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Leading by Excellence Since 1983 Certified to ISO 9001:2008 Specialty 01 02 Custom Custom Products
Leading by Excellence Since 1983 Certified to ISO 9001:2008 Specialty 01 02 Custom Custom Products
Leading by Excellence Since 1983 Certified to ISO 9001:2008 Specialty 01 02 Custom Custom Products

Leading by Excellence Since 1983 Certified to ISO 9001:2008

Leading by Excellence Since 1983 Certified to ISO 9001:2008 Specialty 01 02 Custom Custom Products &
Specialty 01 02 Custom Custom Products & Organic Peptide Technologies Synthesis Synthesis
Specialty
01 02
Custom
Custom
Products &
Organic
Peptide
Technologies
Synthesis
Synthesis
Specialty 01 02 Custom Custom 07 Tools for Cosmetic Products & Organic Peptide Peptide Peptides
Specialty
01 02
Custom
Custom
07
Tools for
Cosmetic
Products &
Organic
Peptide
Peptide
Peptides
Technologies
Synthesis
Synthesis
Synthesis

NEW!

Introducing our latest section, which includes over 4500 new products!

01 Custo m Peptid e Synthesi s
01 Custo
m
Peptid
e
Synthesi s
01 02 Custo Custo m m Peptid Organi e c Synthesi Synthesi s s
01 02
Custo Custo
m m
Peptid Organi
e c
Synthesi Synthesi
s s
Custo Custo m m Peptid Organi e c Synthesi Synthesi s s Specialty 01 02 Custom
Specialty 01 02 Custom Custom 07 Cosmetic Products & Organic Peptide Peptides Technologies Synthesis
Specialty
01 02
Custom
Custom
07
Cosmetic
Products &
Organic
Peptide
Peptides
Technologies
Synthesis
Synthesis

Dear Customers:

Throughout its many years of service, the team at Peptides International has maintained a commitment to offer a continuous stream of innovative products to facilitate ever-expanding areas of peptide research. In our current catalog you will find hundreds of new products re-

flecting the increased expertise of our staff. These new offerings range from useful tools for making peptides (e.g. orthogonally protected amino acids and derivativesfor Click chemistry) to a plethora of biologically active peptides such as Mambalgin-1 and activated KLH (Keyhole

Limpet Hemocynanin) for peptide antigen conjugation. Since publication of a catalog cap

tures just one point in time, we invite you to look for our latest product additions at PEPNET. COM under the “New Products” tab.

Investment in additional state-of-the-art automated synthesis equipment now allows us to produce milligram to kilogram quantities of peptides even more efficiently. All of our produc- tion and distribution operations have also been certified to the ISO 9001:2008 International Quality System Standard, reflecting commitment to the quality of our products and the satis- faction of our customers. New additions to our peptide chemistry team include experts that can handle all of your discovery and development needs, whether your project involves com- plex organic chemistry or standard solid-phase techniques. Scale-up and smooth technol - ogy transfer into drug API products under full-cGMP is also available without any disruption from our cGMP partner, Peptisyntha.

-

We thank you for your interest in our products and services and invite you to search for your peptide needs in our exciting new catalog. Should you require larger quantities than are listed, additional savings may be available by requesting a “bulk quotation”.

We are confident that you will find all of our products competitively priced while giving you extraordinary value and quality that will lead to success in your research.

Sincerely,

Peptides International

success in your research. Sincerely, Peptides International Michael W. Pennington, Ph.D. President and Chief Executive
success in your research. Sincerely, Peptides International Michael W. Pennington, Ph.D. President and Chief Executive

Michael W. Pennington, Ph.D. President and Chief Executive Officer

Michael W. Pennington, Ph.D. President and Chief Executive Officer Jackie B. Spatola Chair, Board of Directors

Jackie B. Spatola Chair, Board of Directors

Since 1983 , Peptides International, Inc. has been an established provider of catalog products and

Since 1983, Peptides International, Inc. has been an established provider of catalog products and custom chemistry services, supporting peptide research and development around world. Built on a passion for excellence, the company has become recognized as a trusted source of high purity , quality products, and cost effective custom chemistry services. The company’s Louisville facility consists of multiple self-contained laboratory suites, a kilo-scale pilot plant, fully equipped quality control laboratories, and supporting quality assurance and business departments. Peptides International is now Certified to ISO 9001:2008, reflecting its commitment to the quality of its products and satisfaction of its customers. Peptides International specializesin biologically active peptides and peptide-related products, glyco-conjugates, defined-length PEGylations, enzyme substrates and inhibitors, amino acid derivatives, combinatorial peptide libraries, and a variety of resins and reagents. Purification of custom-produced products is carried out by conventional techniques such as solvent-solvent extractions, crystallizations, and by preparative chromatograph ic instrumentations – column sizes to 110mm diameter – suitable for ion-exchange, flash-chromatography and reverse phase HPLC methodologies. Whether it is milligram or kilogram scale-up quantities, Peptides International has the expertise and technology to support your drug discovery , development, and manufacturing objectives.

Peptides International, Inc.

Physical Address

Mailing Address

Phone

Fax

Email

Website

Social Media

11621 Electron Drive Louisville, Kentucky 40299

P. O. Box 99703 Louisville, Kentucky 40269-0703

1-502-266-8787

1-800-777-4779 (Toll-free USA and Canada only)

502-267-1329

peptides@pepnet.com

(Local and International Callers)

1-800-777-4779 (Toll-free USA and Canada only) 502-267-1329 peptides@pepnet.com (Local and International Callers)

Table of Contents

Subsections in Bold

Introduction

Table of Contents Subsections in Bold Introduction Peptide Institute vii Distributors viii cGMP ix

Peptide Institute

vii

Distributors

viii

cGMP

ix

Quality

x

Product Information

xi

Product Packaging

xii

Communication

xix

Purchasing

xx

Using the Catalog

xxii

Terms and Conditions

xxiii

Custom Peptide Synthesis

xxviii

Technology Platforms

xxx

Biologically Active Peptides

1

Adrenomedullins and Related Peptides

2

Amylins

9

Amyloid β-Protein Related Peptides

9

Angiotensin and Related Peptides

13

Arg-Gly-Asp "RGD" Peptides

20

Bradykinin and Related Peptides

27

Defensin Peptides

39

Endothelins

47

Enkephalins

51

Experimental

Autoimmune Encephalomyelitis Products

54

Galanins and Related Peptides

57

Ghrelin and Related Peptides

59

Growth Hormone Releasing Factor (GRF, GH-RH) and Growth Hormone Related Peptides

64

Guanylins and Uroguanylins

65

Hepcidin

67

Kisspeptins/Metasins

72

Melanin-Concentrating Hormone and Related Peptides

77

Neuroendocrine Regulatory Peptides

82

Parathyroid Hormone (PTH) and Related Peptides

93

Protease-Activated Receptor (PAR) Peptides

101

RF Amide Related Peptides

107

Stresscopins / Urocortin and Related Peptides

110

Substance P and Related Peptides

111

Toxins

114

Urotensin II and Related Peptides

133

Vasoactive Intestinal Peptide (VIP)

134

Vasopressin, Vasotocin, and Related Peptides

135

ii Order Hotline 1-800-777-4779

502-266-8787

Peptide (VIP) 134 Vasopressin, Vasotocin, and Related Peptides 135 ii Order Hotline 1-800-777-4779 502-266-8787

Table of Contents (cont.)

Table of Contents (cont.) Enzyme Inhibitors and Substrates Assay Methods Substrates Enzyme Inhibitors Angiotensin I

Enzyme Inhibitors and Substrates

Assay Methods Substrates Enzyme Inhibitors Angiotensin I Converting Enzyme Inhibitors Caspase Inhibitors Cathepsin and Thiol Protease Inhibitors

Chymotrypsin and Chymotrypsin-like Inhibitors Collagenase / MMP / Stromelysin Inhibitors

Elastase Inhibitors

/ MMP / Stromelysin Inhibitors Elastase Inhibitors Ubiquitin Proteasome System Inhibitors Examples of

Ubiquitin Proteasome System Inhibitors Examples of Proteolytic Enzymes and Their Inhibitors Enzyme Substrates & Related Compounds ADAM-17 Substrates Aminopeptidases Substrates Calpain Substrates Caspase Substrates Cathepsin and Thiol Protease Substrates Chymotrypsin and Chymotrypsin-like Protease Substrates Coagulation Factor Substrates Collagenase / MMP / Stromelysin Substrates Elastase Substrates Furin and Carboxyl Side of Paired Basic Residue Cleaving Enzyme Substrates Ubiquitin Proteasome System Substrates FRETs Peptides Library Polypeptides Oligopeptides Dipeptides Tripeptides Tetrapeptides

Specialty Products and Services

Click Chemistry Specialty Biologically Active Peptides Derivatizable Cell Penetrating Peptides (CCPs) Other Specialty Peptides Carbohydrates Glycosidase Inhibitors Endotoxins (Synthetic) Antiproliferative Factor Maleimide activated-KLH Specialty Tools for Peptide Synthesis mini-PEG™ CLEAR-OX TM CLEAR TM Peptide Antisera Antisera of Amyloid β-Protein Related Peptides Endothelin Antisera

of Amyloid β-Protein Related Peptides Endothelin Antisera Order Hotline 1-800-777-4779 502-266-8787 137 143 145 147

Order Hotline 1-800-777-4779

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137

143

145

147

151

154

155

157

161

163

164

164

165

169

170

172

174

175

178

181

183

196

199

205

205

205

206

207

209

211

211

211

212

212

216

217

219

221

221

222

226

228

229

233

iii

Table of Contents (cont.)

