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Choledochitis
1
History & Physical Exam
• History
o AMPLE
o OPPQRST
o HISTORY
• Physical Exam
o Inspection
o Auscultation
o Percussion
o Palpation
History
• AMPLE
o Allergies
o Medications – for what condition
o Past Medical History
o Last Meal / LMP
o Events of present illness
• OPPQRST
o Onset
o Provocative
o Palliative
o Quality – character and type
o Radiation / Region
o Setting
o Timing
• HISTORY
o Hospitalization
o Injuries
o Social history / Sugar diabetes
o Tumors / Trauma
o Operations
o Review of systems
o Youth Dz
2
Pic: Leg withpitting edema
• Cardiovascular disease or renal disease
Pitting → graded 1 – 4
• on how deep it pits & how long to return
Mass does not pulsate, does not move, gets larger on bearing down
incisional hernia
Inspection
• investigate asymmetry (eg hernia)
• ascites → m/c reason for ↑ size (in relation to rest of body)
• truncal obesity → Cushing’s
• stomach shape → should be flat (lateral), should be hour glass
(A-P)
• tangential light → outlines shape withshadows
• m/c scars
o Cesarean – usually low (bikini line)
o Cholecystectomy ( usually laparoscopic)
o Appendectomy
• Other causes of scars
o Closed colostomy
o Striae
o Splenectomy
o Liposuction, GSW
o Stab wound
• Ecchymoses → bruises
Auscultation
o Bowel sounds
o Bruits
3
Auscultation
o Borborygmus → bowel sounds [5-35 (N)]
High pitched → use diaphragm
o Appreciate change in pitch → eg.↑ pitch means
bowels are working hard to get past obstruction
o May also ↑ or ↓ in frequency
No bowel sounds → obstruction (late)
↑ bowel sounds → early obstruction
• Late obstruction → vomit
• Adynamic bowel → due to blunt impact or post operative
→ no bowel sounds
• Bruits → swishing noise
o Due to turbulence of blood
o m/c infrarenal AAA, renal artery stenosis
• Percussion
o Liver, spleen, diaphragm
Percussion
o Liver, spleen, diaphragmatic
excursion
o LUQ
Tympanic → air in
stomach
Dull → eaten recently
o Spleen → dull
o Liver → dull
o rest of abdomen → resonance
o bowel obstruction → dull over
obstruction
tympani above
• Palpation obstruction
o Organomegaly
resonance distal to
o Aneurysms obstruction
4
Palpation
• Organomegaly
• Aneurysms
• Mass → where is it? Size? Borders? Pulsate? Pain? Firm/soft? Refer
pain? Mobile? Superficial/deep?
• Palpation start in non-tender quadrant, diagonal to area of pain
• Superficial → palpate in abdominal wall
• Deep → palpate in abdomen
• If mass disappears withabdominal contraction → intraabdominal
mass
• Mass accentuation withabdominal contraction → abdominal wall
mass
• Usually better if mass is mobile
o Benign → only in host tissue
o Malignant → invade surrounding tissue, more inflammation,
causing CT formation = less mobile
Palpation
• Done after auscultation so as not to influence bowel sounds
• Palpation for pain
• If ticklish use pt’s hand
• What type of pain
o Sharp, dull, cramping
• Decrescendo, crescendo pain → luminal organs usually are the cause
• Organomegaly
o Usually liver/ spleen
o Liver RUQ
Detoxifies
Hormones
Over 1000 functions
o Spleen LUQ
Should not be palpable (unless extremely thin)
o Hepatosplenomegaly
usually liver disease
blood forming product disease’s
o m/c aneurysm → AAA (infrarenal)
most are saccular rather than dissecting
palpate with 2 fingers – one on either side of aorta
• separation of fingers on pulsation shows
lateral dilation = AAA pass
• also palpate with 4 fingers on top of aorta
• thinner pt’s = more pronounced pulsation
not likely to rupture AAA on exam
• aorta N diameter max = 3.5 cm
AAA → produces non-mechanical back pain
• Pts are ortho, neuro, and mechanically
intact
o Abdominal rigidity – muscle tension to point “hard as
desktop”
5
Abdominal Exam Tips
• Comfortable room temp
• Pt gowned with abdomen exposed
• Groin uncovered with genitalia draped
• Bladder empty
• Start in non-tender quadrant
• Use Pt’s hand if ticklish
• Normal kidney is non-palpable
• Normal liver may be palpable 8–12 cm at mid-clavicular line
• A palpable spleen is enlarged
Abdominal Regions
• 4 quadrants
o Rt upper
o Lt upper
o Rt lower
o Lt Lower
• 9 Regions
o R/L Hypochondriac 3 upper
o Epigastric
o R/L Lumbar
o Periumbilical
o R/L Pelvic
o Suprapubic/Hypogastric 3 lower
6
Abd Regions
• 4, 6, 9 systems
o 6 = 4 quadrants and epigastric & hypogastric regions
• Epigastric
o Duodenum, pylorus, LL of liver, portion of pancreas, some
transverse colon, some SI, aorta, celiac trunk, renal a.
o Many things can cause pain here
• LUQ
o Upper pole of kidney, adrenals, splenic flexure, spleen, tail of
pancreas, lt renal a, abd aorta, splenic a
• LLL
o Desc Colon, sigmoid, lt common iliac, SI, lower kidney pole,
inferior mesenteric a, lt ovary, fallopian, uterus portion
• RLQ
o Ascending colon, SI, rt ovary, lower kidney, possibly some
liver, appendix, cecum
• RUQ
o Upper kidney, gall bladder, rt renal a, transverse colon portion,
biliary tree, head of pancreas
o usually pain comes from a structure in that Q
Abdominal Exam Test
• Rebound tenderness
o Peritonitis (Rovsing’s sign), push in quadrant with no
pain, but pain is felt in different quadrant usually
diagonally across.
o PN with recoil Palpation
• CVA Tenderness (Costal Vertebral Angle, on back where the
12th rib meets spine)
o Kidney disease
o AKA: Kidney Punch
• Shifting Dullness
o Ascites
o Fluid shifts in different positions
• Psoas Sign
o Appendicitis
o Resisted Rt hip flexion
• Obturator sign
o Appendicitis
o Resisted internal rt hip rotation
7
Abd Exam Test
• Rebound tenderness = peritonitis
o Push in Q catty-corner to pain (in non-tender Q)
o Pain in area of complaint = +
o Pain upon pressure = organ problem
o Pain upon release = peritonitis
• Rovsing’s sign
o For late stage appendicitis (RLQ)
o Inflam. due to obstruction → can spread to
peritoneum
• Costovertebral angle tenderness (CVA)
o Punch kidneys
o Usually kidney disease – possible quadratus
lumborum spasm
• psoas sign/obturator sign → appendicitis possible
DX Imaging
• Barium swallow
• Barium enema
***EGD – Esophagus gastroduodenal ***
• CT scan with contrast Look up and know
• MRI scan with contrast
• Endoscopy
DX Imaging
• KUB (kidney-ureter-bladder) film
o Upright posture & supine position
o So fluid settles in diff. Areas
o Looking for air/fluid levels
o Mesenteric air/fluid → moves a lot
o Non peritoneal air/fluid → more fixed
o See a lot of calcified lymph nodes in
mesentery/omentum
[Higher Kv used – higher contrast – higher grays]
• Barium swallow
o Opaque on x-ray
o Can watch in motion → checks function
o Can follow into duodenum
o Can following into small bowel
o Not a really good dx tool for small bowel
o CO2 tablets withbarium to push barium to walls of
bowel
• CT scan withcontrast
o IV iodine
o Or barium
• MRI withcontrast
o IV usually
o Not very useful with hollow organs
• Endoscopy
o Problem with this test → very technical,
interpretive skill needed
8
Abd Distention
• Mechanical Distention – Matter inside or outside the lumen
that physically obstructs the movement of material through
the bowel
o Neoplasms (intraluminal / extraluminal)
o Post operative adhesions
o Abscess
o Pregnancy
o Hernias
o Volvulus
o Intussusception
• Non-mechanical obstruction
o Ascites
o Excess gas
o Trauma
o Infection peritonitis
Abd Distension
• SI, LI, stomach, liver, spleen
• ↑ size of an organ can cause ab distention
• m/c cause of distension is obstruction
o due to intraluminal (m/c) mass or extraluminal
Mechanical Abd Distention
• Post operative adhesion can traverse a lumen
• Crohn’s → abscesses
• Appendicitis →abscesses
• Incarcerated hernia (can cause bowel strangulation)
• Volvulus - twisting of bowel
o Inverted U shape (or V-shape)
o M/c sigmoid or cecal region
o Obstruction prone to volvulus
o Fecal bolus may be twisted off
• Intussusceptions → telescoping of bowel {c/cx
adhesions, paralysis, ischemia, trauma}
9
Abd Pain Pattern
• Diffuse
o Visceral pain Usually not a sign of peritonitis
o Organ involvement
• Focal
o Parietal pain
o Organ distention
o Peritonitis
Abd Pain Patterns
• Diffuse
• Focal → peritonitis
o Unless full blown → diffuse → entire peritoneum filled
with bacteria
Abd Pain
• Burning
o PUD, GERD, confirmed with a nasogastric tube,
worn for 24 hours to measure pH in middle and lower
esophagus.
o Epigastric pain should also include cardiac workup,
heartburn type pain can be a MI
• Cramping (usually from organ distention)
o Biliary colic [typically from gallbladder disease],
IBD, IBS, Mesenteric Ischemia
• Colicky [very painful initially eventually becoming less to
none painful.
o Renal stones, biliary colic, appendicitis
• Achy
o Constipation, appendicitis, AAA(saccular)
• Knife-Like(usually very serious)
o AAA (Dissecting / saccular rupture)
o Pancreatitis
• Sudden onset
o Perforation [peptic ulcer perforates], obstruction
[ectopic pregnancy], pancreatitis,
o Ruptured ectopic
10
Abd Pain
• Diffuse
o Early appendicitis
o AAA
o IBD – Inflammatory bowel disease [Crohn’s and
Ulcerative colitis – typically of the left colon]
o Peritonitis – if diffuse peritonitis, if the peritonitis is
localized the so will the pain
o Trauma
o Obstruction
• Epigastric
o PUD
o GB disease
o Hepatic disease
o Cardiac disease
o Pancreatitis
• RUQ
o Biliary tree disease
o PUD
o Pancreatitis
o Renal disease
o Cardiopulmonary disease
• LUQ
o PUD
o Pancreatitis – particularly of the tail
o Splenic disease, Infectious mono, lymphoma,
leukemia,
o Renal disease
o Cardiopulmonary disease
• RLQ
o Late appendicitis, pain will migrate to RLQ
o Crohn’s disease, most commonly affects distal ileum
o Obstruction, cecal volvulus, overian cysts
o Reproductive disease
o AAA
• LLQ
o Diverticulosis/it is
o Obstruction, sigmoid vovulus
o UC – Ulcerative colitis
o Reproductive disease
o AAA
11
• Periumbilical
o Obstruction
o Early appendicitis
o AAA
o Mesenteric Thrombosis, thrombosis of one of the
mesenteric arteries, the more proximal the obstruction
the greater the damage.
o Pancreatitis
Abd Pain
• Nonspecific abd pain 35% - gastritis, heartburn,
overeating
• Acute appendicitis 17%
• Intestinal obstruction 15% - especially with patients
who have had previous surgery. Blount force trauma,
common from a MVA seat belt
• Urological disease 6%
• Gallstone disease 5%
• Colonic divertiucli 4%
• Abd trauma 3%
• Malignancy 3%
• Perforated Peptic ulcers 3%
• Pancreatitis 2%
• Ruptured AAA <1%
• IBD <1%
• Gastroenteritis <1%
• Mesenteric Ischemia <1%
12
Abd Pain
• Burning – epigastric usually
• Cramping – usually from organ distention
o Early distention disease is usually not painful
o Organ capsule must be distended to cause pain
o usually in peristaltic organ
• Colicky – crescendo/decrescendo
o Usually indicate obstruction in hollow lumen
Eg. Renal/gall stones
• Achy – hardest to dx
o Anything from constipation to AAA
• Knife–like – usually serious → constant pain
o AAA, pancreatitis
• Sudden onset – usually serious
13
November 6th, 2000
74 year old female, woke with back pain, back pain progressed
through the day. Daughter visited her, noted mother not feeling well,
was lying on couch and not feeling well.
Patient tried hot and cold packs to no avail, different positions did
not ease pain.
Lying on floor with feet and legs propped on couch toward end of
day, found this helped and she finally got some sleep for first time
that day.
Short time later patient advised daughter she was “so tired” and went
back to sleep. 15 minutes later she went into full arrest.
Ambulance took her to hospital still under arrest.
Later in day placed on ventilation, with suspected bleeding AAA.
