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Summary
This report highlights recent efforts by affected countries to control the spread
of the avian influenza (H5N1) virus. Included is statistical information on confirmed
human cases and deaths through February 27, 2007. For more background
information on earlier efforts by these countries and international organizations
through September 2006, see CRS Report RL33349, International Efforts to Control
the Spread of the Avian Influenza (H5N1) Virus: Affected Countries’ Responses.
This report will be updated as events warrant.
Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1
U.S. Funding for International Avian Flu Control Efforts . . . . . . . . . . . . . . . 1
Overview of International Response . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2
Antiviral Production . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3
List of Figures
Figure 1. Map of Human H5N1 Cases and Deaths . . . . . . . . . . . . . . . . . . . . . . . . 5
List of Tables
Table 1. Total Number of Human Cases and Deaths by Country Through
February 27, 2007 . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4
Foreign Countries’ Response to the Avian
Influenza (H5N1) Virus: Current Status
Introduction
A strain of the avian influenza virus known as H5N1 first appeared in birds and
humans in Hong Kong in 1997. Since re-surfacing in late 2003, the virus has spread
throughout Asia and caused over 165 reported human deaths from Vietnam to Egypt
while appearing in birds in Africa and Europe. Although media coverage of the virus
abated significantly in 2006, both the number of cases (116 in 2006 versus 97 in
2005) and deaths (80 in 2006 versus 42 in 2005) accelerated. The H5N1 virus has
been confirmed in humans in ten countries, with an overall mortality rate of about
60%.1 The virus disproportionately affects children and young adults. Although
avian influenza is still considered to be extremely inefficient in human-to-human
transmission, there have been cases of limited human-to-human transmission in
Indonesia. Some health authorities continue to stress that H5N1 has the potential to
cause a major human pandemic. In January 2007, the World Health Organization
(WHO) warned that avian influenza could again spread across Asia to Europe in
2007.2
Birds, mostly domestic poultry, remain the primary source of human infection.
Confirmed cases of H5N1 infection in birds have appeared in over 50 countries,
including new outbreaks in East Asia, Central Asia, the Middle East, and Europe in
early 2007.3 In some countries, the virus is considered endemic, meaning that avian
influenza is an ongoing risk to humans in the area.
1
According to the WHO, as of January 22, 2007. [http://www.who.int/csr/disease/
avian_influenza/country/cases_table_2007_01_22/en/index.html]
2
“Europe Warned Over Seasonal Resurgence of Deadly Bird Flu,” Financial Times. January
15, 2007.
3
For a full list of countries with confirmed cases of infection in birds, see
[http://www.oie.int/downld/AVIAN%20INFLUENZA/A_AI-Asia.htm].
4
See CRS Report RL33219, U.S. and International Responses to the Global Spread of
Avian Flu: Issues for Congress by Tiaji Salaam-Blyther.
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total of $31.3 million for U.S. global avian flu activities from those appropriations.
P.L.109-148, FY2006 Defense Department appropriations, included $3.8 billion to
address pandemic influenza. P.L.109-234, FY2006 Emergency Supplemental
Appropriations, provided $2.3 billion for avian and pandemic flu efforts, of which
$30 million was appropriated to USAID for international avian flu efforts and $200
million was appropriated to the Centers for Disease Control and Prevention (CDC)
for global and domestic disease surveillance, laboratory capacity, research, and other
activities. Relevant FY2007 U.S. department and agency budget justifications
included some $205 million for global H5N1 initiatives. As in previous fiscal years,
U.S. agencies and departments might commit additional resources to global avian flu
efforts that were not specifically appropriated for those purposes.
5
For a detailed account of U.S. funding for H5N1, please see CRS Report RL33219, U.S.
and International Responses to the Global Spread of Avian Flu: Issues for Congress, by
Tiaji Salaam-Blyther.
6
“Bird Flu Fever,” Wall Street Journal Asia. January 17, 2007.
7
“Avian Flu Outbreak in Indonesia Prompts Cull of Millions of Birds,” Financial Times.
January 16, 2007.
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cover over 14 billion birds). Critics question whether the immunizations eliminate
or only reduce the level of infection. Skeptics argue that birds that are immunized
but still infected could be a risk to humans and make the virus more difficult to track.
A new confirmed human case in China in January 2007, the first reported case in six
months, renewed alarm about China’s potential to suffer another outbreak.
The countries of the European Union (EU) appear to have successfully stemmed
the spread of the H5N1 virus: no cases have been confirmed in humans and only
limited, sporadic infections in birds have been detected. Health authorities give
credit to strong and consistent veterinary measures carried out by EU governments
as directed by EU legislation.8 On the other side of the spectrum, surveillance in
Africa remains very weak. In Africa, only Egypt suffered further human cases and
deaths in 2006, but concern remains that sub-Saharan Africa lacks the infrastructure
and resources to deal effectively with an outbreak in humans.
