Philippine Society for Developmental and Behavioral Pediatrics

OFFICERS and BOARD OF TRUSTEES 2013

President Ma. Theresa Arranz-Lim, MD Vice-President Bernadette Carpio-Benitez, MD Secretary Jacqueline O. Navarro, MD Assistant Secretary Ermenilda L. Avendao, MD Treasurer Rita Paz Rowena A. De Guzman, MD Assistant Treasurer Agnes G. Falcotelo, MD PRO Ma. Rochelle B. Pacifico, MD PPS Liaison Ma. Noemi T. Salazar, MD Awards and Membership Stella G. Manalo, MD

Position Statement on Stem Cell Therapy for Neurodevelopmental and Behavioral Disorders Philippine Society for Developmental and Behavioral Pediatrics October 8, 2013 The society acknowledges the potential of using stem cell therapy as a treatment option for developmental disabilities. However, there is currently no strong scientific evidence to recommend the use of stem cells as treatment for neurodevelopmental disorders, developmental disabilities and central nervous system disorders including but not limited to autism spectrum disorder, cerebral palsy, global developmental delay and intellectual disability. Since the long term safety and effectiveness of the use of stem cells in humans have not been established at this time, its use for these conditions should be confined to well-designed clinical trials that include the necessary ethical, scientific and regulatory controls. At present, the society strongly encourages the use of evidence-based interventions for developmental and behavioral conditions, under the guidance and recommendation of a Developmental-Behavioral Pediatrician or Neurodevelopmental Pediatrician duly board certified to practice in the Philippines.
References:
Borlongan CV, Weiss MD. Baby STEPS: a giant leap for cell therapy in neonatal brain injury. Pediatr Res. 2011 Jul;70(1):3-9.

Immediate Past President Joselyn A. Eusebio, MD Founding President Perla D. Santos Ocampo, MD

Chen G, Wang Y, Xu Z, Fang F, Xu R, Wang Y, Hu X, Fan L, Liu H. Neural stem cell-like cells derived from autologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy. J Transl Med. 2013 Jan 26;11:21. Gaspard N, Vanderhaeghen P. From stem cells to neural networks: recent advances and perspectives for neurodevelopmental disorders. Dev Med Child Neurol. 2011 Jan;53(1):13-7. Daley GQ. The promise and perils of stem cell therapeutics. Cell Stem Cell. 2012 Jun 14;10(6):740-9. Ichim TE, Solano F, Glenn E, Morales F, Smith L, Zabrecky G, Riordan NH. Stem cell therapy for autism. J Transl Med. 2007 Jun 27;5:30. Kiskinis E, Eggan K. Progress toward the clinical application of patient-specific pluripotent stem cells. J Clin Invest. 2010 Jan;120(1):51-9. Li M, Yu A, Zhang F, Dai G, Cheng H, Wang X, An Y. Treatment of one case of cerebral palsy combined with posterior visual pathway injury using autologous bone marrow mesenchymal stem cells. J Transl Med. 2012 May 18;10:100. Lv YT, Zhang Y, Liu M, Qiuwaxi JN, Ashwood P, Cho SC, Huan Y, Ge RC, Chen XW, Wang ZJ, Kim BJ, Hu X. Transplantation of human cord blood mononuclear cells and umbilical cord-derived mesenchymal stem cells in autism. J Transl Med. 2013 Aug 27;11(1):196. Pabon MM, Borlongan CV. Advances in the cell-based treatment of neonatal hypoxic-ischemic brain injury. Future Neurol. 2013 Mar 1;8(2):193-203.

4th Floor Philippine Pediatric Society (PPS) Building, 52 Kalayaan Avenue, Barangay Malaya, Quezon City 1105 Philippines Telephone: (632) 434-3946 Mobile: (63-922) 8019057 E-mail address: devpedphil@gmail.com

Philippine Society for Developmental and Behavioral Pediatrics

References (continued) Regenberg AC, Hutchinson LA, Schanker B, Mathews DJ. Medicine on the fringe: stem cell-based interventions in advance of evidence. Stem Cells. 2009 Sep;27(9):2312-9. Siniscalco D, Bradstreet JJ, Antonucci N. Therapeutic role of hematopoietic stem cells in autism spectrum disorder-related inflammation. Front Immunol. 2013;4:140. Siniscalco D, Sapone A, Cirillo A, Giordano C, Maione S, Antonucci N. Autism spectrum disorders: is mesenchymal stem cell personalized therapy the future? J Biomed Biotechnol. 2012;2012:480289. Vaccarino FM, Urban AE, Stevens HE, Szekely A, Abyzov A, Grigorenko EL, Gerstein M, Weissman S. Annual Research Review: The promise of stem cell research for neuropsychiatric disorders. J Child Psychol Psychiatry. 2011 Apr;52(4):504-16. Wang F, Maeda N, Yasuhara T, Kameda M, Tsuru E, Yamashita T, Shen Y, Tsuda M, Date I, Sagara Y. The therapeutic potential of human umbilical cord blood transplantation for neonatal hypoxic-ischemic brain injury and ischemic stroke. Acta Med Okayama. 2012;66(6):429-34.

4th Floor Philippine Pediatric Society (PPS) Building, 52 Kalayaan Avenue, Barangay Malaya, Quezon City 1105 Philippines Telephone: (632) 434-3946 Mobile: (63-922) 8019057 E-mail address: devpedphil@gmail.com