31.05.

2013

Morning increase of whole blood viscosity in obstructive sleep apnea syndrome - Clinical Hemorheology and Microcirculation - Volume 22, Number
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Morning increase of whole blood viscosity in obstructive sleep apnea syndrome
Journal Publisher ISSN Subject Issue Pages Subject Group Clinical Hemorheology and Microcirculation IOS Press 1386-0291 (Print) 1875-8622 (Online) Medicine, Biochemistry and Biophysics and Hematology Volume 22, Number 1/2000 21-27 Medicine and Health Add to marked items Add to shopping cart Add to saved items Recommend this article

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Publisher's Copyright Statement PDF (69.0 KB) Authors Lino Nobili1, Giuliano Schiavi1, Emanuela Bozano1, Fabrizio De Carli2, Franco Ferrillo1, Flavio Nobili3
1Dept. of Motor Sciences (Center for Sleep Medicine), University of Genoa, Italy 2Center for Cerebral Neurophysiology, National Council of Research, University of

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Genoa, Italy 3Clinical Neurophysiology Service, Department of Internal Medicine, University of Genoa, Italy Abstract Objective: Patients affected by obstructive sleep apnea syndrome (OSAS) have an increased risk of cardiovascular diseases such as stroke and myocardial infarction. The pathophysiological mechanisms leading to increased vascular risk are still matter of debate. A relative morning hyperviscosity could be one of the leading mechanisms of cardiovascular morbidity which is actually known to be especially high in the morning hours. Methods: Whole blood viscosity (WBV) at seven shear rates, ranging from 0.47 to 118 sec^{-1}, haematocrit (Hct), and plasma fibrinogen (F) concentration, were measured on venous blood samples in 12 patients with OSAS and in 8 healthy controls at 89 p.m. and at 78 a.m. the morning after. WBV values were normalized on Hct by the computation of the standardised normal deviate z on the normal database of the laboratory. Results: No changes were observed in controls. Hct, F and normalized WBV (independently from Hct changes) significantly increased in the morning hours in OSAS patients. Conclusions: Viscosity of whole blood increases in the morning in OSAS patients but not in healthy controls. This condition may be related to the increased susceptibility to cerebral ischemia in patients affected by OSAS, particularly evident in the early morning. Keywords Obstructive sleep apnea syndrome, Obstructive sleep apnea syndrome, Obstructive sleep apnea syndrome, Obstructive sleep apnea syndrome Fulltext Preview (Small, Large)

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31.05.2013

Morning increase of whole blood viscosity in obstructive sleep apnea syndrome - Clinical Hemorheology and Microcirculation - Volume 22, Number

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