Академический Документы
Профессиональный Документы
Культура Документы
Blood Pressure
Carbohydrate Structure
Lipids Energy Budget
Estimating Risk
Identifying Health Risks Prevention and
Cholesterol
Caffeine affecting heart
Treatment of CVD
rate Vitamin C
Dipole
Positive H
Negative O Electrostatic
attraction between water molecules forming Hydrogen bonds Water molecules stick together
Components:
Functions:
Transports; digested food to diff parts of the body, food molecules from storage areas to cells that need them, excretory products to e.g. kidneys or lungs, hormones 2. Keeps body temp regular 3. Acts as a buffer to pH changes
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being lost when a blood vessel is damaged. A series or reactions occurs that leads to the formation of a blood clot. 1. Platelets releases two main substances; serotonin and thromboplastin. 2. Serotonin causes smooth muscle of blood vessels to contract. Blood flow cut off from damaged area. 3. Thromboplastin triggers the conversion of prothrombin (large protein) into thrombin (an enzyme) 4. Thrombin then catalyses the conversion of fibrinogen (soluble protein) to fibrin (solid insoluble fibres) 5. The fibrin fibres tangle together and form a mesh in which platelets and red blood cells get trapped forms a blood clot.
Learn the names of the different valves, arteries and veins for the exam.
as valve.
Arteries:
Narrow lumen. Smaller the further
Veins
Wide lumen Thinner walls (less smooth muscle
away from heart. Smallest branches are arterioles Thick muscular walls with elastic fibres Near heart=more elastic fibres and collagen(for strength and flexibility) Far from heart=more muscle tissue Smooth lining allow easy blood flow No valves Pumps oxygenated blood to the body Blood at high pressure
with few elastic fibres) Less collagen than arteries, but outer tough layer of mainly collagen fibres Has valves to stop backflow Pumps deoxygenated blood to the heart Blood at low pressure
arteries and their elastic wall stretch to accommodate the blood. When the heart relaxes, the elasticity of the artery walls causes them to recoil behind the blood, helping to push the blood forward. Pressure falls further away from heart
effect on the flow of blood through the veins. In the veins, blood flow is assisted by the contraction of skeletal muscles during movement of limbs and breathing. Backflow is prevented by semi lunar valves within the veins The steady flow without pulses of blood means that the blood is under low pressure in veins
atria contract, decreasing the volume of the chamber and increasing the pressure inside the chamber This pushes the blood into the ventricles. AV-valves are open There is a slight increase in ventricular pressure and chamber volume as the ventricles receive the ejected blood from the contracting atria.
contract, increasing their pressure. The pressure becomes higher in the ventricles than the atria, which forces the atrioventricular valves shut to prevent back-flow. The pressure in the ventricles is also higher than in the aorta and pulmonary artery, which forces open the semi-lunar valves and blood is forced out into the arteries.
Phase 3: Diastole The ventricles and atria both relax. The higher pressure in the pulmonary artery and aorta closes the semi-lunar valves to prevent back-flow into the ventricles. Blood returns to the heart and the atria fill again due to the higher pressure in the vena cava and pulmonary vein. This starts to increase the pressure of the atria. As the ventricles continue to relax, their pressure falls below the pressure of the atria and the atrioventrivular valves open this allows blood to flow passively into the ventricles from the atria The atria contract and the whole process starts again.
Pulmonary Artery
Aorta
Pulmonary vein
Vena Cava
Or Atrioventricular valve
Or Atrioventricular valve
What is it?
disease and strokes. Fatty deposits can either block an artery directly, or increase its chance of being blocked by a blood clot (thrombosis) the blood supply can be blocked completely and cells can be permanently damaged.
The endothelium (smooth lining of blood vessel) becomes damaged. result from high blood pressure which puts an extra strain on the layer of cells, or from toxins in cigarette smoke in the bloodstream.
artery is breached. White blood cells leave the blood vessel and move into the artery wall accumulates chemicals e.g. Cholesterol. A fatty deposit builds up called an atheroma A hard swelling called a plaque occurs as fibrous tissue and calcium salts build-up around the atheroma. Artery wall loses some of its elasticity. THIS IS ATHEROSCLEROSIS. Plaques cause the artery to become narrower. This makes it more difficult for the heart to pump blood around the body and can lead to a rise in blood pressure. Now there is a dangerous positive feedback plaques lead to raised blood pressure and raised blood pressure makes it more likely that plaques will form
narrowed coronary arteries (from a formation of a plaque) cannot supply enough oxygenated blood and heart muscle has to start anaerobically respiring.
