, Pakistans nuclear weapons safety and security. 16. Naeem Salik, The Genesis of South Asian Nuclear Deterrence: Pakistans Perspective (Karachi: Oxford University Press, 2009), 284.
17. Abdul Manan, Preventing Nuclear Terrorism in Pakistan: Sabotage of Spent Fuel Cask or a Commercial Irradiation Source in Transportation, in Pakistans Nuclear Future: Worries Beyond War, ed. Henry Sokolski (United States: Institute of Strategic Studies Army War College, 2008), 235. 18. Luongo and Salik, Building Confidence in Pakistans Nuclear Security. 19. Jaspal, Pakistans nuclear weapons safety and security. 20. Peter Levoy, Islamabads Nuclear Posture: Its Premises and Implementation, in Pakistans Nuclear Future: Worries Beyond War, ed. Henry Sokolski (United States: Institute of Strategic Studies Army War College, 2008), 152. 21. Strategic Export Control Division, Ministry of Foreign Affairs, Government of Pakistan, accessed on February 27, 2013, http://www.mofa.gov.pk/mfa/ pages/article.aspx?id=25&type=4. 22. Ibid. 23. Philip E. Coyle and Victoria Samson, The Proliferation Security Initiative: Background, history and Prospects for the Future, International Commission on Nuclear Non-proliferation and Disarmament, 10.
24. Noreen Iftakhar, Safety and Security of Pakistans Civilian Nuclear Industry, South Asian Strategic Stability Institute, Research Paper no.31, 4. 25. Luongo and Salik, Building Confidence in Pakistans Nuclear Security. And also See Safe Port Act Reauthorization: Securing our Nation's Critical infrastructure, United State Senate, Hearing before Committee on Commerce, Science and Transportation, July 21, 2010, 29, accessed on March 1, 2013, http:// www.gpo.gov/fdsys/pkg/CHRG-111shrg67271/html/ CHRG-111shrg67271.htm. 26. Seoul Nuclear Security Summit, Ministry of Foreign Affairs, Peoples Republic of China, March 28, 2012, accessed on March 2, 2013, http:// www.fmprc.gov.cn/eng/wjdt/2649/t920452.shtml. 27. Seoul Summit: Responsible Pakistan seeks civil nuclear tech, The Express Tribune, March 27, 2012, accessed on March 2, 2013, http://tribune.com.pk/ story/355715/seoul-summit-responsible-pakistanseeks-civil-nuclear-tech/. 28. Ibid. 29. Pakistan pledged to establish Nuclear Security Training and Support Center within the region and outside the region in collaboration with 22 countries. See Salik and Luongo, Challenges for Pakistans Nuclear Security. 30. In an interview, Pakistan Ambassador to China Masood Khan, who was also the chief negotiator on Nuclear Security Summit (NSS), told about the stress tests conducted by Pakistan on its nuclear power plants. See Pakistan nuclear plants undergo stress tests, The Nation, March 25, 2012, accessed on March 2, 2013, http://www.nation.com.pk/pakistannews-newspaper-daily-english-online/international/25 -Mar-2012/pak-nuclear-plants-undergo-stress-tests. 31. Iftakhar, Safety and Security of Pakistans Civilian Nuclear Industry, 14. 32. Jaspal, Pakistans nuclear weapons safety and security. And also see Pakistan nuclear plants undergo stress tests, The Nation, March 25, 2012, accessed on March 2, 2013, http://www.nation.com.pk/ pakistan-news-newspaper-daily-english-online/ international/25-Mar-2012/pak-nuclear-plantsundergo-stress-tests. 33. Iftakhar, Safety and Security of Pakistans Civilian Nuclear Industry, 12. 34. Paul K. Kerr and Mary Beth Nikitin, Pakistans Nuclear Weapons: Proliferation and Security Issues, Congressional Research Services, February 13, 2013, accessed March 25, 2013, http://www.fas.org/sgp/crs/ nuke/RL34248.pdf, 1; Malik Qasim Mustafa, Are Pakistans Nuclear Weapons Safe, Institute of Strategic Studies, Islamabad, accessed on March 25, 2013, http://www.issi.org.pk/publicationfiles/1299650081_87535106.pdf, 4. 35. US confident of Pakistan nuclear security, The Express Tribune, August 17, 2012, accessed on March 25, 2013, http://tribune.com.pk/story/423242/ us-confident-of-pakistan-nuclear-security/. 36. Pakistan reiterates nuclear assets are safe, The Express Tribune, August 16, 2012, accessed on March 25, 2013, http://tribune.com.pk/story/422953/ pakistan-reiterates-nuclear-assets-are-safe/.
