CAC/MRL 2-2012

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Codex Alimentarius Commission Maximum Residue Limits for Veterinary Drugs in Foods Updated as at the 35th Session of the Codex Alimentarius Commission (July 2012)

INDEX Veterinary Drug Abamectin Albendazole Amoxicillin Avylamycin Azaperone Benzylpenicillin/Procaine benzylpenicillin Carazolol Ceftiofur Chlortetracycline/Oxytetracycline/Tetracycline Clenbuterol Closantel Colistin Cyfluthrin Cyhalothrin Cypermethrin and alpha-cypermethrin Danofloxacin Deltamethrin Dexamethasone Diclazuril Dicyclanil Dihydrostreptomycin/Streptomycin Diminazene Doramectin Eprinomectin Erythromycin Estradiol-17beta Febantel/Fenbendazole/Oxfendazole Fluazuron Flubendazole Flumequine Page 2 2 3 4 4 5 5 6 7 8 9 10 11 11 12 12 13 14 14 15 15 16 16 17 17 18 19 20 20 21 Veterinary Drug Gentamicin Imidocarb Isometamidium Ivermectin Levamisole Lincomycin Melengestrol acetate Monensin Moxidectin Narasin Neomycin Nicarbazin Phoxim Pirlimycin Porcine somatotropin Progesterone Ractopamine Sarafloxacin Spectinomycin Spiramycin Sulfadimidine Testosterone Thiabendazole Tilmicosin Trenbolone acetate Trichlorfon (Metrifonate) Triclabendazole Tylosin Zeranol Page 22 22 23 23 24 25 25 26 27 28 29 30 30 31 31 32 32 33 34 35 35 36 37 38 38 39 39 40 40

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Codex Alimentarius Commission Maximum Residue Limits for Veterinary Drugs in Foods Updated as at the 35th Session of the Codex Alimentarius Commission (July 2012)
ABAMECTIN (anthelmintic agent)
JECFA Evaluation: 45 (1995); 47 (1996) Acceptable Daily Intake : 0-2 g/kg body weight (1997) Established for the sum of abamectin and (Z)-8,9 isomer by the 1997 JMPR. Residue Definition: Species Cattle Cattle Cattle Tissue Liver Kidney Fat Avermectin B1a. MRL (g/kg) 100 50 100 CAC 26th (2003) 26th (2003) 26th (2003) Notes

ALBENDAZOLE (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Not specified Not specified Not specified Not specified Not specified Tissue Muscle Liver Kidney Fat Milk (g/l) 34 (1989) Except milk, 2-aminosulfone metabolite; Milk, not yet identified. MRL (g/kg) 100 5000 5000 100 100 CAC 20th (1993) 20th (1993) 20th (1993) 20th (1993) 20th (1993) Notes Acceptable Daily Intake: 0-50 g/kg body weight (34th JECFA, 1989).

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AMOXICILLIN (antimicrobial agent)

JECFA Evaluation: Acceptable Daily Intake: Estimated Dietary Exposure 75 (2011) 0-0.07 g/kg body weight on the basis of microbiological effects (75th JECFA, 2011). The 75th JECFA (2001) did not calculate an EDI for amoxicillin owing to the small number of quantifiable residue data points. Using the model diet of 300 g muscle, 100 g live, 50 g kidney, 50 g fat and 1.5 liter of milk with the MRLs recommended, the theoretical maximum daily intake (TMDI) is 31 g/person, which represents 74% of the upper bound of the ADI. Amoxicillin MRL (g/kg) 50 50 50 50 4 50 50 50 50 4 50 50 50 50 CAC 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) Notes

Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Sheep Sheep Sheep Sheep Sheep Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat/Skin

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AVILAMYCIN (antimicrobial agent)

JECFA Evaluation: 70 (2008) Acceptable Daily Intake: 0-2 mg/kg body weight on the basis of a NOAEL of 150 mg avilamycin activity/kg body weight per day and a safety factor of 100 and rounding to one significant figure (70th JECFA, 2008). Residue Definition: Species Pig Pig Pig Pig Chicken Chicken Chicken Chicken Turkey Turkey Turkey Turkey Rabbit Rabbit Rabbit Rabbit Tissue Muscle Liver Kidney Fat/Skin Muscle Liver Kidney Fat/Skin Muscle Liver Kidney Fat/Skin Muscle Liver Kidney Fat/Skin Dichloroisoeverninic acid (DIA). MRL (g/kg) 200 300 200 200 200 300 200 200 200 300 200 200 200 300 200 200 CAC 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) Notes

AZAPERONE (tranquilizing agent)

JECFA Evaluation: Residue Definition: Species Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat 38 (1991); 43 (1994); 50 (1998); 52 (1999) Sum of azaperone and azaperol. MRL (g/kg) 60 100 100 60 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Notes Acceptable Daily Intake: 0-6 g/kg body weight (50th JECFA, 1998).