Table of Contents (cont.) Tools for Peptide Synthesis Amino Acids   240 Click Chemistry Amino Acids
Table of Contents (cont.) Tools for Peptide Synthesis Amino Acids   240 Click Chemistry Amino Acids

Tools for Peptide Synthesis

Amino Acids

 

240

Click Chemistry Amino Acids

240

l-Amino

Acids

245

d-Amino

Acids

244

Amino Acid Esters

 

245

Side Chain Derivatives of Amino Acids

246

Boc-Protected

l-Amino

Acids

247

Boc-Protected

d-Amino Acids

250

Unusual Boc-Amino Acids

251

Boc-N-Methyl Amino Acids

258

Boc-Amino Acid

Esters

258

Fmoc-Protected

l-Amino Acids

259

Fmoc-Protected

d-Amino Acids

263

Unusual Fmoc-Amino Acids

 

264

Fmoc-N-Methyl Amino Acids

270

Z-Protected l-Amino Acids

271

Unusual Amino Acids

 

273

Resins

274

Unsubstituted Resins for Solid Phase Synthesis

274

Chlorotrityl Resins

276

Boc-Amino Acid-Pam Resins

279

Fmoc-Amino

Acid-Wang Resins

281

Fmoc-Amino Acid-Rink-Amide MBHA Resins

283

TentaGel Resins

285

Reagents

291

Condensation Reagents, Additives, Linkers, and Other Reagents for Peptide Synthesis

291

Boc-Amino Acid-Pam Linker Reagents

293

Protein Ligation Synthesis Reagents

294

PyClocK ®

295

dPEG ®

296

Laboratory Equipment

311

Tubing and Connectors

311

Specialty Glassware

311

Replacement Screw Caps and Septa

313

HF Apparatus and Parts

313

Recombinant Proteins

Cytokines and Growth Factors

388-429

314

Clusterins

320

Defensins

323

GH (Growth Hormone)

368

IFI30 (γ-Interferon-Inducible Lysosomal Thiol Reductase)

379

Interlukins

IL1F7 (Human Interleukin Family 1, Member 7)

429

IL1F10 (Human Interleukin Family 1, Member 10)

430

Insulin

431

iv Order Hotline 1-800-777-4779

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IL1F10 (Human Interleukin Family 1, Member 10) 430 Insulin 431 iv Order Hotline 1-800-777-4779 502-266-8787

Table of Contents (cont.)

Table of Contents (cont.) Recombinant Proteins (continued) Leptin 433 Midkines 445   Pleiotrophin

Recombinant Proteins (continued)

Leptin

433

Midkines

445

 

Pleiotrophin

462

Prolactin

465

RBP1 (Recombinant Human Retinol Binding Protein-1)

474

SCF (Stem Cell Factor)

477

TNF (Tumor Necrosis Factor)

489

Chemokines

510

Hormones

556

Enzymes

562

Protein Kinases

614

Recombinant and Natural Proteins

629

Heat Shock Proteins

753

Allergy Proteins

758

Maleria

Proteins

758

Mumps Protein

758

Shiga Like Pprotein

758

Viral Antigens SARS Proteins

758

Viral Antigens SARS Proteins Borrelia Protein

759

Viral Antigens - Chagas Protein

760

Viral Antigens - Herpes Simplex Virus

760

Viral Antigens - Chlamydia Trachomatis

761

Viral Antigens - Hepatitis C Virus

762

Viral Antigens - Hepatitis A Virus

767

Viral Antigens - Hepatitis B Virus

768

Viral Antigens - Hantaan Virus

768

Viral Antigens -Feline Leukemia Virus

768

Viral Antigens - Hepatitis D Virus

768

Viral Antigens - Hepatitis E Virus

768

Viral Antigens - Hepatitis B Surface Antigens

769

Viral Antigens - Cytomegalo Virus

770

Viral Antigens - Varizella Zoster Virus

771

Viral Antigens - Toxoplasma Gondii Proteins

771

Viral Antigens - Treponema Pallidum Proteins

771

Viral Antigens - Human Immunodeficiency Virus

772

Viral Antigens - Human T-Lymphotrophic Virus

775

Viral Antigens - Human Papillomavirus Virus

776

Viral Antigens - Epstein-Barr Virus

776

Viral Antigens - Encephalitis Virus

777

Viral Antigens - Measles Virus

778

Viral Antigens - Rubella Virus

778

Viral Antigens - Chikungunya Virus

778

Viral Antigens - Parvovirus

778

Viral Antigens - Influenza Virus

778

Viral Antigens - West-Nile Virus

781

Viral Antigens - Dengue Virus

781

Antigens - West-Nile Virus 781 Viral Antigens - Dengue Virus 781 Order Hotline 1-800-777-4779 502-266-8787 v

Order Hotline 1-800-777-4779

502-266-8787

v

Table of Contents (cont.)

Table of Contents (cont.) Recombinant Proteins (continued) Anti - Human Cytokines 784 Monoclonal Antibodies,

Recombinant Proteins (continued)

Anti - Human Cytokines

784

Monoclonal Antibodies, Anti-Human Chemokines

789

Monoclonal Antibodies, Anti-Human Lymphocytes

790

Monoclonal Antibodies, Anti-Mouse Cytokines

792

Monoclonal Antibodies, Anti-Mouse Lymphocytes

793

Monoclonal Antibodies, Anti-Viral

794

Polyclonal Antibodies, Anti-Human

795

Monoclonal Antibodies, Anti-Human Heat Shock Proteins

797

Monoclonal Antibodies, Anti-Human Enzymes

797

Monoclonal / Polyclonal Antibodies, Miscellaneous Antibodies

804

vi Order Hotline 1-800-777-4779

502-266-8787

797 Monoclonal / Polyclonal Antibodies, Miscellaneous Antibodies 804 vi Order Hotline 1-800-777-4779 502-266-8787

From its very inception, Peptides International has been proud to distribute the superb products manufactured by the Peptide Institute of Osaka, Japan.

The biologically active peptides synthesized

known for their excellent quality . In addition to its historic link with the Peptide

Institute, Peptides International works with other key suppliers around the world to supplement its own manufact ured products to provide a complete portfolio of peptides and related products, as well as tools for peptide synthesis and research.

by the Peptide Institute are well

synthesis and research. by the Peptide Institute are well The Peptide Institute is a leading supplier

The Peptide Institute is a leading supplier of biologically active peptides, enzyme substrates and inhibitors, and peptide antisera. Customers in Japan may wish to contact this company directly.

Peptide Institute, Inc.

4-1-2 Ina Minoh-Shi Osaka 562 Japan

Phone

(0727) 29-4121

Fax

(0727) 29-4124

http://www.peptide.co.jp

Phone (0727) 29-4121 Fax (0727) 29-4124 http://www.peptide.co.jp Order Hotline 1-800-777-4779 502-266-8787 vii

Order Hotline 1-800-777-4779

502-266-8787

vii

Distributors

In Japan: http://www.peptide.co.jp
In Japan:
http://www.peptide.co.jp

viii Order Hotline 1-800-777-4779

Osaka, Japan Email: info@peptide.co.jp http://www.peptide.co.jp

In Switzerland:

info@peptide.co.jp http://www.peptide.co.jp In Switzerland: Lucerne, Switzerland Email: info@lubio.ch

Lucerne, Switzerland

Email: info@lubio.ch

http://www.lubio.ch/

In Benelux:

Email: info@lubio.ch http://www.lubio.ch/ In Benelux: Huissen, The Netherlands Email: info@bio-connect.nl

Huissen, The Netherlands Email: info@bio-connect.nl http://www.bio-connect.nl/

In Europe, Latin America, Australia, and New Zealand:

In Europe, Latin America, Australia, and New Zealand: San Diego, CA USA Email: axxora-usa@axxora.com

San Diego, CA USA Email: axxora-usa@axxora.com http://www.axxora.com/index.php

502-266-8787

Australia, and New Zealand: San Diego, CA USA Email: axxora-usa@axxora.com http://www.axxora.com/index.php 502-266-8787

cGMP Partner

cGMP Partner Expertise & Reliability for YOUR cGMP Peptides Peptides International and Peptisyntha have partnered to

Expertise & Reliability for YOUR cGMP Peptides

Peptides International and Peptisyntha have partnered to create a seamless stream of technology and expertise, allowing you to focus on the project, not project management.

and expertise, allowing you to focus on the project, not project management. Order Hotline 1-800-777-4779 502-266-8787

Order Hotline 1-800-777-4779

502-266-8787

ix

Quality

Now Certified to ISO 9001:2008

Quality Policy

It is Peptides International's goal is to achieve complete customer satisfaction by addressing customer needs and delivering what we promise.