DNR given by son, patient pronounced late that night, early morning
AAA
• S/sx
o Most are asymptomatic
o Pulsating sensation in the abdomen
o Abdominal pain (unchanged by position)
o LBP (unchanged by position)
o Bruit
o Radiating pain into legs
o Cold ↓ extremities, peripheral pulse loss
o Chock
o Sudden death
• Imaging
14
o Plain films, 75% of the time seen on plain films
o MRI, CT
AAA
• Cannot find a position of comfort
• Non-mechanical lesion
• Wyatt’s mother → only had back pain, no abd pain
• Normal aorta → 2-2.5cm (average size according to Dr.
Wyatt)
• See AAA → 75-90% on x-ray
• >3.5 cm = AAA
• 90% infrarenal , above common iliac a.
o can extend into c. iliac a. (2/3)
• Add 20-30% to size seen on x-ray = actual size of AAA
• If pt has AAA = most have coronary artery disease
o Chances are they have HTN and atherosclerosis
• Atherosclerosis
o Is a long-term vasculitis (inflammatory)
o Not just fat/cholesterol deposition
o Chronic inflammation → calcifies
• Pt known to lose leg or atrophy due to embolization
• Rupture → STAT surgical emergency
Dissecting/Saccular
• Dissecting A – pts are very sick, usually dead in 8-10 hrs, usually not seen by
chiropractors
• Blood is in the wall of the artery, due to the pressure separating the of the internal
lumen.
• Saccular – m/c to see
• Dissecting – m/c in thoracic
o usually post traumatic
o doesn’t cause as much widening as saccular
o harder to recognize on x-ray
AAA
• Most asymptomatic (3-5cm (small))
• 3-5 cm
o Monitor 3, 6, 9 months
o At least once a year
o Advise patient to watch for belly pain, discoloration, numbness in the
legs, extremities become cold and or blue, get into doctors office ASAP
• 5-7 cm
o Patient runs must greater risk of rupture, when over 7cm have a 90%
probability of rupture.
o only elective surgery if asymptomatic
• Blood if very irritating to peritoneum
o Leaking blood → focal pain
• Stent → inside vessel
• Graft → replaces vessel
15
[Picture – Aortic dissection]
16
AAA
• TX
o 3.5 – 5 cm – careful observation
o 5-7 cm – elective surgery (10% rupture/yr)
o > 7 cm – non elective surgery (25% rupture /6 months)
o symptomatic – non elective
• Surgical procedures
o Open laparotomy
o Endoscopic stint placement
• Less than50% withrupture survive
Anorexia
Causes
o Infection
o Neoplasm (particularly malignant)
o IBD
o Constipation
o GERD
o PUD
o Swallowing disorder
Anorexia
• Muscle wasting is visible, there is not enough protein in the body
thus the body begins to “digest” it’s own muscle
• Not the psycho case (nervosa)
• Unwillingness to eat:
o Flu, reflux, peptic disorders, loss of will to live
• GI problems or systemic disease
• Ex: liver CA (stage 4)
o Anorexia, cachexia (mm wasting), ascites
Belching, Bloating, Flatulence
• Aerophagia, the swallowing of air as you speak, eat, sleep
o Most common cause of belching, bloating, and
flatulence
• Insoluble carbohydrate ingestion
• Mal-absorption intolerance
• Lactose intolerance
• Diarrhea
17
GI Bleeding
• Upper GI
o Esophageal varices
o Esophageal CA
o Esophagitis
o PUD gastric CA
o Hiatal Hernia
o Swallowed Hemoptysis
GI Bleeding
• Lower GI
o Mesenteric thrombosis
o Meckel’s diverticulum
o Volvulus / intussusception
o Colon CA
o Colonic Polyps
o IBD (Crohn’s, UC)
o Diverticulosis/itis
o Hemorrhoids
o Anal Fissures
18
GI Bleeding
• Upper GI vs Lower GI
• Divided by ligament of Treitz
o AKA – suspensory Ligament of duodenum
o At duodenojejunal junction
o Helps maintain C-shape
Upper GI S/SX
• Hematemesis
o Acute ↑ GI bleed above stomach
o Massive GI bleed into stomach
o M/c cause → esophageal disease, m/c esophageal varices
Coffee ground emesis
• in gastric acids for some hours
• Can also B cause by esophageal varices
• Very common in alcoholics
• Prostatitis
• PID – Pelvic Inflammatory DZ
• Endometriosis
• Esophageal CA
o Known for coffee ground emesis usually if any emesis
• Esophagitis
o Mechanical → eg. Swallowing
o Infection
• PUD → usually Coffee ground
• Swallowed hemoptysis
o Can be from pulmonary disease
• GI bleed scan
o Can see location of bleeds
Lower GI S/SX
• Hematochezia – bright red blood/rectum (BRBPR)
o 95% are from the colon down
o usually not small bowel
o m/c cause hemorrhoids
o Blood streaked stool
Suggests that something within the bowel is bleeding
and as the stool passes by it becomes streaked. (e.g.
polyp)
• Melena – black, tar-like stool
o Enzymes in GI turn blood black
o Chronic ↑ GI bleed – melena (or upper portion of ↓ GI)
o Must have a lot of bleeding
• Blood streaked stools - ↓ GI only
o Bleeding in lumen
• Occult blood in stools
o Only seen from a hemoccult, Guiac test
o Suggest bleeding higher up
o Reagent turns blue → + for blood
o Must have 3 tests to determine N or blood presence
o Associated with occult cancer
Lower GI Causes
• Meckel’s diverticulum
o Remnant of vitelline or omphalomesenteric duct
• Diverticulitis → m/c to cause pain & bleeding than diverticulosis
19
Constipation/Diarrhea
• Constipation, obstipation - Intestinal obstruction; severe
constipation
o Fecal impaction
o Poor fiber intake (bulk helps hold water and is non-
digestible thus aids in maintenance of bowel)
o Poor fluid intake (water)
Poor bowel hygiene, what kinds of food and
fluids you intake.
o Colon cancer
o IBD
o Psychiatric cause, anxiety or high stress creates a
pseudo fight or flight response to the body
o Medications
o Hemorrhoids
o Increased iron supplementations, seen common with
infants who have are consuming iron fortified
formula.
• Diarrhea
o Infection, most common cause for diarrhea, stomach
flu – viral gastroenteritis. Fungal infections of the
bowel would be suggestive of immunosuppression,
i.e. aids, or chemotherapy
o IBD
o IBS, young females under high stress conditions
o Stress
o Colon CA, alternating constipation and diarrhea
o Psychiatric cause
o Medications, antibiotics and parasympathomimetic
o Lactose intolerance
20
Constipation
• Decrease in volume of stool
• One of the most common conditions in the USA today
o Spinal manipulation has been shown to improve 50% of
constipation cases. Mechanism is unknown.
• Fecal impaction – dry & hard
o Most severe form of constipation
• Poor fiber & fluid intake & poor bowel hygiene → m/c cause
o Bowel hygiene – going to the bathroom when you have the
urge
Gastrocolic reflex – reflex to defecate
Colon CA
• Can cause alternating constipation & diarrhea
Diarrhea
• Increase in stools volume (usually loose watery stools)
• results from parasympathomimetics
• m/c cause = infection, usually viral gastroenteritis
• IBD → Crohn’s & Ulcerative colitis
• IBS → usually alternates (constipation & diarrhea)
21
Heart burn/ Indigestion
• Dyspepsia
• Gastritis – most common cause, large fatty meal
• GERD/Reflux Esophagitis – reflux esophagitis causes
permanent damage to the esophagitis
• Excess intestinal gas
• Gas entrapments (hepatic/splenic flexures)
Hepatosplenomegaly
• Hepatomegaly
o Cirrhosis
o Hepatitis
o Pancreatic CA
o Hepatobiliary CA
o Cholangitis
o Late right sided CHF, portal hypertension as a result
of vena cava hypertension
o Infectious Mono, an acute febrile illness caused by the Epstein-
Barr virus invades WBCs, a member of the Herpesviridae family;
frequently spread by saliva transfer; characterized by fever, sore throat,
enlargement of lymph nodes and spleen, and leukopenia that changes to
lymphocytosis during the second week; the circulating blood usually
contains abnormal, large lymphocytes that have a resemblance to
monocytes, and there is heterophil antibody that may be completely
adsorbed on beef erythrocytes, but not on guinea pig kidney antigen.
Collections of the characteristic abnormal lymphocytes may be present
not only in the lymph nodes and spleen, but in various other sites, such
as the meninges, brain, and myocardium. Fatigue, n/v.
• Epstein Barr virus
o Lymphoma, malignancy of the lymphocytes
o Leukemia, malignancy of WBCs
• Acute and chronic forms
• Effects younger and older individuals
22
Hepatomegaly
• Inferior portion of liver becomes convex, the normal liver is concave,
when it becomes enlarged it losses that convex
• Most common cause → alcoholism → alcohol hepatitis = cirrhosis
o 70 to 80% of the livers parenchymal cells have to be damaged
in order to see alcohol hepatitis. Once damage reached 85 to
90% the liver cannot regenerate.
• S/SX:
• Jaundice
• Yellow sclera
• Peripheral edema
• Bleeding tendencies
• Ascites
• Hepatitis
o Viral hep → most common is hep C
o Alcoholic hep
o Idiopathic hep
• Pancreatic CA
o Can block hepatic vessels
o Obstruct common bile duct
• Cholangitis
o Inflammation of bile duct system
o Associate with a tri-ad – Charcot Triad
23
Splenomegaly
Causes:
• Anemias
• Infectious mono
• HIV, affects T cells: virus self replication in an altered form:
clade B-HIV1 may produce clade A or C which produce
other clades. AIDS vac in trials.
• Leukemia
• Lymphoma
• Myeloma, cancer of bone marrow, cancer of plasmacytes,
multiple myeloma is the most common primary malignancy
of bone in adults: 70% of all bone CA are mets
• Polycythemia Vera, severe over production of red blood cells
which results in thrombosis and infarcts all over body.
Mature & blast cells: prone to infection- can’t produce more
WBCs.
Splenomegaly
• Spleen cleans out dead RBCs & immune response
• Anemia’s → abnormal RBCs (production-extramedullary
hematopoesis). 90-120 day lifespan
• Reactive polycythemia
o Body makes more RBCs for O2 compensation in
higher altitudes
• Polycythemia vera
o Overproduction of RBCs
o Bruising, thrombocytosis
24
Hernia Examination in Men
• Fingertip at most dependent portion of scrotum
• Invaginate scrotal wall to external inguinal ring
• Gently insert finger into canal along spermatic cord
• Move finger lateral and cephalad
• Pt coughs, strains or performs Valsalva maneuver
• Findings
o Normal or no hernia
You should feel nothing
o Inguinal hernia
Small indirect hernia may slightly tap end of
finger
Large direct hernia may be palpable as mass
Direct inguinal hernia may be felt by pad of
finger
o Spermatic cord tenderness (funiculitis) septic or
aseptic
o Spermatic cord lipoma
o Hydrocele, smooth fluid filled sac located within the
scrotum
[Photo of large inguinal hernia causing right shift of the penis, with a
large hernia auscultate and note any bowel sounds suggestive that the
intestines are now contained within the hernia]
Hernias
• Indirect inguinal hernia
o Most common type, M=F
o Thru deeper (lateral)(internal) portion of inguinal
ring (entrance to canal)
o Taps finger on examination
• Direct inguinal hernia
o M>F
o > 40 yrs
o Through (superficially)(medial) external inguinal ring
(exit from canal)
o Touches side of finger on examination
o Easily reduced, rarely enters scrotum
• Femoral hernia (Femoral = Female)
o Least common, elderly, F>M, 3:1
o Through femoral ring/canal, compression can cause
neuro or vessel damage
o Often asymptomatic (even strangulated) but can be
very painful. Can form a mass if large enough.
25
In the older female you must consider lymphadenotomy
via metastasis
Hiccoughs
• Transient
o High emotion, temp change
o Gastric distention
o Alcohol ingestion
• Persistent
o Uremia, hyperventilation, IDDM
o Meds (steroids, barbiturates)
o General Anesthesia
o Thoracic disorder (pneumonia, CA)
o Gastric disorder (PUD, CA, GERD)
Hiccoughs
• Spasm of diaphragm
• May be cause by eating/drinking too fast or too much causing
distention on the diaphragm
• Intractable form → hiccoughs all your life
• Temp change → usually hot to cold
• Uremia → urea in blood irritates diaphragm
• Hyperventilation
• Diabetes
• Steroids and barbiturates
• Prostatectomy
Jaundice
• Direct Bilirubin (think liver and surrounding liver)
o Extrahepatic obstruction
Calculi, neoplasm, stricture
Metastatic CA, Pancreatic CA
o Hepatocellular disease
Hepatitis
Cirrhosis
o Meds (eg. Estrogen)
o Jaundice of pregnancy
o Itching is a common symptom of jaundice
o Bilirubin builds up in the body and deposited/stored
in the body, ie. Skin, eyes
• Indirect Bilirubin (think away from the liver)
o Hemolysis (breakdown or RBCs)
Congenital anemias
Acquired anemias
o Poor marrow production
o Neonatal jaundice
26
o Impaired conjugation from medications, some
medications interfere with the conjugation of bilirubin
Jaundice
• Yellowing of skin
o Icterus → yellow sclera
• Direct Bilirubin deposition
o Cholelithiasis (gall stones)
• Earlier seen in eyes
• Usually eyes and trunk
• Indirect
o Classic congenital → sickle cell
o Neonatal jaundice → treated by placing baby
under UV light
GU S/SX
• CVA (costoverteberal angle) Pain
• Dysuria
• Polyuria
• Urethral Discharge
• Impotence
• Hematuria
• Oligoria/anuria
• Pelvic Pain
• Proteinuria
• Scrotal Swelling
GU S/SX
• Kidneys → electrolyte balance
• Micturition reflex → urge to
urinate
27
28
CVA Pain
• Nephrolithiasis
• Pyelonephritis
• Glomerulonephritis
• Renal CA – **patient cannot find a position of comfort, pain
cannot be reproduced with postioning pt.