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BENZYLPENICILLIN/PROCAINE BENZYLPENICILLIN (antimicrobial agent)

JECFA Evaluation: 36 (1990); 50 (1998) Acceptable Daily Intake: 30 g-penicillin/person/day (50th JECFA, 1998). Residues of benzylpenicillin and procaine benzylpenicillin should be kept below this level. Residue Definition: Species Cattle Cattle Cattle Cattle Chicken Chicken Chicken Pig Pig Pig Tissue Muscle Liver Kidney Milk (g/l) Muscle Liver Kidney Muscle Liver Kidney Benzylpenicillin. MRL (g/kg) 50 50 50 4 50 50 50 50 50 50 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Applies to procaine benzylpenicillin only. Applies to procaine benzylpenicillin only. Applies to procaine benzylpenicillin only. Notes

CARAZOLOL (beta-adreniceptor-blocking agent)

JECFA Evaluation: 38 (1991); 43 (1994); 52 (1999) Acceptable Daily Intake: 0-0.1 g/kg body weight (43rd JECFA, 1994). ADI based on the acute pharmacological effects of carazolol. Residue Definition: Species Pig Tissue Muscle Carazolol. MRL (g/kg) 5 CAC 26th (2003) Notes The concentration at the injection site two hours after treatment may result in an intake that exceeds the acute RfD and therefore, an appropriate withdrawal period should be applied.

Pig Pig Pig

Liver Kidney Fat/Skin

25 25 5

26th (2003) 26th (2003) 26th (2003) The concentration at the injection site two hours after treatment may result in an intake that exceeds the acute RfD and therefore, an appropriate withdrawal period should be applied.

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CEFTIOFUR (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat Milk (g/l) Muscle Liver Kidney Fat 45 (1995); 48 (1997) Desfuroylceftiofur. MRL (g/kg) 1000 2000 6000 2000 100 1000 2000 6000 2000 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Notes Acceptable Daily Intake: 0-50 g/kg body weight (45th JECFA, 1995).

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CHLORTETRACYCLINE/OXYTETRACYCLINE/TETRACYCLINE (antimicrobial agent)

JECFA Evaluation: 45 (1995); 47 (1996); 50 (1998); 58 (2002) Acceptable Daily Intake: 0-30 g/kg body weight (50th JECFA, 1998). Group ADI for chlortetracycline, oxytetracycline and tetracycline. Residue Definition: Species Cattle Cattle Cattle Cattle Fish Giant prawn (Paeneus monodon) Pig Pig Pig Poultry Poultry Poultry Poultry Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Milk (g/l) Muscle Muscle Parent drugs, singly or in combination. MRL (g/kg) 200 600 1200 100 200 200 CAC 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) Applies only to oxytetracycline. Applies only to oxytetracycline. Notes

Muscle Liver Kidney Muscle Liver Kidney Eggs Muscle Liver Kidney Milk (g/l)

200 600 1200 200 600 1200 400 200 600 1200 100

26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003)

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CLENBUTEROL (adrenoceptor agonist)

JECFA Evaluation: Residue Definition: Species Cattle Tissue Muscle 47 (1996) Clenbuterol. MRL (g/kg) 0.2 CAC 26th (2003) Notes Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Due to the potential abuse of this drug, the MRLs are recommended only when associated with a nationally approved therapeutic use, such as tocolysis or as an adjunt therapy in respiratory diseases. Acceptable Daily Intake: 0-0.004 g/kg body weight (47th JECFA, 1996).

