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UAS Pharmaceuticals Pty. Ltd.

A.B.N. 64 093 394 748

Neutriderm Anti Dandruff Shampoo


Common cutaneous conditions lead to dandruff, itch, and inflammation Dandruff, also called scurf or pityriasis capitis - describes any excess flaking of dead skin cells, especially from the scalp. While normal light shedding remains discreet, some people suffer unusually obvious exudates, often accompanied by greasiness and irritation. Skin diseases that cause dandruff include seborrheic dermatitis and dry pityriasis, the most common conditions, plus atopic dermatitis, pityriasis versicolor, tinea capitis, psoriasis, and contact dermatitis. Seborrheic dermatitis causes greasy ashen chunks of dead skin to shed from scalp, ears, nose, and other oily areas, sometimes accompanied by itch, inflammation, or hair loss. White or yellow scales collect on dark clothing. Called cradle cap in infants, seborrheic dermatitis may be the single most chronic inflammatory skin condition, with cycles of inactivity and flare up. Generated by hyper seborrhea in the presence of certain fungi, dermatitis runs in families, made worse by stress, fatigue, weather, acne, infrequent shampooing, lotions with alcohol, and obesity. Parkinsons disease, head injury, stroke, and HIV are also linked. Neutriderm Anti Dandruff Shampoo targets all primary etiological agents of seborrheic dermatitis. Dry pityriasis occurs when insufficient sebum production combines with a dehydrated environment. Simple aridity generates desquamation of fine, dry, white scales. Neutriderm Anti Dandruff Shampoo has ingredients to regulate hypo seborrhea. Atopic dermatitis has a strong genetic component, although its exact pathway is not elucidated. Fungi are not the causative agents of this chronic inflammatory skin disease, associated with asthma and hay fever, but rather serve as exogenous triggers. Others include food, dust mites, topical irritants, psychology, and climate. Chronic dermatophyte infections also plague atopic patients. Neutriderm Anti Dandruff Shampoo targets several of the triggers for atopic dermatitis. Pityriasis versicolor (tinea versicolor) afflicts neck, upper trunk, and arms with a chronic non-inflammatory infection caused by lipophilic fungus of the genus Malassezia, marked by irregular macular patches that appear lighter or darker than normal skin. Neutriderm Anti Dandruff Shampoo inhibits both Malassezia and seborrhea. Tinea capitis is an infection of the scalp caused by fungi of the genera Trichophyton and Microsporum, characterized by scaly patches and a few dry brittle hairs. Neutriderm Anti Dandruff Shampoo inhibits a broad range of pathogenic fungi. Psoriasis rapidly turns dead skin cells into large, thick, silvery scales, most commonly on the knees, elbows, trunk, and scalp. Diagnosis of the desquamative disease, believed to be immune-mediated and not contagious, is based on appearance, not blood tests or diagnostic procedures.

15 Cansdale Place, Castle Hill, NSW 2154, Australia Tel: 61 2 9899 4310, Fax: 61 2 9899 5871, Email: admin@uaspharma.com Website: www.uaspharma.com

UAS Pharmaceuticals Pty. Ltd.