• Renal Abscess
• Spinal disorder
CVA Pain
• Lungs, kidneys, adrenals, liver on rt, stomach on lt
• Murphy’s punch
• M/c cause by kidney conditions
• Also spinal disorder → eg. Quadratus lumborum spasm
• 80% of renal stones → Ca based
• pyelonephritis → infection of renal pelvis
• glomerulonephritis → usually aseptic
o preceded by strep throat
o occurs if entire antibiotics are not taken
• Renal abscess occurs in – diabetes, drug users, TB, chronic renal
disease
Dysuria
• Cystitis (pn located in the suprapubic/hypogastric area)
• Urethritis (gonoccal infection, also Non-gonoccal urethritis
usually Clamydia)
• Vaginitis
• Prostatitis
• Chemical irritants
• Urethral Diverticulum
• Bladder CA – symptoms only present late in disease,
accounts for high mortality of that dz.
Polyuria
[Excess production and voiding large amounts of urine; increased
number of voids and /or volume of voids]
• Cystitis/ Lower UTI
• Upper UTI
• DM
• DI {Triad – Polyuria, Polydipsia, Polyphagia} ADH
hormone; controls H2O loop
• Meds (Diuretic) CHF / HTN
• Anxiety
• Hypokalemia
29
Urethral Discharge
• Prostatitis
• UTI
• Interstitial cystitis
• Vaginitis
• Gonococcal urethritis
• NGU (Chlamydia)
Urethral Discharge
• Discharge can be bloody, contain pus, have an odor
o The discharge occurs when not urinating
• Prostatitis → septic or aseptic
o Typically middle aged men
o Microscopically could contain blood, exudate and or WBC
• Interstitial cystitis → most common in diabetics
o Due to immunosuppression and glucose in the urine
• Vaginitis → most common type: yeast infection (candida)
• Gonococcal urethritis → the “clap”
• Most common STD → Chlamydia (in U.S.) most cases are
asymptomatic
Impotence
• Psychogenic
• DM
• Vascular insufficiency
• Meds
• Neurologic disease
• Systemic disease
Hematuria
• T.I.C.S.
o Trauma
Renal damage
Severe exercise
o Tumor
Bladder CA
Renal CA
o Infection
Glomerulonephritis
Pyelonephritis
o Calculi, stones
o Cystitis (Renal),
o Surgery
30
o Sickle cell disease
Hematuria
• 2 types: macro & microscopic (occult)
• Macro → usually more significant, Gross hematuria is when blood can
be seen with the naked eye.
• Painful types & painless types
o Painless types – worse prognosis usually
o CA – tends to be ignored
• Menstruation is the most common cause of hematuria, especially
towards the end of her cycle. If microscopic levels found then wait
couple of days and retest
Trauma
• Sever exercise → eg. Repetitive microtrauma (running cause bouncing
of the kidneys)
• Renal damage is possible, costal vertebral pain will present, is
suspected, request a UA, if UA is negative then consider
musculoskeletal
Cysts
• Over 50% of population have these
• Usually small
• But can be acquired
Sickle Cell Anemia
• 3 main s/sx → ischemia, infarction, infection
31
Pelvic Pain
• Dysmenorrhea
• Fibroids (leiomyoma)
• Adhesions
• Cystitis
• Endometriosis,
• IBD, due to the sigmoid colons location
Pelvic Pain
- referring anteriorly
- Most common cause = constipation / intestinal gas (left side)
• Dysmenorrhea (Most common organic cause)
o Painful (outside normal, severe pain) during menses
o Cause: thyroid problem, infection, pre menopause, fibroids,
endometriosis
• Fibroids
o Benign tumor of uterus (Uterina leiomyoma → smooth
muscle tumor with fibrosis tissue interlaced)
o Found on plain films of lumbar spine – very common
o Possible to become malignant
o Can be very large
• Adhesions post operative
• Cystitis → m/c cause = e. coli
• IBD → Crohn’s, Ulcerative Colitis
Proteinuria
• Nephritic syndrome
• Malignant HTN
• CHF
• DM, damages the kidneys
• Sickle Cell disease
• Idiopathic proteinuria, found in another wise healthy adult,
all other labs return normal, no physical signs. Some
patient’s simply leak proteins without an underlying cause
and the condition is self limiting
• Pyelonephritis
• Pregnancy
• Myeloma, leukemia, lymphoma
o Make certain to review Bence-Jones Proteins
Proteinuria
• Protein not normally in urine because it’s too large
• Occurs with damage to basement membrane
• Malignant HTN → Increased BP, enough to cause tissue
damage
32
Scrotal swelling
• Testicular torsion
• Epididymitis
• Trauma, direct bruising
• Hernia, auscultation of the scrotum which reveals bowel
sounds
• Tumor, Testicular cancer one of the most aggressive of
cancers in regards to the speed it travels.
• Hydrocele
• Varicoceles
Scrotal swelling can be the scrotum or the contents of the scrotum
Scrotal Swelling
• Testicular torsion
o Spermatic cord & vessels twist
o Jumping up and then landing helps to “untwist” the
testicular torsion
o Testicular torsion is an emergent condition
o
ADDITIONAL NOTES:
• Varicocele → “bag of worms”, varicose veins
• Hydrocele → fluid filled, tubular cysts
Dysuria
• Painful urination (burn)
• Cystitis → bladder infection
o F > M, due to poor urinary hygiene (“holding it”)
o M/c than urethra because shorter
o M/c → e. coli
o Then Proteus Moralis
o TX: pure cranberry juice for 2 wks (boronic acid takes place of
antibiotics)
o Anteverted bladder → not all urine is excreted
• Urethritis
o Most common cause → gonorrhea,
o Secondary → chlamydia
o Bladder and urethra CA can cause urethritis
o Fungal → candida albicans
• Vaginitis – infection of vagina or vaginal introitus (opening)
o Due to poor hygiene
o Most common fungal infection → yeast infection (candida
albicans
• Prostatitis
o 2 forms → septic / aseptic
o Septic → bacteria
o Aseptic → autoimmune/antibody reaction
o Cause pelvic and rectal pain, discharge from penis,
o Capacitated → can be caused by stones → stasis backup
• Chemical irritants
o Latex on condoms
o Meds
33
o Detergent
o Lubricants
o Cologne
o Douche
• Urethral diverticulum
o Out pouching of hollow mucosa
o Can become obstructed and infected
o Can be due to bladder CA
o Diabetics get recurrent cystitis and other infections all the time
o Air gets in wall of bladder → holds bacteria → bladder ruptures
→ death
• Polyuria – excessive urination production
o Cystitis/lower UTI (hurts to hold urine)
o DM → micro neuropathy (vessels supplying bladder
o Hypokalemia → osmotic pressure gradient
34
Test Two Start Now
EXAM II
ESOPHAGUS
- Propel food from the oral pharynx [not mouth] to the stomach
- No real digestive functions
- Can swallow standing on your head because of peristalsis
- Lower 2/3 smooth involuntary muscle, Upper 1/3 striated
voluntary muscle (only voluntary smooth mm. In body)
- Epiglottis keeps food from going into trachea
- Primary Peristalsis (Reflex-initiated by swallowing)
o Initiated by swallowing
o Propels food
- Secondary Peristalsis (peristalsis in lower 2/3)
o Not initiated by swallowing, done so by the food
which is already in the esophagus
o Propels food through lower esophagus
- Tertiary Peristalsis (Curling phenomenon; Cork screw
appearance)
o Seen in the elderly
o No propulsion
Fibrillation of the esophagus; doesn’t
cause any movement; is due to aging
and breakdown of myenteric plexus/
usually seen in elderly
ESOPHAGEAL TUMORS
- Where food gets stuck
1. Thoracic inlet
2. Pharyngeal Esophageal Sphincter (Larynx)
3. Aortic Knob (because of aorta uncoiling leaves an
indentation in the esophagus)
a. When the aorta uncoils due to aging and
atherosclerotic Disease
4. Left Atrium
5. Cardiac Sphincter (lower esophageal)
Patients can usually with great accuracy point to the location
where the bolus is “stuck”
35
ESOPHAGEAL NEOPLASMS
- Malignant tumors are most common (85-95%)
- Leiomyoma is the most common benign tumor of the
esophagus(Fibroid in the uterus)
o Sessile broad, wide base
o Pedunculated has a stalk
o Most are sessile
o Most in lower esophagus (because of reflux)
- Most tumors occur in the lower esophagus
o Due to reflux
- Squamous cell carcinoma is most common, squamous
cells line the esophagus
- 7.6/100,000 cases in USA
- 130/100,000 cases in China
o Because their diet is high of nitrites, smoked
foods
- M:F 3:1
- Most patients greater than 60 years of age
- Most are asymptomatic because there is NO expansion
in the lumen, NO bleeding, not much pain,
hematemesis or melena
- Dysphagia is a late symptom
o Leads to these being unknown until metastasis
- Patients don’t know they have usually until they
become malignant
- Adenomas, lipomas, angiomas all possible in the GI
tract. Think of the structures in the GI tract and the
types of tumors associated with that type of tissue
- 9 out of 10 esophageal tumors are malignant
o Esophageal tumors present very late
ESOPHAGEAL CANCER
- Causes obstruction of the hollow lumen
- Etiology
o Alcohol abuse associated with 80-90% of cases
Cirrhosis Portal HTN Esophageal
Varices CA
Higher incidence of reflux (irritating to
epithelium)
36
Alcoholics are usually smokers
Alcohol also irritates the esophagus itself
o Cigarette Smoking
Cigarettes swallow nitrites [via salvia
and swallowing air]CA
o Nitrate Ingestion
o Chronic Achalasia, poor relaxation of the
proximal end
Esophageal spasm (stenosis)
Proximal end dilates; food gets stuck &
irritates and ferments
• Common sign is very bad breath
especially when they belch
Swallow dysphagia regurgitation
o Chronic GERD/Barrett’s Esophagus
o CA obstruction of hollow organregurgitation
- Differential Diagnosis
o Achalasia
o Diffuse Esophageal Spasm (DES)
Like the cold ice cream chest pain that is
never ending and 10x worse
Pain lasts min to hours
o Esophageal Rings
Fibrocartilaginous ring that narrow the
esophagus
Schatzki’s Upper esophageal ring
Lower ring
o Scleroderma (Progressive Systemic Sclerosis,
newest term)
Connective tissue disease
Hardening of the interstitial tissues
narrowing and lack of peristalsis
dysphagia
ESOPHAGEAL CANCER
- Physical Findings
o Dysphagia
mc symptom
usually asymptomatic until late stages of
CA
motor problem – dysphagia with both
solids & liquids
obstruction – dysphagia with solids early
& progresses to dysphagia with fluids
37
CA cachexia occurs/wt loss just skin
& fat
o Weight Loss, suggestive that CA has
metastasized
o Cervical Adenopathy
Virchow’s nodes
• Enlargement of supraclavicular
lymph node
• Common with GI malignancy
• Many times is first sign
o Hematemesis – vomiting of blood / Hemoptysis –
spitting up blood
o Hoarseness
Due to compression or destruction of
recurrent laryngeal in the mediastinum
o Cough with clear sputum
o Mets to liver, pleura, lungs with associated signs
and symptoms
Mc presentation if mets to lung is
asymptomatic
- Diagnostic Imaging
o Double contrast esophagram
o (With a barium swallow the “shoulder” sign is
key 90° cutoff
now use endoscopy instead
get lung & ab CT/MRI to check for mets
o Esophagoscopy
o Chest/abdominal CT
o Abdominal MRI
Mediastinum lymph nodes would be
involved with esophageal cancer if
metastasis has occurred
- Laboratory Tests
o Done also to check for mets
o CBC
o Blood Chemistries
o Liver Enzymes, again looking metastasis, liver is
a common area for the metastasis to occur
- Treatment
o Resection if no mets
En bloc Resection during surgery to
see if they get all out
Take out CA with normal tissue around it
38
Lab makes sure clean tissue is found
around CA to ensure complete removal
Only done if no mets
o Stomach/colon used for replacement
o Radiation Therapy
Targets rapidly changing/high turnover
cells
• CA cells
• Hair
• Gonads
• Bone marrow
Some divide too fast or too slow and are
unaffected
• Ex; renal cell CA outpaces
chemo/radiation
Radiation not very effective with this
cancer
o Chemotherapy
- Prognosis
o Surgery 20-50% (all based on 5 year survival
rate)
o Radiation 6-20%
Have a node
Not very effective again, due to
surrounding organs and tissues
o Chemotherapy 15-80%
Kills cells that are in the S1 phase
(immature cells) that are rapidly dividing
Hair, gonads, bone marrow are all
affected because they turn over very
rapidly
39
ESOPHAGEAL INFLAMMATION
ESOPHAGITIS
- Reflux Esophagitis
- Acute Ulcerative Esophagitis
- Esophageal PUD
- Crohn’s esophagitis
- Infectious Esophagitis
o More commonly in immune suppressed patients
- Chemical Esophagitis
REFLUX ESOPHAGITIS
- Reflux of gastric contents with damage
o Contents reflux up through cardiac sphincter with
force and through the lower esophageal
sphincter
o Causing linear and nonlinear erosions of the
esophageal lining
- Progression of GERD
- Incompetent LES
- Often associated with hiatus hernia
o Protrusion of the stomach through the hiatus
- 30-60’ (minutes) post-prandial/reclining heartburn
- NOT GERD GERD damage is reversible
o Is “GERD” gone wild
o Permanent damage to esophagus
o More severe thus causes strictures
- TX with Nexium
o GERD tx: Prilosec & Prevacid
o Due to incompetent lower esophageal sphincter
40
INFECTIOUS ESOPHAGITIS
Infection of the esophagus is rather unusual
- Immunosuppressed patients
o AIDS
o Malignancies
o Diabetes
o Burn patients
o Transplant
(Long term corticosteroid treatment)
- Organisms
o Herpes Simplex
o Candida Albicans
Typically found in the vaginal region of
females and faces of children
Pic: Candida Esophagitis, occurs
especially with immunocompromised
patients
o CMV (Cytomegalovirus), causes encephalitis in
kids
- Dysphagia, Odynophagia (Painful swallowing), Chest
Pain – more of a burning sensation instead of a
crushing pain
- Treated with Antibodies
MECHANICAL ESOPHAGITIS
- Swallowed object becomes lodged
- Lodge at narrowed portions
o Laryngopharynx
o Aorta
o Gastroesophageal junction
o Left Atrium (not very often unless preexisting
CHF)
- Objects include coins, pills, bone pieces
o 3 main groups that do this: Elderly, children, and
insane
- Leads to ulceration, maybe perforation
o Which can lead to mediastinitis
- Treated with an EGD, scope with surgical attachments
on the end.