Cattle

Liver

0.6

26th (2003)

Cattle

Kidney

0.6

26th (2003)

Cattle

Fat

0.2

26th (2003)

Cattle

Milk (g/l)

0.05

26th (2003)

Horse

Muscle

0.2

26th (2003)

Horse

Liver

0.6

26th (2003)

Horse

Kidney

0.6

26th (2003)

Horse

Fat

0.2

26th (2003)

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CLOSANTEL (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat 36 (1990); 40 (1992) Closantel. MRL (g/kg) 1000 1000 3000 3000 1500 1500 5000 2000 CAC 20th (1993) 20th (1993) 20th (1993) 20th (1993) 20th (1993) 20th (1993) 20th (1993) 20th (1993) Notes Acceptable Daily Intake: 0-30 g/kg body weight (40th JECFA, 1992).

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COLISTIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Sheep Sheep Sheep Sheep Sheep Goat Goat Goat Goat Pig Pig Pig Pig Chicken Chicken Chicken Chicken Chicken Turkey Turkey Turkey Turkey Rabbit Rabbit Rabbit Rabbit Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Eggs Muscle Liver Kidney Fat Muscle Liver Kidney Fat 66 (2006) Sum of colistin A and colistin B. MRL (g/kg) 150 150 200 150 50 150 150 200 150 50 150 150 200 150 150 150 200 150 150 150 200 150 300 150 150 200 150 150 150 200 150 CAC 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31 (2008) 31st (2008) 31st (2008) 31st (2008)
st

Acceptable Daily Intake: 0-7 g/kg body weight (66th JECFA, 2006).

Notes

The MRL includes skin + fat

The MRL includes skin + fat

The MRL includes skin + fat

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CYFLUTHRIN (insecticide)
JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Fat Milk (g/l) 48 (1997) Cyfluthrin. MRL (g/kg) 20 20 20 200 40 CAC 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) Notes Acceptable Daily Intake: 0-20 g/kg body weight (48th JECFA, 1997).

CYHALOTHRIN (insecticide)
JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Pig Pig Pig Pig Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Muscle Liver Kidney Fat 54 (2000); 58 (2002); 62 (2004) Cyhalothrin. MRL (g/kg) 20 20 20 400 30 20 20 20 400 20 50 20 400 CAC 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) Notes Acceptable Daily Intake: 0-5 g/kg body weight (62nd JECFA, 2004).

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CYPERMETHRIN AND ALPHA-CYPERMETHRIN (insecticide)

JECFA Evaluation: 62 (2004) Acceptable Daily Intake: JECFA established a common ADI of 0-20 g/kg bw for both cypermethrin and alpha-cypermethrin. Residue Definition: Total of cypermethrin residues (resulting from the use of cypermethrin or alpha-cypermethrin as veterinary drugs). MRLs(g/kg) 50 50 50 1000 100 50 50 50 1000 CAC 29th (2006) 29th (2006) 29th (2006) 29th (2006) 29th (2006) 29th (2006) 29th (2006) 29th (2006) 29th (2006) Note

Species Cattle Cattle Cattle Cattle Cattle Sheep Sheep Sheep Sheep

Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat

DANOFLOXACIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat 48 (1997) Danofloxacin. MRL (g/kg) 200 400 400 100 200 400 400 100 100 50 200 100 CAC 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24 (2001) 24th (2001) 24th (2001) 24th (2001)
th

Acceptable Daily Intake: 0-20 g/kg body weight (48th JECFA, 1997).

Notes

Fat/skin in normal proportion.

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DELTAMETHRIN (insecticide)
JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Chicken Salmon Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Eggs Muscle Muscle Liver Kidney Fat 52 (1999); 60 (2003) Deltamethrin. MRL (g/kg) 30 50 50 500 30 30 50 50 500 30 30 30 50 50 500 CAC 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) Notes Acceptable Daily Intake: 0-10 g/kg body weight (1982). Established by the 1982 JMPR.

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DEXAMETHASONE (glucocorticosteroid)
JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Pig Pig Pig Horses Horses Horses Tissue Muscle Liver Kidney Milk (g/l) Muscle Liver Kidney Muscle Liver Kidney 70 (2008) Dexamethasone. MRL (g/kg) 1.0 2.0 1.0 0.3 1.0 2.0 1.0 1.0 2.0 1.0 CAC 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) Notes Acceptable Daily Intake: 0-0.015 g/kg body weight (42nd JECFA, 1995).