A.B.N. 64 093 394 748

Contact dermatitis describes inflammation that results when hair dyes, gels, sprays, even some dandruff medications come in contact with some skin. Fungi metabolize sebum, trigger dandruff Dandruff gets blamed on dry skin, oily skin, shampooing too much, not shampooing enough, poor diet, rich diet, stress, and styling products. Any can be partly true, but current science has established the essential actors to be a genus of cutaneous yeasts called Malassezia, in the kingdom Fungi. When hungry Malassezia encounter excess sebum, dandruff ensues. The lipophilic microbes have a taste for that savory mix of glycerides, free fatty acids, wax, and squalene more commonly known as skin oil, which explains why dandruff flares in puberty as hormones activate sebaceous glands. A high density of glands makes scalp uniquely susceptible to mycotic infection. Normally as the epidermis replaces itself, dead skin cells push out and flake off in about a month. In the presence of Malassezia with seborrhea, however, cells can slough off in two to seven days, resulting in large, oily, visible clumps on hair and clothing. Neutriderm Anti Dandruff Shampoo contains multiple compounds designed to inhibit the fungi, dampen the seborrhea, slow the cell cycle, and hide the evidence. Pathology pinned on Malassezia Malassezia lives in harmony with healthy scalps unless it feeds on excess sebum and proliferates, causing acidic irritation and increased cell turnover. A frenzy of scratching with an avalanche of scales, clumped together in a flood of sebum, litters hair and clothing. Ten million specimens of Malassezia may live on a single human head. Current research blames Malassezia globosa as the species most responsible for seborrheic dermatitis and dandruff, as well as for pityriasis versicolor (tinea versicolor). Malassezia globosa feeds on fat, so it thrives in areas rich in sebaceous glands: scalp, face, and upper body. It metabolizes the triglycerides in sebum through the expression of lipase. An irritating byproduct, oleic acid, penetrates the stratum corneum and triggers an inflammatory response in susceptible people. Homeostasis thus disturbed the erratic cleavage of corneocytes results. Malassezia reproduce by unilateral budding, leaving prominent scars on mother cells, which may be bottle-shaped, globose, ovoid, or cylindrical, and have thick multilayered cell walls made of Mann proteins (75 to 80 percent), lipids (15 to 20 percent), and chitin (one or two percent). The fungi do not spread out evenly along the stratum corneum. Rather they clump on some corneocytes while leaving others alone, suggesting a defect in controls, perhaps antimicrobial peptides or nitric oxide.
15 Cansdale Place, Castle Hill, NSW 2154, Australia Tel: 61 2 9899 4310, Fax: 61 2 9899 5871, Email: admin@uaspharma.com Website: www.uaspharma.com

UAS Pharmaceuticals Pty. Ltd.


A.B.N. 64 093 394 748

Oily scalp: Pathogenic Malassezia yeasts feast on scalp oils. Age: Dandruff usually begins in young adulthood, when sebaceous glands are stimulated by testosterone, and continues into middle age. Gender: More men than women suffer with dandruff, further suggesting a role for testosterone. Illness: Adults with neurological diseases like Parkinsons are more likely to develop seborrheic dermatitis and dandruff, as are people recovering from heart attack and stroke and those with compromised immune systems. Dandruff and baldness share the common etiology of hyper seborrhea, but are there any other links? One 2006 Iranian study finds that of participants who are not shedding hair, only nine percent carry Malassezia, but of the participants who are suffering hair loss, 90 percent carry the yeast - 10 times more. Neutriderm Anti Dandruff Shampoo controls serious dandruff Dandruff can be controlled. Mild cases may require nothing more than daily shampooing with a gentle cleanser to remove flakes. Even stubborn scaling responds to advanced medicated shampoos such as Neutriderm Anti Dandruff Shampoo. New generation formulas contain several ingredients, including surfactants to cleanse, conditioners to impart luster and volume, and therapeutic ingredients to cut scaling and seborrhea. Early dandruff formulas were based on coal tar, zinc pyrithione, or selenium sulphide. Neutriderm Anti Dandruff Shampoo, the only true multilateral antidandruff shampoo, reduces flakiness and itch dramatically because it deploys the most potent antimicrobial agent - Climbazole. Early dandruff shampoos worked, but Coal tar (Tegrin, Neutrogena T/Gel) operates by slowing cell turnover. But dark, viscose, and tar can stain blond, gray, or bleached hair, irritate some skin, and make users smell a bit like telephone poles. Coal tars and pitches go into creosote, naphthalene and anthracene oils, coatings, pesticides, ointments, creams, cleansing bars, and shampoos. Occupational exposure is associated with various cancers in pitch loaders, briquette and electrical workers, lens polishers, and roofers. After California required coal-tar shampoos over 0.5% to carry cancer warnings, some brands stopped selling there, others replaced their active ingredients with something else. The US Food and Drug Administration, however, maintain that coal-tar concentrations under 5% are safe. Zinc pyrithione (Head & Shoulders, Pert Plus, and Selsun) operates by inactivating bacteria, fungi, mildew, and algae, as first reported in the 1930s. Now the highest-grossing
15 Cansdale Place, Castle Hill, NSW 2154, Australia Tel: 61 2 9899 4310, Fax: 61 2 9899 5871, Email: admin@uaspharma.com Website: www.uaspharma.com

UAS Pharmaceuticals Pty. Ltd.