The company is committed to the Quality Management Sysyem and through review of quality objectives and metrics, is working towards its improvement and effectiveness.

Specifications and Purity Assays

Each product is accompanied by a detailed lot-specific analytical data sheet contain - ing all specifications. In addition to specification data, additional test results can be made available upon customer request. Product integrity is assured using techniques that include thin layer chromatography, high performance liquid chromatography, opti- cal rotation, nuclear magnetic resonance, IR spectroscopy, and mass spectrometry.

Peptide Institute

Products from the Peptide Institute of Osaka, Japan are manufactured under strict quality control standards and are accompanied by analytical data sheets directly

from the Institute. Peptide International products are designated by a distinguish them from those produced by the Peptide Institute.

x Order Hotline 1-800-777-4779

502-266-8787

distinguish them from those produced by the Peptide Institute. x Order Hotline 1-800-777-4779 502-266-8787 -PI suffix

-PI suffix to

Product Information

Net Peptide Weight

Some products from the Peptide Institute are distributed in premeasured vials. These are indicated by the suffix -s, or -v in their catalog number. The net peptide weight is precisely determined by amino acid analysis after acid hydrolysis, HPLC, and/or UV absorption, and the value is indicated clearly on the vial label. The indicated weight is only for the net peptide molecule, and the weights of any constituents (water or acetic acid) are excluded from the quantity. The amount of usable peptide meets and may exceed its advertised quantity.

Stability and Storage

Complex peptides and antisera should generally be kept dry and frozen to prevent unnecessary deterioration, although they are stable at ambient temperature for sev - eral days. Almost all biologically active peptides are readily soluble in water or any

suitable buffer solution. Stability of peptides in solution is relatively low even below

-20 °C.

possible. If the solution must be stored overnight, it should be kept in a freezer at temperatures lower than -20 °C. When prolonged storage has occured, homogene - ity of the peptide in the solution should be reconfirmed prior to use. Please refer to the following table and to our website for additional information regarding stability and storage conditions.

Therefore a peptide solution, once prepared, should be used as soon as

Therefore a peptide solution, once prepared, should be used as soon as Order Hotline 1-800-777-4779 502-266-8787

Order Hotline 1-800-777-4779

502-266-8787

xi

Product Information

Product Storage Conditions

Product

Series Number

Storage Condition

L- & D-Amino Acids

2700 & 2800

RT

Boc-Amino Acids

2000 & 5000

4 °C

Fmoc-Amino Acids

1700, 1800, & 5000

4 °C

Unusual Amino Acids

5000

4 °C

Reagents

1000

Varies:

 

RT,

 

4

°C,

 

or

 

-20 °C

Unsubstituted Resins

1000 & 9000

RT

Substituted Resins

1000, 10000, 1100, 11000, 1200, 12000, 1300, 1400, & 9000

4

°C

All CLEAR Resins

1200, 12000

4 °C

Peptides

3000 & 4000

-20 °C

Inhibitors

3000 & 4000

-20 °C

Substrates

3000

-20 °C

Antisera

8000, 80000, & 14000

-20 °C

Carbohydrates

24000

-20 °C

RT
RT

=Room Temperature4

4 °C
4 °C

=

Refrigerator

= Freezer24000 -20 °C RT =Room Temperature 4 4 °C = Refrigerator All products (except RT) are

All products (except RT) are stored in freezers for inventory purposes.

xii Order Hotline 1-800-777-4779

502-266-8787

All products (except RT) are stored in freezers for inventory purposes. xii Order Hotline 1-800-777-4779 502-266-8787

Product Information

All of the products listed in this catalog are rigorously tested and the purity of the products is guaranteed according to the following criteria:

1000 Series

These reagent grade chemicals are of a quality confirmed by our chemists in Japan and the USA to be acceptable for peptide synthesis.

1100, 1200, 1300,1400, 10000, 11000 and 12000 Series

These substituted resins are manufactured in our Louisville, Kentucky facility . The parameters, described on the analytical data sheet included with each resin, are substitution, percent racemization (where appropriate), bead size, and percent cross-linking.

1700 Series

Fmoc-Amino Acids of the 1700 Series: No free amino acid is detectable by TLC when 100 micrograms is applied to the plate. Purity determined by HPLC analysis is higher than 98%.

2000 Series

Amino acids of the 2000 Series: The homogeneity of the amino acids is moni - tored by thin layer chromatography (TLC) and is guaranteed to yield a single

spot when 50 micrograms is applied to the plate.

acids is higher than 99.9% except in the case of serine, which is frequently con - taminated by more than 1% enantiomeric serine; data are available on request. Optical purity is determined by Reversed-Phase High-Performance Liquid Chromatography (RP-HPLC) using chiral derivatizing reagents.

The optical purity of amino

(RP-HPLC) using chiral derivatizing reagents. The optical purity of amino Order Hotline 1-800-777-4779 502-266-8787 xiii

Order Hotline 1-800-777-4779

502-266-8787

xiii

Product Information

Amino Acid Esters and Side Chain Derivatives of the 2000 Series: The following letters are used to designate the different grades:

AA:

A single spot is always detectable by two dif ferent TLC systems when 200 micrograms is applied to the plate. Homogeneity higher than 99% as determined by paper electrophoresis is guaranteed.

A:

A trace of impurity might be detectable by TLC, but the maximum range is less than 2%.

B:

Contamination of less than 3% might be detectable.

Boc- and Z-Amino Acids of the 2000 Series:

The optical purity of the component amino acids is always higher than 99.9%, and contamination by the sec-butyl group is guaranteed to be less than 0.05%. The following letters are used to designate the dif ferent grades:

AA:

A single spot is detectable by TLC when 200 micrograms is applied to the plate. The amount of contamination detectable by HPLC, if any, is less than 0.5%.

A:

A trace of impurity might be detectable by TLC, but the maximum range determined by HPLC is less than 1%.

B:

Contamination of less than 2% might be detectable by HPLC.

AA-A:

This compound is synthesized as material of grade AA, but may gradu- ally decompose to grade A within one year, even under cold storage conditions.

A-B:

This compound is synthesized as material of grade A, but may gradu- ally decompose to grade B within one year, even under cold storage conditions.

xiv Order Hotline 1-800-777-4779

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decompose to grade B within one year, even under cold storage conditions. xiv Order Hotline 1-800-777-4779

Product Information

3000 Series

Amino Acids and Peptide Derivatives of the 3000 Series:

are used to designate the different grades:

The following letters

AA:

A single spot is detectable by TLC when 100 micrograms is applied to the plate. The amount of contamination detectable by HPLC is less than 1%.

A:

A trace of impurity might be detectable by TLC when 100 micrograms is applied to the plate. The amount of contamination detectable by HPLC is less than 2%.

B:

Contamination of less than 4% might be detectable by HPLC.

A-B:

This compound is synthesized as material of grade A, but may gradu- ally decompose to grade B within one year, even under cold storage conditions.

4000 Series

Biologically Active Peptides of the 4000 Series: All of these peptides are chemically synthesized using carefully selected amino acid derivatives from our products, and strictly purified to come up to our quality standards. Impurities detectable by ordinary gradient HPLC systems are less than 1% and a single TLC spot upon application of 50 micrograms is detected in almost all of our peptides, except Met-containing peptides. Some additional minor peaks on HPLC or minor spots on TLC are detectable with Met-containing peptides since they may be easily oxidized to Met-sulfoxide even during analysis. The peptides which are followed by the words “Purity Information” and letter symbols, such as “Purity Information: Q P in this catalog”, can be explained as follows:

Information: Q P in this catalog”, can be explained as follows: Order Hotline 1-800-777-4779 502-266-8787 xv

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Product Information

Q P :

Q

Q

Q

E :

X :

Z :

These compounds have some inherent instability. During storage, even under freezer conditions, a trace of impurity may become visible by TLC analysis. The amount of impurity determined by HPLC is less than 1%.

These compounds have some inherent instability. Their purity is guar- anteed to be higher than 97% by HPLC.

The purity of these compounds is guaranteed to be higher than 97% by HPLC.

The purity of these compounds is guaranteed to be higher than 95% by HPLC.

5000, 6000, and 53000 Series

These unusual amino acids, amino acid derivatives, and other of

resent an expansion of quality products from Peptides International and are

synthesized under appropriately high purity criteria.

ferings rep-

14000 Series

Peptide Antisera are sold in vials as amorphous powders which are obtained after lyophilization from 0.001 M Phosphate Buffer (pH 7.0). The specificity and sensitivity are determined by the enzyme immunoassay technique specified; the data for each vial are given on an attached sheet.