DICLAZURIL (antiprotozoal agent)

JECFA Evaluation: Residue Definition: Species Poultry Poultry Poultry Poultry Rabbit Rabbit Rabbit Rabbit Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat/Skin Muscle Liver Kidney Fat Muscle Liver Kidney Fat 45 (1995); 50 (1998) Diclazuril. MRL (g/kg) 500 3000 2000 1000 500 3000 2000 1000 500 3000 2000 1000 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Notes Acceptable Daily Intake: 0-30 g/kg body weight (50th JECFA, 1998).

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DICYCLANIL (insecticide)
JECFA Evaluation: Residue Definition: Species Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat 54 (2000); 60 (2003) Dicyclanil. MRL (g/kg) 150 125 125 200 CAC 28th (2005) 28th (2005) 28th (2005) 28th (2005) Notes Acceptable Daily Intake: 0-7 g/kg body weigh (54th JECFA, 2000).

DIHYDROSTREPTOMYCIN/STREPTOMYCIN (antimicrobial agent)

JECFA Evaluation: 43 (1994); 48 (1997); 52 (1999); 58 (2002) Acceptable Daily Intake: 0-50 g/kg body weight (48th JECFA, 1997). Group ADI for combined residues of dihydrostreptomycin and streptomycin. Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Pig Pig Pig Pig Sheep Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Milk Sum of dihydrostreptomycin and streptomycin. MRL (g/kg) 600 600 1000 600 200 600 600 1000 600 600 600 1000 600 600 600 1000 600 200 CAC 24th (2001) 24th (2001) 24th (2001) 24th (2001) 26th (2003) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 26th (2003) Notes

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DIMINAZENE (trypanocide)
JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Milk (g/l) 34 (1989); 42 (1994) Diminazene. MRL (g/kg) 500 12000 6000 150 CAC 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) Limit of quantitation of the analytical method. Notes Acceptable Daily Intake: 0-100 g/kg body weight (42nd JECFA, 1994).

DORAMECTIN (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Tissue Muscle 45 (1995); 52 (1999); 58 (2002); 62 (2004) Doramectin. MRL (g/kg) 10 CAC 22nd (1997) Notes High concentration of residues at the injection site over a 35 day period after subcutaneous or intramuscular administration of the drug at the recommended dose. Acceptable Daily Intake: 0-1 g/kg body weight (58th JECFA, 2002).

Cattle Cattle Cattle

Liver Kidney Fat

100 30 150

22nd (1997) 22nd (1997) 22nd (1997) High concentration of residues at the injection site over a 35 day period after subcutaneous or intramuscular administration of the drug at the recommended dose Depending on the route and/or time of administration the use of doramectin in dairy cows may result in extended withdrawal periods in milk. This may be addressed in national/regional regulatory programmes.

Cattle

Milk

15

29th (2006)

Pig Pig Pig Pig

Muscle Liver Kidney Fat

5 100 30 150

24th (2001) 24th (2001) 24th (2001) 24th (2001)

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EPRINOMECTIN (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Fat Milk (g/l) 50 (1998) Eprinomectin B1a. MRL (g/kg) 100 2000 300 250 20 CAC 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) Notes Acceptable Daily Intake: 0-10 g/kg body weight (50th JECFA, 1998).

ERYTHROMYCIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Chicken Chicken Chicken Chicken Chicken Turkey Turkey Turkey Turkey Tissue Muscle Liver Kidney Fat Eggs Muscle Liver Kidney Fat 66 (2006) Erythromycin A MRL (g/kg) 100 100 100 100 50 100 100 100 100 CAC 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) 31st (2008) The MRL includes skin + fat The MRL includes skin + fat Notes Acceptable Daily Intake: 0-0.7 g/kg body weight (66th JECFA, 2006).

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ESTRADIOL-17BETA (production aid)

JECFA Evaluation: Residue Definition: Species Cattle Tissue Muscle 25 (1981); 32 (1987); 52 (1999) Estradiol-17beta. MRL (g/kg) unnecessary CAC 21st (1995) Notes Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Acceptable Daily Intake: unnecessary (32nd JECFA, 1987); 0-0.05 g/kg body weight (52nd JECFA, 1999).

