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DENDRIMERS
VARUNI.
A
B.TECH IT
DENDRIMERS
ABSTRACT:
1. INTRODUCTION:
The monomers that attach to the core form the first branches (Tomalia
called them the First Generation). On the successive generations, two monomers
will attach to the ends of the monomers in the previous generation. At the
terminating generation, a terminal functional group is added to the tail of the
monomer.
1. SYNTHESIS OF DENDRIMERS:
Dendrimers are produced in an iterative sequence of reaction steps, in
which each additional iteration leads to a higher generation dendrimer. The
creation of dendrimers, using specifically-desingned chemical reactions, is one
of the best examples of controlled hierarchical synthesis, an approach that
allows the 'bottom-up' creation of complex systems.Each new layer creates a
new 'generation' with double the number of active sites(called end groups) and
approximately double the molecular weight of the previous generation. One of
the most appealing aspects of technologies based on dendrimers is that it is
relatively easy to control their size, composition and chemical reactivity very
precisely.
1. CLASSIFICATION OF DENDRIMERS:
1. PROPERTIES OF DENDRIMERS:
Most of the chemical properties of the molecule depend on types of
terminal groups. The physical properties of the molecules, such as solubility and
viscosity are also affected by the terminal groups.
Some of these dendrimers have diameters that are greater than ten
nanometers. The molecular weights range from about 50,000 to 200,000 g/mol.
The outer surface area of the molecule increases with the number of
generations. There is a significant of void space within the molecule. These
voids consist of channels and cavities4. These unique geometries give the
molecule special properties such as adhesiveness and ability to entrap foreign
molecules. The calculations of the molecular weight and other useful quantities
about the dendrimer molecules are presented in a paper by Tomalia
The number of terminal groups is easily calculated as follows:
Number of terminal groups = Nc (Nr)G
Where Nc is the number of branches at the core (core multiplicity); Nr is the
number of branches on each monomer unit (repeating unit multiplicity); G is the
number of generation. The degree of polymerization can be computed using
these quantities.
Degree of Polymerization =
:
where Mc, Mr, and Mt are the molecular weight of the core, the repeating
monomer, and the terminal group respectively.
Theoretically, dendrimers are monodispersive. All molecules have the
exact process, same molecular weight and structure. Due to minor defect during
the synthesizing the polydispersity index is about 1.001. Polydispersity of
1.0007 for PAMAM has been reported. The intrinsic viscosity of dendrimers has
a peculiar behavior. It increases with increasing molecular weight (number of
generations). Contrary to linear polymers, the viscosity will reach a maximum
value then starts to decline. It is suggested that the space between the branches
is smaller in higher generation dendrimers than lower generation dendrimers.
The decline in viscosity is a consequence of prohibiting the interaction of the
outer branches between molecules at a higher generation. The glass transition
temperature (Tg) of dendrimers follows similar trend. It reaches to a maximum
Tg and levels off at higher molecular weights. This behavior is explained by the
absence of entanglement at higher molecular weights.
1. APPLICATIONS OF DENDRIMERS:
1. MEDICAL APPLICATIONS :
Dendrimers are “stealth molecules” that have many potential
applications, including diagnostic and therapeutic applications. By customizing
and controlling dendrimer “architecture,” nanotechnologists are developing
dendrimers for drug delivery, diagnostic imaging and as carriers of genetic
material. Dendrimers can easily move across biological membranes and they
can store a wide range of metals, organic or inorganic molecules among their
branches. Companies developing these synthetic molecules claim that most
dendrimers don’t trigger the immune system when injected or used topically,
and have low cytotoxicity (that is, toxicity to cells). However, some forms of
dendrimers can induce clotting in the bloodstream - a potential concern for in
vivo applications.
1. GENE DELIVERY:
1. ANTISEPTIC TREATMENT:
1. INDUSTRIAL APPLICATIONS:
Dendrimers could also be used in coatings and materials, electronics and
photonics. A look at the patent assignees for dendrimer technology reveals the
wide range of potential applications - patents are assigned to chemical,
petroleum, tire, cosmetics and pharmaceutical companies, among others.
1. CATALYSIS:
1. ORGANOSILICANE COATINGS:
1. SENSORS:
1. LIGHT HARVESTING:
1. DENDRIMER FILM:
1. INTERPHASE APPLICATIONS:
1. DENDRIMERS IN PURIFICATION:
1. DENDRIMER AS A CARRIER:
The invention includes a method of killing bacteria in a body of water
applying a dendrimer containing a water purification material such as a
bactericide to a carrier, placing the carrier with the dendrimer by immersing the
carrier with the dendrimer containing the water purification material in a body
of water and allowing water to contact the dendrimer containing the water
purification material such as a bactericide to release the bactericide there from
to kill bacteria in the body of water. In this method the dendrimer can be
removed from the body of water after release of the water purification material
and a fresh water purification material is releasable secured to the dendrimer
followed by placing the dendrimer with the freshwater purification material
back into the body of water to continue the water purification thereof. While a
water purification material is attached to the dendrimer by ionic bonding
includes antimicrobial agents such as bactericides, other water purification
materials such as clarifiers or algaecides can also be secured to the dendrimer to
enable one to deliver the water purification materials to the fluids. If desired at
least two water purification materials such as two different antimicrobial agents
can be secured to the dendrimer to provide a wider range of effectiveness.
1. OTHER APPLICATIONS:
There are also some others applications like: for cellular transport, as
artificial cells, for diagnostics and analysis, as protein / enzyme mimics or
modeling, for manufacture of artificial bones, for development of topical
microbicide creams; antimicrobial, antiviral (e.g. for use against HIV) and
antiparasitic agents, for biomedical coatings (e.g. for artificial joints), as
artificial antibodies and biomolecular binding agents, for carbon fibre coatings
and ultra thin films, as polymer and plastics additives (e.g. for lowering
viscosity, increasing stiffness, incorporating dyes, compatibilisers, etc.) for
creation of foams (i.e. synthetic zeolites or insulating material), as building
blocks for nanostructured materials, as dyes and paints, as industrial adhesives,
for manufacture of nanoscale batteries and lubricants, as decontamination
agents (trapping metal ions), for ultrafiltration, molecular electronics for data
storage, 3D optical materials, for light-harvesting systems, quantum dots, liquid
crystals, printed wire boards, etc.
1. CONCLUSION:
The special properties such as adhesiveness and ability to entrap
foreign molecules. Make dendrimers useful in various applications. Thus use
of dendrimers has been teeming in many fields. Due to its cost use of
dendrimers are limited but research are been carried out to produce dendrimers
at low cost and to use in many applications. One can synthesize with certain
molecular mass and structural conformation. The dendrimer topologies provide
many special properties such as in interphase applications and in nanoscale
reactors. The unique physical and chemical properties of dendrimers have
demonstrated great versatilities in variety of applications. . Dendrimers have
successfully been used in medicinal applications such as diagnostic tools and
eventually in drug delivery.