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Day 1
Objective Self Assessment
Complete sample test materials NBME CD-ROM for NBME or download from www.nbme.org General overview of Read Through Section First Aid material to be covered Introductory Material from First Aid, and Skim Section II Basic Metabolism Chapters 5 & 6, and sample Lippincotts questions at end of each Biochemistry chapter. Bookmark figure 6.2 and refer to it before studying each biochemical pathway.
Day 2
Objective Structure & Metabolism of Carbohydrates
Continue Biochemistry
Assignments Chapters 11, 12, 13 & questions Source Lippincotts Biochemistry Details Est. Time Review the digestion of sugars and disorders 3 hrs of fructose, galactose, and lactose metabolism. Spend more time on glycogen metabolism, its regulation, and related disorders. Use Figure 13.7 to memorize the glycogen storage disease Know the start and end points, hormonal 1.5 hrs regulation. Energy yield and various fates of pryruvate. Study it by comparison to glycolysis. Know 1 hr the reactions & regulation unique to gluconeogenesis. Focus on start and end points, place in overall 1 hr metabolism, and regulation. Shim reactions an focus on G6PD deficiency 1 hr
Lippincotts Biochemistry
Chapter 8 & questions, Review Lippincotts Figure 6.2 again! Biochemistry Chapter 9 & questions Chapter 10 & questions Lippincotts Biochemistry Lippincotts Biochemistry Source Lippincotts Biochemistry
Day 3
Objective Lipid Metabolism
Continue Biochemistry
Assignments Chapter 17 & questions Details Est. Time Focus on roles of pancreatic lipase and bile 3 hrs salts. Fatty acid metabolism: know where synthesis occurs, relationship to glucose metabolism, and role of triacylglycerols for storage of fatty acids. Review mobilization of and oxidation of fatty acids. Finally, carefully review eicosnoids, focusing on figure 17.20 Gain senses of what these are, but do not 1 HR memorize structure of pathways. Focus on related disorders instead, using figures 18.10, 19.4 Review Cholesterol synthesis (esp. the role of 2 hrs HMG CoA reductase) and its regulation. Understand synthesis and role of bile salts. Review biology of lipoproteins and their role in atherogenesis. Key figure are 20.12, 20.14, 20.16 Know the major enzymes deficiencies in 1 hr 36 steroid synthesis and know where steroid receptors act in the cell. Study figures 20.19,
Phospholipids &Glycolipids
Steroid Hormones
Lippincotts Biochemistry
20.20
Day 4
Objective Protein & Enzymes
Continue Biochemistry
Assignments Chapter 1-4 & questions Source Lippincotts Biochemistry Details Est. Time Become familiar with basic properties of 4 hrs amino acids, levels of protein structure, hemoglobin, and collagen. For enzymes, focus on appreciating (not memorizing) the Michaelis-Menten equation, types of enzyme in clinical diagnosis. Learn the various pancreatic proteases and 2 hrs how they are regulated. Understand transamination and oxidative deamination, but dont memorize Pathways. Spend more time on urea cycle and ammonia metabolism focus on figures 21.4, 21.11, 21.17 Emphasize relevant disorders. Focus on 1 hr figures 22.2, 22.16
Lippincotts Biochemistry
Lippincotts Biochemistry
Day 5
Continue Biochemistry
Source Lippincotts Biochemistry Lippincotts Biochemistry Lippincotts Biochemistry Lippincotts Biochemistry Details Est. Time Focus on the porphyrias and bilirubin 1 hr metabolism. Focus on figures 23.5 and 23.7 Know what they are and know the related 1 hr disorders. Dont get too bogged down in details just study figures 14.12 and 15.14, then move on. Know the daily energy requirements and 3 hrs vitamin deficiencies. Focus on absorption of vitamin B12 and pernicious anemia, as well as vitamin D. Focus on figures 28.12, and 28.18 Understand differences between de novo and 2 hrs salvage purine synthesis. Study purine degradation and the Pathophysiology of gout and ADA deficiency. Study figures 29.7, 29.9,29.10 Details Est. Time Synthesize the information youve reviewed 5 hrs this week by studying insulin, glucagon, the fed/starved states, and the metabolic aspects of diabetes mellitus. Time spent on these topics will be VERY WORTHWHILE Details Est. Time Study general principles of pharmacology. 2 hrs Specific agents will be covered with relevant organ systems. Know different types of adrenergic and 5 hrs cholinergic receptors cold. Study figures 3.3, 3.6, 4.2, 5.2, 6.15, and 7.10. Details Est. Time Rely heavily on charts. Start building buzzword 10 hrs associations with characteristics of each organism and how is identified (with a special stain, culture medium, etc.) Also, time spent with Qbank questions here will be golden