Antiviral Production9
Production of the antiviral treatment oseltamivir (marketed as Tamiflu) has
accelerated. Swiss manufacturer Roche produced approximately 190 million courses
of the drug in 2006, and claimed that it could produce up to 400 million courses
annually in the future. In response to pressure and increased demand, Roche granted
licenses to drugmakers in India and China to produce less expensive versions of the
antiviral, and dozens of countries now have stockpiles of the treatment.10 However,
concern about Tamiflu’s effectiveness against mutations of H5N1 were raised when
a new strain in Egypt was found to be resistant to oseltamivir. An alternative drug,
zanamivir (marketed as Relenza), was effective against the strain, but it is more
expensive and more difficult to use and ship than oseltamivir.11 The discovery of a
new strain underscored the difficulty and expense of governmental programs to
stockpile antiviral treatment as the virus mutates. Most scientists continue to argue
that oseltamivir at present remains the most effective and promising treatment.
8
“Highly Pathogenic Avian Influenza A/H5N1 - Update and Overview of 2006,”
Eurosurveillance, Vol. 11, Issue 12. December 21, 2006.
9
For more information, see CRS Report RL33159, Influenza Antiviral Drugs and Patent
Law Issues, by Brian T. Yeh.
10
“Scientists Still Wary of Bird Flu Pandemic,” Wall Street Journal Asia. January 16, 2007.
11
“New Strain of Bird Flu Found in Egypt is Resistant to Antiviral Drug,” New York Times.
January 18, 2007.
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Source: World Health Organization: Cumulative Number of Confirmed Human Cases of Avian
Influenza A/H5N1 Reported to the World Health Organization as of February 27, 2007,
[http://www.who.int/csr/disease/avian_influenza/country/cases_table_2007_02_27/en/index.html].
Azerbaijan12
There were eight confirmed human cases of Avian Influenza and five deaths in
2006. The World Bank provided funding for the improvement of laboratories
involved in avian flu detection, prevention, and treatment in Azerbaijan. The
program, announced in November 2006, also involves measures to provide training
and equipment for the Azerbaijani veterinary service and to expand the country’s
public awareness campaign. No new cases have been reported since March 2006.
12
This section prepared by Kim Klarman, Information Research Specialist, 7-6088.
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Cambodia13
WHO reports that there have been six confirmed human cases of avian influenza
in Cambodia since February 2005. All six Cambodians have died from the H5N1
avian influenza. Health experts predict that more cases in Cambodia are likely.
Cambodia has had difficulty monitoring its poultry stocks, because its poultry farms
are small and numerous, many chickens roam freely, and transportation and
communications links are poorly developed.14 Despite warnings, many villagers have
eaten birds that had been infected rather than go hungry. U.N. experts estimated that
Cambodia needs $18 million to develop programs to stem the spread of the virus.15
China16
The Chinese Center for Disease Control reported one human case of avian
influenza in China on January 8, 2007, China’s first in six months. The man who fell
ill in December 2006, a 37-year-old from the eastern province of Anhui, appeared to
make a complete recovery within a month. His case of avian influenza is being
counted as a 2006 case by the World Health Organization, bringing China’s total of
human cases for the year 2006 to 22, with 8 deaths.17
The close proximity of millions of people, birds, and animals in southern China
has made it a common breeding ground for deadly viruses that jump the species
barrier to humans, including the H5N1 virus. Additionally, China’s poor public
health infrastructure and the communist government’s traditional lack of
transparency have made international health specialists particularly concerned that
China could become the origin of an H5N1 global flu pandemic.
13
This section prepared by Mari-Jana “M-J” Oboroceanu, Information Research Specialist,
7-6329.
14
For more information on the avian flu in Cambodia, see CRS Report RL32986,
Cambodia: Background and U.S. Relations, by Thomas Lum.
15
“Cambodia Needs $18 Million for Bird Flu Fight — UN,” Reuters, December 16, 2005.
16
This section prepared by Hannah Fischer, Information Research Specialist, 7-8989.
17
For earlier efforts by the Chinese government to contain the virus, see CRS Report
RL32227, SARS, Avian Flu, and Other Challenges for China’s Political, Social, and
Economic Transformation, by Kerry Dumbaugh and Wayne Morrison.
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for indications that Chan, an expert on avian influenza and SARS, has autonomy
from Beijing. In the past, China has been criticized for withholding information and
specimens about infectious diseases from the WHO.
