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PHILADELPHIA, PA.
OSTEOMYELITIS of the mandible develops, in the majority of cases, from some peridental infection wherein the entire structure of the bone, including the bone marrow, becomes involved by direct extension. Such diseases as tuberculosis, diabetes, syphilis, the anaemias, leucoemias and other dyscrasias, may so lessen the resistance of the mandibular tissues by impairment of their blood supply that micro6rganisms, ordinarily harmless saprophytic opportunists, may become apparently pathogenic for some reason or other and cause serious bone infections.
In presenting these two cases of congenital syphilitic osteomyelitis of the mandible, coexisting simultaneously in sisters, we shall make no attempt to fully discuss the subjects of either congenital syphilis or osteomyelitis but rather to confine ourselves to the more important facts, with occasional comments. When we first saw these patients, in the fall of 1927 and the spring of 1928, they were white girls of nineteen and twenty-one years of age respectively. Their chief complaints were identical-pain and swelling about the lower jaw, and their histories, family and past medical, can be considered as one. They were two of a family of six children, all having the same mother but different fathers. The first child was a girl who developed normally; in 1927 she was thirty-one years old, married, perfectly healthy, with three healthy children. We have lost track of her since then. Her father died soon after her birth and the mother soon remarried. The other five children are the result of this latter union. The first one was a boy, who was very sickly and died about a week after birth. The second was a girl, the older of our two patients. The third, which followed in one year, was a girl who died very shortly after birth; described as "a puny little thing." Our second patient followed along after another year and five years later still another girl was born, who up until the summer of 1931 had always been perfectly well, and is still, as far as we know. We could get no information about husband No. one, excepting that he was always well. It was very difficult to get any information from husband No. two about himself; he was surly and non-co6perative, refused to answer questions bearing on a history of syphilis and also refused to have a Wassermann taken. He said there had never been anything the matter with him. The mother was, on the other hand, very co6perative. She told what she could remember of the infancy and childhood of the two girls under our consideration, said she had never been sick and submitted to having a Wassermann taken which was negative to all antigens. The infancy and early childhood of these girls was apparently devoid of any of the more common early manifestations of congenital syphilis. They recalled that they had had a few of the customary exanthematous diseases of childhood, the natures of which were more or less uncertain to them, and it is of course quite possible that what was thought to have been merely one of those maladies that any child is expected to have might well have been a secondary stage of congenital syphilis. Aside from that they were *Read before the Philadelphia Academy of Surgery, March 5, 1934.
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girl, excepting for her jaw. Within the past year she had lost 30 pounds, however. Generally speaking, there were no objective signs indicative of syphilitic infection, other than the r6ntgenographical findings already described. Her Wassermann had been determined and found to be strongly positive and treatment was in progress. A wide external incision beneath the chin liberated a quantity of free pus and a few small sequestra were also removed. From that time early in I928, until March, 1931, the bone destruction had extended through the entire body and into both rami and further external drainage had been necessary on two occasions. The tissues overlying the mandible were greatly swollen; within the mouth there was a mass of eburnated gray bone extending from angle to angle with severe soft tissue ulceration and externally there were three fistulh discharging pus. She was, moreover, suffering intense pain at the site of the left mental foramen. An injection of I cubic centimetre of 95 per cent. alcohol at this point gave her relief for two weeks but then the pain returned, more severe than ever. Rbntgenograms taken at this time showed extensive necrosis of the mandible and many areas of proliferative changes and new bone formation. The following month, April, 1931, we removed the entire mandible, or rather what remained of it, and the patient recovered rapidly. The tissues healed within a month, and although the soft tissues naturally retracted from lack of bony support, her appearance was not in the least revolting and she soon was able to control her tongue and lips and eat soft foods. She put on weight, married, went to the country to live, had an apparently perfectly healthy baby and was very happy.
Before concluding we want to differentiate in a very cursory manner the more common types of osteomyelitis of the mandible that may be encountered. As stated in the opening paragraph of this presentation the most common type is that which develops by direct extension from peridental infection. This process is usually a purely primary regional affair, there being no definite predisposing systemic disease at that time. The bone breaks down rapidly and sequestra usually form in from three to -six months, during which time the repair begins with new bone formation. Other types, as diabetic, tuberculous, syphilitic, chemical, dyscrasic, etc., are all secondary to systemic affections and occur because of an impaired blood
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The dyscrasic type, which may develop in severe anemias, leucoemias, agranulocytosis, etc., is always secondary to severe soft tissue destruction in the mouth and, like the diabetic type, presents nothing out of the ordinary. The chemical type can usually be traced to the occupation of the patient or to the taking of some form of tonic or medicine, as, for example, radium water. We have seen severe necrosis and osteomyelitis of the mandible from such a cause. Phosphorus necrosis used to be not uncommon but is a curiosity now because of the prohibitive legislation against the use of yellow phosphorus in the match industry. The red amorphous phosphorus is non-poisonous. A severe mercurial stomatitis may pass into an osteomyelitis. The use of radium for therapeutic purposes in or about the mouth, or the contact of radio-active salts within the mouth, may also result in an osteomyelitis, and in these cases, as in syphilis, there is apt to be a sclerosis with very slow sequestrum formation. In conclusion, the histories just outlined indicate two cases of congenital syphilitic osteomyelitis in sisters. Up to about i866 but very few cases of bone involvement in congenital syphilis were on record. Today, however, it is recognized that the bones are most frequently involved in this type of infection. The absence of well-defined sequestra in the mandible, the sclerosis of bone resembling ivory in the mandible, the osteoporosis of the long bones with spontaneous fractures, and the extensive necrosis of the mandibie with the accompanying formation of new bone all go to make up the picture of this deplorable condition in these most unfortunate girls.
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