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IV B.Tech I Semester Supplementary Examinations, February 2007
TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS
(Chemical Engineering)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
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4. Discuss the past, present and future status of calcium gluconate in pharmaceutical
industry. [16]
5. With a flow sheet explain the manufacturing process of phthalic anhydride from
naphthalene. [16]
7. By means of a sketch explain the design and operation of Portable Autoclaves. [16]
8. Describe with diagram, the process of sterilization by filtration. What the advan-
tages and disadvantages of such method. [16]
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Code No: RR410808 Set No. 2
IV B.Tech I Semester Supplementary Examinations, February 2007
TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS
(Chemical Engineering)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆
1. (a) Explain the principle, reaction involved and the technique of limit test for
chloride [8]
(b) What happens when [8]
i. Ferrous salt reacts with thioglycolic acid in alkaline medium
ii. Barium chloride is treated with sulphates
iii. Arsenic compounds are treated with concentrated hydrochloric acid
iv. Dithizone is treated with lead compounds
3. Discuss the testing method for safe use of fluorescence. Enlist its important prop-
erties? [16]
4. Discuss the materials required and the manufacturing process for manufacture of 1
metric ton aspirin. [16]
6. Explain the sugar coating process for tablets. Comment its merits and demerits.
[16]
7. By means of a sketch explain the design and operation of Portable Autoclaves. [16]
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Code No: RR410808 Set No. 3
IV B.Tech I Semester Supplementary Examinations, February 2007
TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS
(Chemical Engineering)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆
1. (a) Explain the principle, reaction involved and the technique of Limit test for
chloride [8]
(b) Complete the following equations [4x2=8]
Zn/HCL
i. HAsO3 −−−−−→
ii. AsH3 + Hgcl2 −→
iii. SO42+ + BaCl2 −→
iv. P b2+ + C6 H5 N = NCSNHNHC6 H5 −→
2. How do you test safety and purity aspects of riboflavin? Discuss various aspects of
above? [16]
3. Discuss the testing method for safe use of procaine hydrochloride. Enlist its im-
portant uses? [16]
4. Describe various properties and uses of calcium gluconate and aspirin. [16]
8. Discuss the use of the following for sterilization of pharmaceuticals. Describe how
they are applied? [8x2=16]
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Code No: RR410808 Set No. 4
IV B.Tech I Semester Supplementary Examinations, February 2007
TECHNOLOGY OF PHARMACEUTICALS AND FINE CHEMICALS
(Chemical Engineering)
Time: 3 hours Max Marks: 80
Answer any FIVE Questions
All Questions carry equal marks
⋆⋆⋆⋆⋆
1. (a) Write the principle and reaction involved in the following limit tests. [4x2=8]
i. Arsenic
ii. Lead
(b) Explain the impurities in pharmaceuticals arising out of raw materials used
in the manufacturing [8]
2. Outline the synthesis of para-amino salicylic acid and isonicotinic acid hydrazide.
Write their uses. [16]
3. Discuss the testing method for safe use of isonicatinic acid hydrazide. Enlist its
important uses? [16]
4. Describe in detail methods for recovery of penicillin from crude fermentation liquor.
Give an account of various grades of penicillin. [16]
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