Objective Assignments Heme, Porphyrins, Chapter 23 Serotonin, Histamine and Catholamines Gylcosaminglycans and Skim Chapter 14, 15 Glycoproteins Nutrition and Vitamins Chapter 27, 28
Nucleotide Metabolism
Chapter 29
Day 6
Finish Biochemistry
Source Lippincotts Biochemistry
Day 7
Objective Pharmacokinetics & Pharmacodynamics Autonomic Drugs
General Pharmacology
Assignments Chapter 1, 2 Chapters 3 7 Source Lippincotts Biochemistry Lippincotts Biochemistry
Day 8
Objective Bacteria
Begin Microbiology
Assignments Chapter 1 15 Source Clinical Microbiology made Ridiculously Simple
Day 9
Continue Microbiology
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Objective Antibiotics
Assignments Chapter 28 33
Fungi
Chapter 20
Antifungal
Chapter 34
Details This is high yield material, read, review and continue to do Qbank questions to keep building buzzword associations. Clinical This is high yield material, read, review and Microbiology made continue to do Qbank questions to keep Ridiculously Simple building buzzword associations. Lippincotts This is high yield material, read, review and Pharmacology continue to do Qbank questions to keep building buzzword associations. Source Details Clinical This is high yield material, read, review and Microbiology made continue to do Qbank questions to keep Ridiculously Simple building buzzword associations Lippincotts Review antiviral agents, particularly Pharmacology mechanisms of action. Clinical This is high yield material, read, review and Microbiology made continue to do Qbank questions to keep Ridiculously Simple building buzzword associations Lippincotts Review antiprotozal and antihelminthic agent, Pharmacology particularly multi-drug regimens Underground Good for group study and another way to Clinical Vignettes keep sharpening buzzword recall. Microbiology
1.5hr
1 hr
Day 10
Objective Viruses
Finish Microbiology
Assignments Chapter 22-29 Est. Time 6 hrs
Antiviral Parasites
1 hr 2 hrs
Chapter 35, 36
1 hr 3 hrs
Day 11
Objective Review Immunology
Chapter 1 Chapter 2
Hemostasis
Chapter 3
Focus on mechanisms of cellular injury and 0.5 hr differences between necrosis & apoptosis Distinguish mechanisms and histological 1 hr characteristics of acute vs. chronic inflammation Know coagulation cascade, types of embolism, 1 hr and types of shock. 0.5 hr Focus on immune deficiency disorders, 0.5 hr autoimmunity, and collagen vascular disease Distinguish between tumor suppressor genes 1 hr & oncogences, know mechanisms of carcinogenesis, and the properties of malignant cells. Quickly review 0.5 hr Review vitamin deficiencies to refresh biochem memory 0.5 hr
Day 12
Cellular Biology
38
Cell Membranes
Chapter 1
Details Est. Time Know mechanisms of DNA repair, different 3.5 hrs types/roles of RNA, mechanism of translation, and molecular biology techniques. Focus on figure 30.2, 30.16, 30.19, 30.22,31.11, 32.9 BRS Cell Biology & Know properties of membranes and 1 hr Histology membrane proteins BRS Cell Biology & Know contents of nuclei, and RNA Histology import/export mechanisms. BRS Cell Biology & Review organelles and function Histology BRS Cell Biology & Know different types of collagen, basement Histology membrane composition, and other ECM components. BRS Cell Biology & Review types of epithelia and locations of Histology each. Review connective tissue focusing on bone histology 0.5 hr
Nucleus
Chapter 2
Cytoplasm
Chapter 3
0.5 hr
Extracellular Matrix
Chapter 4
1 hr
Epithelia & Connective Chapter 5,6 Tissue Day 13 Objective Cell Physiology Embryology Cellular Physiology & General Embryology Assignments Chapter 1 Chapter 1-4
1.5 hrs
BRS Embryology Board Simulator Series Body Systems Review Source BRS Embryology
Details Est. Time Know mechanisms of ion transport, action 1 hr potentials. Know stages from zygote through embryo. 3 hrs Review 3 Germ cell layers and their derivative tissues. 1.5 hrs Good opportunity to identify weakness in organ system areas. 2 hrs
Day 14
Thorax
Details Know the congenital cardiac abnormalities, and fetal circulation. Also understand the stages of fetal lung maturation. Est. Time 3.5 hrs
Thoracic Anatomy
Chapter 12 (Also use Netters Atlas for reference ) Histology of thoracic Chapters 11, 15 viscera
High Yield Gross 3 hrs Anatomy BRS Cell Biology & Be able to distinguish arteries and veins in 1 hr Histology cross section. Understand architecture of the gas diffusion barrier in the lungs.