Myocardial Infarction (Heart Attack): coronary artery
becomes fully blocked, heart muscle starved of oxygen. Many as a result of atherosclerosis. A clot that forms in a blood vessels is known as a thrombosis
brain
Either from bleeding from damaged blood capillaries
outcome The statistical chance of something unfavourable happening is supported by scientific research e.g. The actual risk of dying from CVD is 60% higher for smokers than non-smokers. Peoples perception may be different from actual risk
May overestimate the risk e.g. May have known someone who
smoked and died from CVD, therefore think if you smoke you will die of CVD. Articles and media give constant exposure which make people worry Underestimate risk, could be due from lack of information making them unaware of the factors that contribute to diseases like CVD.
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Diet high in saturated fats increases blood cholesterol level leads to atheroma formation, which leads to blood clots and therefore heart attack or stroke. High is salt increases risk of high blood pressure. High blood pressure increases risk of damage to the artery walls, which increases risk of atheroma formation leads to CVD. Smoking CO combines with haemoglobin and reduces amount of oxygen transported in the blood. Inactivity lack of exercise increases risk of CVD as it increases blood pressure
Genetics - inherit particular alleles that make them more likely to have high blood pressure or high blood cholesterol, more likely to suffer from CVD 2. Age risk of developing CVD increases with age. Arteries lose some of their elasticity 3. Gender men are 3 times more likely to suffer from CVD than pre-menopausal women
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Antihypertensives
Include diuretics, beta-blockers,
Statins
Reduce blood cholesterol
Sympathetic nerve inhibitors, ACE inhibitors Reduce high blood pressure less chance of damage to artery walls. Benefits different antihypertensives work in different ways, so can be given in combination. Blood pressure can be monitored at home Risks coughs, swelling of the ankles, impotence, tiredness, fatigue and constipation. Not serious compared to risks of high blood pressure
level by reducing amount of cholesterol abosorbed by the gut Block the enzyme in the liver that is responsible for making cholesterol Benefits reduce risk of developing CVD and atherosclerosis forming Risks muscle and joint aches, nausea, constipation, diorrhoea
Anticoagulants
E.g. Warfarin. Reduce blood clots
(thrombosis) blood clots are less likely to form at sites of damage in artery walls. Interferes with production of prothrombin
Benefits used to treat people who
already have blood clots or CVD or who have just had heart surgery. Prevent any existing blood clots from growing any larger and prevent any new blood clots from forming
Risks if person is badly injured, the
reduction of blood clotting can cause excessive bleeding, which can lead to fainting or even death. Other side effects are allergic reactions, osteoporosis and swelling of the tissues.
less sticky so they dont clump together to form a blood clot e.g. aspirin, clopidogrel Benefits can be used to treat people who already have blood clots or CVD, (but cant get rid of existing blood clots) Risks side effects including, irritates stomach lining, rashes, diarrhoea, nausea, liver function problems and excessive bleeding
considered to be one of the most common factors in the development of CVD. Systolic pressure pressure in the artery is at its highest, ventricles have contracted and forced blood into arteries Diastolic pressure pressure is at its lowest in the artery when the ventricles are relaxed
What determines blood pressure? Contact between blood and the walls cause friction, this
impedes the flow of blood peripheral resistance If the smooth muscles in the walls of an artery contract, the vessels constrict , increasing resistance blood pressure is raised. If the smooth muscles relax, the lumen is dilated, so peripheral resistance is reduced and blood pressure falls. Any factor that causes arteries or arterioles to constrict can lead to elevated blood pressure e.g. Natural loss of elasticity with age, adrenaline, high-salt diet.
organisms. Most carbohydrates are large, complex molecules composed of long chains of monosaccharides Glucose is a monosaccharide with 6 carbon atoms in each molecule
Structure of alpha- glucose.
bonds in a condensation reaction When 2 monosaccharides join together, they form a disaccharide Names of disaccarides: 1. Maltose glucose and glucose with a 1-4 glycosidic bond 2. Lactose glucose and galactose, 1-4 glycosidic bond 3. Sucrose glucose and fructose, 1-2 glycosidic bond
Two alpha glucose molecules can be joined together by a CONDENSATION REACTION in which a molecule of water is formed from two OH groups in the two molecules
Lots of glucose molecules are joined together by 1-4 glycosidic bonds to from amylose.
