Insulin

Insulin
Apidra (insulin glulisine [rDNA origin] injection) Apidra SoloSTAR (prefilled) Apidra Cartridge Humalog Vial (insulin lispro) Humalog Cartridge Humalog Pen (prefilled) NovoLog Vial (insulin aspart) NovoLog PenFill NovoLog FlexPen (prefilled) Humulin R (Regular) Vial a Novolin R Vial (Regular human insulin) ReliOn/Novolin R Vial Humulin N (NPH) Vial
Humalog

Manufacturer
sanofi-aventis sanofi-aventis sanofi-aventis

Onset (approximately)
1530 minutes 1530 minutes 1530 minutes

Peak (approximately)
0.52.5 hours 0.52.5 hours 0.52.5 hours 0.52.5 hours 0.52.5 hours 0.52.5 hours 13 hours 13 hours 13 hours 24 hours 80120 minutes 80120 minutes 28 hours 28 hours 412 hours 412 hours 412 hours

Duration (approximately)
5 hours or less 5 hours or less 5 hours or less 5 hours or less 5 hours or less 5 hours or less 35 hours 35 hours 35 hours 58 hours 8 hours 8 hours 1424 hours 1424 hours 24 hours 24 hours 24 hours

RAPID ACTING

Apidra

Eli Lilly & Company 1530 minutes Eli Lilly & Company 1530 minutes Eli Lilly & Company 1530 minutes Novo Nordisk Novo Nordisk Novo Nordisk 1020 minutes 1020 minutes 1020 minutes

NovoLog

SHORT ACTING

Eli Lilly & Company 3060 minutes Novo Nordisk Novo Nordisk 30 minutes 30 minutes

Eli Lilly & Company 12 hours

Humulin N Pen

INTERMEDIATE ACTING

Humulin N (NPH) Pen (prefilled) Novolin N PenFill (NPH human insulin isophane) Novolin N Vial (NPH human insulin isophane) ReliOn/Novolin N Vial

Eli Lilly & Company 12 hours Novo Nordisk Novo Nordisk Novo Nordisk 1.5 hours 1.5 hours 1.5 hours

All insulins listed are U-100 strength. All insulins should be refrigerated at 3646 F. a: Also available in U-500 by prescription only. b: Lantus and Levemir release at a relatively constant rate over a 24-hour period. c: Pens in use (open) should not be stored in the refrigerator.
www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH

Need to Roll Room Temperature Briskly 10+ Storage Range (5986 F) Times?
Up to 28 days Up to 28 days Up to 28 days Up to 28 days Up to 28 days Up to 28 days c Up to 28 days Up to 28 days Up to 28 days Up to 28 days N/A Up to 42 days Up to 28 days Up to 14 days c 14 days Up to 42 days Up to 42 days No No No No No No No No No No No No Yes Yes Yes Yes Yes

Cartridge Sizes
N/A N/A 3 mL N/A 3 mL N/A N/A 3 mL 3 mL N/A N/A N/A N/A N/A 3 mL N/A N/A

Pens That Fit the Cartridges

N/A N/A OptiClik N/A Autopen N/A N/A NovoPen 3, NovoPen Junior N/A N/A N/A N/A N/A N/A NovoPen3, NovoPen Junior N/A N/A

AMYLIN MIMETIC
Amylin is co-secreted in the beta cells of the pancreas along with insulin. Its a first-in-class injectable medication used with mealtime insulin to control blood sugar in adults with type 1 or type 2 diabetes.

SYMLIN (pramlintide acetate) injection SymlinPenTM (pramlintide acetate) pen-injector Amylin Pharmaceuticals, Inc. The amount of SYMLIN used depends on whether the patient has type 1 or type 2 diabetes. * For type 2 diabetes - start SYMLIN at 60 mcg injected subcutaneously, just before major meals (meal must have at least 250 calories or 30 grams of carbohydrate). * For type 1 diabetes - start SYMLIN at 15 mcg injected subcutaneously, just before major meals (meal must have at least 250 calories or 30 grams of carbohydrate). Type 2: 120 mcg Type 1: 60 mcg with major meals Insulin-induced low blood sugar (severe hypoglycemia): Low blood sugar is a serious side effect of insulin therapy. When you use Symlin and insulin, your blood sugar may drop too low, especially if you have type 1 diabetes. If this low blood sugar (severe hypoglycemia) happens, it is seen within three hours after a Symlin injection. Severe low blood sugar makes it hard to think clearly, drive a car, use heavy machinery, or do other risky activities where you could hurt yourself or others. When you first start Symlin, your healthcare professional should tell you to reduce the dose of insulin you take before meals by 50 percent. Future insulin changes should be directed by your healthcare professional based on blood sugar testing. It is critical to the safe and effective use of Symlin that you understand your healthcare professionals instructions, follow them carefully, and take your Symlin exactly as prescribed. Nausea is the most common side effect of Symlin. Mild nausea is more likely during the first weeks after starting Symlin and usually does not last long. Talk to your healthcare professional for advice on how to manage nausea.