41
ESOPHAGEAL VARICES
Enlarged tortuous veins in the esophagus, typically occurring in the
lower 1/3 of the esophagus
- Varicose veins of the esophagus
o Alcohol is the most common cause portal
hypertension (pressure increased in portal
venous system, blood backs up)
- Lower 1/3 submucosal veins involved
- 1/3 of patients bleed
o Alcohol Cirrhosis Esophageal Varices
Bleeding out
- Caused by portal HTN by hepatic cirrhosis
- Highest mortality of any UGI bleed
o Peptic Ulcer Disease most common reason for
UGI bleed
- Coffee ground emesis, hematemesis
o Time depends on which you will see
- Treated with sclerotherapy, compression
o Compression Bougie balloon down the
lower esophagus and the balloon flattens out the
varices
o Sclerotherapy inject hardening agent that
hardens (sclerosis) the walls so they can no
longer extend also used in peripheral vascular
disease
- S/Sx
o Pt has some pain and dysphagia
o Symptoms are not extreme
ESOPHAGEAL DIVERTICULA
Localized outpouching of tubular viscus
- Usually acquired (congenital forms are rare)
- Two Types:
o Traction (extraesophageal)
Mediastinal mass (inflamed lymph node
next to esophagus)that as it grows
attaches to the esophagus as patient
swallows and breaths it pulls on the wall
months to years creates a weak
spot that allows the outpouching
Something pulls on esophagus from the
outside
• Eg; an attached neoplasm
42
• Most common in middle
esophagus.
o Because most lymph nodes
are in mediastinum their
enlargement can cause
them to become adherent to
the esophagus
o Pulsion
Weakness in the esophageal wall (where
the vessels enter a lot of time) that
eventually becomes weak and forms a
diverticula
Occurs from a pushing out of a weak area
of the esophageal wall where the small
micro vascularity occurs to supply blood
to the esophagus
Most common lower/upper esophagus.
ZENKER’S DIVERTICULUM
- Pulsion Type
- Occurs at pharyngoesophageal junction
o Can be very large in size
- Loss of upper esophageal sphincter laxity
- Retains food
- Signs/Symptoms
o Halitosis
o Spontaneous Regurgitation
“Verp” – ½ vomit/ ½ burp
o Nocturnal choking
The position they are in
Recommended not to eat within a few
hours
Neck mass
Can sometimes see peristalsis in the
mass
- Complications – Aspiration (inhaling something that
wasn’t there Aspiration pneumonia – which has a
43
high mortality rate), abscess (walled off chronic
infection), bronchiectasis (chronic obstruction of the air
flow that results in fluid build up infection; 3 layered
mucous, foul smelling sputum)
MISCELLANEOUS DIVERTICULA
- Epiphrenic Diverticulum
o Occur in lower esophagus
o Normally asymptomatic
- Middle Esophageal Diverticulum
o Usually traction
o From mediastinal lymphadenitis
G.E.R.D.
- GERD reflux esophagitis Barrett’s esophagus.
Esophageal. CA always rule out cardiac Disease first
- Cough & bronchospasm or laryngitis from aspiration
- Early satiety GERD get “full” quickly
- Chocolate fat & caffeine contents cause GERD
episode
- Tobacco when chemicals are swallowed
- Commonly assoc. with hiatal hernia (>70%)
- Nitroglycerin will make anginal chest pain better
o Makes GERD chest pain worse
- Gastroesophageal Reflux Disease
- Reflux of gastric contents into lower esophagus
-
- Incompetent lower esophageal sphincter
o Stuff from your stomach comes back up into the
lower esophagus because the esophageal
sphincter is not functioning correctly
o Believes because of aging
o Reflux Esophagitis Barrett’s Esophagus
Squamous cell carcinoma
o Heavier a person is the more chance they can
have because increase in intra-abdominal
pressure
- Incidence
o 60% of adults have heartburn
o 80% of pregnant women have GERD
- S/Sx
o Heartburn (pyrosis)
o Dysphagia
44
o Regurgitation
o Sour taste in the mouth
o Can be confused with angina pectoris
o Chronic cough
o Bronchospasm, due to irritation of the bronchi
airway
o Laryngitis
o Early Satiety (Getting full fast)
o Belching/Bloating
- Contributing Factors
o Chocolate (caffeine and fat), Yellow Onions,
Peppermint, Garlic
o Tobacco (nicotine and causes sphincter to relax),
Alcohol (fat and causes sphincter to relax),
Caffeine
o 70% of GERD suffers have a hiatal hernia
o Beta Blockers (control BP and angina), Ca++
Channel Blockers, nitroglycerin
Causes dilation of lower esophageal sphincter
o Gastric Acid Hypersecretion
- Diagnosis
o 24 esophageal pH monitoring
o E.G.D. – final dx for GERD
o U.G.I
o Manometry, to rule out diffuse esophageal
spasms
- Treatment
o Avoid triggers (diet modification)
o Proton pump inhibitors
o H2-blockers (cimetidine – Prilosec )
o Antacids
o Fundoplication
Reserved for pts with daily reflux
Stomach is wrapped around esophagus
Three types
• Nissen (complete)
• Posterior (partial)
• Anterior (partial)
o Drink excessive amount of water, water helps to
dilute the acid and provide weight to the stomach
to pull the hiatal hernia down.
45
BARRETT’S ESOPHAGUS
- Pre-malignant
- Associated with chronic reflux (5-10% incidence)
- Stratified squamous manifests to columnar epithelium,
a pre cancer action
- Increased risk of adenocarcinoma
o 30-50 times increased risk to develop
adenocarcinoma of the esophagus
o 500/100,000 people with Barrett’s esophagus
who have GERD
- Dx
o EGD, biopsy almost always accompanies an
EGD
o Biopsy
- Rx
o Laser Ablation
o Fundoplication
o Surgical Resection (En Bloc if area is large
enough)
ESOPHAGEAL ACHALASIA
- Spasm (shut tight)of lower esophagus with pre-stenotic
dilation which makes peristalsis ineffective
- Chest pain can occur when peristalsis is attempted
o Pain usually colicky
- Functional esophageal obstruction
- Inadequate relaxation of the LES
- Ineffective Peristalsis
- 1/100,000 incidence; 30-50 y/o
- S/Sx
o Solid/liquid dysphagia, patient indicates they can
feel the food sticking usually in the lower chest
o Chest pain
o Vomiting of undigested food
o Aspiration, can develop pneumonia and die
o May be confused with angina
o Colicky type pain
46
Crescendo/decrescendo type pain
Stone, Ureters
- Etiology
o Degeneration of myenteric plexus
Viral
• Herpes Zoster
• Measles Virus
Autoimmune
o Not completely understood, true etiology not
known
47
- Diagnosis
o EGD with manometry
o UGI
o Tests to rule out other causes (eg: EKG)
Especially with age group one wants to
rule out MI
- Treatment
o Medical
Smooth muscle relaxants (70% effective)
• Nitrates
• Calcium channel blockers
• Botulinum toxins injection
mechanical dilation (90& effective)
• Bouginage mechanical dilation
Esophagomyotomy (90% effective), incise
into the muscle (sphincter – draw back,
reflux)
- Prognosis
o Excellent with appropriate RX
o Long standing Disease increases risk of CA
SCLERODERMA
- Aka: progressive systemic sclerosis (PSS)
- Means hardening of the skin
o Primarily effects the skin, but is not limited to the
skin
o Tissue thickens and hardens
o Severe hardening of lips to point must be tube
feed
- Sometimes must replace the esophagus
o Parastasis is affected, thus difficulty in
swallowing, reflux
- Kidneys are often affected as well
- Vessels become calcified, thickened and hardened
- Female>Male Early teens to 20’s
- Smooth mm relaxants used if esophagus does not need
replacing, patient receives temporary relief, usually do
not work
- Multisystem disorder often affecting the esophagus
o Lose ability to have peristalsis
o Becomes very narrow and can develop strictures
o EGD used to diagnose
- 75% have esophageal involvement
48
- Fibrosis and inelasticity results
- Signs & Symptoms
o Dysphagia
o Esophageal reflux/regurgitation
o S/Sx associated with scleroderma
- Diagnosis
o EGD
o UGI
- Reaction with smooth muscle relaxants
- Etiology - unknown
49
o Coated so that it will pass the stomach and be
absorbed in the small bowel
GASTRIC ANATOMY
- Stomach functions
o B12 absorption (intrinsic factor)
o storage
o mixing
o mineral absorption
o breakdown of proteins and absorption of amino
acids
o absorption of alcohol (irritating to the stomach)
o some medications absorbed in stomach
- Rugae (rippled surface of the interior of the stomach)
o increases surface area inside the stomach for
production of HCl and pepsin
- GE Junction
o Gastroesophageal Reflux Disease
- Fundus
o Usually holds gas
Magenblase air in the stomach
- Antrum
- Pylorus
o Narrowed portion of the distal most aspect of the
stomach
o Pyloric Sphincter b/w stomach and duodenum
help prevent outflow of gastric juices that
could lead to PUD
o Pyloric stenosis prevents outflow, causes
regurgitation
- Curvatures
o Lesser curvature
o Greater curvature
More metabolically active (because of
where food sits)
Also where most diseases of the stomach
occur
- Estimated that 3 – 5 cc of blood is lost with each aspirin
taken that is not buffered
50
EGD ANATTOMY
- Normal antrum and pylorus (pictures)
GASTRIC PERISTALSIS
GASTRIC TUMORS
GASTRIC CANCER
90% of tumors in the esophagus are malignant
- Occurs anywhere in the stomach
o With a greater occurrence in the greater
curvature of the stomach due to the gravity of
material to this area of greater metabolism
- Incidence of proximal CA is increasing
- 2 - 4X more common in 1st degree relatives
- Male: Female 1.6:1
- > 55 y/o
- 7/100,000/year
- Most common in blood group A
- No symptom complex presented early in the Disease
- Pic: Linitis Plastica, an invasive form of gastric
carcinoma , not a single tumor mass, the tumor cells
spread throughout the entire stomach without causing a
single tumor.
