CLINICAL and RESEARCH ANALYTICS

for
BACKGROUND Dundee Edinburgh Cancer Informatics Programme Harnessing Excellence in Research, a collaboration between two health boards and a biomedical informatics company, is a two year, industry-led project nearing completion. There are two main strands: Research Analytics service: secure web-based service for clinical research offering a high performance analytics platform in a controlled environment with role-based access, and audit trail ensuring security, safety and traceability of data. Clinical Analytics application: developing configurable cancer pathway visualisations with integrated analytics.
the

CANCER
Authors: Dr Rachel Knight, Dr Alexander Henzing, Mrs Pamela Brankin, Dr Catherine Kelly

METHODS Development of a Research Analytics platform to support collaborative research on clinical and genetic datasets in a secure online environment. The Clinical Analytics application has seen development of analytics tools to facilitate real-time analysis of the patient journey and automation of the collection and collation of Clinical Performance Indicators, with pathway and clinical metrics designed by Clinical Informaticists and Clinical Specialists.

ARIDHIA PLATFORM

RESULTS A Research Analytics environment for collaborative project based work, providing analytics with SQL, machine learning, R and charting tools on a scalable clustered computing platform. The environment offers managed sharing protocols, cohort selection and de-identification at source and at sharing level with secure data transfer, audit and monitoring tools in a shared hosting infrastructure. Configurable cancer pathways created for breast, lung, prostate, melanoma and ovarian cancer. Ability for service throughput overview, pathway level analytics and pre-defined cancer specific analytics with Quality Performance Indicators for breast and lung cancers.

CONCLUSIONS DECIPHER Health provides a scalable informatics platform supporting linked phenotype-genotype datasets from consented patient cohorts across multiple cancer types. The Research Analytics platform enables the analysis of large, complex de-identified datasets, linking clinical, patient, genomic, imaging and treatment outcome data. This platform will form the basis for the Stratified Medicine Scotland Innovation Centre. The Clinical Analytics application enables healthcare professionals to view a cancer-focused view of clinical patient information at different stages of the cancer pathway, including configurable cancer pathways visualisations for breast, lung, prostate, melanoma and ovarian cancer for service level care.

Clinical Outcome Metrics

Survival by Histology (Ovarian)

CA125 Response
pr status
18987(60.2%)

PR/ER Status
er status
22358(70.89%)

Grade of tumour by year of diagnosis

2000
1901 1749 1936 1950 1920 1769 1977 1781 1860 1838

1893

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1 year survival by stage

5 year survival by stage

10 year survival by stage

Re-admissions within 30 days of surgery

Survival 30 days after surgery

Radiotherapy delivered within 45 minutes of home

20000

1693

1666

1733

15000
Complete response

1500
15000

50

100

100

98

70

grade
10509(33.32%)
prstatus erstatus

count

count

<1%
i Survival at 90 days following radical or adjuvant radiotherapy i Chemotherapy episodes delivered within 30 minutes of home

TARGET

2%

ACTUAL

TARGET

100%
i Patients who died registered on the End of Life care register and Liverpool Care Pathway

70%
i
No response

ACTUAL

10000

count

Positive Negative Borderline 10000 Unknown

Positive Negative Borderline Unknown

1 1000 2 3 4

7372(23.37%)
5000 5000

Mortality at 30 days following systemic therapy

i Patients starting adjuvant systemic therapy within 90 days of surgery

Patients admitted as emergency during course of radio / chemotherapy

500
1733(5.49%) 76(0.24%)

518

499

520

589 498 505

627

1816(5.76%)
0 100 0 100 0 100 0 100

227(0.72%)
0
CHEMO

85

55

91

50
RADIO

0 Positive Negative Borderline Unknown Positive Negative

71

60

58

42

41

90% 85%

TARGET

ACTUAL

TARGET

100%

55%

ACTUAL

Treatment 80% Disease 20%

TARGET

100%

91%

ACTUAL

TARGET

100%

50%

ACTUAL

25%

20%

prstatus

erstatus

Borderline

Unknown

0 2003 2005 2007

27

32

Year of diagnosis

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