SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 16.04.2010

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 1 of 9
1. Identification of the substance/mixture and of the company/undertaking
Product Information
Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS
Use of the
Substance/Mixture
Reagent for analysis, Solvent

Company: Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0
Emergency telephone: Please contact the regional Merck representation in your country.
Responsible/issuing person: EQ-EPS * e-mail: prodsafe@merck.de

2. Hazards identification
GHS Classification
Carcinogenicity, Category 2 H351: Suspected of causing cancer.
Acute toxicity, Category 4, Oral H302: Harmful if swallowed.
Skin irritation, Category 2 H315: Causes skin irritation.
Specific target organ toxicity - repeated
exposure, Category 2
H373: May cause damage to organs through
prolonged or repeated exposure.
EC Classification
Xn; R22 - 48/20/22
Xi; R38
Carc.Cat.3; R40
For the full text of the R-phrases mentioned in this Section, see Section 16.

3. Composition/information on ingredients
Formula CHCl CHCl (Hill)
CAS-No. 67-66-3
Index-No. 602-006-00-4
EC-No. 200-663-8
Molar mass 119,38 g/mol

4. First aid measures

After inhalation: fresh air. If breathing stops: mouth-to-mouth respiration or mechanical
ventilation. Oxygen mask if necessary! Immediately call in physician.

After skin contact: wash off with plenty of water. Remove contaminated clothing.

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.

If swallowed: Caution Aspiration hazard Keep respiratory tract clear. Call a physician
immediately. Subsequently administer: activated charcoal (20 - 40 g in 10% slurry). In case of
spontaneous vomiting: Risk of aspiration. Pulmonary failure possible. Call in physician.

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 2 of 9
Notes to physician
Treatment
Laxative: Sodium sulfate (1 tablespoon/1/4 l water).

5. Fire-fighting measures

Suitable extinguishing media
Use extinguishing measures that are appropriate to local circumstances and the surrounding
environment.

Specific hazards during fire fighting
Not combustible.
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Hydrogen chloride gas, Phosgene

Special protective equipment for fire-fighters
Do not stay in dangerous zone without self-contained breathing apparatus. In order to
avoid contact with skin, keep a safety distance and wear suitable protective clothing.

Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.

6. Accidental release measures

Personal precautions
Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation.

Environmental precautions
Do not empty into drains.

Methods for cleaning up
Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up
affected area. Do not inhale vapours.

7. Handling and storage
Handling

Advice on safe handling
Work under hood. Do not inhale substance. Avoid generation of vapours/aerosols.

Storage

Further information on storage conditions
Protected from light. Tightly closed.

Store below +30C.

8. Exposure controls/personal protection

Personal protective equipment
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 3 of 9

Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter AX (EN 371)

Hand protection
full contact:
Glove material: Viton
Glove thickness: 0,70 mm
Break through time: > 480 min
splash contact:
Glove material: butyl-rubber
Glove thickness: 0,7 mm
Break through time: > 10 min

The protective gloves to be used must comply with the specifications of EC irective 89/686/EEC
and he resultant standard EN374, for example. KCL 890 Vitoject (full contact), KCL 898
Butoject (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to
EN374 with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet and supplied by
us as well as to the purpose specified by us. When dissolving in or mixing with other substances
and under conditions deviating from those stated in EN374 please contact the supplier of CE-
approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Eye protection
Safety glasses

Hygiene measures
Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands
and face after working with substance.

9. Physical and chemical properties
Form liquid

Colour colourless

Odour sweet

pH no data available

Viscosity, dynamic 0,56 mPa.s
at 20 C

Melting point -63 C

Boiling point/boiling range ca. 61 C

Ignition temperature not combustible

Flash point Method: DIN 51755 Part 1
does not flash

Oxidizing properties no data available

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 4 of 9
Flammability no data available

Lower explosion limit not applicable

Upper explosion limit not applicable

Vapour pressure 211 hPa
at 20 C

Relative vapour density 4,25

Density 1,48 g/cm3
at 20 C

Solubility/qualitative no data available

Water solubility 8 g/l
at 20 C

Partition coefficient: n-
octanol/water
log Pow: 2 (25 C)
Method: (experimental)
(IUCLID) No appreciable bioaccumulation potential is to be
expected (log Pow 1-3).
Evaporation rate no data available


10. Stability and reactivity

Conditions to avoid
Strong heating.

Materials to avoid
Risk of explosion with:

Alkali metals, Alkaline earth metals, peroxi compounds, Fluorine, alcoholates, strong alkalis,
Sodium hydroxide, Methanol, alkali hydroxides, Alcohols, organic nitro compounds, alkali amides,
Oxygen, bases, nitrogen oxides, Amines, Ammonia, Iron, in powder form, Aluminium, magnesium,
metal alloys, sensitive to shock

Violent reactions possible with:

phosphines, bis(dimethylamino)dimethyl tin, Metals, in powder form, nonmetallic hydrogen
compounds

Hazardous decomposition products
in the event of fire: See chapter 5.