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Wireless Drug Delivery System An Innovative Approach and its Awareness among Health Care Professionals
Mehwish Tanveer*, Tariq Ali^, Munazza Khalid*, Daniya Anwer*, Anum Shahnawaz*, Huma Talib*, Israh Ausaf * *Pharm D Graduates, ^Assistant Professor DOW College of Pharmacy, DOW University of Health Sciences
ABSTRACT Micro-electronic devices have become integral part of our lives. This review examines emerging technology in drug delivery system that is wireless controlled microchip technology. For this purpose, a review based survey was conducted to find the level of awareness among health care professionals. Wireless drug delivery system (WDDS) is an innovative approach to enhance patient compliance which is a major issue especially in patients with chronic ailments that require daily complex dosage regimen. The microchips devices implanted in patients and controlled by microprocessor wireless communication. WDDS has the potential to improve patient compliance. It is an intelligent system which provides real time dose schedule tracking and physicians to adjust the treatment while away from patient. INTRODUCTION A perspective drug delivery system may be defined as mechanism to introduce therapeutic agent into the body. Drug delivery systems had an enormous impact on medical technology and enabling the use of entirely new therapies [1]. Our lives have been revolutionized due to the invention of micro-electronic devices. They are present in our automobiles, cellular phones and computers [2]. This stimulated the development of innovative technologies in drug delivery system. Recent advances created the possibility to meet the patient need. For this a new drug delivery system is designed that is wireless control drug delivery system that works through microchip [3]. Microchip: Microchips are smart medical implants that can dispense drugs into the bloodstream as a result of wireless signals sent to it from the medical implant communication service (MICS)[4]. These chips offer a range of advantages including localized delivery, delivery on demand, controlled drug release, dose checking and physician remotely adjust treatment schedule [5]. This smart implant can be injected under the skin in the doctor's office in about 30 minutes using a local anesthetic and lasts about four months before needing to be replaced [7]. Need of Wireless Drug Delivery System: Wireless drug delivery system has the potential to improve patient compliance as it is a major
Fig. 1 The Microchip implant contains 100 or more tiny reservoirs curved into silicon wafer. On wireless command the lid a sandwich of platinum and titanium foil vaporizes and reRESULTS OF AWARENESS SURVEY leases the drug stored underneath
medical issue, especially in chronic diseases. Such issues include simply forgetting (65%); concerns about the drugs (45%) and feeling the drug is unnecessary (43%) because of long term and complex drug regimen [8]. Therefore, it is of a great advantage to find a drug delivery device that is capable of controlled release of a wide variety of drugs that can be safely implanted inside the body [10]. If future research is promising, the technology could be used to treat a wide range of conditions that require frequent or daily injections. Food and Drug Administration Status To achieve marketing approval, implantable drug delivery devices are submitted to the Food and Drug Administration (FDA) for approval as combination products and expects to get the
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8. Wertheimer A. Medication Compliance Research: Still So Far to Go. Journal of Applied Research. 9. Maloney J.M, Uhland S, Polito b, Sheppard N, Pelta C, Santin J.T. Electro thermally activated microchip for implantable drug delivery & biosensing, journal of controlled release, 109 244-255,2012. 10. Viral Shah, Kruti Patel, U.M. Upadhyay Injecting New Ideas Into Drug Delivery Systems-A Brief Review on Microchips as Controlled Drug-Delivery System. The Pharma Review, JAN 2010. 11. Trafton A. MIT News Office Clinical trial of the programmable, implantable device shows promise in treating osteoporosis. 12. Laura J, Martin M. Drug-Delivery Microchip Could Replace Daily Injections. 13. Boyle R. A wirelessly controlled pharmacy dispenses drug from within your abdomen. 2012. 14. Johnson R.C. Wireless Implant Meters Drug Doses. 2012. 15. Improving patient compliance with low-cost wireless technologies. 2006. 16. Lavan D, Mcguire T, Langer R. Small scale system for in vivo drug delivery. Nature biotechnology. 17. Rebecca Boyle A Wirelessly Controlled Pharmacy Dispenses Drugs From Within Your Abdomen, 2012 Feb.
Fig. 2. Pharmacy inside your body and successes so it is difficult to predict the success of innovative products. So new technologies are only useful if they can be commercialized, and drug delivery applications cannot be commercialized without a regulatory environment sufficiently adaptable to support marketing approval of innovative products [5]. It seems to have an innovative discovery for mankind which has pharmacy on a chip, enhancing patient compliance. In a nutshell, microchip provides a new treatment option for clinicians where sub-optimal performance of conventional dosing methods is inconvenient in terms of safety, efficacy and pain. This avoids the compliance issue and points to a future where you have fully automated drug regimens.
REFERENCES 1. David A Lanvan, Terry McGuire & Robert Langer Small-scale systems for invivo drugdelivery. 2. Santini J, Richards AC, Scheidt R, Cima MJ & Langer R Microchips as controlled drug delivery devices Angew Chem.Int.Ed.2000,39,2396 -2407. 3. Dolan B. Results from wireless, implantable drug delivery device study. Science Transitional Medicine, 2012. 4. Johnson R.C. Wireless Implant Meters Drug Doses. 2012. 5. Staples M. Microchips and controlled-release drug reservoirs. Wiley online library. 2010. 6. Maloney J. M. an implantable microfabricated drug delivery system. International Mechanical Engineering Congress. 2003. 7. Pandolfino J.E , Richter J.E , Ours T , Guardino J.M , Chapman J, Kahrilas P T. Ambulatory Esophageal pH Monitoring Using a Wireless System. The American Journal of Gastroenterology (2003) 98, 740749.