Bacterial Enzyme Inhibitors

The microbial enzyme inhibitors (Microbial Products) listed in this catalog are isolated from cultured media of microorganisms. Many of these compounds are inherently unstable and thus difficult to categorize using our normal standards of purity. The homogeneity of these compounds cannot be guaranteed except for their specific inhibitory activities. Additional data for these series of compounds are available upon request.

xvi Order Hotline 1-800-777-4779

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Additional data for these series of compounds are available upon request. xvi Order Hotline 1-800-777-4779 502-266-8787

Product Packaging

The biologically active peptides listed in this catalog are sold primarily as amorphous powders which have been lyophilized from aqueous or dilute acetic acid solutions. They are available in two package forms: screw-capped bottles (indicated as “Bulk”) and injection vials (indicated with a -v or –s suffix at the end of each catalog code number).

Screw-capped Bottles

The amorphous powder of each peptide is thoroughly dried over desiccant in vacuo and then weighed in a bottle. The weight indicated on the label represents the gross weight of the amorphous powder, which includes the peptide as well as the accompanying water and acetic acid, if any. The amount of water and acetic acid in each amorphous powder is precisely determined by elemental analysis, Karl Fischer titration or gas chromatography . In some cases, peptides contain hydrochloride or ammonia instead of acetic acid. The observed values of such accompanying constituents are given in the structural formula of the respective peptide described in this catalog. For example, code PBK-4002 Bradykinin is described as follows:

PBK-4002 Bradykinin Bulk 100 mg Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg • 2AcOH • 3H 2 O (M.W. 1060.2 • 120.10 • 54.05)

The total molecular weight of this amorphous powder is calculated to be 1234.4,

which consists of 1060.2 for the net bradykinin molecule, 120.10 for two mol

ecules of acetic acid and 54.05 for three molecules of

100 mg of this powder contains a net weight of 85.9 mg of bradykinin molecules. Amounts of the accompanying water and acetic acid vary with the lot; the exact value in the purchased peptide is available on request.

water. This means that

-

in the purchased peptide is available on request. water. This means that - Order Hotline 1-800-777-4779

Order Hotline 1-800-777-4779

502-266-8787

xvii

Product Packaging

Vials

Peptides with constant weights are lyophilized and sealed under nitrogen in indi- vidual vials. Net peptide weights are precisely determined by amino acid analy - sis after acid hydrolysis, HPLC analysis and/or UV absorption measurement,

and is clearly indicated on the label of each vial.

the net peptide molecule and does not include the weight of any additional con - stituents (water, acetic acid, etc.). For example, code PBK-4002-v Bradykinin is described as follows:

The indicated weight is only

PBK-4002-v Bradykinin Vial 0.5 mg Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg (M.W. 1060.2)

This indicates that each vial contains ca. 0.5 mg of Bradykinin and the exact weight is indicated on the label (for example, 0.53 mg) and the analytical data sheet (for example, 0.53 mg, 0.50 micromol). The weight is precisely determined

by quality control, insuring the quantity in each vial even if the content seems

to be quite small.

prepared by injecting a given volume of a suitable solvent into the vial using a calibrated syringe and dissolving the contents thoroughly . The peptide content in each vial is relatively small and accurately measured, and the peptide should not be taken out of the vial to prepare a solution with a guaranteed concentration.

A peptide solution of a known concentration can be easily

xviii Order Hotline 1-800-777-4779

502-266-8787

concentration. A peptide solution of a known concentration can be easily xviii Order Hotline 1-800-777-4779 502-266-8787

Communication

Special Issue CUSTOM Chemistry CLICK Issue A Newsletter from Peptides International Enzymes Gone Wild! Inhibitors
Special Issue
CUSTOM
Chemistry
CLICK Issue
A Newsletter from Peptides International
Enzymes Gone Wild! Inhibitors to the Rescue!
PRESORTED
STANDARD
U.S.
Postage
PAID
PEPTIDES
INTERNATIONAL
Volume 24, No. 1, 2011
A Newsletter from Peptides International
PI Debuts New Technology Platform
The
peptide
business
has
become
com-
is a Rommel ‘custom’ satisfy
moditized
in
recent
years
as
more
and
more
low-cost,
PRESORTED
Pennington Joins PI Team as CTO
STANDARD
quick
turnaround
sources
appear
around
world.
Growing AcCUSTOMed to New Challenges
U.S.
Postage
Yet
researchers
pursuing
peptide-based
drug
devel-
Peptides
International
proud-
PAID
tional's
recently
opment
projects
increasingly
more
complex
ly
announces
the
addition
of
PEPTIDES
njoy
perusing
structures
and
services
that
often
exceed
the
capa-
Dr.
Michael
Pennington
to
the
INTERNATIONAL
rom
you!
bilities
of
many
of
these
service
Peptides
company’s
executive
team
as
International,
with
long
history
of
providing
peptides,
has
Chief
Technical
Officer
effec-
roducts,
New
st
just
completed
major
commitment
in
personnel
and
tive
December
1
, 2010.
that
will
allow
it a
to
the
custom
chemistry
needs
the
most
Background
demanding
researchers
and
their
ever
increasing
challenges.
Pennington
has
spent
over
Addition
of
the
new
resources
has
resulted
the
designation
of
years
research
and
devel-
Volume 24, No. 2, 2011
“complex
custom
peptides”
as
PI’s
newest
Technology
Platform
(see
with
the
PEPNET
Vol.
22
No.
2).
This
designation
provides
of equipment integrated, with immediate the scale-up.
an
as management in of Group
Dr.
Michael
Pennington
and
was
most
company-wide
effort
that
not
only
meets
customers
Chief
Technical
Officer,
President
and
COO
A Newsletter from Peptides International
Peptides
International
synthetic
needs,
but
can
offer
additional
services
in
areas
such
as
Meet
Bachem
Bioscience
Inc.,
the
utiful
San
analytical
testing,
technology/process
development,
and
"The Clickables"
King
of
Prussia
(Pennsylvania)
facility.
n Diego,
07
Leading
this
effort
Dr.
Michael
Pennington,
peptide
the
author
of
nearly
100
technical
publications,
a in custom seek providers. well-known
industry
expert
with
over
20
years
of
experience
meeting
just
such
on
editorial
boards
several
He industry and
challenges
(see
inset).
Joining
Dr.
Pennington
and
PI’s
existing
a has Bachem Dr. are of number journals, He of recently opment serves 20 company’s
and
on
the
Scientific
Advisory
Boards
of
a
Peptides International Introduces New Product Line
team
of
research,
production,
and
QC
scientists
are
Dr.
Satendra
drug
development
companies.
is also
Chauhan
and
Dr.
Talan
(see
page
2),
who
bring
unique
co-principal
is at investigator have the
on
several
NIH
grants
and
breadth
and
experience
to
this
team.
PI
laboratories,
updated
an
adjunct
faculty
member
the
Department
What is Click Chemistry?
and
expanded
in
2007,
are
now
further
enhanced
with
state-
Chemistry
Villanova
University.
Mike
his
S 2011
tional's
entry
Selective
orthogonal
labeling
peptides
has
PRA=Propargyl-Gly)
while
using
the
other
with
labeling
PEPNET Newsletter
is served Michelle
wife
recently
moved
of in to
Kentucky
and
its
use We
been
limited
by
the
need
page 3
to
to thiol
and
molecule
(e.g.
The
possibilities
employing
this
of Azido-PEG).
see PI Debuts
enjoying
their
new
property
in
horse
country.
tides.
amine
groups
in
the
target
peptide
interact
type
allow
almost
limitless
selective
label
in to cell hope
of strategy
orward
hear-
ShK
with
maleimido,
Linker
halo-acetyl
Biotin
and
NHS-esters
incorporation.
Peptides
now
offers
new
Changes
for International of
of
the
desired
labeling
molecule.
When
more
assortment
these
types
building
block
tools
a to
a aid
in
Dr.
Pennington's
addition
has
had
an
than
one
thiol
or
amine
in
specific
the
application
of
Click
chemistry
to
many
different
systems.
is present
had and of immediate
tes and much
impact
at
PI.
Along
with
broadened
custom
peptide
peptide,
it
to
get
selective
incorporation
without
is difficult
of side use
emphasis,
many
initiatives,
quality
using
special
protecting
groups
to
minimize
reactions.
Clickable Cell-Penetrating Peptides
procedures
have
introduced
or
implemented.
At
Click
chemistry,
the
name
popularized
by
Nobel
Dr. new been
Cell-penetrating
peptides (CPP)
have ty
received
considerable
FITC
a Laureate involves
the
same
time,
Channa
a Basava,
who
been
lead-
Sharpless
of
the
Scripps
Research
Institute,
Dr. Barry
interest
applications
because
of
their
abili-
ing
the
company's
technical
for drug discovery
and
organiza-
the
incorporation
of
in commercial products,
permeate
the
cell
Arg-1
tions,
has
expanded
his
efforts
the
areas
specialty
groups
that
other-
below)
Azido-TAT Peptide
(TAT-3734-PI)
membrane
and
allow
products
and
technologies,
business
development,
and
wise
do
not
in
aining Labeling Molecule
for
or
cargo
sales
and
Chief
biological
molecules
molecules
to
be
deliv-
O
TMR
marketing management.
Michael
into
both
the
or occur peptide
C
CH
+
N
N
N
RKKRRQRRR
NH
ered
into
the
cytosol.
Peptide
C
CH
2
CH CH
2
2
keynote
and
labeling
mol-
NH
These
peptides
were
Peptide chemistry is constantly changing. The PEPNET newsletter
will keep you abreast of many of the exciting new developments
arising in the expanded field of peptide chemistry. PEPNET has
been published regularly since 1987.
2
O
Alkyne
Azido
ides
To
Lys-22
ecules.
These
groups
initially
discovered
Component
Component
ngress,
then
react
"click",
analogs,but
to synthesize
from
the
venom
of
ShK
011,
in
achieving
- high
selec-
Not only is PI able
(TAMRA
-A 35 amino acid
our scientists can
native ShK and custom
as fluorophores
wasps
and
the
TAT
peptide isolated from
helianthus
also attach labels such
TM
spacers, as shown.
topic,
the Caribbean sea
tivity
under
mild
and FITC)
or Biotin
with mini-PEG
(Trans-Activator
of a
anemone, Stichodactyla
ultiple
conditions.
+
Transcription)
protein
CLICK
[Cu]
onal:
• Proactive
• Friendly
Service
derived
from
HIV.
and Value
Clickable
Building
Strict Confidentiality
sive
Product Quality
Project Management
They
typically
have
Block
Tools
be
high
content
of
argi-
ng,
nine
residues.
CPPs
The
most
popular
use
or
can
functionalized
O
of
Click
chemistry
for
he
with
alkynes
or
azido
biological
molecules
N
RKKRRQRRR
NH
groups
which
allow
involves
a
cyclo-addi-
2
for
transport
of
tion
reaction
and using
O
N
cargo
molecules
such
an
azido-containing
to payload cytotoxic kinase be the
Peptide
C
CH
CH
CH
2
2
as
drugs,
component
an
N
NH
2
siRNA
molecules
alkyne-containing
or
inhibitor
component
that
react
"Clicked" TAT
sequences.
Peptides
in
the
presence
of
(I)
International
i
Cu
to
form
a
1,4
pleased t
disubstituted
1,2,3
triazole
(see figure).
For peptide
HIV,
(TAT-3
chemistry applications, the
incorporating
TAT (49-57)
be increased by
number of possibilities can
one of the
chain (e.g.
respective components
within a peptide
Product Quality and
,
Our web site of fers online ordering, new products, and other use
-
ful information.
There are also scientific references, and links to
There are also scientific references, and links to industry organizations. Social Media Just as peptide
There are also scientific references, and links to industry organizations. Social Media Just as peptide