Cattle

Liver

unnecessary

21st (1995)

Cattle

Kidney

unnecessary

21st (1995)

Cattle

Fat

unnecessary

21st (1995)

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FEBANTEL/FENBENDAZOLE/OXFENDAZOLE (anthelmintic agent)

JECFA Evaluation: Residue Definition: 38 (1991); 45 (1995); 50 (1998) Sum of fenbendazole, oxfendazole and oxfendazole sulphone, expressed as oxfendazole sulphone equivalents. MRL (g/kg) 100 500 100 100 100 100 500 100 100 100 500 100 100 100 500 100 100 100 500 100 100 100 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Notes Acceptable Daily Intake: 0-7 g/kg body weight (50th JECFA, 1998). Group ADI

Species Cattle Cattle Cattle Cattle Cattle Goat Goat Goat Goat Horse Horse Horse Horse Pig Pig Pig Pig Sheep Sheep Sheep Sheep Sheep

Tissue Muscle Liver Kidney Fat Milk (g/l) Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Milk (g/l)

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FLUAZURON (insecticide)
JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Fat 48 (1997) Fluazuron. MRL (g/kg) 200 500 500 7000 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Notes Acceptable Daily Intake: 0-40 g/kg body weight (48th JECFA, 1997).

FLUBENDAZOLE (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Pig Pig Poultry Poultry Poultry Tissue Muscle Liver Muscle Liver Eggs 40 (1992) Flubendazole. MRL (g/kg) 10 10 200 500 400 CAC 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) Notes Acceptable Daily Intake: 0-12 g/kg body weight (40th JECFA, 1992).

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FLUMEQUINE (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Pig Pig Pig Pig Sheep Sheep Sheep Sheep Trout Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle 42 (1994); 48 (1997); 54 (2000); 60 (2002); 62 (2004); 66 (2006) Flumequine. MRL (g/kg) 500 500 3000 1000 500 500 3000 1000 500 500 3000 1000 500 500 3000 1000 500 CAC 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) Muscle including normal proportion of skin Notes Acceptable Daily Intake: 0-30 g/kg body weight (62nd JECFA, 2004).

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GENTAMICIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat Milk (g/l) Muscle Liver Kidney Fat 43 (1994); 48 (1997); 50 (1998) Gentamicin. MRL (g/kg) 100 2000 5000 100 200 100 2000 5000 100 CAC 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) Notes Acceptable Daily Intake: 0-20 g/kg body weight (50th JECFA, 1998).

IMIDOCARB (antiprotozoal agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Fat Milk 50 (1998), 60 (2003) Imidocarb. MRL (g/kg) 300 1500 2000 50 50 CAC 28th (2005) 28th (2005) 28th (2005) 28th (2005) 28th (2005) Notes Acceptable Daily Intake: 0-10 g/kg body weight (50th JECFA, 1998).

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ISOMETAMIDIUM (trypanocide)
JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Fat Milk (g/l) 34 (1989); 40 (1992) Isometamidium. MRL (g/kg) 100 500 1000 100 100 CAC 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) Notes Acceptable Daily Intake: 0-100 g/kg body weight (40th JECFA, 1992).

IVERMECTIN (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Pig Pig Sheep Sheep Tissue Liver Fat Milk Liver Fat Liver Fat 36 (1990); 40 (1992); 54 (2000); 58 (2002) 22,23-Dihydroavermectin B1a (H2B1a). MRL (g/kg) 100 40 10 15 20 15 20 CAC 20th (1993) 20th (1993) 26th (2003) 20th (1993) 20th (1993) 20th (1993) 20th (1993) Notes Acceptable Daily Intake: 0-1 g/kg body weight (40th JECFA, 1992).

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LEVAMISOLE (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Pig Pig Pig Pig Poultry Poultry Poultry Poultry Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat 36 (1990); 42 (1994) Levamisole. MRL (g/kg) 10 100 10 10 10 100 10 10 10 100 10 10 10 100 10 10 CAC 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) Notes Acceptable Daily Intake: 0-6 g/kg body weight (42nd JECFA, 1994).

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LINCOMYCIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Chicken Chicken Chicken Chicken Pig Pig Pig Pig Tissue Milk Muscle Liver Kidney Fat Muscle Liver Kidney Fat 54 (2000); 58 (2002); 62 (2004) Lincomycin. MRL (g/kg) 150 200 500 500 100 200 500 1500 100 CAC 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) Additional MRL for skin with adhering fat of 300 g/kg. Additional MRL for skin with adhering fat of 300 g/kg. Notes Acceptable Daily Intake: 0-30 g/kg body weight (54th JECFA, 2000).