Djibouti18
WHO officials confirmed one human infection in Djibouti in a young girl in
April 2006, the first human case in the horn of Africa. The case was not fatal. In
response, authorities in Djibouti initiated a program to slaughter domestic poultry,
but met resistance from farmers because of the lack of a compensation program.
Health Minister Abdallah Abdillahi Miguil appealed to the international community
for funding for training, surveillance networks, and laboratory equipment, saying that
over $4.4 million would be needed to fight the spread of the virus. No more cases
have appeared after the initial confirmation.
Iraq19
The WHO confirmed three cases of human infection in Iraq, the third
retrospectively after a shipment of specimens for external verification was disrupted.
The first two were fatal, but the third recovered. Iraq has not reported any new cases
since the initial outbreak.
Egypt20
In Egypt, the first case of the H5N1 virus in humans was detected in March
2006. Since then, 22 people have been reported to have contracted the avian flu,
second only to Indonesia in number of cases and deaths in 2006. With one exception,
all the deceased were women. Traditionally, in rural parts of the country, women are
in charge of tending birds that are domestically kept, making them more vulnerable
to the H5N1 virus.
In late 2006, the Egyptian Ministry of Health and Population informed the WHO
of three new human cases. All three cases were fatal, and all three victims were
from a 33-member extended family in Gharbiyah province. It is believed that the
deceased had contact with sick ducks. The surviving family members remain
healthy, but were under close observation by the Ministry of Health and Population
following the deaths. In December 2006, Egypt requested financial and technical aid
to bolster its prevent efforts. Geographically, Egypt’s heavily populated Nile valley
has had one of the largest concentrations of bird flu infection. The Nile valley lies
on a major migratory route for wild birds.
18
This section prepared by Hussein Hassan, Information Research Specialist, 7-2119.
19
This section prepared by Hussein Hassan, Information Research Specialist, 7-2119.
20
This section prepared by Hussein Hassan, Information Research Specialist, 7-2119.
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Indonesia21
In 2006, Indonesia outpaced all other countries in number of confirmed human
cases and deaths. Fifty-one Indonesians died from the H5N1 virus in 2006 and early
2007, bringing the total number of deaths to date since the first outbreak in July 2004
to 63. One of the early 2007 deaths was a woman from Tangerang, Banten Province,
whose son was also hospitalized with a confirmed case of H5N1. Their shared
infection again prompted questions of whether the virus was transmitted by
human-to-human contact or by exposure to the same environmental source.
Of the measures, restructuring the poultry industry may prove to be the most
challenging. Unlike Vietnam and Thailand, with mostly commercial poultry farming,
most chickens are reared in small “backyard” operations in Indonesia. Although
authorities in Jakarta ordered that all non-commercially reared birds in the affected
provinces should be killed, the compensation program (12,500 rupee, or about $1.40
per bird) is seen as too modest to be successful. Public opposition is widespread.
Research indicates that approximately 20% of all stray cats roaming the major
cities of Indonesia are infected with H5N1, worrying scientists of the ability of the
virus to attack and spread among mammals.22 Only 44 hospitals around the vast
country are currently prepared to handle the virus, although additional hospitals are
reportedly being readied. The Indonesian government recently began culling poultry
in the three highest-risk provinces and the city of Jakarta.
Laos23
The first case of an H5N1 human infection in Laos was confirmed in February
2007, although the country had reported outbreaks in poultry since 2004. Tens of
thousands of birds were lost through infection or culling on commercial farms;
however, the vast majority of poultry-rearing in Laos takes place on smaller,
family-run farms. Some experts argue that there is an urgent need for foreign health
organizations to focus upon and assist Laos, given its proximity to other countries
with the disease and the lack of government capacity, particularly its weakness in
21
This section prepared by Susan Chesser, Information Research Specialist, 7-9547.
22
“Stray Cats Found with Bird Flu Virus,” South China Morning Post. January 16, 2007.
23
This section prepared by Barbara Salazar Torreon, Information Research Specialist, 7-
8996.
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surveillance. The central and local governments have limited capabilities for
collecting and disseminating information, monitoring avian populations, and
conducting laboratory analysis to confirm cases of the virus. In addition, according
to a U.S. government assessment team that visited Laos, Cambodia, and Vietnam, the
country’s health care system faces “severe limitations” and would be “quickly
overwhelmed” in the event of a large-scale human outbreak. The FAO and the
WHO reportedly have strong working relationships with the Lao government. In
October 2005, the United States signed a cooperation agreement with Lao officials
in which it pledged $3.4 million to Laos for controlling outbreaks of avian flu.
