V.

Pathophysiology
NON MODIFIABLE FACTORS: A%e+ Gen er an CONTRIBUTING FACTORS: Aspirin intake for 5 MODIFIABLE FACTORS: Coffee intake

E"i&it t$eir effe&ts on t$e C)&"oo*)%enase

I(paire (#&osa" efense to a&i

Disr#ption of (#&o#s 'arrier

Epi%astri& pain

U"&er '#rro!s eep into t$e %astro #o ena" (#&osa

T$innin% of t$e arteria" !a""s

Weakene !a""s r#pt#re

UPPER GASTRO INTESTINAL BLEEDING

Me"ena

Lo! -e(o%"o'in Le.e" Li%$t $ea e ness an !eakness ,a"e ,a"pe'ra" &on/#n&ti.a ,a""or+ poor skin t#r%or an poor &api""ar) refi""