MELENGESTROL ACETATE (production aid)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Fat 54 (2000); 66 (2006) Melengestrol acetate. MRL (g/kg) 1 10 2 18 CAC 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) Notes Acceptable Daily Intake: 0-0.03 g/kg body weight.

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MONENSIN (antimicrobial agent)

JECFA Evaluation: Acceptable Daily Intake: 70 (2008); 75 (2011) 010 g/kg body weight on the basis of a NOAEL of 1.14 mg/kg body weight per day and a safety factor of 100 and rounding to one significant figure (70th JECFA, 2008).

Estimated Dietary Exposure: Using the revised MRL, the theoretical maximum daily intake (TMDI)

from the 70th JECFA was recalculated, resulting in a value of 481 g/person, which represents 80% of the upper bound of the ADI (75thJECFA, 2011).
Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Sheep Sheep Sheep Sheep Goats Goats Goats Goats Chicken Chicken Chicken Chicken Turkey Turkey Turkey Turkey Quail Quail Quail Quail Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Monensin. MRL (g/kg) 10 100 10 100 2 10 20 10 100 10 20 10 100 10 10 10 100 10 10 10 100 10 10 10 100 CAC 32nd (2009) 35th (2012) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) Notes

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MOXIDECTIN (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Tissue Muscle 45 (1995); 47 (1996); 48 (1998); 50 (1998) Moxidectin. MRL (g/kg) 20 CAC 22nd (1997) Notes Very high concentration and great variation in the level of residues at the injection site in cattle over a 49 day period after dosing. Acceptable Daily Intake: 0-2 g/kg body weight (45th JECFA, 1995).

Cattle Cattle Cattle Deer Deer Deer Deer Sheep Sheep Sheep Sheep

Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat

100 50 500 20 100 50 500 50 100 50 500

22nd (1997) 22nd (1997) 22nd (1997) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997)

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NARASIN (antimicrobial agent)

JECFA Evaluation: 70 (2008); 75 (2011) Acceptable Daily Intake: 0-5 g/kg body weight on the basis of a NOAEL of 0.5 mg/kg body weight per day and a safety factor of 100 (70th JECFA, 2008). Residue Definition: Species Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Narasin A. MRL (g/kg) 15 50 15 50 15 50 15 50 15 50 15 50 CAC 35th (2012) 35th (2012) 35th (2012) 35th (2012) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 34th (2011) 34th (2011) 34th (2011) 34th (2011) Notes

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NEOMYCIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Chicken Duck Duck Duck Duck Goat Goat Goat Goat Pig Pig Pig Pig Sheep Sheep Sheep Sheep Turkey Turkey Turkey Turkey Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Eggs Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat 43 (1994); 47 (1996); 52 (1999); 58 (2002); 60 (2003) Neomycin. MRL (g/kg) 500 500 10000 500 1500 500 500 10000 500 500 500 500 10000 500 500 500 10000 500 500 500 10000 500 500 500 10000 500 500 500 10000 500 CAC 23rd (1999) 28th (2005) 28th (2005) 23rd (1999) 28th (2005) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Notes Acceptable Daily Intake: 0-60 g/kg body weight (47th JECFA, 1996).

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NICARBAZIN (antiprotozoal agent)

JECFA Evaluation: Residue Definition: Species Chicken Chicken Chicken Chicken Tissue Muscle Liver Kidney Fat/Skin 50 (1998) N,N'-bis(4-nitropheyl)urea. MRL (g/kg) 200 200 200 200 CAC 23rd (1999) 23 (1999) 23rd (1999) 23 (1999)
rd rd

Acceptable Daily Intake: 0-400 g/kg body weight (50th JECFA, 1998).

Notes Broilers. Broilers. Broilers. Broilers.

PHOXIM (insecticide)
JECFA Evaluation: Residue Definition: Species Goat Goat Goat Goat Pig Pig Pig Pig Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat 52 (1999); 62 (2004) Phoxim MRL (g/kg) 50 50 50 400 50 50 50 400 50 50 50 400 CAC 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) 26th (2003) Notes Acceptable Daily Intake: 0-4 g/kg body weight (52nd JECFA, 1999).