o Aggressive, Infiltrated carcinoma invades
entire organ and cause thickening of entire organ
- rarely found before stage 3 or 4
o S/SX
Cramps
Loss of appetite
Very low bleeding
No ulceration
Poor intrinsic factor production
- Risk factors
o Diet rich in additives (smoked, pickled)
o Atrophic gastritis
Inflammatory disease of the stomach
where there is atrophy of the rugae
Sequela : B12 deficiency pernicious
anemia
o Pernicious anemia
o Tobacco use
o Ethnic groups: Hispanic, Japanese
o Polyps
51
Growth into lumen
Sessile and pedunculated
Usually premalignant mass (some benign)
o H. pylori infection
PUD [peptic ulcer dz] associated with H.
pylori
o Barrett’s Esophagus
o **Picture showing the effects of 'linitis plasticus'
which thickens the wall of the stomach; a
particularly nasty and almost always fatal (near
100%)
- DX
o Stool guaiac test test for blood
o Any male > 40 with anemia, has GI
malignancy until proven otherwise
52
- FOB, fecal occult blood test
o Will have black tarry stool if blood occurs in the
stool
- Hemoglobin <12g/dl
- Hematocrit <35
- EGD - esophagogastroduodenoscopy
- UGI (not done very often anymore)
- CT/MRI for nodes mets
o Any male over the age 40 who is anemic has
a GI malignancy until proven otherwise
(blood loss from the malignancy)
GASTRIC CA PATHOLOGY
- 90% Adenocarcinoma, due to the abundance of
glandular tissue, {adeno-, glandular}
- 6% Lymphoma, malignancy of lymphocytes
{mediastinum area is the most common area for a
lymphoma}
- < 4% Gastric Sarcoma
- < 1 % Leiomyosarcoma
GASTRIC CA Rx/Tx
• TREATMENT
o Surgical resection, quit often an en bloc
gastrectomy (resect until healthy tissue is found)
o Node resection (when larger then 1cm)
o Radiation non-beneficial (tumors are non-
sensitive to radiation)
o Chemotherapy non beneficial, research has
shown this treatment has very low benefit for
gastric cancer. Chemotherapy is designed to
“attack” fast growing tissue, i.e. those with rapid
turnover – gonads, for instance.
- PROGNOSIS
o No s/sx until late in course, primarily due to the
size of the hollow organ. It takes a rather large
amount before it interferes with the function of
the stomach
o 18% 5 year survival rate
57% with local Disease (stage I)
19% with regional spread (stage II)
2% with distal mets (staged III)
53
BENIGN GASTRIC TUMORS
- Leiomyoma – fibroid tissue usually found in the uterus,
benign tumor of smooth muscle
o Common tumor
o Rarely symptomatic
o Only with obstruction
- Adenoma – benign tumor of glandular tissue, aka
polyps
o Polyps
o Most of the stomach tumors are hyperplastic (an
adenoma with an increase in the number of cells
– a reaction to chronic gastritis – a reaction to
chronic inflammation)
o Most remain benign
o Can obstruct
o Over 2cm, have malignant potential
GASTRITIS
- All Types have the following characteristics:
o Erythema – reddening (aka injected)
o Hemorrhage Atrophic gastritis – associated with
o Erosions anemia
- Types
o Erosive
o Non-erosive, non-specific
o Specific
- S/sx
o Post-prandial (after eating) indigestion/pain
o Nausea and vomiting
o Bloating
- 50% have H. pylori (spiral shaped bacteria)
EROSIVE GASTRITIS
- Etiology
o NSAID’s [non-steroidal anti-inflammatory drug – Ex: ibuprofen]
o Alcohol(ism), portal HTN – venous congestion
decreases the removal of waste from the
stomach blood supply.
o Stress from major illness (burns)
- Hemorrhage also common with this Disease
54
- Usually asymptomatic
- Can produce pain, hematemesis, n/v
- Diagnosed with EGD
SPECIFIC GASTRITIS
- Ménétrier’s Disease
o Giant fold gastritis (the rugae become very large)
o Enlarged thickened gastric rugae
Get hypoproteinemia due to enlarged
rugae
• Cause’s edema, pleural effusions,
etc.
o Severe protein loss
Proteins are metabolized in stomach
o Hypoproteinemia
o Idiopathic
- Granulomatous gastritis
o Crohn’s Disease (a chronic inflammatory
granulomatous bowel Disease), TB, sarcoidosis
(idiopathic autoimmune disease that normally
affects the lymph nodes of the chest, found
primarily in young black males)
o Treat specific disorder
55
- Phlegmonous gastritis
o Phlegmon – aggressive large abscess
o Abscess from fungal, bacterial, parasitic infection
o Emergent gastrectomy and IV antibiotics
Nasty and not very high survival rate.
o Treatment is the removal of the stomach.
o Common among AIDS patients
(immunosuppressed)
56
o Normal cell renewal; turnover
Diabetics do not prone to ulcers
Chemo patients
- 500,000/year
- Duodenal: Gastric 2:1
- Predisposing factors
o High stress
Increase histamine cause ↑ acid
production
Activates sympathetics and shunt blood
away from stomach
o Cigarette Smoking
Swallowed chemicals
o NSAID use
Irritating to the gastric mucosa – COX
inhibitors stop prostaglandin production
which stops blood flow to the stomach
and inhibits protection to lining
o Delayed gastric emptying
Food stays in stomach & irritates
• Diabetics
o Decreased bowel function,
high incident of PUD d/t
micro-neuropathies.
- H. pylori (produces urease) there is a inferred or
coincidental correlation between H. pylori existence and
ulcers
o Increases gastric acid secretion
o 75% of patients are infected with H. pylori
o 75% have recurrence in 1 year without
antibiotics
o 20% with recurrence with antibiotics
- NSAID use
o Cause decrease bicarbonate the base which
counter acts stomach acid and pepsin, mucus
and blood flow
o Aspirin is most ulcerogenic, buffered aspirin
helps protect stomach but still begins to break
down in the duodenum thus the increase in
ulcers in this area
o 40x increased risk of PUD
57
Signs and Symptoms
- Epigastric Pain
o Burning
o Gnawing
o Cramping
- Relieved by foods and or antacids (short term - pt. can
become addicted)
o Gastric ulcers - eating makes it better
o Duodenal ulcers - eating makes it worse
- Pain is clustered (days-weeks)
- Long symptom free periods (weeks-months-years)
- Changes in pain
o If relapse and pain is worse this time
May mean CA
May mean ulcer may perforate
Differential Diagnosis
- GERD
- Reflux Esophagitis, most common condition confused
with PUD
- Gastric CA, particularly if there is a change in the pain
pattern
- Gastritis
- Pancreatitis
- Cholecystitis
- Cardiac disease
Diagnostic Workup
- Endoscopy
o Esophagogastroduodenoscopy (EGD), almost
universally the means of diagnosis
o 95% accurate (5% due to human error)
o Biopsy ALL lesions
Larger tend to be more malignant
Ragged edge to be more malignant
o Cancer / benign cannot be differentially
diagnosed by sight
o Also biopsy for H. pylori
- Upper GI
o BaSO4
o Not as reliable as EGD
o No biopsy capabilities
58
TREATMENT
- Antibiotic therapy (clarithromycin – which is harsh on
the stomach lining)
- Omeprazole (Prevacid)
- H+ pump inhibitors
- Stop Smoking
- Stop NSAID use
- Diet Changes
o Bland Diet
- Stress Reduction
o Because of sympathetic reaction
o Valium (classic drug prescribed)
- Manipulation in conjunction with medical therapy has
been proven beneficial to the patient
o Don’t use milk anymore because the sugar in it
can help feed the bacterial and can actually
make the ulcer work in the long run
COMPLICATIONS
- GI Hemorrhage (Number 1 biggie)
o Most common (50% of all UGI bleeding)
o 10-20% is bleeding clinically significant
Cause sx and problems
o 80% stop bleeding spontaneously
o Mortality rate is 6-10% of the 20% who do not
stop bleeding spontaneously
Occult blood don’t know it’s there
o Anemia
o Cancer
- Perforation (Number 2 biggie)
o 5% incidence
o Usually on anterior wall
Because it’s thinner
o Zollinger-Ellison should be considered
- Gastric Outlet Obstruction
o At pylorus or duodenal bulb
o 2% Incidence
o From tissue obstruction scar tissue (fibrosis)
obstruction
Zollinger-Ellison Syndrome
o Uncommon cause for PUD
o Occur because of Gastrin secreting tumors
(gastrinoma)
o Cause multiple peptic ulcers
59
o Perforation is relatively common
Bleed outs common
o 2/3 of gastrinomas are malignant
Will metastasize
Can lead to death
o Hard to manage these cases due to the
continuous production of gastrin from the tumor
HIATUS HERNIAS
- Herniation of a portion of the stomach into the thoracic
cavity (mediastinum) through diaphragmatic hiatus
EPIDEMIOLOGY
- 50% of patients over 50
- Female: Male 4:1
- Often associated with GERD
- 90% with EGD esophagitis have a hernia
- Etiology unknown, age most likely culprit due to
weakening of the sphincteric
- May be congenital or post-traumatic
- Bowel and stomach in the middle of the chest
compressing the lungs and heart is termed a Bochdalek
TYPES OF HERNIAS
- Sliding (most common)
- Paraesophageal (AKA: Rolling Esophageal Hernia)
- Short Esophagus
- Intrathoracic Stomach
Heartburn
o Because also have GERD
- Dysphagia
- Regurgitation
- Chest Pain (burning)
- Postprandial fullness
o After eating
- GI Bleeding
- Dyspnea
- Hoarseness
o Irritation of larynx from GERD
60
- Cough
o Irritation and to keep stuff from going into the
trachea
- Wheezing
PARAESOPHAGEAL HERNIA
- Second most common
- AKA: Rolling Hiatus Hernia
- GE junction in normal position
- Fundus herniates through diaphragm
- Usually asymptomatic
- Should be surgically reduced
- May become strangulated
o More strangulation rather than GERD
o Lead to ischemia (loss of blood supply)
MISCELLANEOUS HERNIAS
- Short Esophagus Type
o Variation of sliding
o Uncommon
o Congenitally short esophagus
- Intrathoracic Stomach
o Very rare
o Entire stomach in chest
o Incompatible with life
DIAGNOSTIC WORKUP
- Exclude other more serious conditions
61
- EGD
- UGI
- Blood tests non-specific
- Will find rugae above the hemidiaphragm
DIFFERENTIAL DIAGNOSIS
- PUD
- Angina
- Esophagitis
- GERD
- DES (Diffuse Esophageal Spasm)
- Achalasia
- Diverticulum
- Esophageal Cancer
TREATMENT
- Diet changes
o Avoid caffeine, chocolate, mint, etc.…
o Avoid drugs (Ca++ channel blockers)
- Weight loss
- Small meals
- Sleep with head elevated
- Manipulation
- Antacids, H+ pump inhibitors, etc.…
- Surgery for refractive disease
COMPLICATIONS
- Erosive esophagitis
- Ulcerative esophagitis
- Barrett’s esophagitis
- Stricture
- GI hemorrhage
Colon
- Review normal anatomy and structure of the color
- Review blood supply to colon
o Blood supply interruption
Mesenteric Thrombosis
• Diabetics
• Trauma causing vasocompression
- Colonoscopes used to view the colon
Tapeworm –
62
- S/SX abdominal pain, weight loss
-
63
- D/DX (other diseases which cause cramp type pain and
diarrhea)
o Crohn’s Disease
o UC
o Diverticulitis
o Colon CA
o PUD
o Chronic pancreatitis
o Biliary Disease
- TX
o High fiber diet – helps bulk up the stool and
helps retain fluid
o Fiber supplementation (psyllium)
o Anti-spasmodics
Imodium
Lonotil
Bentyl
o Eliminate stress
o > 60% respond to RX within 1 year
CROHN’S DISEASE
- Chronic granulomatous inflammatory Disease
- Regional enteritis (aka for Crohn’s)
- Debilitating, often requiring surgery
- 1:1000 population
- Caucasians, Jews
- Unknown etiology
- Affects young people
- Pathophysiology
o Location
33% involve terminal ileum
50% involve distal ileum/proximal colon
20% involve colon only
Can involve any portion of GI tract
o Transmural DISEASE
Inflammation (granulation tissue)
Ulceration
Stricture
Fistula – abnormal opening between
spaces not normally connected
Abscess
- S/SX
64
o Abdominal distention/bloating
o Mass suggests abscess formation
o Crampy abdominal pain (RLQ)
o Hyperactive Bowel Sounds
o Non-bloody/bloody diarrhea
o Perianal fissures/fistulas
o Bowel obstruction
o Crohn’s arthropathy
o Low grade fever, pallor
o Weight loss, fatigue
- Diagnostic Evaluation
o CBC
Anemia
Decreased H&H
o Electrolyte imbalance
o Vitamin B12 deficiency
o Endoscopy
o UGI
o LGI
- Presentation Patterns
o Chronic inflammatory Bowel Disease (mc)
o Intestinal obstruction from stricture abscess
o Fistula formation
o Perianal disease
o Extraintestinal
- D/DX
o UC
o IBS
o Infectious colitis (yersinia, TB, Salmonella)
o Parasitic infection (amoebiasis)
o Ischemic colitis
o Diverticulitis
o Colon CA
- TX
o Nutritional supplementation
o Low residue diet with obstruction
o High fiber diet with diarrhea
o Medications
Sulfasalazine
Corticosteroids
Immunosuppressive drugs
o Monitor vitamin levels
65
o Surgery for obstruction, fistulae, etc.