Customer Support:

Eli Lilly & Co. (800) 545-5979 Novo Nordisk (800) 727-6500 sanofi-aventis (800) 633-1610

www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH

Insulin
Insulin
Lantus Vial (insulin glargine [rDNA origin] injection) Lantus Cartridge

Manufacturer

Onset (approximately)
1.5 hours

Peak (approximately)
None
b

sanofi-aventis

sanofi-aventis
Lantus Lantus

1.5 hours

None

LONG ACTING

Lantus SoloSTAR (prefilled) Levemir Vial (insulin detemir [rDNA origin] injection) Levemir FlexPen (insulin detemir [rDNA origin] injection) Humalog Mix 75/25 Vial

sanofi-aventis

1.5 hours

None

Novo Nordisk

50120 minutes

Relatively flat

Levemir

Novo Nordisk

50120 minutes

Relatively flat

INTERMEDIATE/RAPID ACTING

Eli Lilly & Company

1530 minutes

0.52.5 hours

Humalog Mix 75/25 Pen (prefilled) NovoLog Mix 70/30 Vial (70% insulin aspart protamine suspension/30% aspart) NovoLog Mix 70/30 FlexPen
NovoLog Mix 70/30 FlexPen

Eli Lilly & Company

1530 minutes

0.52.5 hours

Novo Nordisk

1020 minutes

2.4 hours

Novo Nordisk

1020 minutes

2.4 hours

Humulin 50/50 Vial (50% NPH/50% Regular)

Eli Lilly & Company

3060 minutes

0.52.5 hours

INTERMEDIATE/SHORT ACTING

Humulin 70/30 Vial (70% NPH/30% Regular)

Eli Lilly & Company

3060 minutes

0.55 hours

Humulin 70/30 Pen (prefilled)

Humulin 70/30 Pen

Eli Lilly & Company

3060 minutes

24 hours

Novolin 70/30 Vial (70% NPH/30% Regular)

Novo Nordisk

30 minutes

212 hours

ReliOn/Novolin 70/30 Vial

All insulins listed are U-100 strength. All insulins should be refrigerated at 3646 F. a: Also available in U-500 by prescription only. b: Lantus and Levemir release at a relatively constant rate over a 24-hour period. c: Pens in use (open) should not be stored in the refrigerator.

Novo Nordisk

30 minutes

2-12 hours

www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH

Duration (approximately)
24 hours

Room Temperature Storage Range (5986 F)

Up to 28 days

Need to Roll Briskly 10+ Times?

No

Cartridge Sizes
N/A

Pens That Fit the Cartridges

N/A

24 hours

Up to 28 days

No

3 mL

OptiClik

24 hours

Up to 28 days

No

N/A

N/A

Up to 24 hours

Up to 42 days

No

N/A

N/A

Up to 24 hours

Up to 42 days

No

3 mL

N/A

Up to 24 hours

Up to 28 days
c

Yes

N/A

N/A

Up to 24 hours

Up to 10 days

Yes

N/A

N/A

Up to 24 hours

Up to 28 days

Yes

N/A

N/A

Up to 24 hours

Up to 14 days

Yes

3 mL

N/A

Up to 24 hours

Up to 28 days

Yes

N/A

N/A

Up to 24 hours

Up to 28 days

Yes

N/A

N/A

Up to 24 hours

Up to 10 days

Yes

N/A

N/A

24 hours

Up to 42 days

Yes

N/A

N/A

24 hours

Up to 42 days

Yes

N/A

N/A

Customer Support:

Eli Lilly & Co. (800) 545-5979 Novo Nordisk (800) 727-6500 sanofi-aventis (800) 633-1610

www.DiabetesHealth.com / PRODUCT REFERENCE GUIDE 2010 / DIABETES HEALTH