industry organizations.

Social Media

and links to industry organizations. Social Media Just as peptide chemistry is ever-changing, Peptides

Just as peptide chemistry is ever-changing, Peptides International knows the way it conveys these changes will also vary over time. Look for us on Facebook, Google+, LinkedIn, Twitter, and other new outlets as they appear.

If you wish to receive your own copy of this catalog or to be entered onto the subscription list for the newsletter , please place a request by contacting the company via telephone, fax, or email ( peptides@pepnet.com).

the company via telephone, fax, or email ( peptides@pepnet.com ) . Order Hotline 1-800-777-4779 502-266-8787 xix

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xix

Purchasing

Peptides International's customer service representatives are prepared to help process your orders, assist with product information, and answer technical questions. Orders can be placed by mail, telephone, fax, or email.

Address:

Mailing Address

Peptides International

or

Physical Address

Peptides International

P. O. Box 99703 Louisville, Kentucky

11621 Electron Drive Louisville, Kentucky

40269-0703

40299-3861

USA

USA

Telephone:

1-502-266-8787 (Local and International Callers)

1-800-777-4779 Toll-free (USA and Canada)

Customer service representatives are available during the following times to assist you:

Monday through Thursday - 8:30 AM - 6:00 PM (EST / EDT time) Friday - 8:30 AM - 5:00 PM (EST / EDT time)

Fax:

1-502-267-1329

Email:

peptides@pepnet.com

Web site:

(EST / EDT time) Fax: 1-502-267-1329 Email: peptides@pepnet.com Web site: xx Order Hotline 1-800-777-4779 502-266-8787

xx Order Hotline 1-800-777-4779

502-266-8787

(EST / EDT time) Fax: 1-502-267-1329 Email: peptides@pepnet.com Web site: xx Order Hotline 1-800-777-4779 502-266-8787

Orders

When placing an order please specify:

• Customer ID Number

• Company or Institution

• Billing Address

• Shipping Address

• Purchase Order Number or Credit Card information

• Catalog Code Number

• Quantity and Product Description

• Quote Number, if applicable

• Telephone Number

• Fax Number

• Email Address

• Shipping Requirements

• VAT, if applicable

Minimum Orders

Peptides International does not require a minimum order but encourages repeat customers to combine small orders, w hen possible, to minimize handling and shipping costs.

w hen possible, to minimize handling and shipping costs. Purchasing Confirming Orders Please mark all confirming

Purchasing

Confirming Orders

Please mark all confirming orders clearly to avoid duplication.

Back Orders

Should an item be temporarily out

of stock, this will be indicated in

the “back order” column of the

customer’s invoice. Mo st back order are shipped within two weeks.

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xxi

Using the Catalog

Catalog Key

• This catalog has been designed to provide unique, concise information for each product, with the intention of enabling easy navigation and ordering.

• For further information or specific questions regarding a product, please contact a Peptide International customer service representative.

1

2

Biologically Active Peptides

(All Are Acetate Form Unless Otherwise Indicated)

Biologically Active Peptides (All Are Acetate Form Unless Otherwise Indicated)

Toxins

3

w-Agatoxins

B.M. Olivera, G.P. Miljanich, J. Ramachandran, and M.E. Adams, Annu. Rev. Biochem., 63, 823 (1994). (Review) O.D. Uchitel, Toxicon, 35, 1161 (1997). (Review)

4

8

10

ω-Agatoxin IVA

ω-Aga-IVA

(Funnel Web Spider, Agelenopsis aperta)

5

PAG-4256-s

6

0.1 mg

7

380

9

-20 °C
-20 °C

vial

11 Lys-Lys-Lys-Cys-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys-Lys-Trp-Gly-Gly-Thr-Pro-Cys-Cys-Arg-Gly-Arg-Gly-Cys-Ile-

Cys-Ser-Ile-Met-Gly-Thr-Asn-Cys-Glu-Cys-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala (Disulfide bonds between Cys 4 -Cys 20 , Cys 12 -Cys 25 , Cys 19 -Cys 36 and Cys 27 -Cys 34 )

12 (M.W. 5202.2) C 217 H 360 N 68 O 60 S 10

13 P-type Ca 2+ Channel Selective Blocker

14 I.M. Mintz, V.J. Venema, K.M. Swiderek, T.D. Lee, B.P. Bean, and M.E. Adams, Nature, 355, 827 (1992). (Original) T.J. Turner, M.E. Adams, and K. Dunlap, Science, 258, 310 (1992). (Pharmacol.) H. Nishio, K.Y. Kumagaye, S. Kubo, Y.-N. Chen, A. Momiyama, T. Takahashi, T. Kimura, and S. Sakakibara, Biochem. Biophys. Res. Commun., 196, 1447 (1993). (Chem. Synthesis & Biological Activity) • This compound is distributed exclusively through Peptides International under license agreement with the University of Utah.

1. Major Product Section, designated as Biologically Active Peptides, Enzyme Inhibitors & Substrates, Specialty Products & Technologies, or Tools for Peptide Synthesis.

2. Subsection Heading

3. Product Section (may include article and / or references)

4. Product Name

5. Product Code

6.

7. Price (in US Dollars)

Peptides International strives to give accurate content, including product information, quantities, and pricing. Policies, pricing, and item availability are subject to change without notice. While Peptides International makes a good faith effort to ensure that the information displayed is accurate, we are not responsible for typographical errors or technical inac- curacies.

8. Alternate Name (when applicable)

9. Storage Temperature (see page for key)

10. Synthetic, Originally From

(when applicable)

11. Sequence (when applicable/available)

12. Molecular Weight, Formula, and CAS Number (when available)

13. Description (when applicable/available)

14. References (when available)

Unit Size

xxii Order Hotline 1-800-777-4779

502-266-8787

(when applicable/available) 14. References (when available) Unit Size xxii Order Hotline 1-800-777-4779 502-266-8787

Terms and Conditions

Applicable Terms

These Terms and Conditions of Sale

shall become part of every order , sale,

between

buyer and Peptides International.