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Diabetes Mellitus
Sheeba Wajid Student M.Sc. Biochemistry, University of Karachi What is Diabetes? Diabetes mellitus is a chronic disease in which blood glucose level becomes high, either because some special type of cells (the islet of Langerhanss cells) of pancreas do not secrete enough insulin or pancreatic beta cells do not respond towards insulin. Classification of Diabetes Mellitus Diabetes is generally grouped into two major types. The first one is insulin dependent diabetes mellitus (IDDM) and the other is non-insulin dependent diabetes mellitus (NIDDM). Another type is also known and that is gestational diabetes. In type-1 diabetes, the beta cells that synthesize insulin get destroyed. This type of diabetes strats in early childhood. Symptoms of IDDM may include rapid weight loss, frequent urination, increased hunger, increased thirst, blurred vision and tiredness. It is treated by diet and regular exercise is recommended. Page 19 Scientific article/ Biomedical Sciences Sheeba_wjid@yahoo.com
On the other hand, Type-2 or non-insulindependent (NIDDM) diabetes is more common than type-1 diabetes. In this kind of disease, either the pancreas does not make enough insulin or the body cells do not respond to insulin. Symptoms of type-2 diabetes are closely similar to that of Type1 diabetes. Long term effects include heart disease, kidney problems and other disorders of vision and nerve damage. It is treated by diet, exercise, medications and insulin injections and by controlling weight. While Gestational diabetes is different from other types as it occurs in some pregnant women. It can also be cured by diet, exercise and weight loss. It is unique in the sense that it usually disappears after childbirth. Prevalence Rate of Diabetes Mellitus Prevalence rates of diabetes mellitus vary amongst populations. Pronounced changes in our surroundings and new generation lifestyle cause globalization and due to this, both obesity and diabetes rates greatly increase. Hence a new word diabesity has also been introduced for the aforementioned disease. It has been estimated by the World Health Organization (W.H.O.) that the global number of diabetic persons will become double over the next 25 years. In Sindh province of Pakistan, the prevalence of Type-2 DM was 13.9% and in Baluchistan, it was 8.6%. Alternative Medicines The use of alternative medicines has increased throughout the world for treatment of diabetes mellitus. The use of such type of medicines can be differentiated into pharmacological category (namely herbal treatments), physical remedies (acupuncture) and dietary approaches. Some plants have been shown to contain
hypoglycemic agents. Such plants include Aloe vera, Osmium sanctum, Trigonella foenum-graecum, Ficus carica, Opuntia streptacantha, Gymnema sylvestre and Momordica charantia. These plants have been regarded to have potent anti-diabetic activity. Diabetic Meal Plan If you intend to control your blood sugar, you should focus on foods that your body digests slowly but make sure that the foods should be nutritious too. Beans are rich in fiber that decrease your digestion process. Grains are also high in fiber and are able to lower glycemic index.
to do exercise when they have less blood sugar level than 250 mg/dl. Exercise should be avoided in case of health problems including damage to the blood vessels of the eye, damage to the nerves and circulation to extremities, kidney damage and cardiovascular problems such as angina, embolism. Some Precautions For Diabetics Who Exercise To avoid injuries and wounds in feet, wear protective foot wears. People with diabetes should monitor their blood glucose level carefully before, during, and after workouts.
Some of the fruits and vegetables (broccoli, bell peppers, onions, string beans and eggplant are typically low in calories) are also a good source of lowering weight. With these foods there are some high glycemic index foods. Diabetics should avoid white rice, white pasta, white flour, white sugar, caffeine foods, alcohol and artificial sweeteners. Who Can Exercise? It is advisable by the doctors to the patients
If your glucose levels are above 300 mg/dl or under 100 mg/dl you should avoid exercise. Insulin should be injected away from the muscles to avoid hypoglycemia. Before exercising, diabetics should avoid alcohol and beta-blockers, which is the major cause to increase hypoglycemia.
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Naey Charagh
Quick Facts Name: Dr. Hidayat Hussain Birth Date: 27th July 1974 Education: PhD Organic Chemistry Current Position: Visiting Scientist (Visiting Faculty), Department of Biological Sciences and Chemistry, University of Nizwa, Nizwa, Sultanate of Oman Research Achievements: To date he has authored and coauthored over 140 scientic publications in reputed internationally peer reviewed research journals cumulative impact factor of over 275 along with over 850 citations.
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NAYS is the torch-bearer in mobilizing young scientists; researchers, professionals and scholars on a platform by providing them an enabling environment to collaborate and exchange their fruitful innovative ideas and information in multidisciplinary science domains. These Scientists are supported by an advisory council that includes crew of highly qualified professors for their guidance. It is helpful for young researchers for their advancement, to enrich their knowledge and to prove their flair in research oriented subjects. Moreover, NAYS firmly believes that engaging young scientists (and utilizing their capabilities by better orientation, improvisation and execution would definitely bring a remarkable boom of science and technology in Pakistan.