- Complications
o Obstruction
o Abscess formation
o Fistula formation (inter-organ, skin)
o Perianal fissures
o Colon carcinoma
o Hemorrhage/shock
o Malabsorption
ULCERATIVE COLITIS
- Epidemiology
o Chronic superficial inflammation
o Unknown etiology
o Aka-idiopathic proctocolitis
o 100/100,000 incidence
o m/c 14 – 38 years
o 15-20 % of pts require colectomy
- Presentation patterns
o 70 % relapsing
o 20 % chronic continuous
o 10 % fulminate (toxic megacolon)
- S/SX
o Abdominal distention
o Abdominal pain/tenderness (LLQ, LUQ)
o Blood diarrhea
o Fevers
o Dehydration
o Extraintestinal
Liver Disease
Sclerosing cholangitis
Arthritis
Ocular Disease (uveitis, iritis)
- DX workup
o Comprehensive H&P
o Laboratory studies
CBC (anemia, elevated ESR)
SMAC (electrolytes, LFTs)
UA (dehydration)
o Sigmoidoscopy
o Double-contrast BE
- D/DX
o Crohn’s Disease
o Bacterial infection
66
o IBS
o Protozoal infection
o Colon CA
o Diverticulitis
o Ischemic Bowel DISEASE
- TX
o Correct nutritional deficiencies
o May need “bowel rest” with TPN
o Folate supplementation (decrease CA Risk)
o Low roughage diet during exacerbation
o Meds
Sulfasalazine
corticosteroids
o colectomy/colostomy
Crohn’s Disease
67
o Cramping or steady pain in the right lower
quadrant or periumbilical area
o Examination reveals focal tenderness in the
right lower quadrant
Intestinal obstruction
o Narrowing of the small bowel may occur as a
result of inflammation of fibrotic stenosis
o Patients report postprandial bloating,
cramping pains, and loud borborygmi
Extraintestinal manifestations
Oral aphthous ulcers
Increased prevalence of gallstones due to
malabsorption of bile salts
Nephrolithiasis with urate or calcium oxalate stones
Complications
Abscess
Obstruction
Fistulas
Perianal disease
Carcinoma – Patient’s with colonic disease are a t a
greater risk of developing colonic carcinoma
Hemorrhage – unusual in Crohn’s disease (except for
Crohn’s colitis)
Malabsorption – from bacterial over-growth in
patients with fistulas
68
No specific treatment exists for Crohn’s disease, treatment is
directed toward symptomatic improvement and controlling
the disease process
APPENDICITIS
- Inflammation of appendix secondary to obstruction
- Clinical symptom complex
o Periumbilical/diffuse pain
o RLQ pain
12-244 hrs later
Sign of regional peritonitis
Rebound tenderness
High fever
o Can rupture
o May cause diffuse peritonitis
o May result in abscess formation
DIVERTICULAR DISEASE
- Epidemiology
o Herniation of mucosa and submucosa through
muscularis from low fiber diet
o Occur at vasa recta (weakened area)
o Diverticulosis is asymptomatic
o Diverticulitis is symptomatic
o Most respond well to antibiotics
o Up to 30% require surgery
- S/SX
o Diverticulosis exam is normal
o LLQ pain mc
o Pain relieved with BM
o Abdominal guarding
o Rebound tenderness suggests peritonitis
o +/- small amount of blood in stool
DIVERTICULAR BLEEDING
- 70% (of the bleeding) occurs in right colon
- bleeding is painless
- resolves spontaneously in 60%
- erosion of vessels from fecalith
- 15 – 20 % re-bleed within 5 yrs
69
- Diagnostic workup
o CBC (elevated WBC with diverticulitis)
o Microcytic anemia
o BE
o Sigmoidoscopy
o Abdominal CT for abscess formation
- D/DX
o IBS
o Crohn’s DISEASE
o UC
o Colon CA
o Ischemic Colitis
o Infectious Colitis
- TX
o Increased dietary fiber
o Regular exercise ("a wonderful tx for constipation" BTW)
o Broad spectrum antibiotics
o IV Antibiotics in severe cases
o Surgical resection/re-anastomosis
1COLORECTAL CANCER
• 2nd leading cause of CA deaths in USA
o 135K new cases per year
o 50K deaths per year
• 15% of all cancers (except skin cancers)
• Peak incidence in the 7th decade
• Location
o Descending colon 40%
o Rectosigmoid 30%
o Cecum / ascending 25%
o Transverse 10%
• Note: Any male with anemia has a malignancy until
proven otherwise
Risk Factors
• Hereditary polyposis syndromes
o Familial polyposis, teens to 30's, pts have
thousands of polyps
o Gardner’s Syndrome
• Inflammatory bowel diseases
• History of previous colorectal CA
• 1st degree relative with colorectal CA
70
• Age >40
• High fat, low fiber diet
• Regional radiation therapy
o (eg. Female receives radiation for ovarian cancer
- if the colon is in the port, the fast turnover of the
epithelial cells makes them prone to damage
from the radiation, due to the effect of radiation
on fast growing tissue) [brain tumors can be
treated with sterotactic radiation]
Clinical Presentation
• Normally unremarkable
• DRE finds 50% of tumors
• Palpable abdominal mass
o (mets most likely, not the colon cancer itself)
• Abdominal tenderness
• Alternating constipation / diarrhea
• Hepatomegaly (mets)
• Rectal bleeding
• Hematochezia – "passage of blood in the stools"
• Melena
• Blood streaked stool
• Occult blood [blood mixed in with the stool]
• Abdominal distension
o Obstruction – colon blows up like a baloon
o Initial symptom in 15% of patients
• Pencil thin stools
• Intusseception - telescoping
• Volvulus – twisted on itself
• Weight loss, suggest stage 3 or 4 carcinoma
• Anorexia
• Malaise
Clinical Investigation
• Anemia (microcytic)
o Any male patient over 40 with rectal bleeding is
to be considered positive for colon cancer
• Positive FOB test (Fecal Occult Blood testing)
• Elevated CEA (used for Rx response) –
o Carcinoembryonic antigen
• Elevated LETS
• Colonoscopy
71
• Double contrast BE (barium enema)
• CT for staging
• CAR (chest is a common place for mets of colon
cancer)
• 25% have mets at presentation, they are in stage four
of the cancer
Differential Diagnosis
• Diverticular disease
• bowel stricture
• inflammatory bowel diseases
• adhesions
• mets
• extraluminal masses (ovarian mass)
• AVMs – arterial venous malformations
Cancer Staging
• Duke classification system – used almost universally for
these patients.
• A - confined to the mucosa-submucosa
Essentially a carcinoma in situ
• B - invasion of muscularis
Into the lymph and blood vessels
• C - Local (lymph) node involvement
• D - distant mets (liver, lung, brain)
Treatment
• Surgical resection
o 70% are resectable at presentation
note that the resection can be done for
pallative reasons and does not offer a
"cure" per se.
o 45% cured by primary resection
• Radiation therapy (stages B & C)
• Chemotherapy (stages B & C)a
o 5-fluoroucacil
o Levamisole
• FOB q 6 months (Fecal Occult Blood testing)
• Colonoscopy q year x 2 years, then q 3 years
• CEA levels (Carcinoma Embryonic antigen)
Prognosis
• Duke A: >80%
72
• Duke B: 60%
• Duke C: 20%
• Duke D: 03%
Overall 5-year survival rate 50%
COLON POLYPS
- 50% patients have polyps
o hyperplastic
o adenomas
o lipomas
o leiomyomas
- Sessile / pedunculated
- 25% patients with colon cancer have polyps
Signs / Symptoms
- most are asymptomatic
- rectal bleeding most common
- cramps
- abdominal pain
- obstruction
- anal polyps may prolapse
Diagnosis
- DRE
- Endoscopy
- Double contrast BE
Treatment
- Careful observation (hyperplastic, lipoma)
- endoscopic surgery
- open laparotomy
SIGMOID DIVERTICULITIS TX
- ↑ dietary fiber
- Broad spectrum antibiotics
- Reg. Exercise
- IV antibiotics in severe cases
- Surgical resection/re-anastomosis
73
- Colorectal CA
o 2nd leading cause of CA deaths in US
1. lung CA
2. colorectal CA
3. Breast CA
o Most common CA is skin CA
o 135,000 new cases/year
o 50,000 deaths/yr.
o 15% of all cancers (except skin cancers)
o peak incidence in the 7th decade
o Location
Lower colon – 40%
rectosigmoid - 30 %
cecum / ascending – 25 %
transverse – 10%
- 2 types of CA can occur
o adenocarcinoma
o squamous cell CA – Most common with HPV
(condylomata)
- Risk factors
o Hereditary polyposis syndromes
Familial polyposis
Gardner’s syndrome
• Polyposis & osteoma in skull
o Inflammatory bowel Disease
o H/o previous colorectal CA
o 1st degree relative with colorectal CA
o age > 40
o high fat, low fiber diet
o regional radiation therapy
- Clinical presentation
o Normally unremarkable
o DRE finds 50% of tumors
o Palpable abdominal mass (mets)
o Abdominal tenderness
o Alternating constipation/diarrhea
o Hepatomegaly (mets)
Mets usually to liver (stage 4 colorectal
Ca)
• Liver drains all of GI
o Rectal bleeding
Hematochezia
Melena
Blood streaked stool
74
o Abdominal distention
Obstruction
Initial sx in 15%
o Pencil thin stools
o Intussusceptions
o Volvulus
o Wt loss
o Anorexia
o Malaise
o Colon CA can cause lumbar & sacral back pain
- Clinical investigation
o Anemia (microcytic)
o Positive FOB test
o Elevated CEA (used for RX response)
o Elevated LFTs
o Colonoscopy
o Double contrast
o CT for staging
o CXR
o 25% have mets at presentation
- D/DX
o Diverticular Disease
o Bowel stricture
o Inflammatory bowel Disease
o Adhesions
o Mets
o Extraluminal masses (ovarian)
o AVMs (Arterial venous malformations)
- Cancerous staging
o Duke Classification system
A – confined to the mucosa – submucosa
B – Invasion of muscularis
C – local node involvement
D – Distant mets
- TX
o Surgical resection
70% are respectable at presentation
45% cured by primary resection
o radiation therapy (Stages B & C)
o chemotherapy (stages B & C )
5-flourouracil
levamisole
o FOB (fecal occult blood) every 6 months
75
Guaiac test finds occult blood in feces
o Colonoscopy every year x 2 years, then every 3
years
o CEA level
Carcinogenic embryonic antigen
- Prognosis
o Duke A – 80 %
o Duke B – 60%
o Duke C – 20 %
o Duke D – 3 %
o Overall 5 yr. survival rate – 50 %
COLON POLYPS
- Most non-inflammatory CA arise from polyps
- 50 % patients have polyps
o Hyperplastic
o Adenomas
o Lipomas
o leiomyomas
- sessile/pedunculated
- 25% pts with colon CA have polyps
- S/SX
o Most are asymptomatic
o Rectal bleeding mc
o Cramps
o Abdominal pain
o Obstruction
o Anal polyps may prolapse
- DX
o DRE
o Endoscopy
Complicated with severe inflammation
disease
May perforate bowel
Do BE instead
o Double contrast BE
- TX
o Careful observation (hyperplastic, lipoma)
o Endoscopic surgery
o Open laparotomy
76
Test Three and Final
3/24/03
Small Bowel Diseases
- Usually result in some form of malabsorption
CELIAC SPRUE
- aka: Gluten enteropathy non-tropical sprue
- Gliadin protein fraction in gluten
o Wheat
o Rye
o Barley
o oats
- Gluten intolerance
- 50-500/100,000 people
- incidence ↑ during 1-36 months
- F>M
o Mc to find in a child
- Clinical Presentation
o May B normal presentation
o WT ↓
o Dyspepsia (indigestion)
o FTT in children (failure to thrive)
o Bloating
o Diarrhea
o Pallor/fatigue (anemia)
o Angular cheilosis
o Osteomalacia
o dermatitis
- Lab tests
o Iron ↓ anemia
o Folic acid ↓
o B 12 ↓
o Antigliadin IgA/IgG ↑
o Small bowel biopsy
Show villi atrophy
Signs of inflammation
77
- D/DX
o IBS (mc d/dx)
More mucous in IBS stools
Age 20 - 40
o Laxative abuse
Can form addiction to the point where the
body won't function without them
o Intestinal Parasites
o Tropical Sprue
o Lymphoma
- TX/PX
o Gluten Free Diet
o Iron supplementation
o Folate supplementation
WHIPPLES DISEASE
[No relation to Mr. Whipple, i.e NOT the pathologic
compulsion to squeeze bathroom tissue]
- Caused by bacteria
- Men 30 - 60
- Multisystem Disease
- Tropheryma whippelii (gram +)
- Aka: intestinal lipodystrophy
- Uncommon disease
- 30-60 yr. olds
- M>F
- Clinical Presentation
o Malabsorption
Diarrhea
Bloating/cramps
Anorexia
Wt ↓ / fatigue
Anemia
o Extra intestinal
Arthritis
• Can be peripheral or sero-negative
Pleuritic chest pain (localized pain)
Pericarditis
Osteomalacia
- Pathology
o Bacteria never cultured; needs human cells
o No human to human transmission
o Don't know how it is transmitted
78
o Bacteria will change appearance – note slide of
polarized light microscopy in lecture
o Response 2 antibiotics confirms dx
- D/DX [big shock. This list is starting to look familiar]
o Celiac sprue
o Lymphoma
o Crohn’s disease
o Short bowel syndrome
Take portion of bowel out
Get malabsorption
o Pancreatic insufficiency
Fatty stools
o Lactose intolerance
- TX/PX
o Antibiotics
Trimethoprim
Sulfamethoxazole
o TX with vitamin deficiencies
o Iron supplementation
o Patients respond well to antibiotics – and quickly
LACTOSE INTOLERANCE
- Can have a transient form in people that are ill
- 1 in 6 pts have it
- Have malabsorption symptoms
o But vitamin deficiencies are usually not as bad
- Insufficient concentration of lactase
- Results in fermentation of lactose
- Aka: milk intolerance
o Misnomer, lots of things other than milk can
cause symptoms
- 50 million R affected
- > 85% Asian American affected
- > 60 % African American affected
- < 25% Caucasians affected
- Clinical presentation
