Clindamycin

Therapeutic Category Antibiotic Pharmacologic class: Antibiotic Use\ Indications Treatment against aerobic and anaerobic streptococci (except enterococci), most staphylococci, Bacteroides sp and Actinomyces; used topically in treatment of severe acne, vaginally for Gardnerella vaginalis or bacterial vaginosis; alternate treatment for toxoplasmosis; prophylaxis in the prevention of bacterial endocarditis in high-risk patients undergoing surgical or dental procedures in patients allergic to penicillin; may be useful in PCP Pharmacological Effects Reversibly binds to 50S ribosomal subunits preventing peptide bond formation thus inhibiting bacterial protein synthesis; bacteriostatic or bactericidal depending on drug concentration, infection site, and organism. Adverse Reaction Gastrointestinal: Diarrhea Dermatologic: Rashes Gastrointestinal: Pseudomembranous colitis (more common with oral form), nausea, vomiting Other: Hypotension, urticaria, Stevens-Johnson syndrome, eosinophilia, neutropenia, granulocytopenia, thrombocytopenia, elevated liver enzymes, thrombophlebitis, sterile abscess at I.M. injection site, polyarthritis, rare renal dysfunction

Precautions/Warnings/Contraindication Dosage adjustment may be necessary in patients with severe hepatic dysfunction; can cause severe and possibly fatal colitis; use with caution in patients with a history of pseudomembranous colitis; discontinue drug if significant diarrhea, abdominal cramps, or passage of blood and mucus occurs Pregnancy category: B Interactions: CYP3A3/4 enzyme substrate Dosing Avoid in neonates (contains benzyl alcohol) Oral: 150-450 mg/dose every 6-8 hours; maximum dose: 1.8 g/day Brand Available: Parentrals Dalacin C phosphate 600mg/4ml IV

Tablets: Dalacin C phosphate 150mgcapsule Dalacin C phosphate 300mg capsule