Nigeria24
In February 2007, the WHO confirmed the presence of H5N1 virus in a
22-year-old deceased female from Lagos. H5N1 virus had been identified in poultry
outbreaks in Nigeria. The WHO is working with the government of Nigeria to carry
out surveillance and investigate any additional reports of suspected cases. The
outbreak in Nigeria is notable because Nigeria is the most populous country in Africa
and because health authorities view it as the likely source of H5N1 detected in
poultry in Niger and Cameroon. Nigeria’s poultry population is estimated at 140
million, with backyard farmers accounting for 60 percent of all poultry producers.25
USAID worked with the U.S. Department of Agriculture (USDA) and other
organizations to respond to H5N1 in Djibouti and Nigeria and deployed thousands
of Personal Protective Equipment (PPE) sets for surveillance and culling purposes
and is also supported communications and public awareness efforts in the country.27
In addition, USAID disseminated more than 25,000 public awareness tool kits and
supported the reproduction of these kits in sub-Saharan Africa. The kits include key
messages and educational materials for preventing the spread of H5N1 in animals
and for limiting human exposure.
24
This section prepared by Tom Coipuram, Information Research Specialist, 7-4296.
25
“WHO Experts on Bird Flu Arrive in Nigeria,” Agence France Presse. February 5, 2007.
26
“Region: Cases and Context. H5N1 has been confirmed in Niger and Cameroon in areas
along the U.N. Integrated Regional Information Networks (IRIN) reports, February 2006.
27
USAID Situation Update #37, “Avian and Pandemic Influenza Management and Response
Unit, May through June 9, 2006. [http://www.usaid.gov/our_work/global_health/home/
News/ai_docs/ai_update_060906.pdf]
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Thailand28
One of the hardest hit countries during the early outbreaks of the human H5N1
virus, Thailand has had 25 cases of confirmed infection and 17 deaths since the
disease began affecting humans there in 2004. Thai officials have taken an
aggressive stance towards the spread of the disease, but continued to struggle with
periodic outbreaks in poultry and 3 human deaths in 2006. In early 2007, the
discovery of avian flu in pigeons and other wild birds in the Suphan Buri province
in northeastern Thailand worried health officials. Of particular concern is the spread
of the virus by wild birds migrating through Thailand.
Turkey30
In 2006, Turkey reported 12 confirmed cases of human H5N1 virus, which
resulted in the deaths of four children. Researchers reported that the deaths were
caused by migratory birds that carried the virus from Asia to Turkey. Although
Turkish officials were criticized for their slow detection and acknowledgment of the
initial virus outbreak, the Turkish Ministry of Agriculture and Rural Affairs
reportedly is taking an active role. Their efforts include surveillance, along with
promotion of the central government’s public awareness campaign, prohibitions
against the transportation of poultry and hunting of winged animals, and the
establishment of national and local illness control centers. Turkey’s prevention
efforts have been closely followed by the international health community because of
concern that the virus will spread to other areas of Europe.
Vietnam31
Vietnam has undertaken a robust culling and immunization program for its
poultry farming industry, and no human cases were reported in 2006. However,
28
This section prepared by Kim Klarman, Information Research Specialist, 7-6088.
29
See CRS Report RL33349, International Efforts to Control the Spread of the Avian
Influenza (H5N1) Virus: Affected Countries’ Responses, coordinated by Emma
Chanlett-Avery, which outlines Thailand’s efforts to combat the virus.
30
This section prepared by Kim Klarman, Information Research Specialist, 7-6088.
31
This section prepared by Mari-Jana “M-J” Oboroceanu, Information Research Specialist,
7-6329.
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outbreaks in poultry resurfaced in early 2007, reinforcing concern that the virus could
re-emerge in humans.
African Union (AU). The AU and the government of Mali hosted the 4th
International Conference on Avian Influenza in Bamako, Mali, December 6-8, 2006,
attended by health and agricultural ministers from around the world. The conference
was intended to provide insight into worldwide efforts to boost financial support for
preparedness and the latest information on regional strategies and vaccinations. The
U.S. Special Representative on Avian and Pandemic Influenza, John E. Lange,
announced that the United States would increase its original pledge of $334 million,
which was first announced in Beijing in January 2006 and raised to $362 million in
June 2006, to a total of $434 million.32 The leading donors at the Mali summit were
the European Commission and the European Union ($131 million); the United States
($100 million); Canada ($92.5 million); and Japan ($67 million).
32
U.S. State Department Press Release, December 11, 2006, at [http://www.state.gov/r/pa/
prs/ps/2006/77616.htm].
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detection kits to speed up the quarantine process through quick and accurate testing
of samples.
In January 2007, Japan pledged a total of $4 billion in assistance over the next
five years to ASEAN nations to enhance cooperation in a wide range of areas
including avian influenza prevention and control. The same month Australia pledged
to provide $5 million in assistance to ASEAN countries to fund laboratory
improvements, disease spread monitoring, and response team improvements.