Day 15
Objective Cardiovascular Physiology
Cardiovascular System
Assignments Chapter 3 Source BRS Physiology Details Est. Time Review hemodynamic, electrophysiology, 1.5 hrs cardiac cycle, blood pressure regulation, response to exercise, volume loss, altitude. Understand pre-load, after-load, Frank-Starling curve and condition. Study this chapter thoroughly 1.5 hrs
Cardiac Pathology
Chapter 10
BRS Pathology
39
Study this chapter thoroughly Know drugs used to treat CH, HTN, arrhythmias, angina, and hyperlipidemia
1 hr 5 hrs
Day 16
Objective Assignments Respiratory Physiology Chapter 4 Respiratory Pathology Chapter 14 Respiratory Pharmacology Clinical Vignettes Chapter 22
Lippincotts Pharmacology Volume 1: Cases 1-19, Volume Underground 2: Cases 52-66 Clinical Vignettes Patho-physiology Chapters 10, 12 (and a BRS Cell Biology & histological atlas for further Histology review
Familiarize yourself with lymph nodes architecture and understand the spleen. Understand RBC, WBC, platelet
3 hrs
Day 17
Objective Anemia Hematopoietic & Lymph reticular Neoplasia Hemorrhagic Disorders Drugs affecting coagulation Anticancer Drugs Clinical Vignettes
Finish Hematology
Assignments Chapter 11 Chapter 12 Source BRS Pathology BRS Pathology Details Est. Time Know Patho physiology and lab differentiation 2 hrs of various etiologies of anemia Distinguish between leukemia & lymphoma. 2 hrs Understand different types of each. Know how to diagnose and correct each disorder. 1 hr 1.5 hrs 1.5 hrs 2 hrs
BRS Pathology Lippincotts Pharmacology Lippincotts Pharmacology Underground Clinical Vignettes Patho-physiology Source BRS Embryology
Day 18
Objective Embryology of Gut and Body Cavities
Gastrointestinal System
Assignments Chapters 10, 16 Details Est. Time Understand rotation of gut and related 1.5 hrs malformations. Know which structures are derived of foregut, midgut, hindgut, in addition to vascular supplies. 2 hrs 1.5 hrs 1 hr
Abdominal Anatomy
Chapter 3 (Also refer to Netters atlas) Histology of GI Tract Chapter 6 GI Physiology Chapter 6
High Yield Gross Anatomy BRS Cell Biology & Know layers of gut wall. Understand liver Histology structure, portal blood flow, and bile flow BRS Physiology Understand innervations of gut and gut hormones Source BRS Pathology BRS Pathology Details Study this chapter thoroughly Study this chapter thoroughly
Day 19
Objective Gastrointestinal Pathology Hepatobiliary and Exocrine Pancreatic
Gastrointestinal System
Assignments Chapter 15 Chapter 16 Est. Time 2 hrs 2 hrs
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Lippincotts Know GI drugs as well as antiemetic Pharmacology Underground Good opportunity for group review Clinical Vignettes Patho-physiology Source BRS Embryology High Yield Gross Anatomy Details
2 hrs 2 hrs
Day 20
Objective Embryology of GU
Genitourinary System
Assignments Chapter 6, 13, 14 Est. Time 3 hrs
Anatomy of Pelvis and Chapters 4, 5 Perineum Histology of GU Organs Chapter 18, 19, 20
Know the maturation sequence of 3 hrs spermatocytes and ovarian follicles. Know the anatomy of the nephron. BRS Cell Biology & Know the maturation sequence of 3 hrs Histology spermatocytes and ovarian follicles. Know the anatomy of the nephron. Source BRS Physiology Lippincotts Pharmacology BRS Pathology BRS Pathology BRS Pathology Details Est. Time 1.5 hrs 1.5 hrs Study this chapter thoroughly 1.5 hrs
Day 21
Objective Renal Physiology Diuretics Renal & Urinary Tract Pathology Male Reproductive Pathology Female Reproductive Pathology Clinical Vignettes
Endocrine System
Assignments Chapter 5 Chapter 23 Chapter 17 Chapter 18 Chapter 19 Volume 2: Cases 30-51, and 83-103
Know the different types of testicular cancer, 1 hr and the biology of BPH and prostate cancer Understand cervical, uterine cancer 1.5 hrs 2 hrs
Underground Good opportunity for group review Clinical Vignettes Patho-physiology Source BRS Embryology BRS Physiology Lippincotts Pharmacology Lippincotts Pharmacology Underground Clinical VignettesPatho-physiology Board Simulator Series-Body Systems Review Source BRS Embryology
Day 22
Objective Histology of Endocrine System Physiology Insulin and oral hypoglycemic Steroid Hormones Clinical Vignettes
Endocrine System
Assignments Chapter 13 Chapter 7 Chapter 26 Details Est. Time Review structure of endocrine organ, and use 1 hr an atlas for additional pictures. Know hormonal axes 2.5 hrs Know different types of insulin and their half 1.5 hrs lives. Know classes of oral hypoglycemic and side effects. 1 hr Good opportunity of group review 2 hrs
EXAM
Tough questions, but great explanations. Well 1.5 hrs worth the time to push yourself a bit and solidify the material youve learned. Details Know bronchial arches/clefts and their derivatives. Understand the transition from neural plate to mature CNS. Know fate of Est. Time 3 hrs.
