SAFETY DATA SHEET

according to Regulation (EC) No. 1907/2006

Revision Date 10.06.2010

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 1 of 8
1. Identification of the substance/mixture and of the company/undertaking
Product Information
Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv
Use of the
Substance/Mixture
Reagent for analysis

Company: Merck KGaA * 64271 Darmstadt * Germany * Phone:+49 6151 72-0
Emergency telephone: Please contact the regional Merck representation in your country.
Responsible/issuing person: EQ-EPS * e-mail: prodsafe@merck.de

2. Hazards identification
GHS Classification
Carcinogenicity, Category 2 H351: Suspected of causing cancer.
EC Classification
Carc.Cat.3; R40
For the full text of the R-phrases mentioned in this Section, see Section 16.

3. Composition/information on ingredients
Formula CHCl CHCl (Hill)
CAS-No. 75-09-2
Index-No. 602-004-00-3
EC-No. 200-838-9
Molar mass 84,93 g/mol

4. First aid measures

After inhalation: fresh air. If necessary, apply mouth-to-mouth resuscitation or mechanical
ventilation. Keep respiratory tract clear. Consult doctor in the event of any complaints.

After skin contact: wash off with plenty of water. Remove contaminated clothing. Consult a
physician.

After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.

After swallowing: caution if victim vomits. Risk of aspiration! Keep airways free. Drink plenty of
water. Subsequently administer: activated charcoal (20 - 40 g in 10% slurry). Call a physician
immediately.

5. Fire-fighting measures

Suitable extinguishing media
Water, Carbon dioxide (CO2), Foam, Dry powder

Specific hazards during fire fighting
Not combustible.
Vapours are heavier than air and may spread along floors.
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 2 of 8
Ambient fire may liberate hazardous vapours.
Fire may cause evolution of:
Hydrogen chloride gas, Phosgene

Special protective equipment for fire-fighters
Do not stay in dangerous zone without self-contained breathing apparatus. In order to
avoid contact with skin, keep a safety distance and wear suitable protective clothing.

Further information
Suppress (knock down) gases/vapours/mists with a water spray jet. Prevent fire extinguishing
water from contaminating surface water or the ground water system.

6. Accidental release measures

Personal precautions
Do not breathe vapours, aerosols. Avoid substance contact. Ensure adequate ventilation.

Environmental precautions
Do not empty into drains.

Methods for cleaning up
Take up with liquid-absorbent material (e.g. Chemizorb ). Forward for disposal. Clean up
affected area.

7. Handling and storage
Handling

Advice on safe handling
Work under hood. Do not inhale substance. Avoid generation of vapours/aerosols.

Observe label precautions.

Storage

Further information on storage conditions
Tightly closed.

Store at +15C to +25C.

8. Exposure controls/personal protection

Personal protective equipment
Protective clothing should be selected specifically for the working place, depending on
concentration and quantity of the hazardous substances handled. The resistance of the
protective clothing to chemicals should be ascertained with the respective supplier.

Respiratory protection
required when vapours/aerosols are generated.
Recommended Filter type: Filter AX (EN 371)

Hand protection
splash contact:
Glove material: Viton (R)
Glove thickness: 0,70 mm
Break through time: > 120 min

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 3 of 8
The protective gloves to be used must comply with the specifications of EC irective 89/686/EEC
and he resultant standard EN374, for example. KCL 890 Vitoject (splash contact).
The breakthrough times stated above were determined by KCL in laboratory tests acc. to
EN374 with samples of the recommended glove types.
This recommendation applies only to the product stated in the safety data sheet and supplied by
us as well as to the purpose specified by us. When dissolving in or mixing with other substances
and under conditions deviating from those stated in EN374 please contact the supplier of CE-
approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).

Eye protection
Safety glasses

Protective measures
Protective suit

Hygiene measures
Immediately change contaminated clothing. Apply skin- protective barrier cream. Wash hands
and face after working with substance.

9. Physical and chemical properties
Form liquid

Colour colourless

Odour sweet

pH at 20 C
neutral

Viscosity, dynamic 0,43 mPa.s
at 20 C

Melting point -95 C

Boiling point/boiling range 40 C
at 1.013 hPa

Ignition temperature 605 C
DIN 51794

Flash point does not flash

Oxidizing properties no data available

Flammability no data available

Lower explosion limit 13 %(V)

Upper explosion limit 22 %(V)

Vapour pressure 475 hPa
at 20 C

Relative vapour density 2,93

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 4 of 8
Density 1,33 g/cm3
at 20 C

Solubility/qualitative no data available

Water solubility 20 g/l
at 20 C

Partition coefficient: n-
octanol/water
log Pow: 1,25
Method: (experimental)
(Lit.) No appreciable bioaccumulation potential is to be
expected (log Pow 1-3).
Evaporation rate 1,9


10. Stability and reactivity

Conditions to avoid
Heating (decomposition).

Materials to avoid
Risk of explosion with:

Alkali metals, Aluminium, in powder form, nitrogen oxides, nitrogen dioxide, Potassium, sodium
azide, perchloric acid, Nitric acid, Oxygen, aromatic hydrocarbons

Exothermic reaction with:

Alkaline earth metals, Powdered metals, amides, alcoholates, nonmetallic oxides

Hazardous decomposition products
in the event of fire: See chapter 5.

Stabilizer:
2-Methyl-2-butene

Thermal decomposition
> 120 C


Further information
heat-sensitive
Sensitivity to light
unsuitable working materials:
various plastics, rubber, Light metals, Metals, Mild steel
Explosible with air in a vaporous/gaseous state when heated.