Animal cells get energy from glucose. Store excess glucose as glycogen. Lots of side branches glucose can be released quickly. Very compact molecule. Insoluble in water, doesnt cause cells to swell by osmosis. Large molecule, store lots of energy.
Starch is the main energy storage material in plants. Plants store excess glucose as starch Starch is a mixture of two polysaccharides; amylose & amylopectin.
Long, unbranched chain of glucose joined together with glycosidic bonds. Has a coiled structure to make it compact good for storage as you can fit more in to a small space
Long branched chain of glucose . Side branches allow enzymes that break down molecules to get to the glycosidic bonds easily. Glucose can be released quickly
All fatty acids consist of the same structure, but the hydrocarbon tail varies .
hydrolysis reactions Three fatty acids and a single glycerol are joined together by ester bonds A hydrogen atom on the glycerol molecule bonds to a hydroxyl (OH) group on the fatty acid, releasing a molecule of water. Reverse happens in hydrolysis molecule of water added to each ester bond to break it apart, and the triglyceride splits up into 3 fatty acids and one glycerol molecule .
Saturated and unsaturated lipids Saturated animal fats (butter) Unsaturated plants (olive oil). Melt at a lower temp The difference between these 2 types is their hydrocarbon
tails.
Does not have double bonds between carbon atoms every carbon is attached to at least 2 hydrogen atoms. saturated with hydrogen. Has double bonds between carbon atoms. Double bonds cause the chain to kink. If 2 or more, the lipid is called polyunsaturated.
processes which are ongoing, even when you are completely at rest. Basal metabolic rate (BMR) is the name given to energy needed for essential processes.
Normal weight equal energy input and output
Underweight - illness, diet, eating disorder. Excessive exercise, stress, high BMR Overweight overeating and low exercise
It is a lipid made in the body Some is needed to function normally Needs to be attached to protein to be moved around, do the body forms 1. 2. 3. 1. 2. 3.
lipoproteins High density lipoproteins (HDLs) Mainly protein Transport cholesterol from body tissues to the liver where its recycled or excreted. Function is to reduce total blood cholesterol when level is too high Low density lipoproteins (LDLs) Mainly lipid Transport cholesterol from liver to the blood, where it circulates until needed by cells Function is to increase total blood cholesterol when level is too low.
This is because it increases blood cholesterol level. This increases atheroma formation which can lead formation of blood clots which can cause heart attacks and strokes.
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effect of caffeine on the heart rate. Make up a range of caffeine solutions of different concentrations, with control solution with no caffeine Transfer one daphnia into dimple of cavity slide Place slide onto the stage of a light microscope and focus on bating of the heart Place small drop of caffeine solution onto daphnia Count number of heartbeats in 10 secs and multiply by 6 to calculate beats per min. Repeat with all caffeine solutions, keeping all factors constant Compare results to see how caffeine concentration affects heart rate.
Ethical Issues:
Studying animal allows scientists to study things unethical to study using humans 2. But using animals can also be seen as unethical cant give consent 3. Some believe more acceptable to perform experiments on invertebrates than on vertebrates simpler organisms which have much less sophisticated nervous system 4. Could cause distress or suffering to living organism
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Investigation to test how much vitamin C is in fruit juices: 1. Have about 6 different fruit juices of known concentrations 2. Measure out a set volume of DCPIP into a test tube 3. Add one of the fruit juices to the DCPIP, drop by drop, using a 4. 5. 6. 7. 8. 9.
pipette. Gently shake the test tube after each drop of fruit juice is added When the solution turns colourless, record the volume of fruit juice that has been added Repeat experiment twice more, with same solution to record an average Make sure all other variables are kept constant Use the results to make a line graph, showing volume of vitamin C solution against its concentration calibration curve This means an unknown solution can be tested in same way to find vitamin C content