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PIRLIMYCIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Tissue Muscle Liver Kidney Fat Milk 62 (2004) Pirlimycin. MRLs(g/kg) 100 1000 400 100 100 CAC 29th (2006) 29th (2006) 29th (2006) 29th (2006) 29th (2006) JECFA evaluated the effect of pirlimycin residues on starter cultures and for this reason recommended an MRL of 100 g/kg of milk. Codex Members may therefore adapt national/regional MRLs in order to address this technological aspect for trade of fresh liquid milk intended for processing using starter culture. Note Acceptable Daily Intake: 0-8 g/kg bw (62nd JECFA, 2004).

PORCINE SOMATOTROPIN (production aid)

JECFA Evaluation: Residue Definition: Species Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat 52 (1999) Not applicable. MRL (g/kg) not specified not specified not specified not specified CAC 26th (2003) 26th (2003) 26th (2003) 26th (2003) Notes Acceptable Daily Intake: Not Specified (52nd JECFA, 1999).

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PROGESTERONE (production aid)

JECFA Evaluation: Residue Definition: Species Cattle Tissue Muscle 25 (1981); 32 (1987); 52 (1999) Progesterone. MRL (g/kg) unnecessary CAC 21st (2005) Notes Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Acceptable Daily Intake: 0-30 g/kg body weight (52nd JECFA, 1999).

Cattle

Liver

unnecessary

21st (2005)

Cattle

Kidney

unnecessary

21st (2005)

Cattle

Fat

unnecessary

21st (2005)

RACTOPAMINE (production aid)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Pig Pig Pig Pig Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat 40 (1992); 62 (2004); 66 (2006) Ractopamine. MRL (g/kg) 10 40 90 10 10 40 90 10 CAC 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) 35th (2012) The MRL includes skin + fat Notes Acceptable Daily Intake: 0-1 g/kg body weight (66th JECFA, 2006).

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SARAFLOXACIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Chicken Chicken Chicken Chicken Turkey Turkey Turkey Turkey Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat 50 (1998) Sarafloxacin. MRL (g/kg) 10 80 80 20 10 80 80 20 CAC 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) 24th (2001) Notes Acceptable Daily Intake: 0-0.3 g/kg body weight (50th JECFA, 1998).

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SPECTINOMYCIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Chicken Pig Pig Pig Pig Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Milk (g/l) Muscle Liver Kidney Fat Eggs Muscle Liver Kidney Fat Muscle Liver Kidney Fat 42 (1994); 50 (1998) Spectinomycin. MRL (g/kg) 500 2000 5000 2000 200 500 2000 5000 2000 2000 500 2000 5000 2000 500 2000 5000 2000 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) Notes Acceptable Daily Intake: 0-40 g/kg body weight (42nd JECFA, 1994).

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SPIRAMYCIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: 38 (1991); 43 (1994); 47 (1996); 48 (1997) Cattle and chickens, sum of spiramycin and neospiramycin; Pigs, spiramycin equivalents (antimicrobially active residues). MRL (g/kg) 200 600 300 300 200 200 600 800 300 200 600 300 300 CAC 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) 22nd (1997) Notes Acceptable Daily Intake: 0-50 g/kg body weight (43rd JECFA, 1994).

Species Cattle Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Pig Pig Pig Pig

Tissue Muscle Liver Kidney Fat Milk (g/l) Muscle Liver Kidney Fat Muscle Liver Kidney Fat

SULFADIMIDINE (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Not specified Not specified Not specified Not specified Tissue Milk (g/l) Muscle Liver Kidney Fat 34 (1989); 38 (1991); 42 (1994) Sulfadimidine. MRL (g/kg) 25 100 100 100 100 CAC 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) Notes Acceptable Daily Intake: 0-50 g/kg body weight (42nd JECFA, 1994).

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TESTOSTERONE (production aid)

JECFA Evaluation: Residue Definition: Species Cattle Tissue Muscle 25 (1981); 32 (1987); 52 (1999) Testosterone. MRL (g/kg) unnecessary CAC 21st (1995) Notes Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Residues resulting from the use of this substances as a growth promoter in accordance with good animal husbandry practice are unlikely to pose a hazard to human health. Acceptable Daily Intake: 0-2 g/kg body weight (52nd JECFA, 1999).