Day 23
Objective Embryology of Head Neck, & Nervous System
Nervous System
Assignments Chapter 7, 8, 9, 10
41
neural crest cells. Head & Neck Anatomy Neuroanatomy Chapter 8 (also refer to Netter) Chapter 1-23 High Yield Gross Anatomy High Yield Neuroanatomy Source BRS Physiology BRS Pathology Details Understand Synaptic transmission and axonal conduction Know types of CNS infection, tumors, and vascular disorders. Good opportunity of group review. 2 hrs 6 hrs
Day 24
Objective Neurophysiology Neuropathology Clinical Vignettes
Nervous System
Assignments Chapter 2 Chapter 23 Volume 2: Cases 45-61, Anatomy Cases 40-56. Chapters 8,10, 11, 14, 15 Est. Time 2 hrs 2 hrs 2 hrs
Neuropharmacology
Underground Clinical VignettesPatho-physiology Lippincotts Review drugs used to treat epilepsy, Pharmacology Parkinsons. Also review anesthetics and analgesics. Source BRS Embryology High Yield Anatomy Lippincotts Pharmacology Source BRS Pathology Details
3.5 hrs
Day 25
Objective Embryology
Musculoskeletal System
Assignments Chapter 15 Est. Time 1 hr 3.5 hrs 2 hrs 2 hrs
Anatomy of Limbs and Chapters 1, 6, 7 (also use Back Netter) Histology Chapter 7, 8, 10 Anti-inflammatory Chapters 39, 40 Agents and Autacoids
Day 26
Objective Dermatologic Pathology Musculoskeletal Pathology Clinical Vignettes
Musculoskeletal System
Assignments Chapter 21 Details Est. Time Focus on malignancies (melanoma, SCC, BCC) 1.5 hrs and refer to a dermatology atlas so that you can differentiate between them. 1.5 hrs 2.5 hrs
Chapter 22
BRS Pathology
Volume 3: Cases 9-18, and 96- Underground Good opportunity of group review. 104. Also Anatomy: Cases 62- Clinical Vignettes84 Patho-physiology Body Systems II Test I Board Simulator Series-Body Systems Review Touch questions, but great explanations. Well worth the time to push yourself a bit and solidify the material youve learned.
Exam
2 hrs
Day 27
Objective Clinical Vignettes
42
Biostatics
Day 28
Final Review Exam Logistics Rest & Relax
43
Time Frame Week 5 December Week 1 Week 2 Week 3 Week 4 Week 5 January Week 1 Week 2 Week 3 Week 4 Week 5 March Week 1 Week 2 Week 3 Week 4 Week 5
Content Topic to Review Heme/Onc & Pulmonary Heme/Onc & Pulmonary Cardio & Immunology Renal Biochemistry Microbiology Microbiology GI & Embryology Path, Pharm, & Musculoskeletal Neuro Endo & Repoductive
Pages in First Aid 46 pages 46 pages 52 pages 30 pages 52 pages 60 pages 60 pages 54 pages 60 pages 44 pages 42 pages
February Human Behavior course in progress Behavior & Psych Practice questions Practice questions CBCE Exam Shelf Exams 34 pages
This sample schedule is meant to be used as a framework for you to build your own individualized study plan; in addition to First Aid readings, challenge yourself to complete a set number of question bank items per week (or even per day as you get closer to the exam). Many thanks to Taimur Khan and Ryan Roach for their assistance in creating this sample schedule.
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270 260 250 240 230 220 210 200 190 180 170 0
Score
1000 2000 3000 4000 5000 6000 7000 8000 9000 10000 11000 Number of Questions Completed
270 250 Score 230 210 190 170 150 0 20 40 60 80 100 % of studying doing questions y = -0.0069x + 226.63 R = 4E-05
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Number of Respondents
10 15 5 70 60 50 40 30 20 10 0
Number of Respondents
0 59 Pathology 5 Physiology 3 Cardiology 6 Microbiology Inflammation Biochemistry Pharmacolo Neurology Infectious Renal 9 12 3 14 1 10 14 1 4 7 4 1
Endocrine
Anatomy
Pathology
Heme/Onc
Biochemistry
Neurology
Ethics
Biostatistics
Pharmacolo
Studying which subject was most beneficial (i.e. most represented on the test)?
Genetics
Pulmonary
46
Score Distribution
210 190 170 150 130 110 C/O 2010 C/O 2011
Class
C/O 2012
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