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PATHOPHYSIOLOGY OF TETRALOGY OF FALLOT

Predisposing Factors: - Genetics o DiGeorge Syndrome - Age = at birth Precipitating Factors: - Environmental - Stress - Rubella - Alcoholism

Alteration in Fetal Development - Unequal growth of the aorticopulmonary septum

Aorta too large

C. Overriding Aorta

Steals space from Pulmonary artery

B. Pulmonary Stenosis

Prevents ventricular wall closure Right Ventricular Outflow Obstruction Mixing of oxygenated and deoxygenated blood

A. Ventricular Septal Defect

Increase ventricular contraction

Decrease O2 supply to systemic circulation

D. Right Ventricular Hypertrophy

Hypoxia

Cyanosis Tet Spells Dyspnea on exertion Clubbing of fingers and toes Heart murmurs Low birth weight Poor feeding Growth and development may be delayed Polycythemia

If treated

If not treated

Diagnostic Exam: - CBC - 2D Echo - ABG Treatment: - Medications - O2 theraphy - Surgery

Transient increase in resistance to blood flow to the lungs

Worsen tet spells

Decrease organ perfusion *including brain

Partially improved oxygenation

Hypoxic brain injury Organ failure

May improved length and quality of life

DEATH