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Cannabis vs Rx-Antidepressants

I work and have worked for the past 15+ years to a large degree with mood disorders and also so-called chemical dependency etc. Through these years of intense clinical observation, practice and research I have developed a very solid grasp of the bi-polar mechanism which governs the psyche and how it works. What I have observed through these years basically reects the research attached here and in comment referred to as complicated effects. I have (also) found that Cannabis eases depression. The data referred to below shows however that low doses work to reduce depression but high doses can worsen it. This is exactly how the bipolar mechanism referred to above works. The problem with too high doses and too frequent long term usage is the classical picture of any psychotropic agent, and that is that it could switch off the endo-cannabinoid system from producing its own inner effects (or thus building tolerance which could lead to addiction). So basically no psychoactive drug/agent should be used as a long term treatment for depression. In the shorter term, and also taking into account high variation between individuals, it means that low to moderate doses can be effective to ease depression. But regular/too much use and too high doses can hitherto become the very cause for anxiety itself and depression and reduction of someones ability to cope with life, the cannabis (or other psychoactive agent) was used for in the rst place. Obviously this must all be controlled for and/or take into account the great variance among the different strains (some make you feel happy, others make you sleep, others make you active and so on.) The gist here is that too much of something will lead to the very effects that thing can ease in small/er amounts. I believe that a very large portion of the use of cannabis (also of the recreational use) is based on self medication (obviously not always seen so by the user) in terms of persons seeking to ease depression and anxiety. While as mentioned using too much of it leads thus to the very image many uphold regarding long term and too frequent use of lethargy etc., and/or thus the very depression/low seeking ease from. Long term real psychotherapy must be added to short term moderate doses psycho-actives, to uncover and solve deep seated issues which are rooted in early childhood trauma and abuses etc., if not they will end up masking these deeper underlying trauma based issues. And this to the point where mood balance can be maintained as much as possibly from within without external palliatives. Yet this is not a zero sum thing. What does force itself onto us here in this discussion as relevant is that the Rx (Big Pharma) antidepressants are not only synthetic and thus fraught with side effects, but the extreme high costs of these Rx antidepressants. The World Health Organization forecasts that depression will displace heart disease as the heaviest disease burden by 2020. Up to one-third of Americans and 40 percent of Europeans could be classied as having a mental illness, according to a Thomson Reuters Pharma analysis released in March 2012. The Thomson Reuters Pharma analysis found that global sales of antidepressants (Prozac, Zoloft, Lexapro, Paxil and Celexa...) were $15 billion in 2003...

So while one thing is for sure and that is over use of all drugs (also Rx) builds tolerance and can lead to addiction, yet the question that is begged is how much money could be saved if we were to be weaned off of big pharma's synthetic Rx drugs vis-a-vis a medically closely monitored and guided approach in abovementioned terms of low short term doses of natural psychoactives supplemented with real trauma based psychotherapy? References: Cannabis: Potent Anti-Depressant In Low Doses, Worsens Depression At High Doses