DRUG DATA

Generic name: metronidazo e Trade name: F a!" # Metro!" Patient$% do%e: Metronidazo e &''m! (ta) BID Minim*m do%e: +&' m! P,O, tid Ma-im*m do%e: .&' m! P,O, /0 Content: Metronidazo e A1ai a)i it" and Co or: Ca2%* e%: 3.& m! Ta) et%: +''# +&'# 4''# &'' m! In5ection: &''m!6(''m Ro*te o7 Admini%tration: P,O,# I,8,

CLASSIFICATI ON
P:armaco o!ic: Nitroimidazo e T:era2e*tic: Pre!nanc" Cate!or": B

MECHANISM OF ACTION
Direct> actin! tric:omonacide and ame)icide t:at ?or@% in%ide and o*t%ide t:e inte%tine%, It i% t:o*!:t to enter t:e ce % o7 microor!ani%m% t:at contain nitro> red*cta%e# 7ormin! *n%ta) e com2o*nd% t:at )ind to DNA and in:i)it %"nt:e%i%# ca*%in! ce > deat: On%et: Un@no?n Pea@: + :o*r% D*ration: Un@no?n Ha 7> i7e: 0 to < :o*r%

INDICATION
Genera Indication%: >Ame)ic i1er a)%ce%% >Inte%tina ame)ia%i% >Re7ractor" tric:omonia%i% >Bacteria in7ection% ca*%ed )" ame)ic microor!ani%m% >To 2re1ent 2o%to2erati1e in7ection in 2otentia " contaminated co orecta %*r!er" >Bacteria 1a!ino%i% Patient$% Act*a Indication: To 2re1ent 7*rt:er in7ection

CONTRAINDICATIO N
>H"2er%en%iti1it" to dr*! or ot:er nitroimidazo e deri1ati1e% and in7ir%t trime%ter o7 2re!nanc" Preca*tion%: >?it: :i%tor" o7 d"%cra%ia%# CNS di%order# or retina or 1i%*a 7ie d c:an!e% >In 2atient% ta@in! :e2atoto-ic dr*!% or :a1e :e2atic di%ea%e or a co:o i%m Dr*! Interaction%: Dr*!>dr*!: B*%* 7an> ma" increa%e to-icit" Cimetidine: ma" increa%e ri%@ o7 metronidazo e to-icit" Di%* 7iram: ma" ca*%e ac*te 2%"c:o%i% and con7*%ion Lit:i*m: ma" increa%e it:i*m e1e Aar7arin: ma" increa%e anticoa!* ant e77ect% Dr*!> i7e%t" e: A co:o *%e: ma" ca*%e di%* 7iram> i@e reaction% EFFECTS ON LAB TEST RESULTS: >Ma" decrea%e ABC and ne*tro2:i co*nt% >Ma" 7a %e " decrea%e tri! "ceride and aminotran%7era%e e1e %

SIDE EFFECTS
CNS: :eadac:e# %eiz*re%# 7e1er# 1erti!o# %"nco2e# incoordination# in%omnia# 2eri2:era ne*ro2at:" C8:edema# 7 *%:in!# 7 attened T> ?a1e GI: na*%ea# a)domina cram2in!# anore-ia# diarr:ea# 1omitin!# dr" mo*t:# meta ic ta%te GU: 1a!initi%# dar@ened *rine# 2o "*ria# d"%*ria# c"%titi% Hemato o!ic: tran%ient e*co2enia# ne*tro2enia M*%c* o%@e eta : tran%ient 5oint 2ain% Re%2irator": *22er re%2irator" tract in7ection% S@in: ra%:e%

NURSING RESPONSIBILITIES
Be7ore: >Do 2re!nanc" te%t >C:ec@ i7 :"2er%en%iti1e to dr*! >C:ec@ :i%tor" 7or contraindicated i ne%%e% >Re1ie? medication record 7or 2o%%i) e dr*! interaction% >C:ec@ 1ita %i!n% D*rin!: >Gi1e ?it: mea % >Gi1e ?it: 7* ! a%% o7 ?ater >Do not !i1e ?it: Di%* 7iram >In7orm t:at :e ma" e-2erience meta ic ta%te >Monitor 7or ad1er%e reaction% A7ter: > Ad1i%e not to drin@ a co:o or *%e ot:er a co:o >containin! dr*!% > Ad1i%e to re2ort to 2:"%ician 2re%ence o7 ad1er%e e77ect% > Ad1i%e not to ta@e ot:er dr*!% ?it:o*t con%* tin! t:e 2:"%ician > Stre%% im2ortance o7 7o o?in! medication re!imen > recommend not *%in! mo*t:?a%: t:at contain% a co:o

So*rce: De! in# 9*dit:, ;+''<=, Da1i%$ Dr*! G*ide 7or N*r%e%, P:i ade 2:ia: F,A. Da1i% Com2an",

De! in# 9*dit:, ;+''<=, Da1i%$ Dr*! G*ide 7or N*r%e%, P:i ade 2:ia: F,A. Da1i% Com2an",

McCann# 9*dit:, ;+''<=, N*r%in! +''< Dr*! Hand)oo@, P:i ade 2:ia: Li22incott Ai iam% and Ai @in%

De! in# 9*dit:, ;+''<=, Da1i%$ Dr*! G*ide 7or N*r%e%, P:i ade 2:ia: F,A. Da1i% Com2an",

McCann# 9*dit:, ;+''<=, N*r%in! +''< Dr*! Hand)oo@, P:i ade 2:ia: Li22incott Ai iam% and Ai @in%

De! in# 9*dit:, ;+''<=, Da1i%$ Dr*! G*ide 7or N*r%e%, P:i ade 2:ia: F,A. Da1i% Com2an",

McCann# 9*dit:, ;+''<=, N*r%in! +''< Dr*! Hand)oo@, P:i ade 2:ia: Li22incott Ai iam% and Ai @in%

DRUG DATA
Generic name: ome2razo e Trade name: Lo%ec Patient$% do%e: Ome2razo e

CLASSIFICATI ON
P:armaco o!ic: Proton 2*m2 in:i)itor T:era2e*tic: Anti* cer Pre!nanc"

MECHANISM OF ACTION
In:i)it% acti1it" o7 acid ;2roton= 2*m2 and )ind% to :"dro!en>2ota%%i*m adeno%ine tri2:o%2:ata%e at %ecretor" %*r7ace o7 !a%tric 2arieta ce %

INDICATION
Genera Indication: >S"m2tomatic GERD ?it:o*t e%o2:a!ea e%ion% >Ero%i1e e%o2:a!iti%

CONTRAINDICATIO N
H"2er%en%iti1e to dr*! or it% com2onent% >t:o%e ?it: meta)o ic a @a o%i% and :"2oca cemia Preca*tion%: >t:o%e ?it: :"2o@a emia and re%2irator" a @a o%i%

SIDE EFFECTS
CNS: a%t:enia# dizzine%%# :eadac:e GI: a)domina 2ain# con%ti2ation# diarr:ea# 7 at* ence#

NURSING RESPONSIBILITIES
Be7ore: >A%%e%% 7or :"2er%en%iti1it" >C:ec@ medica :i%tor" 7or 2re%ence o7 contraindicated i ne%% >Re1ie? medication :i%tor" 7or 2o%%i) e dr*! interaction% >In7orm o7 2o%%i) e %ide e77ect%