With the placement of an order , the

Terms

Peptides

International shall not be bound by the purchasing conditions of the buyer, even if not explicitly stated. Orders containing addenda or statements that are worded differently or provide for further condi tions will not be accepted unless spe - cifically agreed to in writing by Peptides International.

buyer

and

and

purchase

agreement

to

accept

of

Sale.

the

agrees

Conditions

-

The UN Convention on the International Sale of Goods shall not apply.

on the International Sale of Goods shall not apply. Quotations Quotations must be requested for the

Quotations

Quotations must be requested for the following special situations:

• Custom synthesis of materials not

listed in Peptides International’s website or catalog (custom quotations)

materials

that exceed those listed in Peptides International’s website or catalog (bulk quotations)

as

custom vialing, that are not of fered in website or catalog listings

• Large purchases of multiple items

where a discount is requested (core quotations)

Unless otherwise stated, quotations are valid for 30 days from date of issue.

Quotation prices are valid only for indi - cated product(s) in the quantity , quality, salt form, and lead time specified in the quotation.

Lead times for custom quotations are from date of receipt of an approved purchase order. Lead times for catalog products are subject to inventory status on date of receipt of an approved pur chase order.

Quotations are considered confidential

-

• Packaging

• Quantities

of

specific

alternatives,

such

Order Hotline 1-800-777-4779

502-266-8787

xxiii

Terms and Conditions

and are specific to the product(s) and customer. If appropriate, Non Disclosure Agreements may also be requested.

Quotations are not transferable to other parties without express permission from Peptides International.

Purchases based on accepted quota- tions remain subject to all other Terms and Conditions of Sale.

Prices

All prices are quoted in US Dollars and do not include value-added and/or sales tax, which may be invoiced separately as required. Prices include inner and outer packaging unless specifically noted oth - erwise.

If the prices in Peptides International’ s printed literature vary from the prices published on the Peptides International

website

prices on the website shall prevail.

Shipping and handling charges apply to all shipments and Peptides International reserves the right to add a surcharge for any special shipment requirements ( e.g. dry ice, inert gas).

All product prices are subject to change without notice prior to confirmation of an order, but no product will be shipped at increased prices without prior notifica tion.

Peptides International reserves the right to charge a re-assaying and restocking fee on returned goods.

(www.pepnet.com),

then the

-

Order Placement

Orders may be placed by telephone, fax, email, letter or online using Peptides

International’s

website ( www.pepnet.

com).

xxiv Order Hotline 1-800-777-4779

502-266-8787

Orders resulting from a prior quotation must reference the specific quotation number.

Orders placed verbally or by electronic transmission shall become legally bind - ing only if they have been confirmed by receipt of an invoice number from Peptides International.

Orders received by Peptides International are firm and binding upon the buyer and do not release the parties from their

obligation(s) to deliver or to accept deliv- ery, nor release them from their financial

obligations

Custom

carefully for structures, sequences, and other particulars before placing orders. Peptides International may at its discre - tion accept change orders under condi - tions that provide for recovery of already incurred costs and any additional costs arising from the agreed upon changes.

to Peptides International. orders should be reviewed

Delivery and Acceptance

Agreed upon delivery deadlines refer to the shipment date of the goods. If the delivery deadline is extended by buyer, buyer shall specify an appropri - ate period for acceptable late delivery of the shipment. If the delivery deadline is extended by Peptides International, buyer will be notified of such extension prior to the original shipment deadline.

Peptides International reserves the right to decline orders in the event the product can no longer be made or the customer is in arrears with any commitments or payments.

Buyer is responsible for complying with

national or international laws or regula -

,

tions applicable to shipment, delivery storage, processing or trading of any

national or international laws or regula - , tions applicable to shipment, delivery storage, processing or

Terms and Conditions

specifically designated products.

Force majeure of any kind, unforesee - able operational disruptions, short- falls or failures in delivery by Peptides International’s suppliers, shortages of raw materials, power supplies and/or manpower, strikes, lockouts, problems in procuring means of transport, traf fic obstructions, war, political unrest, acts of terrorism, natural disasters and order of higher authorities exempt the party concerned from the obligation to deliver or to accept delivery for the duration of the disruption and for any consequential damages arising therefrom, but shall not exempt such party from any financial obligations arising from any goods or services already supplied.

Warranty and Warranty Disclaimer

All Peptides International biochemicals

are extensively tested for purity . Each shipment is accompanied by a detailed

lot-specific

(ADS).

the purity, identity and content of its prod- ucts at the time of sale in accordance with the results listed in the ADS.

The buyer shall visually inspect and test products immediately upon receipt to determine whether the condition and quantity of the goods conforms to the ADS and the applicable contractual agreement. All claims must be received in writing within 14 days from date of delivery of the product to the customer and failure to do so shall constitute a waiver by buyer for any and all such claims. Claims must include proof of non-compliance, specifically naming the product, the lot number, and the invoice number.

“Analytical Data Sheet”

Peptides International warrants

Peptides International shall ship replace- ment product for claims for which proof is submitted and which are received within the time period specified above. If the replacement delivery is also non-con forming to the contractual agreement, then the buyer has the right to cancel the order or contract.

Products that are the subject of com - plaint may be sent back only with Peptide International’s agreement and shipping arrangements for the return must be agreed upon by both parties in advance.

Peptides International’s sole obligation

is to replace material up to the extent of

the purchase price, or provide a refund or credit. Peptides International makes no other warranties, express or implied,

including, but not limited to, any implied warranty of merchantability or fitness for

a particular purpose or implied warranty

arising out of a course of dealing, cus - tom, or usage of trade.

-

Use and Limitation of Liability

All products sold by Peptides International are intended solely for laboratory and research use and should not be used in or on human subjects. Peptides International sup - plies such products only for the pur - poses of public research as conducted at experimental and teaching institutes, technical facilities and commercial enti - ties.

It is the responsibility of the buyer to

determine the adequacy of all materials for any intended or specific purpose or use. Peptides International makes no

warranties as to use for an intended or specific purpose.

makes no warranties as to use for an intended or specific purpose. Order Hotline 1-800-777-4779 502-266-8787

Order Hotline 1-800-777-4779

502-266-8787

xxv

Terms and Conditions

Peptides International expressly forbids the distribution of dangerous substances

to private individuals and draws atten tion to the fact that the absence of a hazard warning sign does not indicate that the product concerned is harmless.

Peptides International shall therefore not accept any liability for damage that could arise from the inappropriate handling or from any use in household applications or in humans and animals. Peptides International shall not be liable for any damage as a result of improper use or

storage of its products.

of liability also includes products that have been tampered with or altered by accident or negligence.

Peptide

respect to non-fulfillment or delay of delivery shall be limited to the invoice amount of the goods.

All information contained in catalogs,

brochures, publications and other printed or electronic media is compiled to the

best of Peptide International’

edge.

disclaims any liability for any possible errors or misprints.

Peptides International shall not under any circumstances be liable to buyer for any direct, indirect, special, incidental, or consequential loss or damages (includ - ing, but not limited to, loss of profits, revenue, business, research, research results, opportunity or goodwill) aris - ing from or in any way related to the products or Peptides International’s sale of products, regardless of the legal or equitable theory under which such loss or damages are sought, including breach of warranty or contract, negligence, or strict liability.

s knowl-

-

This limitation

International’s

liability

with

Peptides International hereby

xxvi Order Hotline 1-800-777-4779

502-266-8787

Title and Proprietary Rights

Until full payment of the purchase price, including all secondary claims, the sup - plied products remain the property of Peptides International ( reservation of title).

If the buyer fails to pay for products

despite receipt of late notices, Peptides International reserves the right to with hold any further deliveries to the buyer and to require the return of the unpaid goods, unused and in original packag ing, at the buyer’s expense.

-

-

Terms of Payment

Terms of payment are net 30 days for

qualified buyers.

1.5% per month (18% ANNUAL RATE) will be added to all balances which are 30 or more days past due.

Discount deductions on invoices are

not allowed. Reductions in Peptides International’s invoices may not be made without a credit invoice or note and if made without such, shall be considered

a late or short payment.

Peptides International reserves the right to change the terms of payment to payment in full or in part in advance of shipment.

After an order is accepted or a sale com- mitment is made, any increase in, and all new taxes, excises, duties, or other

governmental

on income) imposed on the production, sale, transportation, import or export of products sold to buyer which Peptides International is required to pay will be added to the price paid by customer for products.

A service charge of

charges (except taxes

is required to pay will be added to the price paid by customer for products. A

Terms and Conditions

Payment may be made by one of the following methods:

Check: Send a check, including any clearing, processing, or other bank charges or fees to:

Peptides International, Inc. P.O. Box 99703 Louisville, KY 40269

Wire Transfer: If not already in US dollars, arrange for conversion of the currency to US dollars, includ - ing shipping and handling charges (included on all invoices). Wire the total amount to the following account:

Bank ABA # 083900680 Account # 5183479840 SWIFT # BRBTUS33

BB&T 401 West Main St. Louisville, KY 40202 USA Contact: Nell Prince Phone (502)-562-7902

Credit Card: Peptides International accepts MasterCard, V isa, and American Express.

Important: After completing one of the steps above please email or fax a con - firming note to Peptides International indicating the date and amount of your payment. You should also include your invoice number or purchase order num - ber to insure proper credit.

Patent Claims, Protection Rights, Consultancy

With any purchase, the buyer acquires the product but no other rights asso

-

ciated

International remains in possession of all intellectual property rights related to the manufacturing and composition of the product.