o May B normal
o Bloating
o Diarrhea
o Cramping
o ABD pain
o Flatulence
- DX work ↑
o Hydrogen Breath test
79
Ingest 50 gm of lactose
↑ in breath hydrogen > 20 ppm in 90 min
o Exclude other disease
o Imaging studies not indicated
- D/DX
o IBS
o IBD
o Pancreatic insufficiency
o Sprue
- TX/PX
o Lactose free diet
Milk
Bread
Candies
Cold cuts
Commercial sauces
o Read labels
o LactAid tablets
o Ca ++ supplementation
o Excellent prognosis
MECKEL’S DIVERTICULUM
- Remnant of vitelline (omphalomesenteric) duct
- Mc misdiagnosed as appendicitis
- Congenital lesion
o 2 % of Population
o failure of obliteration of vitelli intestinal
o duct connecting interesting 2 yolk sac
o mc anomaly of SI
- Found w/in 3 ft of IC valve
- ↓ 12 cm in length
- Complications
o bleeding
o obstruction
o diverticulitis (contains gastric mucosa)
perforation
- RX w/diverticutomy
MESENTERIC ISCHEMIA
- Most painful condition in medicine
- More proximal obstruction of artery → higher mortality
- Occurs as a result of either superior mesenteric arterial
or venous occlusion
80
- Affects the bowel from 2nd part of duodenum 2
transverse colon
- 50% embolic, 25% atheromatous, 10% venous
occlusion
- Overall mortality is approx. 90%
- DX features
o Nothing highly suggestive
o Central abd pain out of proportion
o KUB may B normal
3/25/03
GENITOURINARY DISEASES
URINARY TRACT INFECTIONS
- Can present w/ back pain
- Female UT in close proximity to bacteria From anus
- Normal urinary tract is sterile
- M/c bacterial infection in humans
o Upper Respiratory Tract Infections m/c viral
infection
- Women more prone to infections
o Shorter tract
Bacteria doesn’t have to travel as far
o Hygiene
Wiping A to P NOT P to A
- Lower UTI
o Urethritis
o Cystitis
Infection of urinary bladder
- Upper UTI
o Pyelonephritis
Kidney Infections (Pyelo = pelvis)
PATHOPHYSIOLOGY
- 100,000/ml is threshold
o B/w 10,000 – 100,000 is contaminated
- Must have a certain amount of bacteria in a certain
volume of urine to dx a UTI
o 10,000 – 100,000 ml = contaminated specimen
o > 100,000/ml = UTI → become symptomatic
- Some patients are symptomatic with less
81
- Neonates- m/c in boys from anomalies
o 30 days old or less
- Preschool- m/c in girls from hygiene
- Adults- m/c in women from hygiene
- Four pathways
o Ascending form urethra
o Lymphatic spread
o Hematogenous spread
o Direct extension
Pelvic abscess from ovary or uterus
- Diabetics have sugar in urine that bacteria can feed off
of and therefore are more prone to UTI’s (Infra somatic
cystitis air in wall of bladder from aerobic bacteria)
- Pregnancy → higher risk d/t incomplete emptying or
obstructed ureters
- Risk factors
o Neurologic disease
o Diabetes
o Renal failure
o Pregnancy
- Pathogens
o E. Coli
o Proteus Mirabilis
- Defense Mechanisms
o Low pH
o Normal Micturition
Detrusor mm contracts
Trigone muscle relaxes
o High Osmolarity
82
LOWER UTI
- Presentation inconsistent
o Some asymptomatic, some just have urgency,
some have extreme pain
- testing
- Urinary frequency, with minimal quantity
- Dysuria
- Urgency
- Urge incontinence
- Suprapubic pain
- Hematuria (menstruation most common caused,
bladder infection most common pathogenic cause)
o Gross
Patient will see in toilet
o Microscopic
If the infection is mild to moderate
PYELONEPHRITIS
More common in the immunocompromised population
(diabetic)
Usually secondary to a UTI
Patient will be positive for a kidney punch
- Fever, more prevalent then with a UTI
- CVA pain
- Radiating pain into groin
o Anterior and inner thighs, males will refer to the
ipsilateral testicle
- Chills
o Fever, night sweats
- Malaise
o Fatigue
- Vomiting
- Diarrhea
CLINICAL TESTING
- Clean catch UA
o Wipe w/alcohol pad → start urination → stop →
catch → mid-steam urine → stop before
urination is complete
- Urine Culture & Sensitivity, by culturing you are able to
determine the type of bug and degree of activity level
and then the sensitivity to antibodies so as to determine
treatment plan
- CBC
83
o Elevated WBC, anemia (mild)
- KUB (kidney, ureter, bladder) (a plain film of the
abdomen)
- Ultrasound
- IVP (Intravenous Pyelogram)
o Outlines renal substance
- CT scan
o For tumors or abscess
- Cystoscopy
- Retrograde pyelography (obstruction)
o Dye from urethra up and stops where infection is
o 2 check for stones
Non-gonococcal Urethritis
- NGU is most common STD
- NGU twice as common as gonorrhea (the clap)
- Chlamydia is most common bug
- Often asymptomatic(~25%) especially in women
- Symptoms
o dysuria
o whitish discharge
o meatal edema
• Treatment w/ antibiotics
Gonorrhea
- Neisseria Gonorrhoeae
- Urethra is mc sight of infection
- Contraction rates(single intercourse)
• 20% for males
• 80% for females, will tear up the cervix and cause
sterility if not aggressively treated
- Symptoms
• dysuria
• urethral discharge
• urethral itching
- Treatment w/ antibiotics
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Herpes Simplex
- HSV II infection affecting ~20% of adults
- spread through direct contact
- causes blisters/ulcers around genitals
blisters release clear fluid which contains high levels of
the infected agent
- may also infect the eye, skin, other organs
- no cure, only symptom control
Genital Warts
- Condylomata acuminata
- Cause by form of HPV
- represents 1/3 of cases of STDs, 20 million people
- most people are exposed at some point in life
- treated with antiviral creams, cryotherapy, laser
will reoccur
- Signs/symptoms
o acute colicky CVA/flank pain
o n/v (nausea and vomiting)
o referred pain to testes/vulva/groin
o FCNS suggests infection
- Diagnostic work-up
o UA(hematuria)
o plain film radiography
o renal US
o IVP (intra venous pyelogram)
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- DDx
o pyelonephritis
o cystitis
o diverticulitis
o PID
- Rx
o increased fluid intake, low calcium diet
(contraindicated if an obstruction exists)
o uteroscopic stone removal
o extracorporeal shockwave lithotripsy
- 50% pass within 48 hrs
- 50% recurrence rate without Rx
Glomerulonephritis
- autoimmune inflammation of glomerulus
- synonyms
o post-infectious GN
o acute nephritic syndrome
- epidemiology
o 50% affect < 13 y/o
o Most common cause of chronic renal failure (~25%),
these individuals wind up on dialysis
o post group A beta strep infection mc
o collagen vascular disease(SLE)
o idiopathic
Proteinuria
- normal adult excretes ~150 mg/day short and long chain
proteins (0 - +2 on a UA dipstick)
o 3.5% prevalence in normal adults
o perform 3 separate tests
o You must not assume that finding protein equates
the “normal” amounts excreted. You must rule out all
possible causes.
- positive again-follow up
- negative-dx transient functional proteinuria
- Causes
o IDDM
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o Nephrotic syndrome
o Amyloid
o Lymphoma
o NSAID use
o Orthostatic proteinuria (only when upright)
Nephritic Syndrome
- secondary to GN
- signs/symptoms
o edema(periorbital, scrotal), due to loss of protein
o HTN, damage to kidneys which help regulate
HTN
o hematuria
o proteinuria
Nephrotic Syndrome
- Most common cause is membranous GN
- signs/symptoms
o peripheral edema, protein loss
o ascites
o HTN,
o pleural effusion
o hypoalbuminemia
o hyperlipidemia / hypercholesterolemia
o 1/3 of pts have DM, SLE, amyloidosis
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- altered sensation, electrolyte influenced
- laboratory findings
- elevated BUN/creatinine (creatinine levels are very specific
for renal function)
- electrolyte imbalance
- anemia, platelet dysfunction
88
o drug toxicity
o obstructive uropathy
o renal artery stenosis
- Laboratory findings
o elevated BUN/creatinine
o proteinuria, RBC casts
o electrolyte imbalances
Renal Cysts
- fluid-filled epithelium-lined cavities
- found on 50% of autopsies
- rarely symptomatic
- simple cysts are ~70% of all renal masses
- Polycystic renal disease
o mc hereditary disease in the USA
o 50% have renal failure by age 60
o repeated UTIs, large kidneys, flank pain
o 50% pts also have liver, pancreas cysts
89
o HTN (20-40%) – sudden hypertensive changes
are a red flag
o Weight loss (30-35%)
- Classic Triad (5-10%)
- Treatment
o Nephrectomy – complete removal of the kidney
o Radiotherapy -
o Chemotherapy (5% response rate)
- Prognosis
o Stage I ~90%
o Stage II ~75%
Good prognosis in stage I and II but
because the tumor is typically
asymptomatic during this stage it is not
found during these stages
o Stage III ~20%
o Stage IV ~5%
Prostate Diseases
- prostatitis
- benign prostatic hyperplasia
- prostate carcinoma
- Prostate specific antigen
o normal 0-4 ng/ml (nanograms)
o elevated in:
BPH
prostate CA (not 100% accurate)
post-rectal examination
prostate trauma
Prostatitis
- Men over 50
90
- may be aseptic or septic (infectious or noninfectious)
- Signs/symptoms
o Dysuria (painful urination and in the case the
pain is deep inside the pelvis)
o Polyuria (because they don’t want to urinate thus
they urinate a little at a time)
o pelvic/ back pain
o urethral discharge
o fever
- Dx made by culture and stain of prostate secretions
- Anti-biotics if infectious
DDx
- prostatitis
- prostate CA
- urethral stricture
- Dx workup
- PSA
- protease secreted by epithelial cells
- elevated in ~40% pts w/ BPH
- UA
- Ultrasound to ensure to hidden masses
- Treatment
- avoid caffeine
- avoid medications (cold and allergy drugs)
- medications
- TURP
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- stents
- laser
- coils
- Prognosis is good(>70%)
Prostate Cancer
DDx
- BPH
- prostatitis
- prostate stones
Diagnosis
- elevated PSA (may be normal in 20%)
- elevated acid phos (extracapsular extension)
- biopsy
Treatment (chemo, rad, prostatectomy)
Px depends on stage (~90% w/ stage I)
Testicular Torsion
- Twisting of spermatic cord
- Leads to testicular ischemia / infarct
- 1:4000 incidence
- 70% occur between 1 – 18 y/o
- DDX
o Testicular tumors
o Epididymitis
o Incarcerated hernia
o Orchitis – caused by mumps virus
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o Hydrocele – an obstructive disease where there
is enlargement of the epididymis
Testicular Torsion
- Clinical Findings
o Sudden hemi scrotal pain (10% are painless)
o Swelling
o Nausea and vomiting
o Afebrile – no fever
o 30% patients report previous episode of pain
- Dx based on H and P
- Surgical derotation with suture fixation
Epididymitis
- Septic/traumatic inflammation of epididymis
- >600k visits per year
- occurs in sexually active men
- DDX
o Orchitis
o Testicular torsion
o Hydrocele / varicocele
- Agents
o N. gonorrhoeae
o C. trachomatis
- Clinical presentation
o Tender scrotal swelling
o Erythema
o Dysuria
o Urethral discharge
o Fever
- RX
o Ice packs with scrotal elevation
o Analgesics
o Antibiotics
- Px
o Usually self limited
Hydrocele
- fluid collection in the scrotal space
- if congenital, associated with inguinal hernia
- in adults
o infection
93
o tumor
o trauma
- Clinical presentation
o Scrotal enlargement / pain / radiating to back
o Transillumination
- Rx
o None if asymptomatic
Orchitis
Testicular Cancer
Bladder Cancer
- range from low-grade to high-grade
- cell types
94
o Transitional cell (93%)
o Squamous cell (6%)
o Adenocarcinoma (1%)
- 54,000 new cases/yr; 12,000 deaths
- 4(F)-10(M)% of all cancers
- mc over age 60
- 25% result from occupational exposure
o dye, textile, rubber tire, petroleum workers
- 15-65% associated w/ smoking
- Clinical presentation
o gross painless hematuria
o painless microscopic hematuria
o frequency, urgency – due to bladder becoming
filled with the mass
o mets causes pain in distant organ (eg, back
pain)
- Diagnosis
o H&P History and physical examination
o UA, cystoscopy – and endoscopic procedure for
the bladder
- Rx- chemo, radiations, TURP, cystectomy
- Px- dependent on cell type and grade
Liver Function
- Anatomy
o four lobes – right, left, caudate and quadrate
o Weighs – 3 lbs
- Blood Supply
o hepatic artery (oxygenated blood) (20%)
o hepatic portal vein (nutrients) 80%
o hepatic veins (drain liver)
o holds 1 pint of blood
- Only organ that can regenerate
- 75% damaged before failure
- over 500 functions
- produces bile
- produces plasma proteins
- produces cholesterol
- converts glucose to glycogen
- stores iron
- converts ammonia to urea (one of the reasons that BUN
levels can be elevated in the liver as well as the kidney
- clears drugs
95
- blood clotting
- normal portal venous pressure=5-10 mm Hg (a relatively
low pressure system)
Hepatitis
- liver inflammation
- types
o viral (A, B, C, D, E, X?)