Stabilizer:
Ethanol

Further information
Sensitivity to light
heat-sensitive
incompatible with:
rubber
rubber, various plastics
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 5 of 9

11. Toxicological information

Acute oral toxicity
LD50 rat
Dose: 695 mg/kg
(RTECS)

LDLO human
Dose: 2.514 mg/kg
(RTECS)
Symptoms: Nausea, Vomiting, Aspiration may cause pulmonary oedema and pneumonitis.
Acute inhalation toxicity
LCLO human
Dose: 124,1 mg/l, 5 min
(RTECS)

LC50 rat
Dose: 47,7 mg/l, 4 h
(IUCLID)
Symptoms: Cough, Shortness of breath, absorption
Acute dermal toxicity
Symptoms: absorption
Skin irritation
rabbit
Result: slight irritation
(IUCLID) Drying-out effect resulting in rough and chapped skin.
Eye irritation
rabbit
Result: slight irritation
(IUCLID)
Further information
Systemic effects:
After absorption:
Dizziness, inebriation, agitation, spasms, narcosis, respiratory arrest
After long-term exposure to the chemical:
drop in blood pressure, Headache, ataxia (impaired locomotor coordination), Stomach/intestinal
disorders, cardiovascular disorders
Damage of:
Liver, Kidney, Cardiac
Effect potentiated by: ethanol
Further data:
Handle in accordance with good industrial hygiene and safety practice.
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 6 of 9

12. Ecological information
Ecotoxicity

Toxicity to fish
LC50
Species: Lepomis macrochirus (Bluegill sunfish)
Dose: 18 mg/l
Exposure time: 96 h
(IUCLID)
Toxicity to daphnia and other aquatic invertebrates.
EC50
Species: Daphnia magna (Water flea)
Dose: 79 mg/l
Exposure time: 48 h
(IUCLID)
EC5
Species: E.sulcatum
Dose: > 6.560 mg/l
Exposure time: 72 h
(IUCLID) (maximum permissible toxic concentration)
Toxicity to algae
IC5
Species: Scenedesmus quadricauda (Green algae)
Dose: 1.100 mg/l
Exposure time: 8 d
(IUCLID) (maximum permissible toxic concentration)
Toxicity to bacteria
EC5
Species: Pseudomonas putida
Dose: 125 mg/l
Exposure time: 16 h
(IUCLID) (maximum permissible toxic concentration)
EC50
Species: activated sludge
Dose: 1.010 mg/l
Exposure time: 3 h
Method: OECD Test Guideline 209

Mobility
Henry constant
14084Pa*m3/mol
(experimental) (IUCLID) Distribution preferentially in air.

Persistence and degradability
Biodegradability
0 %
Exposure time: 14 d
Method: OECD Test Guideline 301C
Result: Not readily biodegradable.

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 7 of 9
Partition coefficient: n-octanol/water
log Pow: 2 (25 C)
Method: (experimental)
(IUCLID) No appreciable bioaccumulation potential is to be expected (log Pow 1-3).
Additional ecological information
Biological effects:
Endangers drinking-water supplies if allowed to enter soil and/or waters in large quantities.
Further information on ecology
Do not allow to enter waters, waste water, or soil!

13. Disposal considerations

Product
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.de you will find country- and substance-specific information as well as contact
partners.
Packaging
Merck product packaging must be disposed of in compliance with the country-specific
regulations or must be passed to a packaging return system. Under www.retrologistik.de you will
find special information on the respective national conditions as well as contact partners.

14. Transport information
ADR/RID
UN 1888 CHLOROFORM, 6.1, III
IATA
UN 1888 CHLOROFORM, 6.1, III
IMDG
UN 1888 CHLOROFORM, 6.1, III
EmS F-A S-A
The transport regulations re cited according to international regulations and in the form applicable
in Germany. Possible national deviations in other countries are not considered.


15. Regulatory information
GHS-Labelling
Hazard pictograms


Signal word
Warning

Hazard statements
H351: Suspected of causing cancer.
H302: Harmful if swallowed.
H373: May cause damage to organs through prolonged or repeated exposure.
H315: Causes skin irritation.

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 8 of 9
Precautionary statements
P302 + P352: IF ON SKIN: Wash with plenty of soap and water.
P314: Get medical advice/attention if you feel unwell.

For use in industrial installations only.
Reduced labelling (125 ml)
Hazard pictograms


Signal word
Warning

Hazard statements
H351: Suspected of causing cancer.

For use in industrial installations only.


Index-No. 602-006-00-4
Labelling according to EC Directives
Symbol(s): Xn Harmful

R-phrase(s): 22-38-40-48/20/22 Harmful if swallowed. Irritating to skin. Limited evidence
of a carcinogenic effect. Harmful: danger of serious
damage to health by prolonged exposure through
inhalation and if swallowed.
S-phrase(s): 36/37 Wear suitable protective clothing and gloves.

Further information
Only for research, development, analysis or specific industrial processes (76/769/EEC).


EC-No. 200-663-8 EC Label
Reduced labelling (125 ml)
Symbol(s): Xn Harmful

R-phrase(s): 22-40-48/20/22 Harmful if swallowed. Limited evidence of a carcinogenic effect.
Harmful: danger of serious damage to health by prolonged exposure
through inhalation and if swallowed.
S-phrase(s): 36/37 Wear suitable protective clothing and gloves.

National legislation
Storage class VCI: 10 - 13 Other liquids and solids

Major Accident Hazard
Legislation:
96/82/EC Update: 2003
Directive 96/82/EC does not apply


Other regulations: Take note of Dir 94/33/EC on the protection of young people at
work. Take note of Dir 92/85/EEC on the safety and health at work
of pregnant workers.

16. Other information
Full text of R-phrases referred to under sections 2 and 3
R22 Harmful if swallowed.
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 107024
Product name: Chloroform for analysis EMPARTA ACS

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 9 of 9
R38 Irritating to skin.
R40 Limited evidence of a carcinogenic effect.
R48/20/22 Harmful: danger of serious damage to health by prolonged
exposure through inhalation and if swallowed.

Regional representation: This information is given on the authorised Safety Data Sheet for
your country.


The information contained herein is based on the present state of our knowledge. It characterizes the product with
regard to the appropriate safety precautions. It does not represent a guarantee of the properties of the product.