The use of trademarks in offers does not provide for the use of such trademarks. Permission for such use must always be obtained from Peptides International in advance and in writing.

Peptides International makes no guaran- tee that the use or resale of its products will not violate the protection or patent rights of third parties.

Peptides International agrees to of

fer

with the product. Peptides

its customers technical support to the

best of its knowledge.

or proposals for the use, application, or

suitability of the products shall not be interpreted as an explicit guarantee of success.

All comments

Applicable Laws

Any legal dispute involving these Terms and Conditions will be governed by the laws of the Commonwealth of Kentucky.

If a provision in these conditions of sale or a provision in the context of other agreements are or become legally unenforceable, only that provision shall become null and void and all remaining provisions shall remain enforceable and in effect.

void and all remaining provisions shall remain enforceable and in effect. Order Hotline 1-800-777-4779 502-266-8787 xxvii

Order Hotline 1-800-777-4779

502-266-8787

xxvii

Custom Peptide Synthesis

Custom Products and Services

If peptides or other products you need are not listed in this catalog, we invite you to try our custom synthesis services. Peptides International has earned the reputation of providing exceptionally high quality custom peptide synthesis products to the research community. We specialize in 5 to 100 mg quantities (or greater) with purity levels of at least 95%. Amino acid analysis ratios, mass spectral data, and analytical HPLC chro- matograms are provided with custom peptides. Areas of expertise include:

Multi-Disulfide Peptides Interested in mini-proteins with multiple disulfide bonds? Peptides International researchers have extensive experience folding these highly complicated molecules to their biologically active forms. Examples include native molecules and analogs of conotoxins, defensins, hepcidins, chemokines, ion channel blockers (ShK, HwTX4, charybdotoxin, iberiotoxin, margatoxin, ProTx-II, mu-conotoxins, etc). They can also customize with labels such as TAMRA, FITC or Biotin using a mini-PEG™ spacer.

Peptide-Protein Conjugates Peptide-protein conjugates have a variety of applications, including the stimulation of antibodies for immunization. These conjugates can be customized as needed, includ - ing combinations with proteins such asAlbumin, Ovalbumin, and Ferritin. Selective het- erobifunctional crosslinkers allow for selective attachment of a Cys-containing peptide to the protein of your choice. Using KLH-MCC will help streamline this reaction, and the product (KLH-6000-PI) is conveniently kept in stock at all times.

Peptide Derivatives Fluorescence resonance energy transfer (FRET) occurs when excitation energy is

transferred from an excited fluorescent donor to a quenching acceptor in a distance-

dependent manner. Cleavage of a scissile peptide

bond within a fluorescence

quenched substrate leads to separation of the intramolecular donor-acceptor pair, thus allowing an increase in fluorescence. The fluorescence increase is proportional to the amount of peptide hydrolyzed. To design a substrate for a newly discovered enzyme

xxviii Order Hotline 1-800-777-4779

502-266-8787

peptide hydrolyzed. To design a substrate for a newly discovered enzyme xxviii Order Hotline 1-800-777-4779 502-266-8787

Custom Peptide Synthesis

or application, contact our specialists to begin a customized Substrates by Design™ project.

Post Translation Modification Including: Glycosylation, Phosphorylation, Fatty Acid Acylation, Pegylation, Cyclization, and Disulfide Bonds

Peptide Synthesis Including: Classical/Solution, Solid-Phase, Native Chemical Ligation, and Dendrimeric RGD Platforms

Peptidomimetics Including: Hydroxyethylene Isostere, Reduced Peptide Bonds, methylketones, Depsipeptides, and Phosphonates

Multi-step Organic Synthesis Including: Novel Amino Acid Derivatives, Stereo Selective Synthesis, Special Protecting Groups

Other Services

Peptides International is an excellent source for production of unusual amino acids and offers rapid, thorough, and cost effective hydrogen fluoride (HF) cleavage proce- dures. Please inquire for additional analytical services.

Confidentiality

All customer requests will be treated with strict confidentiality and non-disclosure

Aldehydes, Chloro-

agreements can easily be put in place.

project management and technology transfer for scale-up production.

W

e offer molecular design consultations,

transfer for scale-up production. W e offer molecular design consultations, Order Hotline 1-800-777-4779 502-266-8787 xxix

Order Hotline 1-800-777-4779

502-266-8787

xxix

Technology Platforms

As additional value, Peptides International has developed technology platforms that assure an intergrated company-wide effort that not only meets researcher's immedi- ate synthetic needs, but can of fer additional services in such areas as analytical testing, technology/process development, and scale-up.

Peptides International's RGD

extensive catalog offerings, custom RGD experience, and technological expertise.

Technology Platform, is a natural outgrowth of its

Defined-Length Multimers PEGylations Conjugates RGD Complex Technology Industry Leading Organic Platform Catalog
Defined-Length
Multimers
PEGylations
Conjugates
RGD
Complex
Technology
Industry Leading
Organic
Platform
Catalog Portfolio
Derivatives
Process Scale-up
Multi-gram Synthesis

Applications and Potential Benefits to Researchers:

• Integrin related RGD research

• NCEs and cancer drug development

• Useful to prepare radiolabeled agents

drug development • Useful to prepare radiolabeled agents • Tumor targeting, imaging and diagnostics • Novel

• Tumor targeting, imaging and diagnostics

• Novel biomaterial research & development

• Tissue repair and wound healing studies

Order Hotline 1-800-777-4779

502-266-8787

xxx

Technology Platforms

The Custom Services Portfolio Platform spans a wide range of technologies rang- ing from traditional solution and solid phase synthesis to peptidomimetics as illus

trated by depsi-peptide bond formation and HET isostere incorporation. Expertise in

multi-step organic synthesis and peptide modi - fication offer a virtually limitless range of custom options extending from glycosylation to fluorescent and

-

Peptide Peptidomimetics Synthesis Post Translational Multi-disulfide Modifications Peptides Multi-step Peptide
Peptide
Peptidomimetics
Synthesis
Post
Translational
Multi-disulfide
Modifications
Peptides
Multi-step
Peptide
Organic
Derivatives
Synthesis
Peptide-
Protein
Conjugates
Derivatives Synthesis Peptide- Protein Conjugates isotopic labeling, cycliz ation, phosphorylation, and more.

isotopic labeling, cycliz ation, phosphorylation, and more.

xxxi Order Hotline 1-800-777-4779

502-266-8787

Conjugates isotopic labeling, cycliz ation, phosphorylation, and more. xxxi Order Hotline 1-800-777-4779 502-266-8787

BIOLOGICALLY ACTIVE PEPTIDES

PEPTIDES INTERNATIONAL

PRODUCT

 

CODE

QTY

PRICE

Biologically Active Peptides

(All Are Acetate Form Unless Otherwise Indicated)

 

Ac-Asp-Glu

 

Ac-Asp-Glu • H 2 O

(Bulk)

 

PDE-4167

25

mg

55

(M.W. 304.26 • 18.02) C 11 H 16 N 2 O 8 • H 2 O Endogenous Excitatory Neurotransmitter

[3106-85-2]

-20 °C
-20 °C

100

mg

155

K.L. Reichert and F. Fonnum, J. Neurochem., 16, 1409 (1969). (Original) K.J. Koller and J.T. Coyle, Eur. J. Pharm., 98, 193 (1984). (Characterization of Receptor) K.J. Koller, R. Zaczek, and J.T. Coyle, J. Neurochem., 43, 1136 (1984). (Localization in Brain) J.H. Neale, T. Bzdega, and B. Wroblewska, J. Neurochem. 75, 443 (2000). ( Review)

 

ACV (Delta-(l-Alpha aminoadipyl)-l-Cysteinyl-Bis-d-Valine)

 

Bis-ACV

 

PAC-3860-PI

25

mg

395

Delta-(l-a-aminoadipyl)-l-Cysteinyl-Bis-d-Valine (M.W. 724.86) C 28 H 48 N 6 O 12 S 2 Precursor for Biosynthesis of Penecillin

-20 °C
-20 °C

100

mg

995

Adjuvant Peptide

 

Adjuvant Peptide

 

PAD-4031-v

0.5

mg

45

N-Ac-Mur-Ala-d-Glu-NH 2 (Mur: Muramic acid) (M.W. 492.48) C 19 H 32 N 4 O 11 [53678-77-6]

-20 °C
-20 °C

vial

Adjuvant Peptide

(Bulk)

 

PAD-4031

25

mg

850

N-Ac-Mur-Ala-d-Glu-NH 2 • 2H 2 O (Mur: Muramic acid)

-20 °C
-20 °C

(M.W. 492.48 • 36.03 ) C 19 H 32 N 4 O 11 • 2H 2 O Muramyl Dipeptide

[53678-77-6]

F.

Ellouz, A. Adam, R. Ciorbaru, and E. Lederer, Biochem. Biophys. Res. Commun., 59, 1317 (1974). ( Original)

S.

Kotani, Y. Watanabe, F. Kinoshita, T. Shimono, I. Morisaki, T. Shiba,

 

S.