Cattle

Liver

unnecessary

21st (1995)

Cattle

Kidney

unnecessary

21st (1995)

Cattle

Fat

unnecessary

21st (1995)

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THIABENDAZOLE (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Goat Goat Goat Goat Goat Pig Pig Pig Pig Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Milk (g/l) Muscle Liver Kidney Fat Milk (g/l) Muscle Liver Kidney Fat Muscle Liver Kidney Fat 40 (1992); 48 (1997); 58 (2002) Sum of thiabendazole and 5-hydroxythiabendazole. MRL (g/kg) 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 CAC 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) 21st (1995) Notes The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. The MRL also covers residues derived from feed containing the residues resulted from agricultural use. Acceptable Daily Intake: 0-100 g/kg body weight (40th JECFA, 1992).

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TILMICOSIN (antimicrobial agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Chicken Chicken Chicken Chicken Pig Pig Pig Pig Sheep Sheep Sheep Sheep Turkey Turkey Turkey Turkey Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Skin/Fat Muscle Liver Kidney Fat Muscle Liver Kidney Fat Muscle Kidney Liver Skin/Fat 47 (1996); 54 (2000); 70 (2008) Tilmicosin. MRL (g/kg) 100 1000 300 100 150 2400 600 250 100 1500 1000 100 100 1000 300 100 100 1200 1400 250 CAC 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 34th (2011) 34th (2011) 34th (2011) 34th (2011) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 23rd (1999) 34th (2011) 34th (2011) 34th (2011) 34th (2011) Notes Acceptable Daily Intake: 0-40 g/kg body weight (47th JECFA, 1996).

TRENBOLONE ACETATE (growth promoter)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Tissue Muscle Liver 26 (1982); 27 (1983); 32 (1987); 34 (1989) Cattle muscle, beta-Trenbolone; Cattle liver, alpha-Trenbolone. MRL (g/kg) 2 10 CAC 21st (1995) 21st (1995) Notes Acceptable Daily Intake: 0-0.02 g/kg body weight (34th JECFA, 1989).

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TRICHLORFON (METRIFONATE) (insecticide)

JECFA Evaluation: 54 (2000); 60 (2003); 66 (2006) Acceptable Daily Intake: 0-2 g/kg bw (60th JECFA, 2003) Residue Definition: JECFA confirmed the MRL for cowss milk and the guidance levels for muscle, liver, kidney and fat of cattle recommended at the 54 th meeting (WHO TRS 900, 2001) MRLs(g/kg) 50 CAC 29th (2006) Notes

Species Cattle

Tissue Milk

TRICLABENDAZOLE (anthelmintic agent)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Cattle Cattle Sheep Sheep Sheep Sheep Tissue Muscle Liver Kidney Fat Muscle Liver Kidney Fat 40 (1992); 66 (2006); 70 (2008) Ketotriclabnedazole MRL (g/kg) 250 850 400 100 200 300 200 100 CAC 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) Notes Acceptable Daily Intake: 0-3 g/kg body weight (40th JECFA, 1993).

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TYLOSIN (antimicrobial agent)

JECFA Evaluation: 70 (2008) Acceptable Daily Intake: 0-30 g/kg body weight based on a microbiological end-point derived from in vitro MIC susceptibility testing and faecal binding data (MICcalc = 1.698) (70 th JECFA, 2008). Residue Definition: Species Cattle Cattle Cattle Cattle Cattle Pig Pig Pig Pig Chicken Chicken Chicken Chicken Chicken Tissue Muscle Liver Kidney Fat Milk Muscle Liver Kidney Fat Muscle Liver Kidney Fat/Skin Eggs Tylosin A. MRLs(g/kg) 100 100 100 100 100 100 100 100 100 100 100 100 100 300 CAC 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) 32nd (2009) Notes

ZERANOL (growth promoter)

JECFA Evaluation: Residue Definition: Species Cattle Cattle Tissue Muscle Liver 26 (1982); 27 (1983); 32 (1987) Zeranol. MRL (g/kg) 2 10 CAC 21st (1995) 21st (1995) Notes Acceptable Daily Intake : 0-0.5 g/kg body weight (32nd JECFA, 1987).