ReedSternberg cell

ReedSternberg cell
ReedSternberg cells (also known as lacunar histiocytes for certain types) are different giant cells found with light microscopy in biopsies from individuals with Hodgkin's lymphoma (aka Hodgkin's disease; a type of lymphoma). They are usually derived from B lymphocytes, classically considered crippled germinal center B cells, meaning they have not undergone hypermutation to express their antibody. Seen against a sea of B cells, they give the tissue a moth-eaten appearance. They are named after Dorothy Reed Mendenhall and Carl Sternberg, who provided the first definitive microscopic descriptions of Hodgkin's disease.[1][2] ReedSternberg cells are large and are either multinucleated or have a bilobed nucleus (thus resembling an "owl's eye" appearance) with prominent eosinophilic inclusion-like nucleoli. ReedSternberg cells are CD30 and CD15 positive, usually negative for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin's lymphoma the absence of ReedSternberg cells has very high negative predictive value. They can also be found in reactive lymphadenopathy (such as infectious mononucleosis, carbamazepine associated lymphadenopathy) and very often in other types of non-Hodgkin lymphomas.
Micrograph showing a classic ReedSternberg cell.

A special type of ReedSternberg cells is the lacunar histiocyte, whose cytoplasm retracts when fixed in formalin, so the nuclei give the appearance of cells that lie with empty spaces (called lacunae) between them.[3] These are characteristic of the nodular sclerosis subtype of Hodgkin's lymphoma.

Micrograph showing a "popcorn cell", the ReedSternberg cell variant seen in nodular lymphocyte predominant Hodgkin lymphoma.H&E stain.

References
[1] Reed D. On the pathological changes in Hodgkin's disease, with special reference to its relation to tuberculosis. Johns Hopkins Hosp Rep 1902;10:133-96. [2] Sternberg C. Uber eine eigenartige unter dem Bilde der Pseudoleukamie verlaufende Tuberculose des lymphatischen Apparates. Ztschr Heilk 1898;19:2190. [3] 8th edition.

Article Sources and Contributors

Article Sources and Contributors

ReedSternberg cell Source: http://en.wikipedia.org/w/index.php?oldid=564635500 Contributors: Arcadian, Attaboy, Aytrus, BorisVM, Borsukers, Cburnett, Cwbvb13, Drchazz, Intangir, Irfinity, Jfdwolff, JjusticeIV, Madhero88, Mikael Hggstrm, Mikebar, Morwen, Nephron, Niels Olson, Nilfanion, PFHLai, Rberlow, Rustavo, Sav vas, Scoops, Sheynhertz-Unbayg, Stevenfruitsmaak, Tony1, Vogon77, Zyryab, 44 anonymous edits

Image Sources, Licenses and Contributors

Image:Reed-Sternberg lymphocyte nci-vol-7172-300.jpg Source: http://en.wikipedia.org/w/index.php?title=File:Reed-Sternberg_lymphocyte_nci-vol-7172-300.jpg License: Public Domain Contributors: Jmarchn, Stevenfruitsmaak Image:Popcorn cell in nodular lymphocyte predominant Hodgkin lymphoma - very high mag cropped.jpg Source: http://en.wikipedia.org/w/index.php?title=File:Popcorn_cell_in_nodular_lymphocyte_predominant_Hodgkin_lymphoma_-_very_high_mag_cropped.jpg License: Creative Commons Attribution-Sharealike 3.0 Contributors: Nephron

License
Creative Commons Attribution-Share Alike 3.0 //creativecommons.org/licenses/by-sa/3.0/