Kusumoto, Y. Tarumi, and K. Ikenaka, Biken J., 18, 105 (1975). (Chem. Synthesis and Immun. Activity)

 

Adrenocorticotropic Hormone (ACTH)

 

ACTH (Human, 1-24)

 

PAC-4109-v

0.5

mg

275

Adrenocorticotropic Hormone (Human, 1-24)

-20 °C
-20 °C

vial

Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-

Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro

(M.W. 2933.4) C 136 H 210 N 40 O 31 S

[16960-16-0]

B. Riniker, P. Sieber, W. Rittel, and H. Zuber, Nature (New Biol.), 235, 114 (1972). (Original; Structure)

and H. Zuber, Nature (New Biol.) , 235 , 114 (1972). ( Original; Structure) Order Hotline

Order Hotline 1-800-777-4779

502-266-8787

1

BIOLOGICALLY ACTIVE PEPTIDES

PEPTIDES INTERNATIONAL

PRODUCT

CODE

QTY

PRICE

Adrenomedullins and Related Peptides

K. Kitamura, K. Kangawa, H. Matsuo, and T. Eto, Drugs, 49, 485 (1995). (Review)

D.A. Schell, R.C. Vari, and W.K. Samson, Trends Endocrinol. Metab., 7, 7 (1996). (Review)

M. Julián, M. Cacho, M.A. Garcia, S. Martin-Santamaria, B. de Pascual-Teresa, A. Ramos, A. Martinez, and F. Cuttitta,

Eur. J. Med. Chem., 40, 737 (2005). (Review)

Adrenomedullin (Human)*

PAD-4278-s

0.1

mg

350

Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-Phe-

-20 °C
-20 °C

vial

Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys-Leu-Ala-

His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Asn-

Val-Ala-Pro-Arg-Ser-Lys-lle-Ser-Pro-Gln-Gly-Tyr-NH 2 (Disulfide bond between Cys 16 -Cys 21 ) (M.W. 6028.7) C 264 H 406 N 80 O 77 S 3 [148498-78-6] Hypotensive Peptide

K.

Kitamura, K. Kangawa, M. Kawamoto, Y. Ichiki, S. Nakamura, H. Matsuo, and T. Eto,

 

Biochem. Biophys. Res. Commun., 192, 553 (1993). (Original)

K.

Kitamura, J. Sakata, K. Kangawa, M. Kojima, H. Matsuo, and T. Eto, Biochem. Biophys. Res. Commun.,

 

194, 720 (1993). (Original; cDNA) • This product is distributed under the license of Shionogi & Co., Ltd. Its use for any purpose other than research is strictly prohibited.

* The biological activity of this peptide is examined by the Division of Pharmacology, Peptide Institute, Inc.

 

Adrenomedullin (Human, 1-25)*

PAD-4325-v

0.5

mg

305

Tyr-Arg-Gln-Ser-Met-Asn-Asn-Phe-Gln-Gly-Leu-Arg-Ser-

-20 °C
-20 °C

vial

Phe-Gly-Cys-Arg-Phe-Gly-Thr-Cys-Thr-Val-Gln-Lys (Disulfide bond between Cys 16 -Cys 21 ) (M.W. 2927.3) C 125 H 192 N 40 O 36 S 3 Vasopressor Fragment of Human Adrenomedullin

T.X. Watanabe, Y. Itahara, T. Inui, K. Yoshizawa-Kumagaye, K. Nakajima, and S. Sakakibara, Biochem. Biophys. Res. Commun., 219, 59 (1996). (Original)

 

Adrenomedullin (Human, 22-52)

PAD-4302-v

0.5

mg

380

Thr-Val-Gln-Lys-Leu-Ala-His-Gln-Ile-Tyr-Gln-Phe-Thr-Asp-

-20 °C
-20 °C

vial

Lys-Asp-Lys-Asp-Asn-Val-Ala-Pro-Arg-Ser-Lys-Ile-Ser-

Pro-Gln-Gly-Tyr-NH 2 (M.W. 3576.0) C 159 H 252 N 46 O 48 [159899-65-7] Adrenomedullin Antagonist

S.

Eguchi, Y. Hirata, H. Iwasaki, K. Sato, T.X. Watanabe, T. Inui, K. Nakajima, S. Sakakibara, and F. Marumo,

Endocrinology, 135, 2454 (1994). (Original)

Adrenomedullin (Rat)*

PAD-4281-s

0.1

mg

340

Tyr-Arg-Gln-Ser-Met-Asn-Gln-Gly-Ser-Arg-Ser-Thr-Gly-Cys-

-20 °C
-20 °C

vial

Arg-Phe-Gly-Thr-Cys-Thr-Met-Gln-Lys-Leu-Ala-His-Gln-

Ile-Tyr-Gln-Phe-Thr-Asp-Lys-Asp-Lys-Asp-Gly-Met-

Ala-Pro-Arg-Asn-Lys-Ile-Ser-Pro-Gln-Gly-Tyr-NH 2 (Disulfide bond between Cys 14 -Cys 19 ) (M.W. 5729.4) C 242 H 381 N 77 O 75 S 5 Hypotensive Peptide

J. Sakata, T. Shimokubo, K. Kitamura, S. Nakamura, K. Kangawa, H. Matsuo, and T. Eto,

Biochem. Biophys. Res. Commun., 195, 921 (1993). (Original; cDNA and Biological Activity)

2 Order Hotline 1-800-777-4779

502-266-8787

Res. Commun. , 195 , 921 (1993). (Original; cDNA and Biological Activity) 2 Order Hotline 1-800-777-4779

BIOLOGICALLY ACTIVE PEPTIDES

PEPTIDES INTERNATIONAL

PRODUCT

CODE

QTY

PRICE

Adrenomedullin 2 (Human)

PAD-4421-s

0.1

mg

290

Intermedin (Human)

-20 °C
-20 °C

vial

Thr-Gln-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-

 

Thr-Cys-Gln-Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-

Gln-Leu-Met-Gly-Pro-Ala-Gly-Arg-Gln-Asp-Ser-Ala-

Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH 2 (Disulfide bond between Cys 10 and Cys 15 ) (M.W. 5100.7) C 219 H 349 N 69 O 66 S 3

Cardiovascular and Renal Regulator / Suppressor for Food Intake and Gastric Emptying

 

M.

Ogoshi, K. Inoue, and Y. Takei, Biochem. Biophys. Res. Commun., 311, 1072 (2003).

 

(Takifugu rubripes Adrenomedullins)

 

Y.

Takei, K. Inoue, M. Ogoshi, T. Kawahara, H. Bannai, and S. Miyano, FEBS Lett., 556, 53 (2004).

 

(Original; Adrenomedullin 2)

 

J.

Roh, C.L. Chang, A. Bhalla, C. Klein, and S.Y.T. Hsu, J. Biol. Chem., 279, 7264 (2004). (Original; Intermedin)

Y.

Fujisawa, Y. Nagai, A. Miyatake, Y. Takei, K. Miura, T. Shoukouji, A. Nishiyama, S. Kimura, and Y. Abe,

 

Eur. J. Pharmacol., 497, 75 (2004). (Pharmacol.)

 

M.M. Taylor, S.L. Bagley, and W.K. Samson, Am. J. Physiol. Regul. Integr. Comp. Physiol., 288, R919 (2005). (Pharmacol.)

K.

Takahashi, K. Kikuchi, Y. Maruyama, T. Urabe, K. Nakajima, H. Sasano, Y. Imai, O. Murakami, and K. Totsune,

Peptides, 27, 1383 (2006). (Histochem.)

 

D.

Bell and B.J. McDermott, Br. J. Pharmacol., 153, S247 (2008). (Review)

Adrenomedullin 2 (Rat)

PAD-4422-s

0.1

mg

290

Intermedin (Rat)

-20 °C
-20 °C

vial

Pro-His-Ala-Gln-Leu-Leu-Arg-Val-Gly-Cys-Val-Leu-Gly-Thr-Cys-Gln-

Val-Gln-Asn-Leu-Ser-His-Arg-Leu-Trp-Gln-Leu-Val-Arg-Pro-Ser-Gly-

Arg-Arg-Asp-Ser-Ala-Pro-Val-Asp-Pro-Ser-Ser-Pro-His-Ser-Tyr-NH 2 (Disulfide bond between Cys 10 -Cys 15 ) (M.W. 5216.9) C 226 H 361 N 75 O 64 S 2 Potent Cardiovascular and Renal Regulator / Suppressor for Food Intake and Gastric Emptying

M. Ogoshi, K. Inoue, and Y. Takei, Biochem. Biophys. Res. Commun., 311, 1072 (2003).

(Takifugu rubripes Adrenomedullins)

Y. Takei, K. Inoue, M. Ogoshi, T. Kawahara, H. Bannai, and S. Miyano, FEBS Lett., 556, 53 (2004).

(Original; Adrenomedullin 2)

J.

Roh, C.L. Chang, A. Bhalla, C. Klein, and S.Y.T. Hsu, J. Biol. Chem.