11. Toxicological information

Acute oral toxicity
LD50 rat
Dose: 1.600 mg/kg
(RTECS)

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 5 of 8
LDLO human
Dose: 357 mg/kg
(RTECS)
Symptoms: Nausea, Vomiting, Risk of aspiration upon vomiting., Aspiration may cause
pulmonary oedema and pneumonitis., Pulmonary failure possible after aspiration of vomit.
absorption

Acute inhalation toxicity
LC50 rat
Dose: 88 mg/l, 30 min
(IUCLID)
Symptoms: mucosal irritations, inebriation, Unconsciousness, narcosis
Acute dermal toxicity
LD50 rat
Dose: > 2.000 mg/kg
Method: OECD Test Guideline 402

Skin irritation
rabbit
Result: Irritations
(IUCLID)
Repeated or prolonged exposure may cause skin irritation and dermatitis, due to degreasing
properties of the product.
Eye irritation
rabbit
Result: slight irritation
(IUCLID)
Risk of corneal clouding.
Sensitisation
Patch test:
Result: negative
(IUCLID)
Genotoxicity in vitro
Mutagenicity (mammal cell test): chromosome aberration.
Result: negative
(National Toxicology Program)
Ames test
Result: positive
Method: OECD Test Guideline 471
Further information
Swallowing may result in damage to the following:
Liver, Kidney
Systemic effects:
After absorption of large quantities:
CNS disorders, Drowsiness, Dizziness, drop in blood pressure, Cardiac irregularities, respiratory
paralysis, depressed respiration
Other information
The following applies to aliphatic halogenated hydrocarbons in general: systemic effect:
narcosis, cardiovascular isorders. Toxic effect on liver, kidneys.
Further data:
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 6 of 8
Handle in accordance with good industrial hygiene and safety practice.

12. Ecological information
Ecotoxicity

Toxicity to fish
LC50
Species: Pimephales promelas (fathead minnow)
Dose: 193 mg/l
Exposure time: 96 h
(ECOTOX Database)
Toxicity to daphnia and other aquatic invertebrates.
EC0
Species: Protozoa
Dose: > 16.000 mg/l
(Lit.)
EC50
Species: Daphnia magna (Water flea)
Dose: 1.682 mg/l
Exposure time: 48 h
Method: DIN 38412
(IUCLID)
Toxicity to algae
IC50
Species: Pseudokirchneriella subcapitata (green algae)
Dose: > 660 mg/l
Exposure time: 96 h
(IUCLID)
Toxicity to bacteria
EC50
Species: Photobacterium phosphoreum
Dose: 2,88 mg/l
Exposure time: 15 min
(IUCLID)
Mobility
Henry constant
329Pa*m3/mol
(experimental) (Lit.) Distribution preferentially in air.

Persistence and degradability
Biodegradability
Result: Not readily biodegradable.
5 - 26 %
Exposure time: 28 d
Method: OECD Test Guideline 301C
After adaption biodegradable.
Partition coefficient: n-octanol/water
log Pow: 1,25
Method: (experimental)
(Lit.) No appreciable bioaccumulation potential is to be expected (log Pow 1-3).
Additional ecological information
Do not allow to enter waters, waste water, or soil!
Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 7 of 8

13. Disposal considerations

Product
Chemicals must be disposed of in compliance with the respective national regulations. Under
www.retrologistik.de you will find country- and substance-specific information as well as contact
partners.
Packaging
Merck product packaging must be disposed of in compliance with the country-specific
regulations or must be passed to a packaging return system. Under www.retrologistik.de you will
find special information on the respective national conditions as well as contact partners.

14. Transport information
ADR/RID
UN 1593 DICHLOROMETHANE, 6.1, III
IATA
UN 1593 DICHLOROMETHANE, 6.1, III
IMDG
UN 1593 DICHLOROMETHANE, 6.1, III
EmS F-A S-A
The transport regulations re cited according to international regulations and in the form applicable
in Germany. Possible national deviations in other countries are not considered.


15. Regulatory information
GHS-Labelling
Hazard pictograms


Signal word
Warning

Hazard statements
H351: Suspected of causing cancer.

Precautionary statements
P281: Use personal protective equipment as required.
P308 + P313: IF exposed or concerned: Get medical advice/attention.


Index-No. 602-004-00-3
Labelling according to EC Directives
Symbol(s): Xn Harmful

R-phrase(s): 40 Limited evidence of a carcinogenic effect.
S-phrase(s): 23-24/25-36/37 Do not breathe vapour. Avoid contact with skin and
eyes. Wear suitable protective clothing and gloves.

Safety Data Sheet
according to Regulation (EC) No. 1907/2006

Catalogue No.: 106054
Product name: Dichloromethane for gas chromatography SupraSolv

The Safety Data Sheets for catalog items are also available at www.merck-chemicals.com
Page 8 of 8
EC-No. 200-838-9 EC Label
Reduced labelling (125 ml)
Symbol(s): Xn Harmful

R-phrase(s): 40 Limited evidence of a carcinogenic effect.
S-phrase(s): 36/37 Wear suitable protective clothing and gloves.

National legislation
Storage class VCI: 10 - 13 Other liquids and solids

Major Accident Hazard
Legislation:
96/82/EC Update: 2003
Directive 96/82/EC does not apply


Other regulations: Take note of Dir 94/33/EC on the protection of young people at
work. Take note of Dir 92/85/EEC on the safety and health at work
of pregnant workers.

16. Other information
Full text of R-phrases referred to under sections 2 and 3
R40 Limited evidence of a carcinogenic effect.

Regional representation: This information is given on the authorised Safety Data Sheet for
your country.


The information contained herein is based on the present state of our knowledge. It characterizes the product with
regard to the appropriate safety precautions. It does not represent a guarantee of the properties of the product.