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Therapeutic Category Antifungal agent Pharmacologic class: Bis triazole derivative Use\ Indications Various fungal infections Cryptococcal meningitis Pharmacological Effects Inhibits fungal cytochrome P-450 (responsible for fungal sterol synthesis); weakens fungal cell walls. Adverse Reaction CNS: headache, dizziness. GI: nausea, vomiting, abdominal pain, diarrhea, dyspepsia, taste perversion. Hematologic: leukopenia, thrombocytopenia. Skin: rash. Other: anaphylaxis. Precautions/Warnings/Contraindication Contraindicated in patients hypersensitive to drug. Use cautiously in patients with neurologic problems, renal disease, or dehydration, and in those receiving other nephrotoxic drugs. Adequate studies havent been done in pregnant women; use only if potential benefits outweigh risks to fetus. Pregnancy category: C Interactions: Alprazolam, chlordiazepoxide, clonazepam, clorazepate, diazepam, estazolam, flurazepam, midazolam, quazepam, triazolam: May increase and prolong levels of these drugs, CNS depression, and psychomotor impairment. Avoid using together. Cimetidine: May decrease fluconazole level. Monitor patients response to fluconazole. Cyclosporine, phenytoin, theophylline: May increase levels of these drugs. Monitor cyclosporine, phenytoin, and theophylline levels. Warfarin: May increase risk of bleeding.Monitor PT and INR. PPIs: May decrease the effect of fluconazole Dosing Adults: 200 mg P.O. or I.V. on first day, then 100 mg once daily for at least 2 weeks. Children: 6 mg/kg P.O. or I.V. on first day, then 3 mg/kg daily for 2 weeks. Brand Available: Diflucan 2mg/ml I.V Diflucan 50mg Cap. Diflucan 150mg Cap.