Malignant Fibrous

Haemophagocytic
Histiocytic Sarcoma Myeloid Metaplasia Histiocytoma/ Fibrohistiocytic Reactive Histiocytosis
syndrome
Nodule
vomiting, anemia and/or thrombocytopenia, 2-
Looks like IMHA (coombs neg), Deeper masses, can be secondary
Clinical picture can be IMTP, vomiting?
Multiple or single nodules 15 years, female > male, 79% coombs 4-19 years old, females> males,
to T cell lymphomas
negative
Albumin Decr (also chol)
Hematocrit Decre anemia 21%
Platelets
Uniform nodular configuration (large bulging
Spleen Diffuse splenomegaly focal or MF nodules Diffuse, uniform, splenomegaly with infarction areas) with necrosis with variable stromal and
blood components
may progress to multiorgan, BM- 53%
Other tissues liver liver, lung, BM, skin
metastasis
can metastasize

diffuse hematopoiesis (myeloid metaplasia),

EMH with myeloid and
erythroid precursors,
Histologic features hemosiderosis, immature cells phagocytosis, lots lymphocytes,
all thorugh red pulp, no giant
cells, thrombi in vessels in liver
centered around vessels, T
vascular thrombosis with segmental splenic
lymphocytes and histiocytes,
infarction, and reactive and proliferative cellular
MNGC, bizarre cells, lots of variable mixtures of lymphoid and spindyloid involves vessel walls and
retisular meshwork containing excess
macrophages/histiocytes - reactive or
cells with variable presence of multinucleated lymphatics, MNGC, low MI, spindle
high mitotic rate, giant cells and EMH variants/ Activated dermal
neoplastic with MNGC (23%)- in absence of
dendritic cells (perivascular
MNGC histiocytosis may be reactive or the
interstitial dendritic cells)
result of IMHA or other causes

Erythrophagocytosis Lots Some excessive (92%)

large cells had- folded crenated or
cerebriform; others looked like plasma cells,
Nuclei or fibroblasts, or macrophages; splenic
Indented nuclei
reticular cells had pleated nuclei
(macrophages) CD18 +,
Interstitial dendritic cells**/
CD11d+/ MHC -II, ß2 integrin CD1, CD11c, MHC II, and CD90 +/
IHC (CD11d),/ Low or inconsistent
CD11d-, CD 1+, CD18+/ CD1, not useful
E-cadherin -
CD11c +
expression of CD1, CD11c

Cutaneous Langerhans cell Epitheliotropic lymphoma

Histiocytoma histiocytoma (mycosis fungoides)
Rare, fatal, phenotype like confined to skin, the nbecome anaplastic and
young dogs (3 yrs) , focal tumor,
Clinical picture spontaneous regression
histiocytoma but does not metastasize, found in mucocutaneous
regress junctions and gingiva
Other tissues Can metastasize but rare

obscures the dermal epidermal junction

Histologic features (classical) or not (pagetoid)

CD8+ a,b T cells;CD1, CD11c, CD3+(50%), CD8+(80%classical, 50%

IHC MHC- II, Langerin, E cadherin + pagetoid), TCR yd+, ab-