o alcoholic hepatitis
o drug-induced hepatitis
o toxic hepatitis(carbon tetrachloride, benzene)
o leptospirosis
o toxoplasmosis
o EBV, CMV, HIV, HIV
Hepatitis A
- caused by HAV (RNA virus)
- fecal-oral route, close family contacts
- 9-45/100,000/yr
o institutionalized children
o day care centers
o male homosexuals
o exposure to imported apes
o undercooked mussels, clams, oysters
- highly contagious
- represents 33% of viral hepatitides in USA
- Clinical presentation
o often asymptomatic(25% adults, 90% <2 y/o)
96
o anorexia, malaise
o hepatomegaly (87%), RUQ tenderness
o splenomegaly rare (9%)
o jaundice
o dark urine(bilirubinuria)
o fever variable (precedes jaundice)
- Workup
o LFTs (Liver Function Test)
o HAV antibody
- Laboratory tests
o ALT/AST(often > 8x normal)
o Bilirubin (usually 5-15x normal)
o Alkaline phosphatase (1-3x normal)
o albumin, prothrombin normal
o WBC most often normal
o hepatitis A IgM
- imaging studies not normally useful
- no such thing as chronic hepatitis A it is an acute disease
whose course rarely exceeds 8 weeks
- acute disease lasting < 6 wks
- rarely prolonged(3-5 mos), no carrier state
- Treatment
o avoid hepatically metabolized drugs
o IV fluid replacement for vomiting (rare)
o steroids not normally helpful
o follow-up as outpatient
o Overall do not over tax the liver, no alcohol
- Px
o <0.1% fatality rate
o 60% w/ fulminant recover
o evidence of previous disease in 40% of adults
Hepatitis B
- acute viral hepatitis(aka serum hepatitis)
- uncommon chronic form(5-10%)
- 4000-5000 deaths/yr from chronic HBV
- incubation 30-180 days
- DNA virus
- 200-300k new acute cases/yr(300 deaths)
- at risk populations(blood transmission)
o IV drug users
97
o homosexual males
o hemodialysis and hemophilic pts
o health care workers
o neonates/infants
- mc in 20-45 y/o
- DDx
o other viral hepatitides
o other viral illness w/ liver involvement
o non-viral hepatitides
- Clinical presentation of acute disease
o most often anicteric and asymptomatic
o anorexia, malaise, n/v
o serum sickness(hives, rash, arthralgia)
o hepatomegaly, splenomegaly(uncommon)
o jaundice, bilirubinuria, +/- fever
- Treatment
o IV fluids for dehydration (increased vomiting over
Hep A)
o treat for hepatic failure, if present
o avoid hepatically metabolized drugs (including
alcohol)
o steroids not helpful
o interferon for chronic cases
o antiviral agents
- famciclovir
- lamivudine
o liver transplant
- prevention
98
o avoid high-risk behaviors
o testing blood supply
o hepatitis B vaccine
- high risk groups(90% effective)
- childhood vaccination
- HBV hyperimmune globulin
o given after needle stick
o given after birth w/ infected mom
o given after sexual exposure
Hepatitis C
- viral infection of the liver with HCV
- non-A, non-B RNA virus
- intermediate incubation(15-150 days)
- Most common cause of non-alcoholic liver disease in
US(40%)
- epidemiology
o transfused hemophiliacs
o IV drug users
o occupational needle sticks
o hemodialysis
- male=female
- 18-39 y/o mc
- Clinical presentation
- gradual symptom onset
- milder that HAV/HBV
- RUQ tenderness
- hepatomegaly
- jaundice
- dark urine(bilirubinuria)
- many are anicteric asymptomatic (75%)
- male=female
- 18-39 y/o mc
- Clinical presentation
o gradual symptom onset
o milder that HAV/HBV
o RUQ tenderness
o hepatomegaly
o jaundice
o dark urine(bilirubinuria)
o many are anicteric asymptomatic(75%)
- immunity after infection is incomplete
99
- fulminant acute disease is rare (0.1%)
- persistent infection is common(50-70%)
- results in chronic hepatitis
- cirrhosis develops in 20-50%
- hepatocellular CA develops in 50%
- DDx(other inflammation hepatic diseases)
- Diagnostic workup
o acute hepatitis c antibody
o LFTs
o biopsy for complications
- Rx
o avoid meds metabolized by liver
o otherwise acute Rx is non-specific
o follow-up for complications
o Interferon may be helpful in relapses
- acute disease lasts <6 wks
- no vaccine
- immune globulin injections are not helpful
Alcoholic Hepatitis
- Most common form of hepatitis
- most common cause of cirrhosis
- SSx similar to other hepatitis x flu-like Sx
- hepatomegaly
- splenomegaly more common than viral
- ascites
Hepatic Cirrhosis
100
- Clinical Presentation
o early
- weakness, fatigability, disturbed sleep
- muscle cramps, weight loss
- advanced
o anorexia, weight loss
o n/v, hematemesis, due to esophageal varices
o jaundice
o hepatomegaly, ascites
o amenorrhea, due to cholesterol production
interference
o impotence in men
- Skin lesions
o spider nevi
o palmar erythema(alcohol abuse)
o glossitis, cheilitis
o ecchymosis
- CNS damage
o Asterixis (intermittent lapse of body position)
o tremor
o delirium
o dysarthria, slurred speech
o coma
- Laboratory findings
o macrocytic anemia
o abnormal LFTs
o decreased albumin
o leukopenia
- Rx
o avoid hepatotoxic meds
o treat disease that caused cirrhosis
o treat complications(ascites, varices, CHF))
101
- SSx
o Fatigue (extreme fatigue)
o pruritus
o ~50% are asymptomatic
o hepatosplenomegaly, jaundice later on
- Laboratory tests
o anti-mitochondrial antibodies (98% specific),
almost pathognomonic for this disease
o abnormal LFTs
- Rx
o Methotrexate, a commonly used chemotherapy
agent, which helps control the over growth of cell
in the bile duct
o colchicine
o ursodiol
o liver transplant
- Px-
o asymptomatic- 10-16 yrs from time of diagnosis
o symptomatic- 7 yrs from time of diagnosis
Hepatic Tumors
- Benign
o Hemangioma
- Most common benign liver tumor
- Vascular tumor
- Asymptomatic
- Found incidentally
o Adenoma
- Rare solitary or multiple tumor
- Usually asymptomatic
- Found in steroid abusers, OCA users
- Malignant
o Hepatocellular Carcinoma (old term Hepatomas)
o Cholangiocarcinoma
o Metastasis (Most common cause liver
malignancy), colon cancer is the most common
malignancy which mets to the liver
102
Hepatocellular CA
- malignant tumor of hepatocytes
- associated with:
o chronic liver disease
o cirrhosis
o HBV, HCV
o hepatotoxins(ETOH, steroids)
- Clinical presentation
o weight loss, anorexia
o ascites
o hepatomegaly
o 33% are asymptomatic
- Diagnostic evaluation
o elevated AFP in ~90% (alpha-fetoprotein – this
protein non-specific)
o elevated LFTs
o MRI
o Ultra Sound/CT-guided biopsy
- Treatment
o dependent on size of lesion/mets
o resection
o chemotherapy
- Px is 20-30% following resection
Cholangiocarcinoma
- Intrahepatic bile duct malignancy
- Rare in USA and Europe – more common in Asia
- Presents as a liver mass
- Associated with liver fluke infestation – more common in
Asian culture
- Slow progression to metastasis
Gallbladder Diseases
Cholelithiasis
- Gallstones
- affects 20,000,000 Americans
- Predisposing factors (Female, forty, fat, flatulence, fair
skin)
o fair skin
o female
103
o obesity
o ~40 y/o
o OCA use
o DM
- ~20% chance of developing biliary colic, passage of
gallstones
- pts are asymptomatic unless passing a stone
- S/Sx
o colicky RUQ pain
o night pain
o refers to right shoulder
o lasts mins to hours depends on the amount of
time is takes for the gallbladder to push the
stone through
- 75% of stones contain cholesterol
- Ultrasound is imaging procedure of choice
- Rx-cholecystectomy, ESWL, dissolution (substances which
will dissolve gallstones)
- Px-good
- Diagnostic workup
o Ultrasound
o MRI/CT to rule out more ominous causes
- Treatment
o laparoscopic cholecystectomy (lap chole)
o open cholecystectomy
o broad-spectrum antibiotics
- Prognosis
o Excellent
o 1% complication rate with lap chole
104
Cholangitis
- inflammation of bile ducts
- complication of cholelithiasis(~1%)
- occurs during 7th decade and older
- Clinical presentation
o Charcot's Triad
- fever/chills
- RUQ pain
- jaundice
o bilirubinuria
- all S/Sx present in 50-85% of pts
- Diagnostic workup
o Ultrasound
o ERCP endoscopic retro( if US is inconclusive)
- Treatment
o biliary decompression
- ERCP(maybe w/ stent placement)
- percutaneous transhepatic biliary
drainage
o broad-spectrum antibiotics
- Prognosis is excellent
- Chronic disease associated w/ porcelain gallbladder, a
premalignant condition
Gallbladder Cancer
Adenocarcinoma most common
- asymptomatic unless disease is advanced
105
- usually found during surgery for stones
Pancreatic Disease
- Acute pancreatitis
- Chronic pancreatitis
- Pancreatic Cancer
Acute Pancreatitis
- most often secondary to biliary disease
- enzymes released into pancreas
- S/Sx
o severe abdominal/back pain
o fetal position
o n/v
o mild jaundice
o shock – as a reaction to the pain
- lipase and amylase levels increased
- CT/MRI for Dx
- Treatment
o IV hydration
o NPO
o NG suction
o pain control
o treat complications
- Prognosis
o 5-10% mortality associated with the shock
o worse in older, sicker patients
Chronic Pancreatitis
- recurrent pancreatitis
- male : female 5:1
- S/Sx
106
o recurrent epigastric/back pain
o abdominal tenderness/guarding
o weight loss
o foul-smelling stools, that are chalky white in color
and float
- associated with alcoholism/biliary disease
- major DDx is pancreatic CA
- KUB may reveal calcifications
- 50% pts die w/in 10 yrs(malignancy)
Pancreatic Carcinoma
- adenocarcinoma
- 2nd mc tumor of GI system (colon cancer is #1)
- m : f 2:1
- mc in head of pancreas, carcinoma in the tail will not cause
jaundice, because it does not block the duct.
- S/Sx
o jaundice
o abdominal pain
o weight loss, anorexia, nausea
o biliary obstruction S/Sx(head tumor)
- CT/MRI are best imaging procedures
- Poor Px from early mets
107