ERRATA 4TH EDITION RAPID REVIEW PATHOLOGY (12-52013)

Page 18 C.2.b. Neutralizeshydroxyl, and NADPQI (letter not number)..FRs. Page 18 D.1.b.cytochrome P450 isoenzyme into a toxic intermediated called NADPQI (letter not the number) (drug FR.) (1) conversion is called CYP2EI (letter, not number) (3) Liver cell necrosis may. Alcohol CYP2EI isoenzymeconverted to NADPQI (letter not number) 1.c.(2) Glutathione.levels of NADPQI (letter not number) Page 18 Margin note corrections 8th from bottom: Glutathione peroxidase: neutralizes H2O2, hydroxyl, NADPQI (letter not number) FRs 3rd from bottom: Acetaminophen poisoning: diffuse chemical hepatitis due to NADPQI (letter not number) 2nd from bottom: Alcohol: induces synthesis of CYP2EI (letter, not number) isoenzyme Page 33 Margin note correction 2nd from bottom: BCl2 gene family:..proapoptotic genes (BAX, BAK) Page 46 Margin note correction Bottom: S phase: synthesis of Page 59 Table 4-2 Under CD4 T cell functions and directly beneath the heading: After Activate B cells to produce: add the following new sentence Memory CD4 TH1 cells critical reservoir for HIV in latency phase Page 72 Make 4-10 schematic smaller so the additional sentence below can be added D.3. add c. When newborns receive RBC transfusions, blood is irradiated to destroy lymphocytes that may produce GVH.

Page 84 2.a.(1) HIV is cytotoxic. Memory CD4 T cells, due to their long life spans, are the critical reservoir for maintenance of latent HIV-1 proviral DNA. Margin note opposite 2.a.(3) Margin note: Memory CD4 T cells: critical reservoir for maintenance latent HIV-1 proviral DNA New Margin note under above: Other reservoir cells: macrophages, dendritic cells 2.b.(2) Follicular dendritic cells.are important (delete the major) reservoir cells Change Margin note next to 2.b. to: Follicular dendritic cells: important (delete major) HIV reservoir during latency Page 291 Fig. 12-11B cis configuration for Asian type of -thal trait is incorrect. Should look like the schematic below.
This is correct

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Page 298 H.2. Propionyl CoA.,in turn, is converted to succinyl CoA Page 312 Table 12-7: Cold antibodies (IgM) Secondary Infectious mononucleosis (anti-i antibodies) Page 357 I.2.a. Evaluates the Factors that are evaluated include XII, XI, IX, VIII. Also correct Margin note next to it: PTT evaluatesVIII. Page 369 Gray shaded area at bottom of page 6 lines down: When newborns receive RBC transfusions, the blood must be irradiated to destroy lymphocytes that may produce transfusion associated-graft versus host disease. The radiation dose cannot kill viruses (e.g., CMV). Special filters that remove leukocytes notably reduce transmission of CMV and other infections. Because a newborns cellular Page 471 Table 19-4 Viral hepatitis Under Hepatitis A 4 Sentences down Second most common reported acute hepatitis in the U.S. Under Hepatitis B in the table, replace the 4th sentence down that starts with Primarily to the following: Primarily contracted via blood: IVDA ~18% of cases, accidental needle stick 4.5% of cases. Most common reported acute hepatitis ComplicationsHepatocellular carcinoma secondary to postnecrotic cirrhosis (10%-15% of cases) Under Hepatitis C in the table Transmission: oral-fecal no., blood yes; IVDA (60% of cases), sexual exposure (20% of cases), accidental needle stick (9% of cases; HCV most common cause of hepatitis in health care workers) Sentence after Transmission, replace the entire sentence with the following: Most common chronic hepatitis (leave out chronic blood borne infection) in the U.S. Third most common reported acute hepatitis in the U.S. Complications: most common cause of hepatocellular carcinoma (HCC) secondary to postnecrotic cirrhosis (leave out the parenthesis with 1-3% risk per year for developing HCC)

Page 490 (discussion of Hepatocellular carcinoma) C.2.a.(4) (a)HBV (3rd most common cause) and HCV (most common cause) (b) Alcoholic cirrhosis (2nd most common cause of HCC) Replace Margin note next to above changes: HCC: MCC HCV postnecrotic necrosis; alcohol/HBV 2nd/3rd MCC Page 607 4.d.(1) Causes partial depolarization of nerves and muscle (delete) (a) Decreased serum ionized calcium causes increased excitability of nerves (b) Due to increased membrane permeability to sodium ions allowing initiation of action potential (c) Increased nerve impulses cause tetanic contractions of peripheral muscle (tetany) DELETE Margin note next to sentence and put in the following: Tetany: membrane permeability to Na+action potentialstetanic contractions muscle Page 709 Table 26-2 DELETE .upper and and. Should read: Destroys lower motor neurons
Poliovirus Encephalitis and myelitisspinal cord Destroys DELETE upper and lower motor neurons. Causes muscle paralysis. Post-polio syndrome: occurs in ~50% of people with previous poliomyelitis. Usually occurs 1530 years after original infection. Increased muscular weakness/ pain in muscle groups already affected. Excessive fatigue.