A.B.N. 64 093 394 748

shampoo in the United States, Head & Shoulders was current science back in the 1950s when it was developed by consumer-products giant Procter & Gamble. Selenium sulfide (Selsun Blue) operates by helping to slow cell turnover and may also reduce Malassezia yeast. Selenium can discolor blond, gray, or chemically treated hair. Salicylic acid and sulfur (Sebulex, T-Sal) operate as a scalp scrub to help eliminate scales, but dryness sometimes leads to more scales. A conditioner can help to counter the dryness. Next-generation shampoos work better Climbazole (Neutriderm Anti Dandruff Shampoo) exerts maximum efficacy against the Malassezia furfur and Malassezia globosa that generate moderate to severe seborrheic dermatitis and dandruff. Pioneering studies of azole technology demonstrate that a shampoo based on Climbazole delivers the most successful reduction of dandruff, redness, and itching, achieved by 80 percent of volunteers. Polyquaterium-10 A complex, cationic polymeric conditioning agent derived from wood cellulose. Provides body while it improves curl bounce and adds fullness to the hair. It further improves wet and dry combing, detangling, and imparts sheen, adding a silky feel to the hair. Citric Acid A naturally-derived, food-grade acid commonly found in citrus fruits and vegetables; maintains proper pH balance and restores acid mantle of the hair and scalp.

Iodopropynyl Butylcarbamate A preservative that prevents the bacterial and microbial contamination of cosmetic products.

Hydrolyzed Wheat Protein is manufactured with carefully monitored hydrolysis to ensure a Complex of Polypeptides ranging in molecular weights from a high of 50,000 down to 300, those of Amino Acids. The object of having such a broad distribution is to provide the damaged hair substrates with a wide range of chain lengths. This optimizes penetration into the cortex thus conditioning and repairing the hair from the inside out while its continuous protective Film-Forming properties fills damaged gaps, and lays the cuticle down by linking platelets of protein molecules. These Penetrating, Bonding & Shielding properties leave a lustrous and mirror-like shine with excellent Conditioning effects. (Not mentioned on label, as you cant put all ingredients on label)

15 Cansdale Place, Castle Hill, NSW 2154, Australia Tel: 61 2 9899 4310, Fax: 61 2 9899 5871, Email: admin@uaspharma.com Website: www.uaspharma.com

UAS Pharmaceuticals Pty. Ltd.


A.B.N. 64 093 394 748

Sodium PCA, otherwise known as the sodium salt of pyrrolidone carbonic acid, is a humectant that is naturally occurring in the skin. It is a derivative of amino acids that is very water absorbing. It is also hygroscopic, meaning that it absorbs moisture from the air. Sodium PCA feeds moisture to the hair. Sodium PCA is non-irritating to the skin and eyes, non-comedogenic and is water and ethanol soluble. It is not soluble in oils. (Not mentioned on label, as you cant put all ingredients on label) The combined effect of Hydrolyzed Wheat Protein & Sodium PCA: Excellent Hair Repair Ingredient Wide Dalton Range (300-50,000) Adds Healthy Shine & Luster Anti-Aging & Skin Moisturizing Excellent Film Former Rich Amino Acid Profile

Lactic Acid has Keratolytic & Exfoliant action. It stablises epidermal proliferation & moisturizes. (Not mentioned on label, as you cant put all ingredients on label) Lifestyle practices affect dandruff In addition to using Neutriderm Anti Dandruff Shampoo to inhibit fungi and dampen seborrhea, these additional steps may reduce dandruff further. Manage stress: Tension can make people susceptible to disease generally and stimulate dandruff production. Shampoo often: Oily scalps should get shampooed vigorously daily to help loosen scales and stimulate circulation. Several times per week, use an updated antidandruff formula such as Neutriderm Anti Dandruff Shampoo, with fungicidal Climbazole, ketoconazole, and botanicals, to inhibit yeast and seborrhea. Let it work: When using a medicated shampoo, massage well and allow lather to contact the scalp for at least five minutes. Rinse thoroughly. Handle gently: Let hair dry naturally instead of blowing it with heat. Brush with steady strokes to carry oil from scalp to strands, which need it to stay healthy. Avoid products: Hair sprays, gels, mousses, and waxes all build up on scalps and make them greasier. Eat right: A diet rich in B and E vitamins, zinc, selenium, and essential fatty acids may help quell dandruff. Get some sun: While prolonged exposure to ultraviolet light damages skin and increases risk of cancer, a few minutes of sun on the scalp can help inhibit fungal proliferation and dandruff.
15 Cansdale Place, Castle Hill, NSW 2154, Australia Tel: 61 2 9899 4310, Fax: 61 2 9899 5871, Email: admin@uaspharma.com Website: www.uaspharma.com

UAS Pharmaceuticals Pty. Ltd.


A.B.N. 64 093 394 748

Climbazole tops newest antifungal trials Neutriderm Anti Dandruff Shampoo stops dandruff more effectively than shampoos based on coal tar, zinc pyrithione, or selenium sulphide, because Neutriderm Anti Dandruff Shampoo incorporates Climbazole, a broad-spectrum antimycotic proven in vitro and in vivo as the most effective against Malassezia furfur (Pityrosporum ovale) and Malassezia globosa, the fungi that generate scales. Plus, Climbazole is hygroscopic, so it does not deplete cutaneous moisture. Proprietary clinical studies of Climbazole, tested in vivo at 0.5% and 1.5% concentrations and compared against common dandruff ingredients as well as placebo, demonstrate dramatic reductions of dandruff. After four weeks, applied three times per week, the score for placebo edges down by just 16 percent, while the score for 0.5% Climbazole falls by 49 percent and the score for 1.5% Climbazole sinks an impressive 66 percent. Success continues at eight weeks; with the 0.5% Climbazole score down by 69 percent and the 1.5% Climbazole score down an astounding 82 percent. A 2001 German study on volunteers with moderate washout and four week reduction in dandruff, skin safety and efficacy of 0.65% Climbazole shampoo follows 30 to severe seborrheic dermatitis of the scalp. After a one week course of treatment, clinical evaluation shows a successful redness, and itching for 80 percent of the volunteers.

A 1996 German trial compares four dissimilar compounds - Climbazole, piroctone olamine, selenium disulfide, and zinc pyrithione - against 22 strains of Malassezia furfur, anthropophilic yeast associated with dandruff. The mean minimum inhibitory concentration (MIC) for Climbazole proves to be just 0.03 m/ml, dramatically less than all others. Zinc pyrithione, the most common ingredient in mass-market dandruff shampoos, requires much greater concentration, 1.0 m/ml. Selenium disulfide requires a full 8.0 m/ml. Piroctone olamine requires 64 m/ml, by far the least active. Neutriderm Anti Dandruff Shampoo contains Climbazole. Another 1996 German study looks at in-vitro MIC's for four azole compounds often used in topical therapy - bifonazole, Climbazole, clotrimazole, and ketoconazole - against 30 isolates of Malassezia furfur, a lipophilic fungus found on scalps with dandruff. Climbazole exerts high antifungal actions, with ketoconazole, bifonazole lower and clotrimazole the least active.

15 Cansdale Place, Castle Hill, NSW 2154, Australia Tel: 61 2 9899 4310, Fax: 61 2 9899 5871, Email: admin@uaspharma.com Website: www.uaspharma.com

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